DE10120413A1 - Acesulfamsalz, Verfahren zu seiner Herstellung und seine Verwendung - Google Patents
Acesulfamsalz, Verfahren zu seiner Herstellung und seine VerwendungInfo
- Publication number
- DE10120413A1 DE10120413A1 DE10120413A DE10120413A DE10120413A1 DE 10120413 A1 DE10120413 A1 DE 10120413A1 DE 10120413 A DE10120413 A DE 10120413A DE 10120413 A DE10120413 A DE 10120413A DE 10120413 A1 DE10120413 A1 DE 10120413A1
- Authority
- DE
- Germany
- Prior art keywords
- acesulfame
- ammonium
- compound
- cation
- salt
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 238000000034 method Methods 0.000 title claims abstract description 6
- YGCFIWIQZPHFLU-UHFFFAOYSA-N acesulfame Chemical class CC1=CC(=O)NS(=O)(=O)O1 YGCFIWIQZPHFLU-UHFFFAOYSA-N 0.000 title claims description 13
- 238000002360 preparation method Methods 0.000 title abstract 2
- 150000001768 cations Chemical class 0.000 claims abstract description 9
- 150000001875 compounds Chemical class 0.000 claims abstract description 9
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 8
- QGZKDVFQNNGYKY-UHFFFAOYSA-O Ammonium Chemical compound [NH4+] QGZKDVFQNNGYKY-UHFFFAOYSA-O 0.000 claims abstract description 7
- 229910052755 nonmetal Inorganic materials 0.000 claims abstract description 7
- 235000013305 food Nutrition 0.000 claims abstract description 5
- 150000001450 anions Chemical class 0.000 claims abstract description 4
- 238000002425 crystallisation Methods 0.000 claims abstract description 3
- 230000008025 crystallization Effects 0.000 claims abstract description 3
- 235000013361 beverage Nutrition 0.000 claims abstract 2
- 229960005164 acesulfame Drugs 0.000 claims description 22
- -1 Non-metal cation Chemical class 0.000 claims description 14
- ATRRKUHOCOJYRX-UHFFFAOYSA-N Ammonium bicarbonate Chemical compound [NH4+].OC([O-])=O ATRRKUHOCOJYRX-UHFFFAOYSA-N 0.000 claims description 8
- 239000001099 ammonium carbonate Substances 0.000 claims description 8
- QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 claims description 6
- 229910000013 Ammonium bicarbonate Inorganic materials 0.000 claims description 4
- 235000012538 ammonium bicarbonate Nutrition 0.000 claims description 4
- 235000012501 ammonium carbonate Nutrition 0.000 claims description 4
- 239000002904 solvent Substances 0.000 claims description 4
- 229910021529 ammonia Inorganic materials 0.000 claims description 3
- 150000001457 metallic cations Chemical class 0.000 claims 2
- 150000008040 ionic compounds Chemical group 0.000 claims 1
- 239000003960 organic solvent Substances 0.000 claims 1
- 239000002243 precursor Substances 0.000 claims 1
- WBZFUFAFFUEMEI-UHFFFAOYSA-M Acesulfame k Chemical compound [K+].CC1=CC(=O)[N-]S(=O)(=O)O1 WBZFUFAFFUEMEI-UHFFFAOYSA-M 0.000 description 8
- NLXLAEXVIDQMFP-UHFFFAOYSA-N Ammonia chloride Chemical compound [NH4+].[Cl-] NLXLAEXVIDQMFP-UHFFFAOYSA-N 0.000 description 6
- 208000002682 Hyperkalemia Diseases 0.000 description 5
- 239000000619 acesulfame-K Substances 0.000 description 5
- 235000011114 ammonium hydroxide Nutrition 0.000 description 5
- 239000013078 crystal Substances 0.000 description 5
- 235000003599 food sweetener Nutrition 0.000 description 5
- 239000003765 sweetening agent Substances 0.000 description 5
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 4
- 235000010358 acesulfame potassium Nutrition 0.000 description 4
- 239000002253 acid Substances 0.000 description 4
- 229910052751 metal Inorganic materials 0.000 description 4
