DE102004051830B4 - Multifunktionales Referenzsystem bei Analytbestimmungen durch Fluoreszenz - Google Patents

Multifunktionales Referenzsystem bei Analytbestimmungen durch Fluoreszenz Download PDF

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Publication number
DE102004051830B4
DE102004051830B4 DE102004051830A DE102004051830A DE102004051830B4 DE 102004051830 B4 DE102004051830 B4 DE 102004051830B4 DE 102004051830 A DE102004051830 A DE 102004051830A DE 102004051830 A DE102004051830 A DE 102004051830A DE 102004051830 B4 DE102004051830 B4 DE 102004051830B4
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Germany
Prior art keywords
analyte
reference substance
substance
luminescence
quenched
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
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DE102004051830A
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German (de)
English (en)
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DE102004051830A1 (de
Inventor
Carina Dr. Horn
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Roche Diagnostics GmbH
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Roche Diagnostics GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to DE102004051830A priority Critical patent/DE102004051830B4/de
Application filed by Roche Diagnostics GmbH filed Critical Roche Diagnostics GmbH
Priority to CA2585041A priority patent/CA2585041C/en
Priority to EP05798048A priority patent/EP1805503A1/de
Priority to HK08103503.6A priority patent/HK1113405B/xx
Priority to JP2007537234A priority patent/JP4954078B2/ja
Priority to PCT/EP2005/011448 priority patent/WO2006045596A1/de
Priority to CN200580036606XA priority patent/CN101048651B/zh
Priority to US11/666,198 priority patent/US8759112B2/en
Publication of DE102004051830A1 publication Critical patent/DE102004051830A1/de
Application granted granted Critical
Publication of DE102004051830B4 publication Critical patent/DE102004051830B4/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/6428—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes"
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/84—Systems specially adapted for particular applications
    • G01N21/8483—Investigating reagent band
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G01N33/582—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with fluorescent label
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/66—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving blood sugars, e.g. galactose
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/6428—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes"
    • G01N2021/6432—Quenching
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/6428—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes"
    • G01N2021/6439—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes" with indicators, stains, dyes, tags, labels, marks
    • G01N2021/6441—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes" with indicators, stains, dyes, tags, labels, marks with two or more labels

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Physics & Mathematics (AREA)
  • Hematology (AREA)
  • Biochemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Urology & Nephrology (AREA)
  • General Health & Medical Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Diabetes (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Optics & Photonics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
DE102004051830A 2004-10-25 2004-10-25 Multifunktionales Referenzsystem bei Analytbestimmungen durch Fluoreszenz Expired - Fee Related DE102004051830B4 (de)

Priority Applications (8)

Application Number Priority Date Filing Date Title
DE102004051830A DE102004051830B4 (de) 2004-10-25 2004-10-25 Multifunktionales Referenzsystem bei Analytbestimmungen durch Fluoreszenz
EP05798048A EP1805503A1 (de) 2004-10-25 2005-10-25 Multifunktionales referenzsystem bei analybestimmungen durch fluoreszenz
HK08103503.6A HK1113405B (en) 2004-10-25 2005-10-25 Multifunctional reference system for use in analyte detection by fluorescence
JP2007537234A JP4954078B2 (ja) 2004-10-25 2005-10-25 蛍光による分析対象物質の決定における多機能参照システム
CA2585041A CA2585041C (en) 2004-10-25 2005-10-25 Multifunctional reference system for analyte determinations by fluorescence
PCT/EP2005/011448 WO2006045596A1 (de) 2004-10-25 2005-10-25 Multifunktionales referenzsystem bei analybestimmungen durch fluoreszenz
CN200580036606XA CN101048651B (zh) 2004-10-25 2005-10-25 多功能荧光分析检测参比体系
US11/666,198 US8759112B2 (en) 2004-10-25 2005-10-25 Multifunctional reference system for analyte determinations by fluorescence

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE102004051830A DE102004051830B4 (de) 2004-10-25 2004-10-25 Multifunktionales Referenzsystem bei Analytbestimmungen durch Fluoreszenz

Publications (2)

Publication Number Publication Date
DE102004051830A1 DE102004051830A1 (de) 2006-04-27
DE102004051830B4 true DE102004051830B4 (de) 2007-12-13

