JP4954078B2 - 蛍光による分析対象物質の決定における多機能参照システム - Google Patents
蛍光による分析対象物質の決定における多機能参照システム Download PDFInfo
- Publication number
- JP4954078B2 JP4954078B2 JP2007537234A JP2007537234A JP4954078B2 JP 4954078 B2 JP4954078 B2 JP 4954078B2 JP 2007537234 A JP2007537234 A JP 2007537234A JP 2007537234 A JP2007537234 A JP 2007537234A JP 4954078 B2 JP4954078 B2 JP 4954078B2
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- Japan
- Prior art keywords
- substance
- analyte
- luminescence
- comparative reference
- luminescence signal
- Prior art date
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- Expired - Fee Related
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- 238000004020 luminiscence type Methods 0.000 claims description 67
- 239000000126 substance Substances 0.000 claims description 60
- 239000012491 analyte Substances 0.000 claims description 58
- 230000000052 comparative effect Effects 0.000 claims description 55
- 239000012925 reference material Substances 0.000 claims description 34
- 238000000034 method Methods 0.000 claims description 24
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- VLLFXWZDQHOGLC-UHFFFAOYSA-N DND-167 dye Chemical compound C=12C=CC=CC2=C(CN2CCOCC2)C2=CC=CC=C2C=1CN1CCOCC1 VLLFXWZDQHOGLC-UHFFFAOYSA-N 0.000 claims description 22
- 239000007788 liquid Substances 0.000 claims description 19
- 239000000463 material Substances 0.000 claims description 16
- 238000004458 analytical method Methods 0.000 claims description 12
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 10
- 229910001868 water Inorganic materials 0.000 claims description 10
- 239000013076 target substance Substances 0.000 claims description 8
- MCEXQZRGUKALLT-VVEOGCPPSA-N acetyloxymethyl 2-[n-[2-(acetyloxymethoxy)-2-oxoethyl]-2-[2-[[6-[bis[2-(acetyloxymethoxy)-2-oxoethyl]amino]-2-[(e)-(5-oxo-2-sulfanylideneimidazolidin-4-ylidene)methyl]-1-benzofuran-5-yl]oxy]ethoxy]-4-methylanilino]acetate Chemical compound CC(=O)OCOC(=O)CN(CC(=O)OCOC(C)=O)C1=CC=C(C)C=C1OCCOC(C(=C1)N(CC(=O)OCOC(C)=O)CC(=O)OCOC(C)=O)=CC2=C1OC(\C=C\1C(NC(=S)N/1)=O)=C2 MCEXQZRGUKALLT-VVEOGCPPSA-N 0.000 claims description 4
- 229910052736 halogen Inorganic materials 0.000 claims description 4
- 150000002367 halogens Chemical class 0.000 claims description 4
- 229910052739 hydrogen Inorganic materials 0.000 claims description 4
- 239000001257 hydrogen Substances 0.000 claims description 4
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 3
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- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 claims description 3
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- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 14
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- 229930027945 nicotinamide-adenine dinucleotide Natural products 0.000 description 4
- DQFBYFPFKXHELB-VAWYXSNFSA-N trans-chalcone Chemical compound C=1C=CC=CC=1C(=O)\C=C\C1=CC=CC=C1 DQFBYFPFKXHELB-VAWYXSNFSA-N 0.000 description 4
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- BOPGDPNILDQYTO-NNYOXOHSSA-N nicotinamide-adenine dinucleotide Chemical compound C1=CCC(C(=O)N)=CN1[C@H]1[C@H](O)[C@H](O)[C@@H](COP(O)(=O)OP(O)(=O)OC[C@@H]2[C@H]([C@@H](O)[C@@H](O2)N2C3=NC=NC(N)=C3N=C2)O)O1 BOPGDPNILDQYTO-NNYOXOHSSA-N 0.000 description 3
- 230000002123 temporal effect Effects 0.000 description 3
- PDKPRWFMRVBCOB-JLHYYAGUSA-N (e)-3-[4-(dimethylamino)phenyl]-1-phenylprop-2-en-1-one Chemical compound C1=CC(N(C)C)=CC=C1\C=C\C(=O)C1=CC=CC=C1 PDKPRWFMRVBCOB-JLHYYAGUSA-N 0.000 description 2
- 108010050375 Glucose 1-Dehydrogenase Proteins 0.000 description 2
- XJLXINKUBYWONI-DQQFMEOOSA-N [[(2r,3r,4r,5r)-5-(6-aminopurin-9-yl)-3-hydroxy-4-phosphonooxyoxolan-2-yl]methoxy-hydroxyphosphoryl] [(2s,3r,4s,5s)-5-(3-carbamoylpyridin-1-ium-1-yl)-3,4-dihydroxyoxolan-2-yl]methyl phosphate Chemical compound NC(=O)C1=CC=C[N+]([C@@H]2[C@H]([C@@H](O)[C@H](COP([O-])(=O)OP(O)(=O)OC[C@@H]3[C@H]([C@@H](OP(O)(O)=O)[C@@H](O3)N3C4=NC=NC(N)=C4N=C3)O)O2)O)=C1 XJLXINKUBYWONI-DQQFMEOOSA-N 0.000 description 2