- 239000002184 metal Substances 0.000 description 4
- 229910052700 potassium Inorganic materials 0.000 description 4
- 239000011591 potassium Substances 0.000 description 4
- VHUUQVKOLVNVRT-UHFFFAOYSA-N Ammonium hydroxide Chemical compound [NH4+].[OH-] VHUUQVKOLVNVRT-UHFFFAOYSA-N 0.000 description 3
- 206010013911 Dysgeusia Diseases 0.000 description 3
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 3
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 description 3
- 208000001647 Renal Insufficiency Diseases 0.000 description 3
- 150000003863 ammonium salts Chemical class 0.000 description 3
- 201000006370 kidney failure Diseases 0.000 description 3
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 2
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 2
- FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 description 2
- NPYPAHLBTDXSSS-UHFFFAOYSA-N Potassium ion Chemical compound [K+] NPYPAHLBTDXSSS-UHFFFAOYSA-N 0.000 description 2
- 229960004998 acesulfame potassium Drugs 0.000 description 2
- 229910052784 alkaline earth metal Inorganic materials 0.000 description 2
- CBHOOMGKXCMKIR-UHFFFAOYSA-N azane;methanol Chemical compound N.OC CBHOOMGKXCMKIR-UHFFFAOYSA-N 0.000 description 2
- 239000002585 base Substances 0.000 description 2
- 229910052791 calcium Inorganic materials 0.000 description 2
- 239000011575 calcium Substances 0.000 description 2
- 235000009508 confectionery Nutrition 0.000 description 2
- 235000005911 diet Nutrition 0.000 description 2
- 230000037213 diet Effects 0.000 description 2
- 229910052749 magnesium Inorganic materials 0.000 description 2
- 239000011777 magnesium Substances 0.000 description 2
- XAEFZNCEHLXOMS-UHFFFAOYSA-M potassium benzoate Chemical compound [K+].[O-]C(=O)C1=CC=CC=C1 XAEFZNCEHLXOMS-UHFFFAOYSA-M 0.000 description 2
- 235000015424 sodium Nutrition 0.000 description 2
- 229910052708 sodium Inorganic materials 0.000 description 2
- 239000011734 sodium Substances 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 235000019605 sweet taste sensations Nutrition 0.000 description 2
- XLXCHZCQTCBUOX-UHFFFAOYSA-N 1-prop-2-enylimidazole Chemical compound C=CCN1C=CN=C1 XLXCHZCQTCBUOX-UHFFFAOYSA-N 0.000 description 1
- 208000009304 Acute Kidney Injury Diseases 0.000 description 1
- 208000026872 Addison Disease Diseases 0.000 description 1
- USFZMSVCRYTOJT-UHFFFAOYSA-N Ammonium acetate Chemical compound N.CC(O)=O USFZMSVCRYTOJT-UHFFFAOYSA-N 0.000 description 1
- BVKZGUZCCUSVTD-UHFFFAOYSA-M Bicarbonate Chemical compound OC([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-M 0.000 description 1
- BVKZGUZCCUSVTD-UHFFFAOYSA-L Carbonate Chemical compound [O-]C([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-L 0.000 description 1
- 208000024172 Cardiovascular disease Diseases 0.000 description 1
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N DMSO Substances CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 description 1
- 206010014418 Electrolyte imbalance Diseases 0.000 description 1
- 206010020772 Hypertension Diseases 0.000 description 1
- 206010020944 Hypoaldosteronism Diseases 0.000 description 1
- 208000033626 Renal failure acute Diseases 0.000 description 1
- FNYLWPVRPXGIIP-UHFFFAOYSA-N Triamterene Chemical compound NC1=NC2=NC(N)=NC(N)=C2N=C1C1=CC=CC=C1 FNYLWPVRPXGIIP-UHFFFAOYSA-N 0.000 description 1
- 238000010669 acid-base reaction Methods 0.000 description 1
- 230000001476 alcoholic effect Effects 0.000 description 1
