CN101048651B - 多功能荧光分析检测参比体系 - Google Patents

多功能荧光分析检测参比体系 Download PDF

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Publication number
CN101048651B
CN101048651B CN200580036606XA CN200580036606A CN101048651B CN 101048651 B CN101048651 B CN 101048651B CN 200580036606X A CN200580036606X A CN 200580036606XA CN 200580036606 A CN200580036606 A CN 200580036606A CN 101048651 B CN101048651 B CN 101048651B
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China
Prior art keywords
analyte
reference material
luminous signal
luminous
sample
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Expired - Fee Related
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CN200580036606XA
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English (en)
Chinese (zh)
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CN101048651A (zh
Inventor
C·霍恩
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F Hoffmann La Roche AG
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F Hoffmann La Roche AG
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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/6428—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes"
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/84—Systems specially adapted for particular applications
    • G01N21/8483—Investigating reagent band
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G01N33/582—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with fluorescent label
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/66—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving blood sugars, e.g. galactose
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/6428—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes"
    • G01N2021/6432—Quenching
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/6428—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes"
    • G01N2021/6439—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes" with indicators, stains, dyes, tags, labels, marks
    • G01N2021/6441—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes" with indicators, stains, dyes, tags, labels, marks with two or more labels

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Physics & Mathematics (AREA)
  • Hematology (AREA)
  • Biochemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Urology & Nephrology (AREA)
  • General Health & Medical Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Diabetes (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Optics & Photonics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
CN200580036606XA 2004-10-25 2005-10-25 多功能荧光分析检测参比体系 Expired - Fee Related CN101048651B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE102004051830A DE102004051830B4 (de) 2004-10-25 2004-10-25 Multifunktionales Referenzsystem bei Analytbestimmungen durch Fluoreszenz
DE102004051830.0 2004-10-25
PCT/EP2005/011448 WO2006045596A1 (de) 2004-10-25 2005-10-25 Multifunktionales referenzsystem bei analybestimmungen durch fluoreszenz

Publications (2)

Publication Number Publication Date
CN101048651A CN101048651A (zh) 2007-10-03
CN101048651B true CN101048651B (zh) 2011-09-14

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Family Applications (1)

Application Number Title Priority Date Filing Date
CN200580036606XA Expired - Fee Related CN101048651B (zh) 2004-10-25 2005-10-25 多功能荧光分析检测参比体系

Country Status (7)

Country Link
US (1) US8759112B2 (https=)
EP (1) EP1805503A1 (https=)
JP (1) JP4954078B2 (https=)
CN (1) CN101048651B (https=)
CA (1) CA2585041C (https=)
DE (1) DE102004051830B4 (https=)
WO (1) WO2006045596A1 (https=)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102008057115B4 (de) * 2008-11-13 2013-11-28 Lre Medical Gmbh Verfahren zur quantitativen Bestimmung der Konzentration von Fluorophoren einer Substanz in einer Probe und Vorrichtung zu seiner Durchführung
MX2011009387A (es) 2009-03-20 2011-09-28 Hoffmann La Roche Elemento de prueba para analizar un fluido corporal y metodo para su medicion.
CN103974655B (zh) * 2011-11-14 2016-03-30 霍夫曼-拉罗奇有限公司 用于检测样品中至少一种分析物的分析仪器
DE102021102505A1 (de) 2020-12-21 2022-06-23 Endress+Hauser Conducta Gmbh+Co. Kg Optochemischer Sensor sowie Verfahren zum Messen von lumineszierenden Analyten in einem Messmedium

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2720370A1 (de) * 1977-05-06 1978-11-16 Max Planck Gesellschaft Optode mit hilfsindikator
US4420566A (en) * 1982-06-10 1983-12-13 Eastman Kodak Company Method and apparatus for detecting sample fluid on an analysis slide
WO1983000931A1 (en) 1981-09-08 1983-03-17 Eastman Kodak Co Method and apparatus for detecting sample fluid
JPS6463842A (en) * 1987-09-03 1989-03-09 Terumo Corp Method and apparatus for measuring concentration of optical material
US5057427A (en) * 1988-04-07 1991-10-15 Sepracor, Inc. Method for resolution of stereoisomers
US5114350A (en) * 1989-03-08 1992-05-19 Cholestech Corporation Controlled-volume assay apparatus
JP2855447B2 (ja) 1989-06-15 1999-02-10 三菱レイヨン株式会社 トナー
ATE106566T1 (de) * 1989-11-21 1994-06-15 Bayer Ag Optischer biosensor.
AU8720891A (en) 1991-01-04 1992-08-17 Iowa State University Research Foundation Inc. An optical probe and method for monitoring an analyte concentration
US5591400A (en) * 1994-10-31 1997-01-07 Minnesota Mining And Manufacturing Company Method for producing an ionic sensor
US5672515A (en) * 1995-09-12 1997-09-30 Optical Sensors Incorporated Simultaneous dual excitation/single emission fluorescent sensing method for PH and pCO2
US6602716B1 (en) * 1997-08-01 2003-08-05 Presens Precision Sensing Gmbh Method and device for referencing fluorescence intensity signals
WO1999046600A1 (en) * 1998-03-11 1999-09-16 Sensors For Medicine And Science, Inc. Detection of analytes by fluorescent lanthanide chelates
DE19903506C2 (de) * 1999-01-29 2002-04-04 Inst Chemo Biosensorik Verfahren, Gefäß und Vorrichtung zur Überwachung der Stoffwechselaktivität von Zellkulturen in flüssigen Medien
EP1394219A1 (en) * 1999-06-09 2004-03-03 Carnegie-Mellon University PH sensitive cyanine dyes as reactive fluorescent reagents
US6204067B1 (en) * 1999-06-17 2001-03-20 Board Of Trustees Operating Michigan State University Methods of identifying modulators of the estrogen receptor
DE10101576B4 (de) 2001-01-15 2016-02-18 Presens Precision Sensing Gmbh Optischer Sensor und Sensorfeld
EP1397672A1 (de) * 2001-06-18 2004-03-17 Presens Precision Sensing GmbH Sauerstoffsensoren auf mikrotiterplatte
DE10151217B4 (de) * 2001-10-16 2012-05-16 Carl Zeiss Microlmaging Gmbh Verfahren zum Betrieb eines Laser-Scanning-Mikroskops
KR101002194B1 (ko) * 2002-05-16 2011-01-13 에프. 호프만-라 로슈 아게 중합체 층의 제조 방법
US7198756B2 (en) * 2002-07-11 2007-04-03 Optical Sensors Incorporated Non-invasive measurement of pH
DE10248555B4 (de) * 2002-10-18 2004-12-02 Roche Diagnostics Gmbh Verfahren und Analysesystem zur Ermittlung der Konzentration eines Analyten in einer Probe, die aus dem Analyten und der Probenmatrix besteht und Testelement dafür

Also Published As

Publication number Publication date
US20080014655A1 (en) 2008-01-17
JP4954078B2 (ja) 2012-06-13
DE102004051830B4 (de) 2007-12-13
CA2585041A1 (en) 2006-05-04
CA2585041C (en) 2011-12-13
CN101048651A (zh) 2007-10-03
HK1113405A1 (en) 2008-10-03
WO2006045596A1 (de) 2006-05-04
US8759112B2 (en) 2014-06-24
DE102004051830A1 (de) 2006-04-27
JP2008518199A (ja) 2008-05-29
EP1805503A1 (de) 2007-07-11

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