- 229910052794 bromium Inorganic materials 0.000 description 2
- 239000011575 calcium Substances 0.000 description 2
- 150000001789 chalcones Chemical class 0.000 description 2
- 229910052801 chlorine Inorganic materials 0.000 description 2
- 238000012790 confirmation Methods 0.000 description 2
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- 239000007850 fluorescent dye Substances 0.000 description 2
- 229910052731 fluorine Inorganic materials 0.000 description 2
- 229910052740 iodine Inorganic materials 0.000 description 2
- 238000000504 luminescence detection Methods 0.000 description 2
- 239000011777 magnesium Substances 0.000 description 2
- 238000012544 monitoring process Methods 0.000 description 2
- 230000002441 reversible effect Effects 0.000 description 2
- 239000012488 sample solution Substances 0.000 description 2
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- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 1
- BHPQYMZQTOCNFJ-UHFFFAOYSA-N Calcium cation Chemical compound [Ca+2] BHPQYMZQTOCNFJ-UHFFFAOYSA-N 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 description 1
- JLVVSXFLKOJNIY-UHFFFAOYSA-N Magnesium ion Chemical compound [Mg+2] JLVVSXFLKOJNIY-UHFFFAOYSA-N 0.000 description 1
- OAICVXFJPJFONN-UHFFFAOYSA-N Phosphorus Chemical compound [P] OAICVXFJPJFONN-UHFFFAOYSA-N 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
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- 125000005577 anthracene group Chemical group 0.000 description 1
- 230000002238 attenuated effect Effects 0.000 description 1
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- 125000000484 butyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 229910052791 calcium Inorganic materials 0.000 description 1
- 229910001424 calcium ion Inorganic materials 0.000 description 1
- 229910052799 carbon Inorganic materials 0.000 description 1
- 125000004432 carbon atom Chemical group C* 0.000 description 1
- 150000001788 chalcone derivatives Chemical class 0.000 description 1
- WWAABJGNHFGXSJ-UHFFFAOYSA-N chlorophenol red Chemical compound C1=C(Cl)C(O)=CC=C1C1(C=2C=C(Cl)C(O)=CC=2)C2=CC=CC=C2S(=O)(=O)O1 WWAABJGNHFGXSJ-UHFFFAOYSA-N 0.000 description 1
- 239000013068 control sample Substances 0.000 description 1
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- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 description 1
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- 238000002474 experimental method Methods 0.000 description 1
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- 238000009472 formulation Methods 0.000 description 1
- 150000002431 hydrogen Chemical class 0.000 description 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 description 1
- 150000002500 ions Chemical class 0.000 description 1
- 239000012464 large buffer Substances 0.000 description 1
- 229910052749 magnesium Inorganic materials 0.000 description 1
- 229910001425 magnesium ion Inorganic materials 0.000 description 1
- 229910052751 metal Inorganic materials 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- 150000002739 metals Chemical class 0.000 description 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 1
- 125000001570 methylene group Chemical group [H]C([H])([*:1])[*:2] 0.000 description 1
- 125000002757 morpholinyl group Chemical group 0.000 description 1
- 238000005375 photometry Methods 0.000 description 1
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 238000002798 spectrophotometry method Methods 0.000 description 1
- 238000004611 spectroscopical analysis Methods 0.000 description 1
- 125000000547 substituted alkyl group Chemical group 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 230000036962 time dependent Effects 0.000 description 1
