DD284045A5 - Verfahren zur herstellung von desulfarohirudinmutanten - Google Patents
Verfahren zur herstellung von desulfarohirudinmutanten Download PDFInfo
- Publication number
- DD284045A5 DD284045A5 DD89330938A DD33093889A DD284045A5 DD 284045 A5 DD284045 A5 DD 284045A5 DD 89330938 A DD89330938 A DD 89330938A DD 33093889 A DD33093889 A DD 33093889A DD 284045 A5 DD284045 A5 DD 284045A5
- Authority
- DD
- German Democratic Republic
- Prior art keywords
- gin
- asn
- arg
- lys
- desulphatohirudin
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/81—Protease inhibitors
- C07K14/815—Protease inhibitors from leeches, e.g. hirudin, eglin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Genetics & Genomics (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Biomedical Technology (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Molecular Biology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- General Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Biotechnology (AREA)
- Diabetes (AREA)
- Microbiology (AREA)
- Physics & Mathematics (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Gastroenterology & Hepatology (AREA)
- Plant Pathology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Tropical Medicine & Parasitology (AREA)
- Hematology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB888817160A GB8817160D0 (en) | 1988-07-19 | 1988-07-19 | Novel proteins |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DD284045A5 true DD284045A5 (de) | 1990-10-31 |
Family
ID=10640714
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DD89330938A DD284045A5 (de) | 1988-07-19 | 1989-07-18 | Verfahren zur herstellung von desulfarohirudinmutanten |
Country Status (13)
| Country | Link |
|---|---|
| EP (1) | EP0352228A3 (da) |
| JP (1) | JPH02117694A (da) |
| KR (1) | KR900001848A (da) |
| AU (1) | AU3804589A (da) |
| DD (1) | DD284045A5 (da) |
| DK (1) | DK355189A (da) |
| FI (1) | FI893451A (da) |
| GB (1) | GB8817160D0 (da) |
| HU (1) | HUT51671A (da) |
| IL (1) | IL91003A0 (da) |
| NO (1) | NO892949L (da) |
| PT (1) | PT91190A (da) |
| ZA (1) | ZA895460B (da) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU614121B2 (en) * | 1988-05-04 | 1991-08-22 | Novartis Ag | Improvements in the production of polypeptides |
| DE4009268A1 (de) * | 1990-03-22 | 1991-09-26 | Consortium Elektrochem Ind | Sekretion von hirudinderivaten |
| GB9010552D0 (en) * | 1990-05-10 | 1990-07-04 | Erba Carlo Spa | Method for the recombinant production of hirudins and novel hirudins |
| US6060451A (en) * | 1990-06-15 | 2000-05-09 | The National Research Council Of Canada | Thrombin inhibitors based on the amino acid sequence of hirudin |
| US6514730B1 (en) | 1991-03-21 | 2003-02-04 | Consortium für elektrochemische Industrie GmbH | Secretion of hirudin derivatives |
| US5837808A (en) * | 1991-08-20 | 1998-11-17 | Baxter International Inc. | Analogs of hirudin |
| US6274553B1 (en) | 1997-01-20 | 2001-08-14 | Japan Energy Corporation | Method for stabilizing peptides and freeze-dried medicinal compositions containing peptides obtained by using the method |
| EP1597279A1 (en) * | 2003-02-27 | 2005-11-23 | National Research Council Of Canada | Peptide inhibitors of thrombin as potent anticoagulants |
| US7795205B2 (en) | 2004-04-12 | 2010-09-14 | Canyon Pharmaceuticals, Inc. | Methods for effecting regression of tumor mass and size in a metastasized pancreatic tumor |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE64956T1 (de) * | 1984-06-14 | 1991-07-15 | Ciba Geigy Ag | Verfahren zur herstellung von thrombininhibitoren. |
| EP0209061B1 (de) * | 1985-07-17 | 1994-01-12 | Hoechst Aktiengesellschaft | Neue Polypeptide mit blutgerinnungshemmender Wirkung, Verfahren zu deren Herstellung bzw. Gewinnung, deren Verwendung und diese enthaltende Mittel |
| FR2607517B2 (fr) * | 1986-12-01 | 1989-12-22 | Transgene Sa | Vecteurs d'expression de variants de l'hirudine dans les levures, procede et produit obtenu |
-
1988
- 1988-07-19 GB GB888817160A patent/GB8817160D0/en active Pending
-
1989
- 1989-07-11 EP EP89810522A patent/EP0352228A3/en not_active Withdrawn
- 1989-07-12 AU AU38045/89A patent/AU3804589A/en not_active Abandoned
- 1989-07-17 IL IL91003A patent/IL91003A0/xx unknown
- 1989-07-17 PT PT91190A patent/PT91190A/pt not_active Application Discontinuation
- 1989-07-17 FI FI893451A patent/FI893451A/fi not_active Application Discontinuation
- 1989-07-18 KR KR1019890010121A patent/KR900001848A/ko not_active Application Discontinuation
- 1989-07-18 JP JP1183826A patent/JPH02117694A/ja active Pending
- 1989-07-18 HU HU893612A patent/HUT51671A/hu unknown
- 1989-07-18 DD DD89330938A patent/DD284045A5/de not_active IP Right Cessation
- 1989-07-18 NO NO89892949A patent/NO892949L/no unknown
- 1989-07-18 ZA ZA895460A patent/ZA895460B/xx unknown
- 1989-07-18 DK DK355189A patent/DK355189A/da not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| PT91190A (pt) | 1990-02-08 |
| HUT51671A (en) | 1990-05-28 |
| JPH02117694A (ja) | 1990-05-02 |
| IL91003A0 (en) | 1990-02-09 |
| ZA895460B (en) | 1990-02-28 |
| FI893451A0 (fi) | 1989-07-17 |
| FI893451A (fi) | 1990-01-20 |
| DK355189D0 (da) | 1989-07-18 |
| NO892949D0 (no) | 1989-07-18 |
| NO892949L (no) | 1990-01-22 |
| GB8817160D0 (en) | 1988-08-24 |
| EP0352228A2 (en) | 1990-01-24 |
| AU3804589A (en) | 1990-01-25 |
| DK355189A (da) | 1990-01-20 |
| EP0352228A3 (en) | 1990-07-11 |
| KR900001848A (ko) | 1990-02-27 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| ENJ | Ceased due to non-payment of renewal fee |