DD251750A5 - Verfahren zur herstellung von 1,2-dithiolan-3-pentansaeure (thioctsaeure) - Google Patents

Verfahren zur herstellung von 1,2-dithiolan-3-pentansaeure (thioctsaeure) Download PDF

Info

Publication number
DD251750A5
DD251750A5 DD86288945A DD28894586A DD251750A5 DD 251750 A5 DD251750 A5 DD 251750A5 DD 86288945 A DD86288945 A DD 86288945A DD 28894586 A DD28894586 A DD 28894586A DD 251750 A5 DD251750 A5 DD 251750A5
Authority
DD
German Democratic Republic
Prior art keywords
acid
thioctic acid
formula
preparation
sodium
Prior art date
Application number
DD86288945A
Other languages
German (de)
English (en)
Inventor
Guenes Giray
Klaus Huthmacher
Axel Kleemann
Thomas Lied
Original Assignee
������@������������k��
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ������@������������k�� filed Critical ������@������������k��
Publication of DD251750A5 publication Critical patent/DD251750A5/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D339/00—Heterocyclic compounds containing rings having two sulfur atoms as the only ring hetero atoms
    • C07D339/02—Five-membered rings
    • C07D339/04—Five-membered rings having the hetero atoms in positions 1 and 2, e.g. lipoic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Ultra Sonic Daignosis Equipment (AREA)
  • Mechanical Treatment Of Semiconductor (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
DD86288945A 1985-04-11 1986-04-09 Verfahren zur herstellung von 1,2-dithiolan-3-pentansaeure (thioctsaeure) DD251750A5 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19853512911 DE3512911A1 (de) 1985-04-11 1985-04-11 Verfahren zur herstellung von 1,2-dithiolan-3-pentansaeure (thioctsaeure)

Publications (1)

Publication Number Publication Date
DD251750A5 true DD251750A5 (de) 1987-11-25

Family

ID=6267677

Family Applications (1)

Application Number Title Priority Date Filing Date
DD86288945A DD251750A5 (de) 1985-04-11 1986-04-09 Verfahren zur herstellung von 1,2-dithiolan-3-pentansaeure (thioctsaeure)

Country Status (9)

