DE10199007I2 - Asymmetrische Diester von 1, 4-Dihydro-2, 6-dimethylpyridine-3, 5- dicarboxylsaure - Google Patents
Asymmetrische Diester von 1, 4-Dihydro-2, 6-dimethylpyridine-3, 5- dicarboxylsaureInfo
- Publication number
- DE10199007I2 DE10199007I2 DE2001199007 DE10199007C DE10199007I2 DE 10199007 I2 DE10199007 I2 DE 10199007I2 DE 2001199007 DE2001199007 DE 2001199007 DE 10199007 C DE10199007 C DE 10199007C DE 10199007 I2 DE10199007 I2 DE 10199007I2
- Authority
- DE
- Germany
- Prior art keywords
- dimethylpyridine
- dihydro
- dicarboxylic acid
- asymmetric diesters
- diesters
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
- C07C205/49—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by carboxyl groups
- C07C205/56—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by carboxyl groups having nitro groups bound to carbon atoms of six-membered aromatic rings and carboxyl groups bound to acyclic carbon atoms of the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
- C07D211/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Heart & Thoracic Surgery (AREA)
- Pharmacology & Pharmacy (AREA)
- Cardiology (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Hydrogenated Pyridines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pyridine Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB848403866A GB8403866D0 (en) | 1984-02-14 | 1984-02-14 | Diphenylalkylaminoalkyl esters |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE10199007I1 DE10199007I1 (de) | 2001-04-12 |
| DE10199007I2 true DE10199007I2 (de) | 2003-01-09 |
Family
ID=10556581
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE2001199007 Active DE10199007I2 (de) | 1984-02-14 | 1985-01-21 | Asymmetrische Diester von 1, 4-Dihydro-2, 6-dimethylpyridine-3, 5- dicarboxylsaure |
| DE8585300384T Expired - Lifetime DE3577703D1 (de) | 1984-02-14 | 1985-01-21 | Asymmetrische diester von 1,4-dihydro-2,6-dimethylpyridine-3,5-dicarboxylsaeure. |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE8585300384T Expired - Lifetime DE3577703D1 (de) | 1984-02-14 | 1985-01-21 | Asymmetrische diester von 1,4-dihydro-2,6-dimethylpyridine-3,5-dicarboxylsaeure. |
Country Status (29)
Families Citing this family (56)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU561213B2 (en) * | 1983-06-02 | 1987-04-30 | Teijin Limited | 1, 4-dihydropyridine derivative |
| US4994476A (en) * | 1984-10-31 | 1991-02-19 | Bristol-Myers Company | Dihydropyridin-3,5-dicarboxylates incorporating aryloxypropanolamine moieties |
| EP0220917B1 (en) * | 1985-10-22 | 1991-01-30 | Sanwa Kagaku Kenkyusho Co., Ltd. | 1,4-dihydropyridine pharmaceutical derivatives and their salts, and the preparation thereof |
| DE3633496A1 (de) * | 1986-10-02 | 1988-04-14 | Hoechst Ag | Kombination von angiotensin-converting-enzyme-hemmern mit calciumantagonisten sowie deren verwendung in arzneimitteln |
| JPH02149563A (ja) * | 1988-11-30 | 1990-06-08 | Nisshin Flour Milling Co Ltd | ２−ハロエトキシカルボニル基を含有する１，４−ジヒドロピリジン誘導体の製造法 |
| IT1275532B (it) * | 1995-07-14 | 1997-08-07 | Recordati Chem Pharm | Uso di derivati 1,4-diidropiridinici per la prevenzione e la terapia della degenerazione aterosclerotica della parete arteriosa |
| IT1279529B1 (it) * | 1995-05-12 | 1997-12-16 | Recordati Chem Pharm | Procedimento di preparazione ed uso degli enantiomeri (s) di derivati 1,4-diidropiridinici per il trattamento dell'insufficienza cardiaca |
