DD216240A5 - Verfahren zur herstellung von 2-naphthylglycylamidocephalosporinen - Google Patents

Verfahren zur herstellung von 2-naphthylglycylamidocephalosporinen Download PDF

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Publication number
DD216240A5
DD216240A5 DD84261875A DD26187584A DD216240A5 DD 216240 A5 DD216240 A5 DD 216240A5 DD 84261875 A DD84261875 A DD 84261875A DD 26187584 A DD26187584 A DD 26187584A DD 216240 A5 DD216240 A5 DD 216240A5
Authority
DD
German Democratic Republic
Prior art keywords
hydrogen
formula
compound
methyl
pharmaceutically acceptable
Prior art date
Application number
DD84261875A
Other languages
German (de)
English (en)
Inventor
Robin D G Cooper
Larry C Blaszczak
Jan R Turner
Preston C Conrad
Byron W Daugherty
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US06/484,128 external-priority patent/US4490370A/en
Priority claimed from US06/516,220 external-priority patent/US4474780A/en
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of DD216240A5 publication Critical patent/DD216240A5/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/22—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with radicals containing only hydrogen and carbon atoms, attached in position 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
    • C07D501/26—Methylene radicals, substituted by oxygen atoms; Lactones thereof with the 2-carboxyl group
    • C07D501/28—Methylene radicals, substituted by oxygen atoms; Lactones thereof with the 2-carboxyl group with the 7-amino radical acylated by an aliphatic carboxylic acid, which is substituted by hetero atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/59—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3 with hetero atoms directly attached in position 3

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Cephalosporin Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
DD84261875A 1983-04-12 1984-04-11 Verfahren zur herstellung von 2-naphthylglycylamidocephalosporinen DD216240A5 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US06/484,128 US4490370A (en) 1983-04-12 1983-04-12 Naphthylglycyl cephalosporin derivatives
US06/516,220 US4474780A (en) 1983-07-22 1983-07-22 Crystalline cephalosporin
US53805083A 1983-09-30 1983-09-30

Publications (1)

Publication Number Publication Date
DD216240A5 true DD216240A5 (de) 1984-12-05

Family

ID=27413675

Family Applications (1)

Application Number Title Priority Date Filing Date
DD84261875A DD216240A5 (de) 1983-04-12 1984-04-11 Verfahren zur herstellung von 2-naphthylglycylamidocephalosporinen

Country Status (12)

Country Link
DD (1) DD216240A5 (enrdf_load_stackoverflow)
DK (1) DK187484A (enrdf_load_stackoverflow)
ES (1) ES8600307A1 (enrdf_load_stackoverflow)
FI (1) FI841438A7 (enrdf_load_stackoverflow)
GR (1) GR79909B (enrdf_load_stackoverflow)
HU (1) HUT34497A (enrdf_load_stackoverflow)
IL (1) IL71500A0 (enrdf_load_stackoverflow)
MA (1) MA20094A1 (enrdf_load_stackoverflow)
NO (1) NO841442L (enrdf_load_stackoverflow)
OA (1) OA07702A (enrdf_load_stackoverflow)
PT (1) PT78405A (enrdf_load_stackoverflow)
ZW (1) ZW4484A1 (enrdf_load_stackoverflow)

Also Published As

Publication number Publication date
ZW4484A1 (en) 1984-10-03
OA07702A (fr) 1985-08-30
PT78405A (en) 1984-05-01
DK187484D0 (da) 1984-04-11
FI841438A0 (fi) 1984-04-11
FI841438A7 (fi) 1984-10-13
ES531530A0 (es) 1985-10-01
IL71500A0 (en) 1984-07-31
NO841442L (no) 1984-10-15
ES8600307A1 (es) 1985-10-01
DK187484A (da) 1984-11-23
GR79909B (enrdf_load_stackoverflow) 1984-10-31
MA20094A1 (fr) 1984-12-31
HUT34497A (en) 1985-03-28

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