Country Link
US (3) US4705867A (fr)
EP (1) EP0197407B1 (fr)
JP (2) JPS61236775A (fr)
AT (1) ATE47138T1 (fr)
DD (1) DD251750A5 (fr)
DE (2) DE3512911A1 (fr)
ES (1) ES8703451A1 (fr)
FI (1) FI861506A (fr)
HU (1) HUT40638A (fr)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3629116A1 (de) * 1986-08-27 1988-03-10 Asta Pharma Ag Verfahren zur herstellung enantiomerenreiner r-(+)-(alpha)-liponsaeure und s-(-)-(alpha)-liponsaeure (thioctsaeure) sowie nonen- beziehungsweise mesylderivate als zwischenprodukte hierfuer
ATE126053T1 (de) * 1989-11-09 1995-08-15 Asta Medica Ag Arzneimittel, welche als wirkstoff schwefel enthaltende carbonsäuren enthalten sowie deren verwendung zur bekämpfung von retroviren.
EP0812590A3 (fr) * 1989-11-09 1999-06-09 ASTA Medica Aktiengesellschaft Utilisation de l'acide R-alpha lipoique comme cytoprotecteur
DE4037440A1 (de) * 1990-11-24 1992-05-27 Basf Ag Verfahren zur herstellung von (6s)-6,8-dihydroxyoctansaeureestern
DE4229914A1 (de) * 1992-09-08 1994-03-10 Basf Ag Verbessertes Verfahren zur Herstellung von R/S-Ï-Liponsäure oder R/S-â-Liponsäure
DE9213914U1 (de) * 1992-10-15 1992-12-03 Asta Medica AG, 6000 Frankfurt Ampulle und Infusionslösung von Thioctsäure in Form der wasserlöslichen Salze der Thioctsäure
EP0855396A1 (fr) * 1997-01-22 1998-07-29 ASTA Medica Aktiengesellschaft Métabolites de l'acide thioctique et leur utilisation
US20050085498A1 (en) * 1998-05-28 2005-04-21 Byrd Edward A. Oral formulation of lipid soluble thiamine, lipoic acid, creatine derivative, and L-arginine alpha-ketoglutarate
US6197340B1 (en) * 1998-05-28 2001-03-06 Medical Research Institute Controlled release lipoic acid
US6191162B1 (en) 1998-05-28 2001-02-20 Medical Research Institute Method of reducing serum glucose levels
US20040259895A1 (en) * 1998-05-28 2004-12-23 Medical Research Institute Oral formulation of lipid soluble thiamine and lipoic acid
US6905707B2 (en) * 1998-05-28 2005-06-14 Medical Research Institute Controlled release arginine alpha ketoglutarate
ES2340488T3 (es) * 1998-10-26 2010-06-04 The Research Foundation Of State University Of New York Sales derivadas del acido lipoico y su utilizacion para el tratamiento de las enfermedades.
US6664287B2 (en) * 2000-03-15 2003-12-16 Bethesda Pharmaceuticals, Inc. Antioxidants
US20070272320A1 (en) * 2006-05-24 2007-11-29 James Roberson Reusable duct wrap
US8785475B2 (en) 2007-04-18 2014-07-22 Cornerstone Pharmaceuticals, Inc. Lipoic acid derivatives
PL2144609T3 (pl) 2007-04-18 2015-04-30 Cornerstone Pharmaceuticals Inc Formulacje farmaceutyczne zawierające pochodne kwasu liponowego
US8263653B2 (en) 2007-04-18 2012-09-11 Cornerstone Pharmaceuticals, Inc. Pharmaceutical formulations containing lipoic acid derivatives
WO2010065069A2 (fr) * 2008-12-01 2010-06-10 In Vasc Therapeutics, Inc. Compositions contenant des inhibiteurs du système rénine-angiotensine-aldostérone et des composés de l'acide lipoïque, et leur utilisation pour le traitement des troubles associés au système rénine-angiotensine-aldostérone
ES2747702T3 (es) 2014-06-19 2020-03-11 Rafael Pharmaceuticals Inc Compuestos farmacéuticos
EP3189033B1 (fr) 2014-06-19 2020-08-05 Rafael Pharmaceuticals, Inc. Composés pharmaceutiques

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB762575A (en) * 1952-04-24 1956-11-28 American Cyanamid Co Omega [3-(1,2-dithiolanyl)] aliphatic acids, salts and esters and the preparation thereof
US2752373A (en) * 1952-12-10 1956-06-26 Du Pont Process for preparing 6, 8-dithiooctanoic acid
US2752374A (en) * 1952-12-10 1956-06-26 Du Pont Preparation of acids having thiol groups on the ultimate and antepenultimate carbons from the carboxyl
US2828321A (en) * 1953-10-19 1958-03-25 American Cyanamid Co Keto aliphatic acid esters and method of preparing the same
US2828322A (en) * 1953-10-19 1958-03-25 American Cyanamid Co Hydroxy thioaliphatic acids and methods of preparing the same
US2809978A (en) * 1953-12-04 1957-10-15 Merck & Co Inc Intermediates useful in the synthesis of alpha-lipoic acid
US3002011A (en) * 1953-12-04 1961-09-26 Merck & Co Inc Intermediates and processes for producing alpha-lipoic acid
US2853497A (en) * 1953-12-04 1958-09-23 Merck & Co Inc 6, 8-bis (hydrocarbon substituted mercapto) 5-hydroxycaprylic acids and delta-lactones thereof
US3049549A (en) * 1954-03-22 1962-08-14 Research Corp Lipoic acid and derivatives
US2789991A (en) * 1954-05-20 1957-04-23 American Cyanamid Co Substituted disulfones
US2792406A (en) * 1954-06-01 1957-05-14 Du Pont Process of preparing alpha-lipoic acid using dichlorooctanoate and metal disulfide
US2980716A (en) * 1954-06-11 1961-04-18 Research Corp Method for preparing 6, 8-dihalooctanoic esters
US2975198A (en) * 1954-07-08 1961-03-14 Research Corp Lipoic acid intermediates
US3033882A (en) * 1958-04-17 1962-05-08 Rech S Et Propagande Scient Octanoic esters and processes for their preparation and utilization
US3223712A (en) * 1960-07-18 1965-12-14 Yamanouchi Pharma Co Ltd Synthesis of thioctic acid and thioctic acid amide