| IT1274480B (it) * | 1995-05-12 | 1997-07-17 | Recordati Chem Pharm | Procedimento migliorato per la preparazione della lercanidipina cloridrato |
| US5912351A (en) * | 1995-05-12 | 1999-06-15 | Recordati, S.A. Chemical And Pharmaceutical Company | Anhydrous 1,4-Dihydropyridines and salts thereof |
| US5696139A (en) * | 1995-05-12 | 1997-12-09 | Recordati S.A., Chemical And Pharmaceutical Company | Use of S-enantiomers of 1,4-dihydropyridine derivatives for treating heart failure |
| US5851636A (en) * | 1995-12-29 | 1998-12-22 | Lantec Products, Inc. | Ceramic packing with channels for thermal and catalytic beds |
| RU2200315C2 (ru) * | 2001-05-25 | 2003-03-10 | Чалкин Станислав Филиппович | Устройство для анализа жидких сред люминесцентным методом |
| US6852737B2 (en) * | 2001-08-06 | 2005-02-08 | Recordati Ireland Limited | Crude and crystalline forms of lercanidipine hydrochloride |
| ITMI20011727A1 (it) * | 2001-08-06 | 2003-02-06 | Recordati Ind Chimica E Farma | Solvati della lercanidipina cloridrato e nuove forme cristalline della lercanidipina cloridrato ottenute da essi |
| ITMI20011726A1 (it) * | 2001-08-06 | 2003-02-06 | Recordati Ind Chimica E Farma | Forme polimorfe della lercanidipina cloridrato |
| OA12905A (en) | 2002-08-19 | 2006-10-13 | Pfizer Prod Inc | Combination therapy for hyperproliferative diseases. |
| US20050101640A1 (en) * | 2002-10-16 | 2005-05-12 | Recordati Ireland Limited | Lisinopril/lercanidipine combination therapy |
| US20040147566A1 (en) * | 2002-10-16 | 2004-07-29 | Amedeo Leonardi | Lisinopril/lercanidipine combination therapy |
| RS20050890A (sr) | 2003-05-30 | 2007-12-31 | Ranbaxy Laboratories Limited, | Supstituisani pirol derivati |
| WO2005107374A2 (en) * | 2004-05-07 | 2005-11-17 | Sun Pharmaceutical Industries Limited | A process for the preparation of 1,4-dihydropyridine-3,5-dicarboxylic acid derivative |
| BRPI0513866A (pt) * | 2004-07-26 | 2008-05-20 | Cotherix Inc | composição, micropartìculas, método para o tratamento da hipertensão pulmonar, e dispositivo de inalação |
| TW200613275A (en) | 2004-08-24 | 2006-05-01 | Recordati Ireland Ltd | Lercanidipine salts |
| US20060134212A1 (en) * | 2004-09-02 | 2006-06-22 | Forest Laboratories, Inc. | Lercanidipine immediate release compositions |
| US20060165789A1 (en) * | 2004-09-09 | 2006-07-27 | Forest Laboratories, Inc. | Lercanidipine modified release compositions |
| US20060165788A1 (en) * | 2004-09-09 | 2006-07-27 | Wattanaporn Abramowitz | Lercanidipine pH dependent pulsatile release compositions |
| KR100616276B1 (ko) * | 2004-09-21 | 2006-08-28 | 일동제약주식회사 | 2,엔-디메틸-엔-(3,3-디페닐프로필)-1-아미노-2-프로판올의제조방법 |
| TW200616681A (en) * | 2004-10-05 | 2006-06-01 | Recordati Ireland Ltd | Lercanidipine capsules |
| KR100651212B1 (ko) * | 2004-10-27 | 2006-12-01 | 제일약품주식회사 | 무정형 레르카니디핀의 제조방법 |
| IL165525A0 (en) * | 2004-12-02 | 2006-01-15 | Motivan Ltd | Intermediates and a process for the manufacturing for antihypertensive dihydropyridine derivative suitable for pharmaceutical compositions |
| AR053023A1 (es) * | 2005-02-25 | 2007-04-18 | Recordati Ireland Ltd | Base libre de lercanidipina, metodos para su preparacion y composiciones farmaceuticas que las contienen |
| AR052918A1 (es) | 2005-02-25 | 2007-04-11 | Recordati Ireland Ltd | Clorhidrato de lercanidipina amorfo |
| KR100638171B1 (ko) * | 2005-03-25 | 2006-10-26 | 건일제약 주식회사 | 2,ｎ-디메틸-ｎ-(3,3-디페닐프로필)-1-아미노-2-프로판올의제조방법 |
