DE10064994A1 - Sulfamidothienopyrimidine - Google Patents
SulfamidothienopyrimidineInfo
- Publication number
- DE10064994A1 DE10064994A1 DE10064994A DE10064994A DE10064994A1 DE 10064994 A1 DE10064994 A1 DE 10064994A1 DE 10064994 A DE10064994 A DE 10064994A DE 10064994 A DE10064994 A DE 10064994A DE 10064994 A1 DE10064994 A1 DE 10064994A1
- Authority
- DE
- Germany
- Prior art keywords
- formula
- compounds
- atoms
- salts
- compound
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 150000001875 compounds Chemical class 0.000 claims abstract description 49
- 150000003839 salts Chemical class 0.000 claims description 27
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- 238000002360 preparation method Methods 0.000 claims description 10
- 125000000217 alkyl group Chemical group 0.000 claims description 9
- 238000000034 method Methods 0.000 claims description 9
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- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 5
- 238000002560 therapeutic procedure Methods 0.000 claims description 5
- 125000003342 alkenyl group Chemical group 0.000 claims description 4
- 125000001072 heteroaryl group Chemical group 0.000 claims description 4
- 239000000825 pharmaceutical preparation Substances 0.000 claims description 4
- 125000002947 alkylene group Chemical group 0.000 claims description 3
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims description 3
- 229940079593 drug Drugs 0.000 claims description 3
- 125000005346 substituted cycloalkyl group Chemical group 0.000 claims description 3
- 241000972349 Ocoa Species 0.000 claims description 2
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- 125000000753 cycloalkyl group Chemical group 0.000 claims description 2
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- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 description 4
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- 229910052784 alkaline earth metal Inorganic materials 0.000 description 3
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- 239000002775 capsule Substances 0.000 description 3
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 3
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- 239000011734 sodium Substances 0.000 description 3
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- 239000000829 suppository Substances 0.000 description 3
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- 229910052623 talc Inorganic materials 0.000 description 3
- DLFVBJFMPXGRIB-UHFFFAOYSA-N thioacetamide Natural products CC(N)=O DLFVBJFMPXGRIB-UHFFFAOYSA-N 0.000 description 3
- HZAXFHJVJLSVMW-UHFFFAOYSA-N 2-Aminoethan-1-ol Chemical compound NCCO HZAXFHJVJLSVMW-UHFFFAOYSA-N 0.000 description 2
- ZWEHNKRNPOVVGH-UHFFFAOYSA-N 2-Butanone Chemical compound CCC(C)=O ZWEHNKRNPOVVGH-UHFFFAOYSA-N 0.000 description 2
- XNWFRZJHXBZDAG-UHFFFAOYSA-N 2-METHOXYETHANOL Chemical group COCCO XNWFRZJHXBZDAG-UHFFFAOYSA-N 0.000 description 2
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 description 2
- BVKZGUZCCUSVTD-UHFFFAOYSA-M Bicarbonate Chemical class OC([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-M 0.000 description 2
- HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 description 2