Also Published As

Publication number Publication date
JPS63183558A (ja) 1988-07-28
HUT40638A (en) 1987-01-28
JPS61236775A (ja) 1986-10-22
JPH0351702B2 (fr) 1991-08-07
EP0197407B1 (fr) 1989-10-11
EP0197407A2 (fr) 1986-10-15
US4966732A (en) 1990-10-30
FI861506A0 (fi) 1986-04-09
US4705867A (en) 1987-11-10
ATE47138T1 (de) 1989-10-15
US4800044A (en) 1989-01-24
DE3512911A1 (de) 1986-10-16
ES8703451A1 (es) 1987-02-16
EP0197407A3 (en) 1987-09-02
JPH0348188B2 (fr) 1991-07-23
FI861506A (fi) 1986-10-12
DE3666226D1 (en) 1989-11-16
ES553850A0 (es) 1987-02-16

Similar Documents

Publication Publication Date Title
DD251750A5 (de) Verfahren zur herstellung von 1,2-dithiolan-3-pentansaeure (thioctsaeure)
DE69210141T2 (de) Herstellung von Fluoxetin und Zwischenverbindungen
DE1958919B2 (de) l-Oxo-5-indanyloxyessigsäuren und solche Verbindungen enthaltende Arzneimittel
DD155898A5 (de) Verfahren zur herstellung von 1-[3-mercapto-(2s)-methyl-propionyl]-pyrrolidin-(2s)-carbonsaeure
CH432519A (de) Verfahren zur Herstellung neuer Alkoxypiperidin-Derivate und ihrer Salze
Mueller-Westerhoff et al. A simple synthesis of symmetrical α-diones from organometallic reagents and 1, 4-dimethyl-piperazine-2, 3-dione
GB2083022A (en) Phenethylamine derivatives and their production
DE2854877A1 (de) N-substituierte omega-thiobutyramide, verfahren zu ihrer herstellung und sie enthaltende arzneimittel
DE2216811A1 (fr)
EP0086453B1 (fr) Dérivés de thiazaspiro, procédé pour leur préparation et compositions pharmaceutiques les contenant
DE2613817A1 (de) Phenylpropionsaeuren, pyruvatverfahren zu ihrer herstellung und verwendung
EP0236884B1 (fr) Procédé pour la préparation de composés phénoxyalcanoltriazoliques et produits intermédiaires à cet effet
DE602005002738T2 (de) Syntheseverfahren und benzoxathiepinzwischenprodukte
EP0074121A1 (fr) Dérivés de 2,3,4,5-tétrahydro-1-benzoxépine-3,5-dione et leur procédé de préparation
DD254005A5 (de) Verfahren zur herstellung von 4-amino-6-fluor-chroman-4-carbonsaeure oder dessen (2r)-methyl-derivat
EP0542671B1 (fr) Dérivés d'hydroquinone substitués comme intermédiaires pour la préparation de dérivés de benzofuranne
EP1373237B1 (fr) Procedes de production d'acides carboxylique d'oxirane
EP0763516B1 (fr) Préparation et utilisation des énantiomères purs des acides 8-halogène-6-hydroxyoctanoiques, leurs esters alkyliques et leurs sels avec les énantiomères purs de l'alpha-méthylbenzylamine
AT363085B (de) Verfahren zur herstellung von neuen substituierten thiazolidin-, thiazan- und verwandten carbonsaeuren und von deren salzen und isomeren
US2439818A (en) Substituted esters of benzoic acid
CA1105937A (fr) Procede pour la preparation de (cycloalkyl)- alkylbenzamides
AT381938B (de) Verfahren zur herstellung von neuen spirobenzofuranonverbindungen
AT371445B (de) Verfahren zur herstellung von neuen cis-4a-phenyl-isochinolinderivaten und ihren saeureadditionssalzen
PL169083B1 (pl) Sposób wytwarzania podstawionego kwasu alkenowego i jego pochodnych PL PL PL
DE1192647B (de) Verfahren zur Herstellung von Thiol- bzw. Thionothiolphosphonsaeureestern