DD219482A5 - Verfahren zur herstellung von spiro-3-heteroazolonen - Google Patents

Verfahren zur herstellung von spiro-3-heteroazolonen Download PDF

Info

Publication number
DD219482A5
DD219482A5 DD83257566A DD25756683A DD219482A5 DD 219482 A5 DD219482 A5 DD 219482A5 DD 83257566 A DD83257566 A DD 83257566A DD 25756683 A DD25756683 A DD 25756683A DD 219482 A5 DD219482 A5 DD 219482A5
Authority
DD
German Democratic Republic
Prior art keywords
hydrogen
acid
solid
spiro
give
Prior art date
Application number
DD83257566A
Other languages
German (de)
English (en)
Inventor
Christopher A Lipinski
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of DD219482A5 publication Critical patent/DD219482A5/de

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D235/00Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D263/00Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/52Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings condensed with carbocyclic rings or ring systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D277/00Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/60Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
DD83257566A 1982-12-06 1983-12-06 Verfahren zur herstellung von spiro-3-heteroazolonen DD219482A5 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US44733782A 1982-12-06 1982-12-06
US06/545,450 US4556670A (en) 1982-12-06 1983-10-28 Spiro-3-hetero-azolones for treatment of diabetic complications

Publications (1)

Publication Number Publication Date
DD219482A5 true DD219482A5 (de) 1985-03-06

Family

ID=27034944

Family Applications (1)

Application Number Title Priority Date Filing Date
DD83257566A DD219482A5 (de) 1982-12-06 1983-12-06 Verfahren zur herstellung von spiro-3-heteroazolonen

Country Status (21)

Country Link
US (1) US4556670A (es)
EP (1) EP0115133B1 (es)
KR (1) KR860001581B1 (es)
AU (1) AU545409B2 (es)
BG (1) BG44708A3 (es)
CA (1) CA1204763A (es)
DD (1) DD219482A5 (es)
DE (1) DE3379043D1 (es)
DK (1) DK558283A (es)
ES (1) ES8601912A1 (es)
FI (1) FI80267C (es)
GR (1) GR78787B (es)
IE (1) IE56345B1 (es)
IL (1) IL70379A (es)
NO (1) NO160001C (es)
NZ (1) NZ206484A (es)
PH (1) PH19622A (es)
PL (1) PL142143B1 (es)
PT (1) PT77760B (es)
RO (1) RO88202B (es)
YU (1) YU43557B (es)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3561198D1 (en) * 1984-03-23 1988-01-28 Pfizer Spiro-indenes and spiro-1,2-dihydro-naphthalenes for treatment of diabetic complications
US4575507A (en) 1985-05-29 1986-03-11 Pfizer Inc. Spiro-imidazolidines as aldose reductase inhibitors and their pharmaceutical use
GB8601100D0 (en) * 1986-01-17 1986-02-19 Cosmas Damian Ltd Drug delivery system
GB2355264A (en) 1999-09-30 2001-04-18 Merck & Co Inc Spirohydantoin derivatives useful as alpha 1a adrenoceptor antagonists
AU2003225077A1 (en) 2002-04-18 2003-11-03 University Of Virginia Patent Foundation Novel sodium channel blockers
JP2006509015A (ja) * 2002-12-04 2006-03-16 メルク エンド カムパニー インコーポレーテッド スピロ環尿素、そのような化合物を含有する組成物、及び使用方法
JO3501B1 (ar) * 2014-12-22 2020-07-05 Servier Lab مشتقات 5-{(بيبرازين - 1-يل)-3-أوكسو - بروبيل}- إيميدازوليدين-2، 4 - دايون كمثبطات ل adamts لمعالجة هشاشة العظام)

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2872454A (en) * 1959-02-03 Spiro-hydantoins from x-chloro-
GB796069A (en) * 1955-12-23 1958-06-04 Ici Ltd Substituted hydantoins
GB818724A (en) * 1956-10-18 1959-08-19 Ici Ltd Hydantoin derivatives
US3532744A (en) * 1967-07-28 1970-10-06 American Home Prod 1- and 2-amino substituted indane and tetralene carboxylic acids
US3985888A (en) * 1969-07-24 1976-10-12 Richardson-Merrell Inc. Methods of inducing sedation using certain spiroalkanone-imides
US3821383A (en) * 1972-07-10 1974-06-28 Ayerst Mckenna & Harrison Compositions for and a method of treating diabetic complications
US4117230A (en) * 1976-10-18 1978-09-26 Pfizer Inc. Hydantoin derivatives as therapeutic agents
US4130714A (en) * 1977-05-23 1978-12-19 Pfizer Inc. Hydantoin therapeutic agents
US4200642A (en) * 1978-08-21 1980-04-29 Pfizer Inc. Spiro-oxazolidindiones
US4181729A (en) * 1979-03-21 1980-01-01 Pfizer Inc. Phenyl or phenoxy substituted spiro-imidazolidinedione derivatives
US4226875A (en) * 1979-04-02 1980-10-07 Pfizer Inc. Novel spiro-oxazolidinediones
US4307108A (en) * 1979-12-26 1981-12-22 Pfizer Inc. Method for lowering sorbitol levels using spiro-imides
US4248882A (en) * 1980-02-12 1981-02-03 Pfizer Inc. Treating diabetes-associated complications with hydantoin amines
JPS5745185A (en) * 1980-07-21 1982-03-13 Eisai Co Ltd Hydantoin derivative and its preparation

