DE10029851A1 - Enantiomerentrennung von Piperidon-Derivaten unter gleichzeitiger in situ Racemisierung des unerwünschten Enantiomers - Google Patents

Enantiomerentrennung von Piperidon-Derivaten unter gleichzeitiger in situ Racemisierung des unerwünschten Enantiomers

Info

Publication number
DE10029851A1
DE10029851A1 DE10029851A DE10029851A DE10029851A1 DE 10029851 A1 DE10029851 A1 DE 10029851A1 DE 10029851 A DE10029851 A DE 10029851A DE 10029851 A DE10029851 A DE 10029851A DE 10029851 A1 DE10029851 A1 DE 10029851A1
Authority
DE
Germany
Prior art keywords
salt
acid
enantiomer
solution
desired enantiomer
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
DE10029851A
Other languages
German (de)
English (en)
Inventor
Hermann Mueller-Boetticher
Gerd-Rainer Bressler
Paul Kreye
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Boehringer Ingelheim Pharma GmbH and Co KG
Original Assignee
Boehringer Ingelheim Pharma GmbH and Co KG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim Pharma GmbH and Co KG filed Critical Boehringer Ingelheim Pharma GmbH and Co KG
Priority to DE10029851A priority Critical patent/DE10029851A1/de
Priority to US09/843,061 priority patent/US6495694B2/en
Priority to IL15308501A priority patent/IL153085A0/xx
Priority to KR1020027016915A priority patent/KR100863922B1/ko
Priority to PCT/EP2001/006552 priority patent/WO2001096306A1/fr
Priority to JP2002510449A priority patent/JP2004503539A/ja
Priority to EP01949395A priority patent/EP1305287A1/fr
Priority to MXPA02012301A priority patent/MXPA02012301A/es
Priority to CA 2409614 priority patent/CA2409614C/fr
Priority to AU2001270563A priority patent/AU2001270563A1/en
Priority to ARP010102869A priority patent/AR028957A1/es
Publication of DE10029851A1 publication Critical patent/DE10029851A1/de
Priority to IL153085A priority patent/IL153085A/en
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D211/72—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D211/74—Oxygen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Hydrogenated Pyridines (AREA)
  • Plural Heterocyclic Compounds (AREA)
DE10029851A 2000-06-16 2000-06-16 Enantiomerentrennung von Piperidon-Derivaten unter gleichzeitiger in situ Racemisierung des unerwünschten Enantiomers Ceased DE10029851A1 (de)

Priority Applications (12)

Application Number Priority Date Filing Date Title
DE10029851A DE10029851A1 (de) 2000-06-16 2000-06-16 Enantiomerentrennung von Piperidon-Derivaten unter gleichzeitiger in situ Racemisierung des unerwünschten Enantiomers
US09/843,061 US6495694B2 (en) 2000-06-16 2001-04-26 Efficient separation of enantiomers of piperidone derivatives by precipitation of the desired eantiomer during in situ racemization of the unwanted enantiomer
JP2002510449A JP2004503539A (ja) 2000-06-16 2001-06-09 望ましくない鏡像体のｉｎｓｉｔｕ同時ラセミ化を伴うピペリドン誘導体の鏡像体の分離
KR1020027016915A KR100863922B1 (ko) 2000-06-16 2001-06-09 피페리돈 유도체의 목적하는 에난티오머를 분리하는 동시에 동일 반응계에서 목적하지 않는 에난티오머를 라세미화시키는 방법
PCT/EP2001/006552 WO2001096306A1 (fr) 2000-06-16 2001-06-09 Separation d'enantionmeres de derives de piperidone avec racemisation in situ simultanee de l'enantiomere indesirable
IL15308501A IL153085A0 (en) 2000-06-16 2001-06-09 Enantiomer separation of piperidone derivatives with simultaneous in situ racemization of the unwanted enantiomer
EP01949395A EP1305287A1 (fr) 2000-06-16 2001-06-09 SEPARATION D'ENANTIONMERES DE DERIVES DE PIPERIDONE AVEC RACEMISATION $i(IN SITU) SIMULTANEE DE L'ENANTIOMERE INDESIRABLE
MXPA02012301A MXPA02012301A (es) 2000-06-16 2001-06-09 Separacion entre enantiomeros de derivados de piperidona con simultanea racemizacion in situ del enantiomero indeseado.
CA 2409614 CA2409614C (fr) 2000-06-16 2001-06-09 Separation d'enantionmeres de derives de piperidone avec racemisation in situ simultanee de l'enantiomere indesirable
AU2001270563A AU2001270563A1 (en) 2000-06-16 2001-06-09 Enantiomer separation of piperidone derivatives with simultaneous in situ racemization of the unwanted enantiomer
ARP010102869A AR028957A1 (es) 2000-06-16 2001-06-15 SEPARACION ENTRE ENANTIoMEROS DE DERIVADOS DE PIPERIDONA CON SIMULTA NEA RACEMIZACIoN IN SITU DEL ENANTIoMERO INDESEADO
IL153085A IL153085A (en) 2000-06-16 2002-11-26 Anentiomeric separation of the history of piperidine while simultaneously recombining the unwanted enantiomer

