DE10050662A1 - Substituierte 3,4-Dihydro-pyrido[1,2-a]pyrimidine - Google Patents

Substituierte 3,4-Dihydro-pyrido[1,2-a]pyrimidine

Info

Publication number
DE10050662A1
DE10050662A1 DE10050662A DE10050662A DE10050662A1 DE 10050662 A1 DE10050662 A1 DE 10050662A1 DE 10050662 A DE10050662 A DE 10050662A DE 10050662 A DE10050662 A DE 10050662A DE 10050662 A1 DE10050662 A1 DE 10050662A1
Authority
DE
Germany
Prior art keywords
alkyl
unsubstituted
polysubstituted
mono
aryl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
DE10050662A
Other languages
German (de)
English (en)
Inventor
Matthias Gerlach
Corinna Maul
Utz-Peter Jagusch
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Gruenenthal GmbH
Original Assignee
Gruenenthal GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gruenenthal GmbH filed Critical Gruenenthal GmbH
Priority to DE10050662A priority Critical patent/DE10050662A1/de
Priority to ARP010104731A priority patent/AR034266A1/es
Priority to BR0114734-0A priority patent/BR0114734A/pt
Priority to JP2002534319A priority patent/JP4315678B2/ja
Priority to SK414-2003A priority patent/SK4142003A3/sk
Priority to DK01978402T priority patent/DK1326866T3/da
Priority to EP01978402A priority patent/EP1326866B1/de
Priority to PT01978402T priority patent/PT1326866E/pt
Priority to SI200130397T priority patent/SI1326866T1/xx
Priority to ES01978402T priority patent/ES2241882T3/es
Priority to AU1052602A priority patent/AU1052602A/xx
Priority to KR10-2003-7005162A priority patent/KR20030036924A/ko
Priority to AT01978402T priority patent/ATE297927T1/de
Priority to NZ525652A priority patent/NZ525652A/en
Priority to CA002425666A priority patent/CA2425666A1/en
Priority to RU2003113966/04A priority patent/RU2003113966A/ru
Priority to CNB018205011A priority patent/CN1255407C/zh
Priority to MXPA03003198A priority patent/MXPA03003198A/es
Priority to AU2002210526A priority patent/AU2002210526B2/en
Priority to PCT/EP2001/011700 priority patent/WO2002030933A1/de
Priority to DE50106542T priority patent/DE50106542D1/de
Priority to PL01361915A priority patent/PL361915A1/xx
Priority to HU0302464A priority patent/HUP0302464A2/hu
Priority to IL15538001A priority patent/IL155380A0/xx
Priority to PE2001001014A priority patent/PE20020435A1/es
Publication of DE10050662A1 publication Critical patent/DE10050662A1/de
Priority to NO20031412A priority patent/NO20031412L/no
Priority to IL155380A priority patent/IL155380A/en
Priority to US10/411,390 priority patent/US7230103B2/en
Priority to EC2003004553A priority patent/ECSP034553A/es
Priority to CO03031095A priority patent/CO5640115A2/es
Priority to ZA200303640A priority patent/ZA200303640B/en
Priority to HK04100342A priority patent/HK1057551A1/xx
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/12—Antidiarrhoeals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/04—Antipruritics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/16—Otologicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pain & Pain Management (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Rheumatology (AREA)
  • Urology & Nephrology (AREA)
  • Dermatology (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DE10050662A 2000-10-13 2000-10-13 Substituierte 3,4-Dihydro-pyrido[1,2-a]pyrimidine Withdrawn DE10050662A1 (de)

Priority Applications (32)

