DD284045A5 - Verfahren zur herstellung von desulfarohirudinmutanten - Google Patents

Verfahren zur herstellung von desulfarohirudinmutanten Download PDF

Info

Publication number
DD284045A5
DD284045A5 DD89330938A DD33093889A DD284045A5 DD 284045 A5 DD284045 A5 DD 284045A5 DD 89330938 A DD89330938 A DD 89330938A DD 33093889 A DD33093889 A DD 33093889A DD 284045 A5 DD284045 A5 DD 284045A5
Authority
DD
German Democratic Republic
Prior art keywords
gin
asn
arg
lys
desulphatohirudin
Prior art date
Application number
DD89330938A
Other languages
German (de)
English (en)
Inventor
Andrew Wallace
Stanley Dennis
Jan Hofsteenge
Stuart R Stone
Original Assignee
����`��@���k��
���@���`������@��k��
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ����`��@���k��, ���@���`������@��k�� filed Critical ����`��@���k��
Publication of DD284045A5 publication Critical patent/DD284045A5/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81—Protease inhibitors
    • C07K14/815—Protease inhibitors from leeches, e.g. hirudin, eglin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Molecular Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Biotechnology (AREA)
  • Cardiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Physics & Mathematics (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
DD89330938A 1988-07-19 1989-07-18 Verfahren zur herstellung von desulfarohirudinmutanten DD284045A5 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB888817160A GB8817160D0 (en) 1988-07-19 1988-07-19 Novel proteins

Publications (1)

Publication Number Publication Date
DD284045A5 true DD284045A5 (de) 1990-10-31

Family

ID=10640714

Family Applications (1)

Application Number Title Priority Date Filing Date
DD89330938A DD284045A5 (de) 1988-07-19 1989-07-18 Verfahren zur herstellung von desulfarohirudinmutanten

Country Status (13)

Country Link
EP (1) EP0352228A3 (da)
JP (1) JPH02117694A (da)
KR (1) KR900001848A (da)
AU (1) AU3804589A (da)
DD (1) DD284045A5 (da)
DK (1) DK355189A (da)
FI (1) FI893451A (da)
GB (1) GB8817160D0 (da)
HU (1) HUT51671A (da)
IL (1) IL91003A0 (da)
NO (1) NO892949L (da)
PT (1) PT91190A (da)
ZA (1) ZA895460B (da)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU614121B2 (en) * 1988-05-04 1991-08-22 Novartis Ag Improvements in the production of polypeptides
DE4009268A1 (de) * 1990-03-22 1991-09-26 Consortium Elektrochem Ind Sekretion von hirudinderivaten
GB9010552D0 (en) * 1990-05-10 1990-07-04 Erba Carlo Spa Method for the recombinant production of hirudins and novel hirudins
US6060451A (en) * 1990-06-15 2000-05-09 The National Research Council Of Canada Thrombin inhibitors based on the amino acid sequence of hirudin
US6514730B1 (en) 1991-03-21 2003-02-04 Consortium für elektrochemische Industrie GmbH Secretion of hirudin derivatives
US5837808A (en) * 1991-08-20 1998-11-17 Baxter International Inc. Analogs of hirudin
NZ336793A (en) * 1997-01-20 2000-08-25 Japan Energy Corp Method for stabilizing peptides by adding an organic acid and then lyophilizing the peptide mixture
WO2004076484A1 (en) * 2003-02-27 2004-09-10 National Research Council Of Canada Peptide inhibitors of thrombin as potent anticoagulants
US7795205B2 (en) 2004-04-12 2010-09-14 Canyon Pharmaceuticals, Inc. Methods for effecting regression of tumor mass and size in a metastasized pancreatic tumor

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0168342B1 (de) * 1984-06-14 1991-07-03 Ciba-Geigy Ag Verfahren zur Herstellung von Thrombin-Inhibitoren
DE3689525D1 (de) * 1985-07-17 1994-02-24 Hoechst Ag Neue Polypeptide mit blutgerinnungshemmender Wirkung, Verfahren zu deren Herstellung bzw. Gewinnung, deren Verwendung und diese enthaltende Mittel.
FR2607517B2 (fr) * 1986-12-01 1989-12-22 Transgene Sa Vecteurs d'expression de variants de l'hirudine dans les levures, procede et produit obtenu