- 230000001960 triggered effect Effects 0.000 description 1
Images
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/64—Fluorescence; Phosphorescence
- G01N21/6428—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes"
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/84—Systems specially adapted for particular applications
- G01N21/8483—Investigating reagent band
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
- G01N33/582—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with fluorescent label
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/66—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving blood sugars, e.g. galactose
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/64—Fluorescence; Phosphorescence
- G01N21/6428—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes"
- G01N2021/6432—Quenching
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/64—Fluorescence; Phosphorescence
- G01N21/6428—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes"
- G01N2021/6439—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes" with indicators, stains, dyes, tags, labels, marks
- G01N2021/6441—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes" with indicators, stains, dyes, tags, labels, marks with two or more labels
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Immunology (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Physics & Mathematics (AREA)
- Hematology (AREA)
- Biochemistry (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Urology & Nephrology (AREA)
- General Health & Medical Sciences (AREA)
- Analytical Chemistry (AREA)
- Biomedical Technology (AREA)
- Microbiology (AREA)
- Cell Biology (AREA)
- Biotechnology (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Diabetes (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Optics & Photonics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
- Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE102004051830A DE102004051830B4 (de) | 2004-10-25 | 2004-10-25 | Multifunktionales Referenzsystem bei Analytbestimmungen durch Fluoreszenz |
| DE102004051830.0 | 2004-10-25 | ||
| PCT/EP2005/011448 WO2006045596A1 (de) | 2004-10-25 | 2005-10-25 | Multifunktionales referenzsystem bei analybestimmungen durch fluoreszenz |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2008518199A JP2008518199A (ja) | 2008-05-29 |
| JP2008518199A5 JP2008518199A5 (https=) | 2011-02-03 |
| JP4954078B2 true JP4954078B2 (ja) | 2012-06-13 |
Family
ID=35427590
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007537234A Expired - Fee Related JP4954078B2 (ja) | 2004-10-25 | 2005-10-25 | 蛍光による分析対象物質の決定における多機能参照システム |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US8759112B2 (https=) |
| EP (1) | EP1805503A1 (https=) |
| JP (1) | JP4954078B2 (https=) |
| CN (1) | CN101048651B (https=) |
| CA (1) | CA2585041C (https=) |
| DE (1) | DE102004051830B4 (https=) |
| WO (1) | WO2006045596A1 (https=) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE102008057115B4 (de) * | 2008-11-13 | 2013-11-28 | Lre Medical Gmbh | Verfahren zur quantitativen Bestimmung der Konzentration von Fluorophoren einer Substanz in einer Probe und Vorrichtung zu seiner Durchführung |
| MX2011009387A (es) | 2009-03-20 | 2011-09-28 | Hoffmann La Roche | Elemento de prueba para analizar un fluido corporal y metodo para su medicion. |
| CN103974655B (zh) * | 2011-11-14 | 2016-03-30 | 霍夫曼-拉罗奇有限公司 | 用于检测样品中至少一种分析物的分析仪器 |
| DE102021102505A1 (de) | 2020-12-21 | 2022-06-23 | Endress+Hauser Conducta Gmbh+Co. Kg | Optochemischer Sensor sowie Verfahren zum Messen von lumineszierenden Analyten in einem Messmedium |
Family Cites Families (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2720370A1 (de) * | 1977-05-06 | 1978-11-16 | Max Planck Gesellschaft | Optode mit hilfsindikator |