Family

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Family Applications (1)

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DE102004051830A Expired - Fee Related DE102004051830B4 (de) 2004-10-25 2004-10-25 Multifunktionales Referenzsystem bei Analytbestimmungen durch Fluoreszenz

Country Status (7)

Country Link
US (1) US8759112B2 (https=)
EP (1) EP1805503A1 (https=)
JP (1) JP4954078B2 (https=)
CN (1) CN101048651B (https=)
CA (1) CA2585041C (https=)
DE (1) DE102004051830B4 (https=)
WO (1) WO2006045596A1 (https=)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102008057115A1 (de) * 2008-11-13 2010-05-20 Lre Medical Gmbh Verfahren zur quantitativen Bestimmung der Konzentration von Fluorophoren einer Substanz in einer Probe und Vorrichtung zu seiner Durchführung
DE102021102505A1 (de) 2020-12-21 2022-06-23 Endress+Hauser Conducta Gmbh+Co. Kg Optochemischer Sensor sowie Verfahren zum Messen von lumineszierenden Analyten in einem Messmedium

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX2011009387A (es) 2009-03-20 2011-09-28 Hoffmann La Roche Elemento de prueba para analizar un fluido corporal y metodo para su medicion.
CN103974655B (zh) * 2011-11-14 2016-03-30 霍夫曼-拉罗奇有限公司 用于检测样品中至少一种分析物的分析仪器

Citations (8)

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US4255053A (en) * 1977-05-06 1981-03-10 Max-Planck-Gesellschaft Zur Forderung Der Wissenschaften E.V. Photometer including auxiliary indicator means
DE3852108T2 (de) * 1987-09-03 1995-03-23 Terumo Corp Vorrichtung und verfahren zur optischen messung der konzentration an material.
DE69513683T2 (de) * 1994-10-31 2000-06-08 Minnesota Mining And Mfg. Co., Saint Paul Ionensensor und Verfahren zu dessen Herstellung
DE19903506A1 (de) * 1999-01-29 2000-08-10 Inst Chemo Biosensorik Verfahren, Gefäß und Vorrichtung zur Überwachung der Stoffwechselaktivität von Zellkulturen in flüssigen Medien
WO2002103334A1 (de) * 2001-06-18 2002-12-27 Presens Precision Sensing Gmbh Sauerstoffsensoren auf mikrotiterplatte
EP1394219A1 (en) * 1999-06-09 2004-03-03 Carnegie-Mellon University PH sensitive cyanine dyes as reactive fluorescent reagents
DE10248555A1 (de) * 2002-10-18 2004-05-06 Roche Diagnostics Gmbh Verfahren zur Erkennung und Kompensation der Unterdosierung von Teststreifen
DE69630531T2 (de) * 1995-09-12 2004-08-12 Optical Sensors Inc., Minneapolis FLUORESZENZMETHODE MIT GLEICHZEITIGER DOPPELANREGUNG/EINFACHEMISSION ZUR MESSUNG VON pH UND pCO2

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US4420566A (en) * 1982-06-10 1983-12-13 Eastman Kodak Company Method and apparatus for detecting sample fluid on an analysis slide
WO1983000931A1 (en) 1981-09-08 1983-03-17 Eastman Kodak Co Method and apparatus for detecting sample fluid
US5057427A (en) * 1988-04-07 1991-10-15 Sepracor, Inc. Method for resolution of stereoisomers
US5114350A (en) * 1989-03-08 1992-05-19 Cholestech Corporation Controlled-volume assay apparatus
JP2855447B2 (ja) 1989-06-15 1999-02-10 三菱レイヨン株式会社 トナー
ATE106566T1 (de) * 1989-11-21 1994-06-15 Bayer Ag Optischer biosensor.
AU8720891A (en) 1991-01-04 1992-08-17 Iowa State University Research Foundation Inc. An optical probe and method for monitoring an analyte concentration
US6602716B1 (en) * 1997-08-01 2003-08-05 Presens Precision Sensing Gmbh Method and device for referencing fluorescence intensity signals
WO1999046600A1 (en) * 1998-03-11 1999-09-16 Sensors For Medicine And Science, Inc. Detection of analytes by fluorescent lanthanide chelates
US6204067B1 (en) * 1999-06-17 2001-03-20 Board Of Trustees Operating Michigan State University Methods of identifying modulators of the estrogen receptor
DE10101576B4 (de) 2001-01-15 2016-02-18 Presens Precision Sensing Gmbh Optischer Sensor und Sensorfeld
DE10151217B4 (de) * 2001-10-16 2012-05-16 Carl Zeiss Microlmaging Gmbh Verfahren zum Betrieb eines Laser-Scanning-Mikroskops
KR101002194B1 (ko) * 2002-05-16 2011-01-13 에프. 호프만-라 로슈 아게 중합체 층의 제조 방법
US7198756B2 (en) * 2002-07-11 2007-04-03 Optical Sensors Incorporated Non-invasive measurement of pH