- RGHNJXZEOKUKBD-SQOUGZDYSA-N D-gluconic acid Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C(O)=O RGHNJXZEOKUKBD-SQOUGZDYSA-N 0.000 description 2
- XTHFKEDIFFGKHM-UHFFFAOYSA-N Dimethoxyethane Chemical compound COCCOC XTHFKEDIFFGKHM-UHFFFAOYSA-N 0.000 description 2
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Landscapes
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- Immunology (AREA)
- Physical Education & Sports Medicine (AREA)
- Gynecology & Obstetrics (AREA)
- Hospice & Palliative Care (AREA)
- Vascular Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Priority Applications (20)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE10064994A DE10064994A1 (de) | 2000-12-23 | 2000-12-23 | Sulfamidothienopyrimidine |
| CZ20031815A CZ20031815A3 (cs) | 2000-12-23 | 2001-12-03 | Derivát sulfamidothienopyrimidinu, způsob jeho přípravy, jeho použití a farmaceutický prostředek, který ho obsahuje |
| MXPA03005714A MXPA03005714A (es) | 2000-12-23 | 2001-12-03 | Sulfamidotienopirimidinas. |
| RU2003122189/04A RU2003122189A (ru) | 2000-12-23 | 2001-12-03 | Сульфамидотиенопиримидины |
| US10/451,183 US7019013B2 (en) | 2000-12-23 | 2001-12-03 | Sulfamidothienopyrimidines |
| CA2432582A CA2432582C (en) | 2000-12-23 | 2001-12-03 | Sulfamidothienopyrimidines |
| PL01361733A PL361733A1 (en) | 2000-12-23 | 2001-12-03 | Sulfamidothienopyrimidines and the use of the same as phosphodiesterase v inhibitors |
| ES01271992T ES2247007T3 (es) | 2000-12-23 | 2001-12-03 | Sulfamidotienopirimidinas para el empleo como inhibidores de la fosfodiesterasa. |
| KR10-2003-7008265A KR20030062438A (ko) | 2000-12-23 | 2001-12-03 | 술파미도티에노피리미딘 |
| EP01271992A EP1353927B1 (de) | 2000-12-23 | 2001-12-03 | Sulfamidothienopyrimidine zur verwendung als phosphodiesterase v-hemmer |
| PCT/EP2001/014102 WO2002051848A2 (de) | 2000-12-23 | 2001-12-03 | Sulfamidothienopyrimidine zur verwendung als phosphodiesterase v-hemmer |
| AT01271992T ATE302781T1 (de) | 2000-12-23 | 2001-12-03 | Sulfamidothienopyrimidine zur verwendung als phosphodiesterase v-hemmer |
| JP2002552942A JP4550361B2 (ja) | 2000-12-23 | 2001-12-03 | スルファミドチエノピリミジン |
| DE50107230T DE50107230D1 (de) | 2000-12-23 | 2001-12-03 | Sulfamidothienopyrimidine zur verwendung als phosphodiesterase v-hemmer |
| SK843-2003A SK8432003A3 (en) | 2000-12-23 | 2001-12-03 | Sulfamidothienopyrimidines and the use of the same as phosphodiesterase v inhibitors |
| CNA018212190A CN1483035A (zh) | 2000-12-23 | 2001-12-03 | 氨磺酰基噻吩并嘧啶 |
| HU0302515A HUP0302515A3 (en) | 2000-12-23 | 2001-12-03 | Sulfanidothienopyrimidines, process for their preparation and pharmaceutical compositions containing them |
| BR0115996-8A BR0115996A (pt) | 2000-12-23 | 2001-12-03 | Sulfamidotienopirimidinas |
| ARP010105889A AR035524A1 (es) | 2000-12-23 | 2001-12-19 | Sulfamidotienopirimidinas, un procedimiento para su preparacion, el uso de las mismas para la preparacion de un medicamento, los medicamentos que las comprenden, un conjunto (kit) que las incluye, las preparaciones farmaceuticas que las contienen, y un procedimiento para preparar estas preparaciones |
| ZA200305659A ZA200305659B (en) | 2000-12-23 | 2003-07-22 | Sulfamidothienopyrimidines and the use of the same as phosphodiesterase V inhibitors. |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE10064994A DE10064994A1 (de) | 2000-12-23 | 2000-12-23 | Sulfamidothienopyrimidine |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE10064994A1 true DE10064994A1 (de) | 2002-07-04 |