Application Number Priority Date Filing Date Title
DE10050662A DE10050662A1 (de) 2000-10-13 2000-10-13 Substituierte 3,4-Dihydro-pyrido[1,2-a]pyrimidine
ARP010104731A AR034266A1 (es) 2000-10-13 2001-10-09 3,4-dihidro-pirido[1,2-a]pirimidinas sustituidas, procedimiento para su preparacion, biblioteca de sustancia que las contienen, medicamentos que contienen estos compuestos, uso de estos compuestos para la preparacion de medicamentos para el tratamiento del dolor, incontinencia urinaria, prurito, tin
RU2003113966/04A RU2003113966A (ru) 2000-10-13 2001-10-10 Замещенные 3,4-дигидропиридо [1,2-а]пиримидины
NZ525652A NZ525652A (en) 2000-10-13 2001-10-10 Substituted 3,4-dihydropyrido[1,2-a]pyrimidines
SK414-2003A SK4142003A3 (en) 2000-10-13 2001-10-10 Substituted 3,4-dihydro-pyrido[1,2-A]pyrimidines, process for producing thereof, medicaments comprising same and their use
DK01978402T DK1326866T3 (da) 2000-10-13 2001-10-10 Substituerede 3,4-dihydro-pyrido[1,2-a]pyrimidiner
EP01978402A EP1326866B1 (de) 2000-10-13 2001-10-10 Substituierte 3,4-dihydro-pyrido[1,2-a]pyrimidine
PT01978402T PT1326866E (pt) 2000-10-13 2001-10-10 3,4-di-hidropirido[1,2-a]pirimidinas substituidas
AU2002210526A AU2002210526B2 (en) 2000-10-13 2001-10-10 Substituted 3.4-dihydro-pyrido[1,2-A]pyrimidines
ES01978402T ES2241882T3 (es) 2000-10-13 2001-10-10 3,4-dihidropirido(1,2-a)pirimidas sustituidas.
AU1052602A AU1052602A (en) 2000-10-13 2001-10-10 Substituted 3.4-dihydro-pyrido(1,2-A)pyrimidines
KR10-2003-7005162A KR20030036924A (ko) 2000-10-13 2001-10-10 치환된 3,4-디하이드로-피리도[1,2-ａ]피리미딘
AT01978402T ATE297927T1 (de) 2000-10-13 2001-10-10 Substituierte 3,4-dihydro-pyrido(1,2-a)pyrimidine
JP2002534319A JP4315678B2 (ja) 2000-10-13 2001-10-10 置換された３，４−ジヒドロ−ピリド［１，２−ａ］ピリミジン類
CA002425666A CA2425666A1 (en) 2000-10-13 2001-10-10 Substituted 3.4-dihydro-pyrido[1,2-a]pyrimidines
BR0114734-0A BR0114734A (pt) 2000-10-13 2001-10-10 3,4-dihidropirido [1, 2-a] pirimidinas substituìdas
CNB018205011A CN1255407C (zh) 2000-10-13 2001-10-10 取代的3,4－二氢吡啶并[1,2－a]嘧啶
MXPA03003198A MXPA03003198A (es) 2000-10-13 2001-10-10 3,4-dihidro-pirido [1,2-a]pirimidinas sustituidas.
SI200130397T SI1326866T1 (en) 2000-10-13 2001-10-10 Substituted 3.4-dihydro-pyrido(1,2-a)pyrimidines
PCT/EP2001/011700 WO2002030933A1 (de) 2000-10-13 2001-10-10 Substituierte 3,4-dihydro-pyrido[1,2-a]pyrimidine
DE50106542T DE50106542D1 (de) 2000-10-13 2001-10-10 Substituierte 3,4-dihydro-pyrido[1,2-a]pyrimidine
PL01361915A PL361915A1 (en) 2000-10-13 2001-10-10 Substituted 3.4-dihydro-pyrido[1,2-a]pyrimidines
HU0302464A HUP0302464A2 (hu) 2000-10-13 2001-10-10 Szubsztituált 3,4-dihidro-pirido[1,2-a]pirimidin-származékok, eljárás az előállításukra, alkalmazásuk és ezeket tartalmazó gyógyszerkészítmények
IL15538001A IL155380A0 (en) 2000-10-13 2001-10-10 SUBSTITUTED 3,4-DIHYDRO-PYRIDO[1,2-a] PYRIMIDINES
PE2001001014A PE20020435A1 (es) 2000-10-13 2001-10-12 3-4-DIHIDRO-PIRIDO[1,2-a]PIRIMIDINAS SUSTITUIDAS
NO20031412A NO20031412L (no) 2000-10-13 2003-03-27 Substituerte 3,4-dihydro-pyrido[1,2-A]pyrimidiner
IL155380A IL155380A (en) 2000-10-13 2003-04-10 3,4 - Dihydro-pyrido [a - 1,2] Pyrimidines are permitted
US10/411,390 US7230103B2 (en) 2000-10-13 2003-04-11 Substituted 3,4-dihydropyrido[1,2-a]pyrimidines
EC2003004553A ECSP034553A (es) 2000-10-13 2003-04-11 3,4-DIHIDROPIRIDO (1,2-a)PIRIMIDINAS SUSTITUIDAS
CO03031095A CO5640115A2 (es) 2000-10-13 2003-04-11 3,4-dihidropirido [1,2-a] pirimidinas sustituidas
ZA200303640A ZA200303640B (en) 2000-10-13 2003-05-12 Substituted 3.4-dihydro-pyrido[1,2-A]pyrimidines.
HK04100342A HK1057551A1 (en) 2000-10-13 2004-01-15 Substituted 3,4-dihydro-pyridoÄ1,2-AÜpyrimidines.