- 239000003513 alkali Substances 0.000 description 1
- 229910052783 alkali metal Inorganic materials 0.000 description 1
- 150000001340 alkali metals Chemical class 0.000 description 1
- 150000001342 alkaline earth metals Chemical class 0.000 description 1
- 229960002576 amiloride Drugs 0.000 description 1
- XSDQTOBWRPYKKA-UHFFFAOYSA-N amiloride Chemical compound NC(=N)NC(=O)C1=NC(Cl)=C(N)N=C1N XSDQTOBWRPYKKA-UHFFFAOYSA-N 0.000 description 1
- 235000019270 ammonium chloride Nutrition 0.000 description 1
- LFVGISIMTYGQHF-UHFFFAOYSA-N ammonium dihydrogen phosphate Chemical compound [NH4+].OP(O)([O-])=O LFVGISIMTYGQHF-UHFFFAOYSA-N 0.000 description 1
- 239000000908 ammonium hydroxide Substances 0.000 description 1
- 125000000129 anionic group Chemical group 0.000 description 1
- 206010003119 arrhythmia Diseases 0.000 description 1
- 230000006793 arrhythmia Effects 0.000 description 1
- 150000001720 carbohydrates Chemical class 0.000 description 1
- 235000014633 carbohydrates Nutrition 0.000 description 1
- 125000002091 cationic group Chemical group 0.000 description 1
- 230000001684 chronic effect Effects 0.000 description 1
- 208000020832 chronic kidney disease Diseases 0.000 description 1
- 208000025302 chronic primary adrenal insufficiency Diseases 0.000 description 1
- 230000003247 decreasing effect Effects 0.000 description 1
- 206010012601 diabetes mellitus Diseases 0.000 description 1
- 238000000502 dialysis Methods 0.000 description 1
- MNNHAPBLZZVQHP-UHFFFAOYSA-N diammonium hydrogen phosphate Chemical compound [NH4+].[NH4+].OP([O-])([O-])=O MNNHAPBLZZVQHP-UHFFFAOYSA-N 0.000 description 1
- 229940116349 dibasic ammonium phosphate Drugs 0.000 description 1
- 235000019621 digestibility Nutrition 0.000 description 1
- 239000012153 distilled water Substances 0.000 description 1
- 238000001647 drug administration Methods 0.000 description 1
- 238000001704 evaporation Methods 0.000 description 1
- 230000008020 evaporation Effects 0.000 description 1
- 230000029142 excretion Effects 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- 239000000796 flavoring agent Substances 0.000 description 1
- 235000019634 flavors Nutrition 0.000 description 1
- 235000013373 food additive Nutrition 0.000 description 1
- 239000002778 food additive Substances 0.000 description 1
- LPLVUJXQOOQHMX-QWBHMCJMSA-N glycyrrhizinic acid Chemical compound O([C@@H]1[C@@H](O)[C@H](O)[C@H](O[C@@H]1O[C@@H]1C([C@H]2[C@]([C@@H]3[C@@]([C@@]4(CC[C@@]5(C)CC[C@@](C)(C[C@H]5C4=CC3=O)C(O)=O)C)(C)CC2)(C)CC1)(C)C)C(O)=O)[C@@H]1O[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@H]1O LPLVUJXQOOQHMX-QWBHMCJMSA-N 0.000 description 1
- 239000003446 ligand Substances 0.000 description 1
- 235000014659 low sodium diet Nutrition 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 230000002232 neuromuscular Effects 0.000 description 1
- 229910052757 nitrogen Inorganic materials 0.000 description 1
- 125000004433 nitrogen atom Chemical group N* 0.000 description 1
- 239000003286 potassium sparing diuretic agent Substances 0.000 description 1
- 229940097241 potassium-sparing diuretic Drugs 0.000 description 1
- 239000011541 reaction mixture Substances 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 238000004611 spectroscopical analysis Methods 0.000 description 1
- 229960002256 spironolactone Drugs 0.000 description 1
- LXMSZDCAJNLERA-ZHYRCANASA-N spironolactone Chemical compound C([C@@H]1[C@]2(C)CC[C@@H]3[C@@]4(C)CCC(=O)C=C4C[C@H]([C@@H]13)SC(=O)C)C[C@@]21CCC(=O)O1 LXMSZDCAJNLERA-ZHYRCANASA-N 0.000 description 1