Family
ID=7668967
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE10064994A Withdrawn DE10064994A1 (de) | 2000-12-23 | 2000-12-23 | Sulfamidothienopyrimidine |
| DE50107230T Expired - Lifetime DE50107230D1 (de) | 2000-12-23 | 2001-12-03 | Sulfamidothienopyrimidine zur verwendung als phosphodiesterase v-hemmer |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE50107230T Expired - Lifetime DE50107230D1 (de) | 2000-12-23 | 2001-12-03 | Sulfamidothienopyrimidine zur verwendung als phosphodiesterase v-hemmer |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US7019013B2 (enExample) |
| EP (1) | EP1353927B1 (enExample) |
| JP (1) | JP4550361B2 (enExample) |
| KR (1) | KR20030062438A (enExample) |
| CN (1) | CN1483035A (enExample) |
| AR (1) | AR035524A1 (enExample) |
| AT (1) | ATE302781T1 (enExample) |
| BR (1) | BR0115996A (enExample) |
| CA (1) | CA2432582C (enExample) |
| CZ (1) | CZ20031815A3 (enExample) |
| DE (2) | DE10064994A1 (enExample) |
| ES (1) | ES2247007T3 (enExample) |
| HU (1) | HUP0302515A3 (enExample) |
| MX (1) | MXPA03005714A (enExample) |
| PL (1) | PL361733A1 (enExample) |
| RU (1) | RU2003122189A (enExample) |
| SK (1) | SK8432003A3 (enExample) |
| WO (1) | WO2002051848A2 (enExample) |
| ZA (1) | ZA200305659B (enExample) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6849638B2 (en) * | 2001-04-30 | 2005-02-01 | Bayer Pharmaceuticals Corporation | 4-amino-5,6-substituted thiopheno [2,3-d] pyrimidines, pharmaceutical compositions containing the same, and their use in the treatment or prevention of pde7b-mediated diseases and conditions |
| MX2007012313A (es) | 2006-04-19 | 2007-11-21 | Boehringer Ingelheim Int | Dihidrotienopirimidinas para el tratamiento de enfermedades inflamatorias. |
| EP1847543A1 (de) | 2006-04-19 | 2007-10-24 | Boehringer Ingelheim Pharma GmbH & Co. KG | Dihydrothienopyrimidine zur Behandlung von entzündlichen Erkrankungen |
| US8071596B2 (en) | 2007-01-12 | 2011-12-06 | Concert Pharmaceuticals, Inc. | Endothelin receptor antagonists |
| US8080549B2 (en) * | 2007-01-12 | 2011-12-20 | Concert Pharmaceuticals, Inc. | Endothelin receptor antagonists |
| EP2117538A1 (en) | 2007-01-24 | 2009-11-18 | Glaxo Group Limited | Pharmaceutical compositions comprising 2-methoxy-5- (5-trifluoromethyl-tetrazol-i-yl-benzyl) - (2s-phenyl-piperidin-3s-yl-) |
| CA2702518A1 (en) | 2007-10-19 | 2009-04-23 | Boehringer Ingelheim International Gmbh | New piperazino-dihydrothienopyrimidine derivatives |
| BRPI0817781A2 (pt) | 2007-10-19 | 2019-09-24 | Boehringer Ingelheim Int | piperazino-diidroteinopirimidinas substituídas com heterociclo |
| PT2215092E (pt) * | 2007-10-19 | 2012-04-10 | Boehringer Ingelheim Int | Piperidino-di-hidrotienopirimidinas substituídas |
| EP2595993B1 (en) | 2010-07-23 | 2018-04-18 | President and Fellows of Harvard College | Tricyclic proteasome activity enhancing compounds |
| US20130059866A1 (en) | 2011-08-24 | 2013-03-07 | Boehringer Ingelheim International Gmbh | Novel piperidino-dihydrothienopyrimidine sulfoxides and their use for treating copd and asthma |