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE10029851A DE10029851A1 (de) 2000-06-16 2000-06-16 Enantiomerentrennung von Piperidon-Derivaten unter gleichzeitiger in situ Racemisierung des unerwünschten Enantiomers

Publications (1)

Publication Number Publication Date
DE10029851A1 true DE10029851A1 (de) 2001-12-20

Family

ID=7646064

Family Applications (1)

Application Number Title Priority Date Filing Date
DE10029851A Ceased DE10029851A1 (de) 2000-06-16 2000-06-16 Enantiomerentrennung von Piperidon-Derivaten unter gleichzeitiger in situ Racemisierung des unerwünschten Enantiomers

Country Status (10)

Country Link
EP (1) EP1305287A1 (fr)
JP (1) JP2004503539A (fr)
KR (1) KR100863922B1 (fr)
AR (1) AR028957A1 (fr)
AU (1) AU2001270563A1 (fr)
CA (1) CA2409614C (fr)
DE (1) DE10029851A1 (fr)
IL (2) IL153085A0 (fr)
MX (1) MXPA02012301A (fr)
WO (1) WO2001096306A1 (fr)

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19528472A1 (de) * 1995-08-03 1997-02-06 Boehringer Ingelheim Kg Neues Verfahren zur Herstellung von Norbenzomorphan einer Zwischenstufe bei Herstellung von pharmazeutisch wertvollen Benzomorphanderivaten, insbesondere von (-)-(1R,5S,S"R)-3'-Hydroxy-2-(2-methoxypropyl-)-5,9,9-trimethyl-6,7 benzomorphan

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0736724B2 (ja) * 1992-08-07 1995-04-26 株式会社スリオンテック 紫外線硬化型粘着剤を用いた播種育苗シート及びその製造方法
ES2173194T3 (es) * 1994-09-23 2002-10-16 Darwin Discovery Ltd Procedimiento de racemizacion utilizado para la preparacion de levobupivacaina y sus analogos.

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19528472A1 (de) * 1995-08-03 1997-02-06 Boehringer Ingelheim Kg Neues Verfahren zur Herstellung von Norbenzomorphan einer Zwischenstufe bei Herstellung von pharmazeutisch wertvollen Benzomorphanderivaten, insbesondere von (-)-(1R,5S,S"R)-3'-Hydroxy-2-(2-methoxypropyl-)-5,9,9-trimethyl-6,7 benzomorphan

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
BEYER,H., WALTER,W.: Lehrbuch der Organischen Chemie, Hirzel Verlag, Stuttgart, 1991, S.344, S.347-349 *

Also Published As

Publication number Publication date
EP1305287A1 (fr) 2003-05-02
CA2409614A1 (fr) 2001-12-20
MXPA02012301A (es) 2003-04-25
WO2001096306A1 (fr) 2001-12-20
CA2409614C (fr) 2008-08-05
KR100863922B1 (ko) 2008-10-17
AR028957A1 (es) 2003-05-28
IL153085A0 (en) 2003-06-24
IL153085A (en) 2008-11-26
JP2004503539A (ja) 2004-02-05
AU2001270563A1 (en) 2001-12-24
KR20030016288A (ko) 2003-02-26

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Legal Events

Date Code Title Description
OM8 Search report available as to paragraph 43 lit. 1 sentence 1 patent law
8127 New person/name/address of the applicant

Owner name: BOEHRINGER INGELHEIM PHARMA GMBH & CO.KG, 55218 IN

8110 Request for examination paragraph 44
R002 Refusal decision in examination/registration proceedings
R003 Refusal decision now final

Effective date: 20120104