- 229960001288 triamterene Drugs 0.000 description 1
- 238000012982 x-ray structure analysis Methods 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D291/00—Heterocyclic compounds containing rings having nitrogen, oxygen and sulfur atoms as the only ring hetero atoms
- C07D291/02—Heterocyclic compounds containing rings having nitrogen, oxygen and sulfur atoms as the only ring hetero atoms not condensed with other rings
- C07D291/06—Six-membered rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Seasonings (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Cosmetics (AREA)
Priority Applications (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE10120413A DE10120413A1 (de) | 2001-04-26 | 2001-04-26 | Acesulfamsalz, Verfahren zu seiner Herstellung und seine Verwendung |
| EP02008467A EP1262110A3 (de) | 2001-04-26 | 2002-04-15 | Nichtmetallsalz von Acesulfamsalz |
| JP2002121258A JP2002363173A (ja) | 2001-04-26 | 2002-04-23 | アセスルファム塩、その製造及び使用法 |
| US10/131,650 US20020160091A1 (en) | 2001-04-26 | 2002-04-24 | Acesulfame salt, process for its preparation and its use |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE10120413A DE10120413A1 (de) | 2001-04-26 | 2001-04-26 | Acesulfamsalz, Verfahren zu seiner Herstellung und seine Verwendung |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE10120413A1 true DE10120413A1 (de) | 2002-10-31 |
Family
ID=7682771
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE10120413A Withdrawn DE10120413A1 (de) | 2001-04-26 | 2001-04-26 | Acesulfamsalz, Verfahren zu seiner Herstellung und seine Verwendung |
Country Status (4)
| Country | Link |
|---|---|
| US (1) | US20020160091A1 (https=) |
| EP (1) | EP1262110A3 (https=) |
| JP (1) | JP2002363173A (https=) |
| DE (1) | DE10120413A1 (https=) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20060124724A (ko) * | 2004-01-26 | 2006-12-05 | 유니버시티 오브 사우스 앨라배마 | 음이온성―스위트너를 기반으로 하는 이온성 액체 및그것의 사용 방법 |
| US9101160B2 (en) | 2005-11-23 | 2015-08-11 | The Coca-Cola Company | Condiments with high-potency sweetener |
| US8017168B2 (en) | 2006-11-02 | 2011-09-13 | The Coca-Cola Company | High-potency sweetener composition with rubisco protein, rubiscolin, rubiscolin derivatives, ace inhibitory peptides, and combinations thereof, and compositions sweetened therewith |
| CN104292181B (zh) * | 2014-09-27 | 2016-10-26 | 安徽金禾实业股份有限公司 | 一种mvr系统浓缩安赛蜜母液的方法 |
| CN106496159B (zh) * | 2016-09-20 | 2018-09-21 | 苏州浩波科技股份有限公司 | 一种安赛蜜大粒度晶体的生产工艺 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL157304B (nl) * | 1970-01-10 | 1978-07-17 | Hoechst Ag | Werkwijze voor het bereiden van zoetmiddelen, onder toepassing van deze werkwijze verkregen gevormd voortbrengsel, alsmede werkwijze voor het bereiden van zoetsmakende verbindingen. |
| US6129942A (en) * | 1997-09-11 | 2000-10-10 | The Nutrasweet Company | Sweetener salts of N-[N-(3,3-dimethylbutyl)-L-α-aspartyl]-L-phenylalanine 1-methyl ester |
| NL1009324C2 (nl) * | 1998-06-05 | 1999-12-07 | Holland Sweetener Co | Bereiding en zuivering van een organisch zout van aspartaam. |
| WO2000000166A2 (en) * | 1998-06-29 | 2000-01-06 | Warner-Lambert Company | Improved oral compositions for control and prevention of tartar, oral malodor, plaque and gingivitis |
| DE50008187D1 (de) * | 1999-05-10 | 2004-11-18 | Abbott Gmbh & Co Kg | Salze von Thrombininhibitoren |