| US4420566A (en) * | 1982-06-10 | 1983-12-13 | Eastman Kodak Company | Method and apparatus for detecting sample fluid on an analysis slide |
| WO1983000931A1 (en) | 1981-09-08 | 1983-03-17 | Eastman Kodak Co | Method and apparatus for detecting sample fluid |
| JPS6463842A (en) * | 1987-09-03 | 1989-03-09 | Terumo Corp | Method and apparatus for measuring concentration of optical material |
| US5057427A (en) * | 1988-04-07 | 1991-10-15 | Sepracor, Inc. | Method for resolution of stereoisomers |
| US5114350A (en) * | 1989-03-08 | 1992-05-19 | Cholestech Corporation | Controlled-volume assay apparatus |
| JP2855447B2 (ja) | 1989-06-15 | 1999-02-10 | 三菱レイヨン株式会社 | トナー |
| ATE106566T1 (de) * | 1989-11-21 | 1994-06-15 | Bayer Ag | Optischer biosensor. |
| AU8720891A (en) | 1991-01-04 | 1992-08-17 | Iowa State University Research Foundation Inc. | An optical probe and method for monitoring an analyte concentration |
| US5591400A (en) * | 1994-10-31 | 1997-01-07 | Minnesota Mining And Manufacturing Company | Method for producing an ionic sensor |
| US5672515A (en) * | 1995-09-12 | 1997-09-30 | Optical Sensors Incorporated | Simultaneous dual excitation/single emission fluorescent sensing method for PH and pCO2 |
| US6602716B1 (en) * | 1997-08-01 | 2003-08-05 | Presens Precision Sensing Gmbh | Method and device for referencing fluorescence intensity signals |
| WO1999046600A1 (en) * | 1998-03-11 | 1999-09-16 | Sensors For Medicine And Science, Inc. | Detection of analytes by fluorescent lanthanide chelates |
| DE19903506C2 (de) * | 1999-01-29 | 2002-04-04 | Inst Chemo Biosensorik | Verfahren, Gefäß und Vorrichtung zur Überwachung der Stoffwechselaktivität von Zellkulturen in flüssigen Medien |
| EP1394219A1 (en) * | 1999-06-09 | 2004-03-03 | Carnegie-Mellon University | PH sensitive cyanine dyes as reactive fluorescent reagents |
| US6204067B1 (en) * | 1999-06-17 | 2001-03-20 | Board Of Trustees Operating Michigan State University | Methods of identifying modulators of the estrogen receptor |
| DE10101576B4 (de) | 2001-01-15 | 2016-02-18 | Presens Precision Sensing Gmbh | Optischer Sensor und Sensorfeld |
| EP1397672A1 (de) * | 2001-06-18 | 2004-03-17 | Presens Precision Sensing GmbH | Sauerstoffsensoren auf mikrotiterplatte |
| DE10151217B4 (de) * | 2001-10-16 | 2012-05-16 | Carl Zeiss Microlmaging Gmbh | Verfahren zum Betrieb eines Laser-Scanning-Mikroskops |
| KR101002194B1 (ko) * | 2002-05-16 | 2011-01-13 | 에프. 호프만-라 로슈 아게 | 중합체 층의 제조 방법 |
| US7198756B2 (en) * | 2002-07-11 | 2007-04-03 | Optical Sensors Incorporated | Non-invasive measurement of pH |
| DE10248555B4 (de) * | 2002-10-18 | 2004-12-02 | Roche Diagnostics Gmbh | Verfahren und Analysesystem zur Ermittlung der Konzentration eines Analyten in einer Probe, die aus dem Analyten und der Probenmatrix besteht und Testelement dafür |
-
2004
- 2004-10-25 DE DE102004051830A patent/DE102004051830B4/de not_active Expired - Fee Related
-
2005
- 2005-10-25 CA CA2585041A patent/CA2585041C/en not_active Expired - Fee Related
- 2005-10-25 US US11/666,198 patent/US8759112B2/en not_active Expired - Fee Related
- 2005-10-25 JP JP2007537234A patent/JP4954078B2/ja not_active Expired - Fee Related
- 2005-10-25 WO PCT/EP2005/011448 patent/WO2006045596A1/de not_active Ceased
- 2005-10-25 EP EP05798048A patent/EP1805503A1/de not_active Withdrawn
- 2005-10-25 CN CN200580036606XA patent/CN101048651B/zh not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| CN101048651B (zh) | 2011-09-14 |
| US20080014655A1 (en) | 2008-01-17 |
| DE102004051830B4 (de) | 2007-12-13 |
| CA2585041A1 (en) | 2006-05-04 |
| CA2585041C (en) | 2011-12-13 |
| CN101048651A (zh) | 2007-10-03 |
| HK1113405A1 (en) | 2008-10-03 |
| WO2006045596A1 (de) | 2006-05-04 |
| US8759112B2 (en) | 2014-06-24 |
| DE102004051830A1 (de) | 2006-04-27 |
| JP2008518199A (ja) | 2008-05-29 |
| EP1805503A1 (de) | 2007-07-11 |
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