Also Published As

Publication number Publication date
FI893451A0 (fi) 1989-07-17
NO892949L (no) 1990-01-22
NO892949D0 (no) 1989-07-18
DK355189D0 (da) 1989-07-18
EP0352228A2 (en) 1990-01-24
FI893451A (fi) 1990-01-20
KR900001848A (ko) 1990-02-27
IL91003A0 (en) 1990-02-09
AU3804589A (en) 1990-01-25
JPH02117694A (ja) 1990-05-02
ZA895460B (en) 1990-02-28
GB8817160D0 (en) 1988-08-24
PT91190A (pt) 1990-02-08
DK355189A (da) 1990-01-20
EP0352228A3 (en) 1990-07-11
HUT51671A (en) 1990-05-28

Similar Documents

Publication Publication Date Title
DE69018920T2 (de) Verwendung von dns-fragmenten, die ein signalpeptid kodieren zur sekretion von reifen proteinen in rekombinanten hefen, expressions-kassetten, transformierte hefen und verfahren zur herstellung dieser proteine.
EP0168342B1 (de) Verfahren zur Herstellung von Thrombin-Inhibitoren
DE3650306T2 (de) Expressions- und Ausscheidungsvektoren für Hirudin mittels transformierter Hefe.
DE3050722C2 (da)
DE69002395T2 (de) N-terminale Fragmente von menschliches Serumalbumin enthaltenden Fusionsproteinen.
EP0307592B1 (de) Varianten des pankreatischen Rinder-Trypsininhibitors, deren Herstellung und Verwendung
DE68923123T2 (de) Herstellung von Proteinen.
DD296965A5 (de) Hefeverarbeitungssystem
EP0293567B1 (de) Vascular-antikoagulierende Proteine, DNA die diese kodieren, Verfahren zu deren Herstellung sowie deren Verwendung
DE3752063T2 (de) Funktioneller DNS-Block und für Hirudin kodierendes Plasmid, transformierte Hefe aud Verfahren zur Herstellung von Hirudin.
DE58907266T2 (de) Polypeptide mit einer die Koagulierung hemmenden Wirkung.
DE3686399T2 (de) Herstellung von thrombin-inhibitoren.
DD229427A5 (de) Verfahren zur gewinnung eines polypeptids
DE69024104T2 (de) Polypeptide und Polypeptidanaloge mit inhibitorischer Aktivität gegenüber menschlicher Elastase
DD212532A5 (de) Verfahren zur stabilisierung und selektion von wirtszellen, die rekombinierende dna enthalten
DE3854678T2 (de) Menschliches Mangansuperoxiddismutase und Behandlungsverfahren.
DE3712985A1 (de) Bifunktionelle proteine
DE69121192T2 (de) Hirudinmutante, deren herstellung, antikoagulans, sekretorischer vektor, durch besagten vektor transformierter mikroorganismus und herstellung eines produkts durch besagten mikroorganismus
DD284045A5 (de) Verfahren zur herstellung von desulfarohirudinmutanten
DE3600571A1 (de) Dna-sequenzen, die fuer proteine mit der biologischen aktivitaet der husi-typi-inhibitoren codieren, gentechnologische verfahren zur herstellung dieser proteine und diese proteine enthaltende arzneimittel
EP0297362A2 (de) Human-Aprotinin, dessen Lys-Rest in Position 15 gegen einen anderen protogenen Aminosäurerest ausgetauscht ist
DE69329083T2 (de) Halbleiteranordnung
DE3716722A1 (de) Gentechnologisches verfahren zur herstellung von angiogeninen
DD284044A5 (de) Verfahren zur herstellung von desulfatohirudinmutanten
EP0677107B1 (de) Thrombininhibitor aus speichel von protostomiern

Legal Events

Date Code Title Description
ENJ Ceased due to non-payment of renewal fee