| US9802954B2 (en) | 2011-08-24 | 2017-10-31 | Boehringer Ingelheim International Gmbh | Piperidino-dihydrothienopyrimidine sulfoxides and their use for treating COPD and asthma |
| JP2015504919A (ja) | 2012-01-25 | 2015-02-16 | プロテオステイシス セラピューティクス，インコーポレイテッド | プロテアソーム活性を調節する化合物 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE19644228A1 (de) * | 1996-10-24 | 1998-04-30 | Merck Patent Gmbh | Thienopyrimidine |
| DE19752952A1 (de) * | 1997-11-28 | 1999-06-02 | Merck Patent Gmbh | Thienopyrimidine |
| DE19819023A1 (de) * | 1998-04-29 | 1999-11-04 | Merck Patent Gmbh | Thienopyrimidine |
| EP1323719A1 (en) * | 1999-03-30 | 2003-07-02 | Nippon Soda Co., Ltd. | Thienopyrimidine compounds and salts thereof and process for the preparation of the same |
-
2000
- 2000-12-23 DE DE10064994A patent/DE10064994A1/de not_active Withdrawn
-
2001
- 2001-12-03 CN CNA018212190A patent/CN1483035A/zh active Pending
- 2001-12-03 RU RU2003122189/04A patent/RU2003122189A/ru not_active Application Discontinuation
- 2001-12-03 AT AT01271992T patent/ATE302781T1/de not_active IP Right Cessation
- 2001-12-03 DE DE50107230T patent/DE50107230D1/de not_active Expired - Lifetime
- 2001-12-03 CZ CZ20031815A patent/CZ20031815A3/cs unknown
- 2001-12-03 CA CA2432582A patent/CA2432582C/en not_active Expired - Fee Related
- 2001-12-03 MX MXPA03005714A patent/MXPA03005714A/es not_active Application Discontinuation
- 2001-12-03 BR BR0115996-8A patent/BR0115996A/pt not_active Application Discontinuation
- 2001-12-03 KR KR10-2003-7008265A patent/KR20030062438A/ko not_active Withdrawn
- 2001-12-03 PL PL01361733A patent/PL361733A1/xx unknown
- 2001-12-03 HU HU0302515A patent/HUP0302515A3/hu unknown
- 2001-12-03 JP JP2002552942A patent/JP4550361B2/ja not_active Expired - Fee Related
- 2001-12-03 WO PCT/EP2001/014102 patent/WO2002051848A2/de not_active Ceased
- 2001-12-03 US US10/451,183 patent/US7019013B2/en not_active Expired - Fee Related
- 2001-12-03 ES ES01271992T patent/ES2247007T3/es not_active Expired - Lifetime
- 2001-12-03 SK SK843-2003A patent/SK8432003A3/sk unknown
- 2001-12-03 EP EP01271992A patent/EP1353927B1/de not_active Expired - Lifetime
- 2001-12-19 AR ARP010105889A patent/AR035524A1/es not_active Application Discontinuation
-
2003
- 2003-07-22 ZA ZA200305659A patent/ZA200305659B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| KR20030062438A (ko) | 2003-07-25 |
| JP4550361B2 (ja) | 2010-09-22 |
| ATE302781T1 (de) | 2005-09-15 |
| PL361733A1 (en) | 2004-10-04 |
| US7019013B2 (en) | 2006-03-28 |
| CN1483035A (zh) | 2004-03-17 |
| WO2002051848A2 (de) | 2002-07-04 |
| ZA200305659B (en) | 2004-08-27 |
| WO2002051848A3 (de) | 2002-10-24 |
| AR035524A1 (es) | 2004-06-02 |
| HUP0302515A3 (en) | 2005-06-28 |
| EP1353927A2 (de) | 2003-10-22 |
| CA2432582C (en) | 2011-01-25 |
| US20040063943A1 (en) | 2004-04-01 |
| ES2247007T3 (es) | 2006-03-01 |
| BR0115996A (pt) | 2004-01-06 |
| MXPA03005714A (es) | 2003-10-06 |
| JP2004516329A (ja) | 2004-06-03 |
| EP1353927B1 (de) | 2005-08-24 |
| CA2432582A1 (en) | 2002-07-04 |
| DE50107230D1 (de) | 2005-09-29 |
| SK8432003A3 (en) | 2003-10-07 |
| CZ20031815A3 (cs) | 2003-10-15 |
| HUP0302515A2 (hu) | 2003-11-28 |
| RU2003122189A (ru) | 2004-12-27 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8139 | Disposal/non-payment of the annual fee |