DK187484A - Naphthylglycyl- og tetrahydronaphthylglycyl-cephalosporin-antibiotika og fremgangsmaade til fremstilling heraf - Google Patents
Naphthylglycyl- og tetrahydronaphthylglycyl-cephalosporin-antibiotika og fremgangsmaade til fremstilling heraf Download PDFInfo
- Publication number
- DK187484A DK187484A DK187484A DK187484A DK187484A DK 187484 A DK187484 A DK 187484A DK 187484 A DK187484 A DK 187484A DK 187484 A DK187484 A DK 187484A DK 187484 A DK187484 A DK 187484A
- Authority
- DK
- Denmark
- Prior art keywords
- tetrahydronaphthylgylycyl
- naphthylgylycyl
- procedures
- preparing
- antibiotics
- Prior art date
Links
- 239000003242 anti bacterial agent Substances 0.000 title description 2
- 229940088710 antibiotic agent Drugs 0.000 title description 2
- 238000000034 method Methods 0.000 title description 2
- 229910052739 hydrogen Inorganic materials 0.000 description 7
- 239000001257 hydrogen Substances 0.000 description 7
- 150000002431 hydrogen Chemical class 0.000 description 5
- -1 nitro, amino Chemical group 0.000 description 3
- 229910052736 halogen Inorganic materials 0.000 description 2
- 150000002367 halogens Chemical class 0.000 description 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 2
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 description 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 description 1
- 125000004656 alkyl sulfonylamino group Chemical group 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 230000006806 disease prevention Effects 0.000 description 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 description 1
- 125000004184 methoxymethyl group Chemical group [H]C([H])([H])OC([H])([H])* 0.000 description 1
- 125000002816 methylsulfanyl group Chemical group [H]C([H])([H])S[*] 0.000 description 1
- 244000005700 microbiome Species 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D501/14—Compounds having a nitrogen atom directly attached in position 7
- C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
- C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
- C07D501/22—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with radicals containing only hydrogen and carbon atoms, attached in position 3
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D501/14—Compounds having a nitrogen atom directly attached in position 7
- C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
- C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
- C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
- C07D501/26—Methylene radicals, substituted by oxygen atoms; Lactones thereof with the 2-carboxyl group
- C07D501/28—Methylene radicals, substituted by oxygen atoms; Lactones thereof with the 2-carboxyl group with the 7-amino radical acylated by an aliphatic carboxylic acid, which is substituted by hetero atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D501/14—Compounds having a nitrogen atom directly attached in position 7
- C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
- C07D501/59—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3 with hetero atoms directly attached in position 3
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Cephalosporin Compounds (AREA)
- Peptides Or Proteins (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Description
hvori R7 og R8 hver for sig er hydrogen, halogen, hydroxy, Cj-C^-alkyl, C^-C^-alkoxy, nitro, amino, C^^-C^-alkanoy 1-amino eller Cj-C^-alkylsulfonylamino, eller hvori R og R8 tilsammen danner en methylendioxy-gruppe, A og B hver for sig er hydrogen eller tilsammen danner en dobbeltbinding, R2 er hydrogen, en amino-beskyttende gruppe, hydroxy eller methoxy, og R3 er hydrogen, eller R2 og R3 tilsammen betegner gruppen
hvor M og L hver for sig er C^-C^-alkyl; R4 er hydrogen, methoxy eller methylthio; R5 er hydrogen, methoxy, methyl, halogen eller methoxymethy1; R6 er hydrogen eller en carboxy-beskyttende gruppe, fremstilles ved en række forskellige fremgangsmåder.
Forbindelserne (I) er oralt virksomme antibiotika med fordelagtig farmakokinetik, og de egner sig specielt til behandling eller forebyggelse af sygdomme fremkaldt af gram-positive mikroorganismer.
Applications Claiming Priority (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US06/484,128 US4490370A (en) | 1983-04-12 | 1983-04-12 | Naphthylglycyl cephalosporin derivatives |
| US48412883 | 1983-04-12 | ||
| US06/516,220 US4474780A (en) | 1983-07-22 | 1983-07-22 | Crystalline cephalosporin |
| US51622083 | 1983-07-22 | ||
| US53805083A | 1983-09-30 | 1983-09-30 | |
| US53805083 | 1983-09-30 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DK187484D0 DK187484D0 (da) | 1984-04-11 |
| DK187484A true DK187484A (da) | 1984-11-23 |
Family
ID=27413675
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK187484A DK187484A (da) | 1983-04-12 | 1984-04-11 | Naphthylglycyl- og tetrahydronaphthylglycyl-cephalosporin-antibiotika og fremgangsmaade til fremstilling heraf |
Country Status (12)
| Country | Link |
|---|---|
| DD (1) | DD216240A5 (da) |
| DK (1) | DK187484A (da) |
| ES (1) | ES531530A0 (da) |
| FI (1) | FI841438A7 (da) |
| GR (1) | GR79909B (da) |
| HU (1) | HUT34497A (da) |
| IL (1) | IL71500A0 (da) |
| MA (1) | MA20094A1 (da) |
| NO (1) | NO841442L (da) |
| OA (1) | OA07702A (da) |
| PT (1) | PT78405A (da) |
| ZW (1) | ZW4484A1 (da) |
-
1984
- 1984-03-12 ZW ZW44/84A patent/ZW4484A1/xx unknown
- 1984-04-10 IL IL71500A patent/IL71500A0/xx unknown
- 1984-04-11 ES ES531530A patent/ES531530A0/es active Granted
- 1984-04-11 GR GR74380A patent/GR79909B/el unknown
- 1984-04-11 OA OA58275A patent/OA07702A/xx unknown
- 1984-04-11 FI FI841438A patent/FI841438A7/fi not_active Application Discontinuation
- 1984-04-11 HU HU841416A patent/HUT34497A/hu unknown
- 1984-04-11 DD DD84261875A patent/DD216240A5/de unknown
- 1984-04-11 NO NO841442A patent/NO841442L/no unknown
- 1984-04-11 DK DK187484A patent/DK187484A/da not_active Application Discontinuation
- 1984-04-11 MA MA20315A patent/MA20094A1/fr unknown
- 1984-04-11 PT PT78405A patent/PT78405A/pt unknown
Also Published As
| Publication number | Publication date |
|---|---|
| DD216240A5 (de) | 1984-12-05 |
| FI841438A0 (fi) | 1984-04-11 |
| GR79909B (da) | 1984-10-31 |
| MA20094A1 (fr) | 1984-12-31 |
| ES8600307A1 (es) | 1985-10-01 |
| OA07702A (fr) | 1985-08-30 |
| IL71500A0 (en) | 1984-07-31 |
| HUT34497A (en) | 1985-03-28 |
| PT78405A (en) | 1984-05-01 |
| DK187484D0 (da) | 1984-04-11 |
| ES531530A0 (es) | 1985-10-01 |
| ZW4484A1 (en) | 1984-10-03 |
| FI841438A7 (fi) | 1984-10-13 |
| NO841442L (no) | 1984-10-15 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| AHB | Application shelved due to non-payment |