| WO2000069283A1 (en) * | 1999-05-13 | 2000-11-23 | The Nutrasweet Company | USE OF ADDITIVES TO MODIFY THE TASTE CHARACTERISTICS OF N-NEOHEXYL-α-ASPARTYL-L-PHENYLALANINE METHYL ESTER |
| US20020081360A1 (en) * | 2000-12-27 | 2002-06-27 | Andreas Burgard | Salts of L-amino acid having improved taste and their preparation |
-
2001
- 2001-04-26 DE DE10120413A patent/DE10120413A1/de not_active Withdrawn
-
2002
- 2002-04-15 EP EP02008467A patent/EP1262110A3/de not_active Withdrawn
- 2002-04-23 JP JP2002121258A patent/JP2002363173A/ja active Pending
- 2002-04-24 US US10/131,650 patent/US20020160091A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| JP2002363173A (ja) | 2002-12-18 |
| EP1262110A2 (de) | 2002-12-04 |
| EP1262110A3 (de) | 2002-12-18 |
| US20020160091A1 (en) | 2002-10-31 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| EP1219182B1 (de) | Salze von L-Aminosäuren mit verbessertem Geschmack und ihre Herstellung | |
| DE10130504B4 (de) | Xanthin- und Phenazon-Acesulfam-H-Komplexe mit verbessertem Geschmack, Verfahren zu ihrer Herstellung und ihre Verwendung | |
| EP0894083B1 (de) | Kreatin-pyruvate und verfahren zu deren herstellung | |
| DE2945790C2 (de) | Neutrales L-Ornithin-L-malat-dihydrat und neutrales L-Lysin-L-malat-monohydrat und Verfahren zu deren Herstellung | |
| DE19653225A1 (de) | Kreatin-pyruvate und Verfahren zu deren Herstellung | |
| DE2309582C3 (de) | Verfahren zur Gewinnung von reinem 7-Dimethylamino-6-desmethyl-6-desoxytetracyclinhydrochlorid aus seinen wäßrigen Rohlösungen und dabei gebildete Komplexverbindung mit Calciumchlorid | |
| EP0533790B1 (de) | Neue salzform von 5-difluormethoxy-2- [3,4-dimethoxy-2-pyridyl)methylsulfinyl]-1h-benzimidazol | |
| DE3438440A1 (de) | Platin-diamin-komplex | |
| DE2359333A1 (de) | Verfahren zur herstellung eines dopapraeparats | |
| DE10120413A1 (de) | Acesulfamsalz, Verfahren zu seiner Herstellung und seine Verwendung | |
| DE1795609A1 (de) | Verfahren zur Herstellung von Cephalosporinderivaten | |
| EP1561754B1 (de) | Verfahren zur Herstellung von 1,2-Diaminocyclohexan-Platin(II)-Komplexen | |
| DE2434549A1 (de) | Verfahren zur herstellung des suesstoffes 6-methyl-3,4-dihydro-1,2,3-oxathiazin4-on-2,2-dioxid | |
| DE2431483C3 (de) | Verfahren zur Herstellung von Alkali- oder Ammoniumsalzen von Insulin | |
| DE2434548A1 (de) | Verfahren zur herstellung des suessstoffes 6-methyl-3,4-dihydro-1,2,3-oxathiazin-4-on-2,2-dioxid-kalium | |
| DE2225332A1 (de) | 1 eckige Klammer auf 4 Hydroxy 3 (hydroxymethyl) phenyl eckige Klammer zu 1 hydroxy 2 aralkylaminoathane | |
| EP1134223B1 (de) | Acesulfam-Metall-Komplexe, Verfahren zu ihrer Herstellung und ihre Verwendung | |
| DE2506151C3 (de) | Doppelsalz aus Betain und Natriumchlorid, Verfahren zu seiner Herstellung und seine Verwendung als Würzmittel | |
| DE2506356C2 (de) | Acylphenoxypropansulfonsäuren, Verfahren zu deren Herstellung sowie diese Verbindungen enthaltende Süßstoffpräparate | |
| DE10130505A1 (de) | Coffein-Komplexe mit verbessertem Geschmack, Verfahren zu ihrer Herstellung und ihre Verwendung | |
| DE2121435A1 (de) | Kasugamycinderivate und Verfahren zu ihrer Herstellung | |
| DE2617308C2 (https=) | ||
| DE1924174C3 (de) | Magnesiumorotatglycinate | |
| DE2136478C3 (de) | Verfahren zur Herstellung von 1 ^-Naphthochinon-Semicarbazon | |
| DE2024805C3 (de) | Verfahren zur Herstellung von 2-Amino-3-chlorpyrazin |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8139 | Disposal/non-payment of the annual fee |