| WO2006134606A1 (en) * | 2005-06-15 | 2006-12-21 | Hetero Drugs Limited | A novel process for the preparation of lercanidipine |
| EP1940790B1 (en) | 2005-09-16 | 2015-09-02 | Glenmark Pharmaceuticals Limited | Polymorphic form of lercanidipine hydrochloride and process for the preparation thereof |
| EP1963254A2 (en) * | 2005-09-21 | 2008-09-03 | Torrent Pharmaceuticals Ltd | Process for the preparation of lercanidipine and amorphous form of lercanidipine hydrochloride |
| US7741317B2 (en) | 2005-10-21 | 2010-06-22 | Bristol-Myers Squibb Company | LXR modulators |
| EP2351569B1 (en) | 2005-10-26 | 2012-08-22 | Asahi Kasei Pharma Corporation | Fasudil in combination therapies for the treatment of pulmonary arterial hypertension |
| EP2111863B1 (en) | 2005-10-26 | 2012-03-28 | Asahi Kasei Pharma Corporation | Fasudil in combination with bosentan for the treament of pulmonary arterial hypertension |
| WO2007054896A1 (en) | 2005-11-08 | 2007-05-18 | Ranbaxy Laboratories Limited | Process for (3r, 5r)-7-[2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4- [(4-hydroxy methyl phenyl amino) carbonyl]-pyrrol-1-yl]-3, 5-dihydroxy-heptanoic acid hemi calcium salt |
| US7888376B2 (en) | 2005-11-23 | 2011-02-15 | Bristol-Myers Squibb Company | Heterocyclic CETP inhibitors |
| US7919506B2 (en) | 2006-03-10 | 2011-04-05 | Pfizer Inc. | Dibenzyl amine compounds and derivatives |
| WO2007120135A1 (en) * | 2006-04-17 | 2007-10-25 | Forest Laboratories, Inc. | Lercanidipine immediate release composition |
| ATE415389T1 (de) * | 2006-05-24 | 2008-12-15 | Cf Pharma Ltd | Verfahren zur herstellung von lercanipidin |
| AU2007280407B2 (en) * | 2006-08-04 | 2012-09-27 | Recordati Ireland Limited | Process for preparing amorphous lercanidipine hydrochloride |
| US20080175872A1 (en) * | 2006-09-28 | 2008-07-24 | Osmotica Corp. | Controlled Release Dosage Form Containing Lercanidipine and a Performance-enhancing Acid |
| CN101663262B (zh) | 2006-12-01 | 2014-03-26 | 百时美施贵宝公司 | 用于治疗动脉粥样硬化和心血管疾病的作为cetp抑制剂的n-(3-苄基)-2,2-(二苯基)-丙-1胺衍生物 |
| JP2010514753A (ja) * | 2006-12-29 | 2010-05-06 | ドンウ シンテック カンパニー リミテッド | レルカニジピン塩酸塩の製造方法 |
| KR100848935B1 (ko) | 2007-05-16 | 2008-07-29 | 주식회사 대희화학 | 생체 촉매 효소를 이용한 광학 선택적 가수분해방법 |
| EA027787B1 (ru) | 2010-06-23 | 2017-09-29 | Крка, Товарна Здравил, Д.Д., Ново Место | Пероральные лекарственные формы, содержащие лерканидипин и эналаприл и их фармацевтически приемлемые соли |
| WO2012037665A1 (en) | 2010-09-24 | 2012-03-29 | Oral Delivery Technology Ltd. | Nitric oxide releasing amino acid ester for treatment of pulmonary hypertension and other respiratory conditions |
| EP2444394A1 (en) | 2010-10-21 | 2012-04-25 | Alembic Pharmaceuticals Limited | Process for the preparation of amorphous form of lercanidipine HCI |
| EP2654729B1 (en) | 2010-12-24 | 2016-05-04 | KRKA, d.d., Novo mesto | Homogenous pharmaceutical oral dosage forms comprising lercanidipine and enalapril or their pharmaceutically acceptable salts together with an organic acid |
| WO2012123966A1 (en) | 2011-03-04 | 2012-09-20 | Arch Pharmalabs Limited | Process for the preparation of 4 -substituted -1, 4-dihydropyridines |
| MX2015014666A (es) | 2013-04-17 | 2016-03-01 | Pfizer | Derivados de n-piperidin-3-ilbenzamida para tratar enfermedades cardiovasculares. |
| WO2016055901A1 (en) | 2014-10-08 | 2016-04-14 | Pfizer Inc. | Substituted amide compounds |