Also Published As

Publication number Publication date
US4556670A (en) 1985-12-03
PH19622A (en) 1986-05-30
YU43557B (en) 1989-08-31
CA1204763A (en) 1986-05-20
ES527780A0 (es) 1985-11-16
PT77760B (en) 1986-05-30
FI80267B (fi) 1990-01-31
DK558283D0 (da) 1983-12-05
DE3379043D1 (en) 1989-03-02
KR840006975A (ko) 1984-12-04
RO88202A (ro) 1985-12-30
YU237183A (en) 1986-02-28
ES8601912A1 (es) 1985-11-16
PT77760A (en) 1983-12-01
PL142143B1 (en) 1987-09-30
IE832854L (en) 1984-06-06
IE56345B1 (en) 1991-07-03
NO160001B (no) 1988-11-21
FI834457A0 (fi) 1983-12-05
IL70379A0 (en) 1984-03-30
NO160001C (no) 1989-03-01
BG44708A3 (es) 1989-01-16
EP0115133B1 (en) 1989-01-25
FI80267C (fi) 1990-05-10
NZ206484A (en) 1987-07-31
FI834457A (fi) 1984-06-07
AU2196883A (en) 1984-06-14
AU545409B2 (en) 1985-07-11
NO834437L (no) 1984-06-07
DK558283A (da) 1984-07-11
KR860001581B1 (ko) 1986-10-10
GR78787B (es) 1984-10-02
RO88202B (ro) 1985-12-31
PL244966A1 (en) 1985-05-21
IL70379A (en) 1988-10-31
EP0115133A1 (en) 1984-08-08

Similar Documents

Publication Publication Date Title
US4436745A (en) Method of inhibiting aldose reductase activity
US4438272A (en) Spiro-(fluoren-9,4'-imidazolidine)-2',5'-diones
EP0034063B1 (en) Hydantoin amines and pharmaceutical compositions thereof
Kapadia et al. The melosatins—a novel class of alkaloids from Melochia tomentosa
Toja et al. 3-Alkyl-2-aryl-3H-naphth [1, 2-d] imidazoles, a novel class of nonacidic antiinflammatory agents
DD261154A5 (de) Verfahren zur herstellung einer hypoglykaemisch wirksamen thiozolidindion-verbindung
DD146602A5 (de) Verfahren zur herstellung neuer spiro-oxazolidindione
DD219482A5 (de) Verfahren zur herstellung von spiro-3-heteroazolonen
DD239793A5 (de) Verfahren zur herstellung von 5-alkyl-1phenyl-2-piperazino-alkylpyrazolin-3-on-verbindungen
DE2730832A1 (de) Thieno-(2,3-c)- und -(3,2-c)pyridine, verfahren zu ihrer herstellung und sie enthaltende arzneimittel
DE10115408A1 (de) Benzofuran-Derivate
DD251972A5 (de) Verfahren zur herstellung von spiroimidazolidinen
EP0159143B1 (en) Spiro-indenes and spiro-1,2-dihydro-naphthalenes for treatment of diabetic complications
DD234265A5 (de) Verfahren zur herstellung von spiro-3-hetero-azolonen
CA1200247A (en) Method of inhibiting aldose reductase activity, compositions therefor and process for preparing spiro-fluorofluoren and spiro-difluorofluoren compounds
DE2241027A1 (de) Verfahren zur herstellung neuer heterocyclischer verbindungen
US4540700A (en) Treatment of diabetic complications with certain spiro-imidazolidine-diones
EP0024560A1 (de) Neue 3-Amino-1-benzoxepin-Derivate und ihre Salze; Verfahren zu deren Herstellung und diese Verbindungen enthaltende Arzneimittel
DE1695963A1 (de) Cycloalkenamin-p-benzochinonaddukte und Verfahren zu ihrer Herstellung
DE2838276A1 (de) Beta -substituierte diketone, verfahren zu deren herstellung und diese enthaltende arzneimittel
DD219772A5 (de) Verfahren zur herstellung von spiro-hydantoin-derivaten
EP0045521B1 (de) Pyrazolobenzazepine, Verfahren zu ihrer Herstellung und diese enthaltende Arzneimittel
DD236529A5 (de) Verfahren zur herstellung eines biologisch aktiven, tetracyclischen spirohydantoin-derivats
AT366673B (de) Verfahren zur herstellung neuer phthalazin-4ylessigs[uren und deren salze
DD273381A5 (de) Verfahren zur herstellung einer spiro-azolonverbindung

Legal Events

Date Code Title Description
NPV Change in the person, the name or the address of the representative (addendum to changes before extension act)
ENJ Ceased due to non-payment of renewal fee