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE10050662A DE10050662A1 (de) 2000-10-13 2000-10-13 Substituierte 3,4-Dihydro-pyrido[1,2-a]pyrimidine

Publications (1)

Publication Number Publication Date
DE10050662A1 true DE10050662A1 (de) 2002-04-18

Family

ID=7659597

Family Applications (2)

Application Number Title Priority Date Filing Date
DE10050662A Withdrawn DE10050662A1 (de) 2000-10-13 2000-10-13 Substituierte 3,4-Dihydro-pyrido[1,2-a]pyrimidine
DE50106542T Expired - Lifetime DE50106542D1 (de) 2000-10-13 2001-10-10 Substituierte 3,4-dihydro-pyrido[1,2-a]pyrimidine

Family Applications After (1)

Application Number Title Priority Date Filing Date
DE50106542T Expired - Lifetime DE50106542D1 (de) 2000-10-13 2001-10-10 Substituierte 3,4-dihydro-pyrido[1,2-a]pyrimidine

Country Status (27)

Country Link
US (1) US7230103B2 (xx)
EP (1) EP1326866B1 (xx)
JP (1) JP4315678B2 (xx)
KR (1) KR20030036924A (xx)
CN (1) CN1255407C (xx)
AR (1) AR034266A1 (xx)
AT (1) ATE297927T1 (xx)
AU (2) AU1052602A (xx)
BR (1) BR0114734A (xx)
CA (1) CA2425666A1 (xx)
CO (1) CO5640115A2 (xx)
DE (2) DE10050662A1 (xx)
EC (1) ECSP034553A (xx)
ES (1) ES2241882T3 (xx)
HK (1) HK1057551A1 (xx)
HU (1) HUP0302464A2 (xx)
IL (2) IL155380A0 (xx)
MX (1) MXPA03003198A (xx)
NO (1) NO20031412L (xx)
NZ (1) NZ525652A (xx)
PE (1) PE20020435A1 (xx)
PL (1) PL361915A1 (xx)
PT (1) PT1326866E (xx)
RU (1) RU2003113966A (xx)
SK (1) SK4142003A3 (xx)
WO (1) WO2002030933A1 (xx)
ZA (1) ZA200303640B (xx)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10310106A1 (de) * 2003-03-06 2004-09-16 Grünenthal GmbH Substituierte Pyridot [1,2-a]pyrimidin-Verbindungen

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20070155738A1 (en) 2005-05-20 2007-07-05 Alantos Pharmaceuticals, Inc. Heterobicyclic metalloprotease inhibitors
EP2379566A2 (en) * 2008-12-22 2011-10-26 Schering Corporation Gamma secretase modulators

