CA2409614C - Separation d'enantionmeres de derives de piperidone avec racemisation in situ simultanee de l'enantiomere indesirable - Google Patents

Separation d'enantionmeres de derives de piperidone avec racemisation in situ simultanee de l'enantiomere indesirable Download PDF

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Publication number
CA2409614C
CA2409614C CA 2409614 CA2409614A CA2409614C CA 2409614 C CA2409614 C CA 2409614C CA 2409614 CA2409614 CA 2409614 CA 2409614 A CA2409614 A CA 2409614A CA 2409614 C CA2409614 C CA 2409614C
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CA
Canada
Prior art keywords
denotes
acid
process according
enantiomer
solution
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CA 2409614
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English (en)
Other versions
CA2409614A1 (fr
Inventor
Hermann Mueller-Boetticher
Gerd-Rainer Bressler
Paul Kreye
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Boehringer Ingelheim Pharma GmbH and Co KG
Original Assignee
Boehringer Ingelheim Pharma GmbH and Co KG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim Pharma GmbH and Co KG filed Critical Boehringer Ingelheim Pharma GmbH and Co KG
Publication of CA2409614A1 publication Critical patent/CA2409614A1/fr
Application granted granted Critical
Publication of CA2409614C publication Critical patent/CA2409614C/fr
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D211/72—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D211/74—Oxygen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Hydrogenated Pyridines (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

La présente invention concerne un procédé pouvant être mise en oeuvre à l'échelle de la technique servant à séparer de manière dynamique des énantiomères de dérivés de pipéridone de formule générale (1) dans laquelle R<1>, R<2>, R<3> et n correspondent aux éléments indiqués dans la description et dans les revendications, en même temps que s'effectue une racémisation in situ de l'énantiomère non converti.
CA 2409614 2000-06-16 2001-06-09 Separation d'enantionmeres de derives de piperidone avec racemisation in situ simultanee de l'enantiomere indesirable Expired - Fee Related CA2409614C (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE10029851.6 2000-06-16
DE10029851A DE10029851A1 (de) 2000-06-16 2000-06-16 Enantiomerentrennung von Piperidon-Derivaten unter gleichzeitiger in situ Racemisierung des unerwünschten Enantiomers
PCT/EP2001/006552 WO2001096306A1 (fr) 2000-06-16 2001-06-09 Separation d'enantionmeres de derives de piperidone avec racemisation in situ simultanee de l'enantiomere indesirable

Publications (2)

Publication Number Publication Date
CA2409614A1 CA2409614A1 (fr) 2001-12-20
CA2409614C true CA2409614C (fr) 2008-08-05

Family

ID=7646064

Family Applications (1)

Application Number Title Priority Date Filing Date
CA 2409614 Expired - Fee Related CA2409614C (fr) 2000-06-16 2001-06-09 Separation d'enantionmeres de derives de piperidone avec racemisation in situ simultanee de l'enantiomere indesirable

Country Status (10)

Country Link
EP (1) EP1305287A1 (fr)
JP (1) JP2004503539A (fr)
KR (1) KR100863922B1 (fr)
AR (1) AR028957A1 (fr)
AU (1) AU2001270563A1 (fr)
CA (1) CA2409614C (fr)
DE (1) DE10029851A1 (fr)
IL (2) IL153085A0 (fr)
MX (1) MXPA02012301A (fr)
WO (1) WO2001096306A1 (fr)

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0736724B2 (ja) * 1992-08-07 1995-04-26 株式会社スリオンテック 紫外線硬化型粘着剤を用いた播種育苗シート及びその製造方法
ES2173194T3 (es) * 1994-09-23 2002-10-16 Darwin Discovery Ltd Procedimiento de racemizacion utilizado para la preparacion de levobupivacaina y sus analogos.
DE19528472A1 (de) * 1995-08-03 1997-02-06 Boehringer Ingelheim Kg Neues Verfahren zur Herstellung von Norbenzomorphan einer Zwischenstufe bei Herstellung von pharmazeutisch wertvollen Benzomorphanderivaten, insbesondere von (-)-(1R,5S,S"R)-3'-Hydroxy-2-(2-methoxypropyl-)-5,9,9-trimethyl-6,7 benzomorphan

Also Published As

Publication number Publication date
EP1305287A1 (fr) 2003-05-02
DE10029851A1 (de) 2001-12-20
CA2409614A1 (fr) 2001-12-20
MXPA02012301A (es) 2003-04-25
WO2001096306A1 (fr) 2001-12-20
KR100863922B1 (ko) 2008-10-17
AR028957A1 (es) 2003-05-28
IL153085A0 (en) 2003-06-24
IL153085A (en) 2008-11-26
JP2004503539A (ja) 2004-02-05
AU2001270563A1 (en) 2001-12-24
KR20030016288A (ko) 2003-02-26

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