| US11248001B2 (en) | 2019-01-18 | 2022-02-15 | Astrazeneca Ab | PCSK9 inhibitors and methods of use thereof |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3985758A (en) * | 1973-02-20 | 1976-10-12 | Yamanouchi Pharmaceutical Co., Ltd. | 1,4-Dihydropyridine derivatives |
| JPS5762257A (en) * | 1980-10-03 | 1982-04-15 | Yoshitomi Pharmaceut Ind Ltd | 1,4-dihydropyridine-3,5-dicarboxylic acid ester or its salt |
| NZ201395A (en) * | 1981-07-30 | 1987-02-20 | Bayer Ag | Pharmaceutical compositions containing 1,4-dihydropyridines and certain of these dihydropyridines |
| EP0080220B1 (en) * | 1981-11-17 | 1986-02-19 | FISONS plc | Dihydropyridines, methods for their production and their formulation and use as pharmaceuticals |
| EP0094159B1 (en) * | 1982-05-10 | 1990-03-14 | Takeda Chemical Industries, Ltd. | Dihydropyridine derivatives, their production and use |
| AU561213B2 (en) * | 1983-06-02 | 1987-04-30 | Teijin Limited | 1, 4-dihydropyridine derivative |
| NO854021L (no) * | 1984-10-26 | 1986-04-28 | Bayer Ag | 1,4-dihydropyridin-hydroksyaminer og fremgangsmaate til fremstilling derav. |
| GB8503424D0 (en) * | 1985-02-11 | 1985-03-13 | Ici Plc | Heterocyclic derivatives |
-
1984
- 1984-02-14 GB GB848403866A patent/GB8403866D0/en active Pending
-
1985
- 1985-01-17 NZ NZ210866A patent/NZ210866A/xx unknown
- 1985-01-21 AT AT85300384T patent/ATE52772T1/de active
- 1985-01-21 DE DE2001199007 patent/DE10199007I2/de active Active
- 1985-01-21 DE DE8585300384T patent/DE3577703D1/de not_active Expired - Lifetime
- 1985-01-21 EP EP85300384A patent/EP0153016B1/en not_active Expired - Lifetime
- 1985-01-28 ZA ZA85656A patent/ZA85656B/xx unknown
- 1985-02-04 IL IL74238A patent/IL74238A/xx not_active IP Right Cessation
- 1985-02-06 IE IE280/85A patent/IE57715B1/en not_active IP Right Cessation
- 1985-02-08 FI FI850535A patent/FI83954C/fi not_active IP Right Cessation
- 1985-02-11 AR AR299475A patent/AR240804A1/es active
- 1985-02-11 EG EG83/85A patent/EG17772A/xx active
- 1985-02-11 CA CA000474009A patent/CA1277666C/en not_active Expired - Lifetime
- 1985-02-11 GR GR850363A patent/GR850363B/el not_active IP Right Cessation
- 1985-02-12 MX MX204305A patent/MX156874A/es unknown
- 1985-02-12 NO NO850521A patent/NO166123C/no unknown
- 1985-02-12 DK DK063085A patent/DK160985C/da not_active IP Right Cessation
- 1985-02-13 AU AU38689/85A patent/AU570534B2/en not_active Expired
- 1985-02-13 DZ DZ850035A patent/DZ748A1/fr active
- 1985-02-13 PT PT79963A patent/PT79963B/pt unknown
- 1985-02-13 ES ES540385A patent/ES540385A0/es active Granted
- 1985-02-13 KR KR1019850000888A patent/KR910005231B1/ko not_active Expired
- 1985-02-14 HU HU85554A patent/HU194171B/hu unknown
- 1985-02-14 PH PH31860A patent/PH20725A/en unknown
- 1985-02-14 US US06/701,672 patent/US4705797A/en not_active Expired - Lifetime
- 1985-02-14 JP JP60027527A patent/JPS60199874A/ja active Granted
-
1987
- 1987-08-19 US US07/086,739 patent/US4772621A/en not_active Expired - Lifetime
-
1988
- 1988-06-28 US US07/212,472 patent/US4968832A/en not_active Expired - Lifetime
-
1990
- 1990-07-02 SG SG485/90A patent/SG48590G/en unknown
-
1997
- 1997-05-14 BR BR1101167-0A patent/BR1101167A/pt active IP Right Grant
- 1997-05-28 LU LU90069C patent/LU90069I2/fr unknown
- 1997-07-11 NL NL970025C patent/NL970025I2/nl unknown
-
2000
- 2000-10-17 NO NO2000011C patent/NO2000011I1/no unknown
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