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4291036A (en) * 1977-08-19 1981-09-22 Chinoin Gyogyszer Es Vegyeszeti Termekek Gyara Rt. Pyrido[1,2-A]pyrimidine derivatives and method of analgesic treatment
EP0182569B1 (en) * 1984-11-12 1992-01-29 CHINOIN Gyogyszer és Vegyészeti Termékek Gyára RT. Use of 1,6-dimethyl-4-oxo-1,6,7,8,9a-hexahydro-4H-pyrido[1,2-a]pyrimidine-3-carboxamide for the prevention and treatment of gastrointestinal damages

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4291036A (en) * 1977-08-19 1981-09-22 Chinoin Gyogyszer Es Vegyeszeti Termekek Gyara Rt. Pyrido[1,2-A]pyrimidine derivatives and method of analgesic treatment
EP0182569B1 (en) * 1984-11-12 1992-01-29 CHINOIN Gyogyszer és Vegyészeti Termékek Gyára RT. Use of 1,6-dimethyl-4-oxo-1,6,7,8,9a-hexahydro-4H-pyrido[1,2-a]pyrimidine-3-carboxamide for the prevention and treatment of gastrointestinal damages

Non-Patent Citations (8)

* Cited by examiner, † Cited by third party
Title
Chemical Abstracts: Vol. 127, 1997, Ref. 275116d *
FÜLOP,F., et.al.: Nitrogen Bridgehead Compounds. In: Pharmazie 38, 1983, H. 4, S.218-220 *
KATRITZKY,Alan,R., et.al.: A Novel Facile Method for the Synthesis of 3,4-Dihydro-2H-pyridol [1,2 -a]pyrimidinium Salts. In: Short Papers, Synthesis1998, S.704-706 *
Vol. 124, 1996, Ref. 250537s *
Vol. 124, 1996, Ref. 260974w *
Vol. 126, 1997, Ref. 171887u *
Vol. 128, 1998, Ref. 294752v *
Vol. 92, 1980, Ref. 110889d *

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10310106A1 (de) * 2003-03-06 2004-09-16 Grünenthal GmbH Substituierte Pyridot [1,2-a]pyrimidin-Verbindungen
DE10310106A8 (de) * 2003-03-06 2004-12-30 Grünenthal GmbH Substituierte Pyrido[1,2-a]pyrimidin-Verbindungen
US7320980B2 (en) 2003-03-06 2008-01-22 Gruenenthal Gmbh Substituted pyrido(1,2-a)pyrimidines and their use as NOS inhibitors

Also Published As

Publication number Publication date
AR034266A1 (es) 2004-02-18
IL155380A (en) 2009-02-11
CN1255407C (zh) 2006-05-10
JP2004511484A (ja) 2004-04-15
CA2425666A1 (en) 2003-04-11
NZ525652A (en) 2005-01-28
ES2241882T3 (es) 2005-11-01
US7230103B2 (en) 2007-06-12
EP1326866B1 (de) 2005-06-15
HK1057551A1 (en) 2004-04-08
US20030229104A1 (en) 2003-12-11
DE50106542D1 (de) 2005-07-21
NO20031412L (no) 2003-04-22
ECSP034553A (es) 2003-05-26
WO2002030933A1 (de) 2002-04-18
EP1326866A1 (de) 2003-07-16
HUP0302464A2 (hu) 2003-11-28
RU2003113966A (ru) 2004-12-10
CN1479740A (zh) 2004-03-03
CO5640115A2 (es) 2006-05-31
KR20030036924A (ko) 2003-05-09
ZA200303640B (en) 2004-08-12
NO20031412D0 (no) 2003-03-27
JP4315678B2 (ja) 2009-08-19
BR0114734A (pt) 2003-07-01
ATE297927T1 (de) 2005-07-15
PE20020435A1 (es) 2002-05-18
IL155380A0 (en) 2003-11-23
PT1326866E (pt) 2005-08-31
PL361915A1 (en) 2004-10-04
AU2002210526B2 (en) 2006-10-19
SK4142003A3 (en) 2003-10-07
MXPA03003198A (es) 2004-05-21
AU1052602A (en) 2002-04-22

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