Patent Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4255053A (en) * 1977-05-06 1981-03-10 Max-Planck-Gesellschaft Zur Forderung Der Wissenschaften E.V. Photometer including auxiliary indicator means
DE3852108T2 (de) * 1987-09-03 1995-03-23 Terumo Corp Vorrichtung und verfahren zur optischen messung der konzentration an material.
DE69513683T2 (de) * 1994-10-31 2000-06-08 Minnesota Mining And Mfg. Co., Saint Paul Ionensensor und Verfahren zu dessen Herstellung
DE69630531T2 (de) * 1995-09-12 2004-08-12 Optical Sensors Inc., Minneapolis FLUORESZENZMETHODE MIT GLEICHZEITIGER DOPPELANREGUNG/EINFACHEMISSION ZUR MESSUNG VON pH UND pCO2
DE19903506A1 (de) * 1999-01-29 2000-08-10 Inst Chemo Biosensorik Verfahren, Gefäß und Vorrichtung zur Überwachung der Stoffwechselaktivität von Zellkulturen in flüssigen Medien
EP1394219A1 (en) * 1999-06-09 2004-03-03 Carnegie-Mellon University PH sensitive cyanine dyes as reactive fluorescent reagents
WO2002103334A1 (de) * 2001-06-18 2002-12-27 Presens Precision Sensing Gmbh Sauerstoffsensoren auf mikrotiterplatte
DE10248555A1 (de) * 2002-10-18 2004-05-06 Roche Diagnostics Gmbh Verfahren zur Erkennung und Kompensation der Unterdosierung von Teststreifen

Non-Patent Citations (1)

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Analytica Chimica Acta, 501, 2004, S. 55-60 *

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102008057115A1 (de) * 2008-11-13 2010-05-20 Lre Medical Gmbh Verfahren zur quantitativen Bestimmung der Konzentration von Fluorophoren einer Substanz in einer Probe und Vorrichtung zu seiner Durchführung
US8334522B2 (en) 2008-11-13 2012-12-18 Lre Medical Gmbh Method for the quantitative determination of the concentration of fluorophores of a substance in a sample and apparatus for carrying out the same
DE102008057115B4 (de) * 2008-11-13 2013-11-28 Lre Medical Gmbh Verfahren zur quantitativen Bestimmung der Konzentration von Fluorophoren einer Substanz in einer Probe und Vorrichtung zu seiner Durchführung
DE102021102505A1 (de) 2020-12-21 2022-06-23 Endress+Hauser Conducta Gmbh+Co. Kg Optochemischer Sensor sowie Verfahren zum Messen von lumineszierenden Analyten in einem Messmedium

Also Published As

Publication number Publication date
CN101048651B (zh) 2011-09-14
US20080014655A1 (en) 2008-01-17
JP4954078B2 (ja) 2012-06-13
CA2585041A1 (en) 2006-05-04
CA2585041C (en) 2011-12-13
CN101048651A (zh) 2007-10-03
HK1113405A1 (en) 2008-10-03
WO2006045596A1 (de) 2006-05-04
US8759112B2 (en) 2014-06-24
DE102004051830A1 (de) 2006-04-27
JP2008518199A (ja) 2008-05-29
EP1805503A1 (de) 2007-07-11

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8364 No opposition during term of opposition
R119 Application deemed withdrawn, or ip right lapsed, due to non-payment of renewal fee