DK187184A - Antibiotisk virksomme 7beta-(2-amino-2-(benzothienyl)acetylamino)-3-cephem-4-carboxylsyrer, fremgangsmaade til fremstilling deraf og mellemprodukt til brug ved fremgangsmaaden - Google Patents
Antibiotisk virksomme 7beta-(2-amino-2-(benzothienyl)acetylamino)-3-cephem-4-carboxylsyrer, fremgangsmaade til fremstilling deraf og mellemprodukt til brug ved fremgangsmaaden Download PDFInfo
- Publication number
- DK187184A DK187184A DK187184A DK187184A DK187184A DK 187184 A DK187184 A DK 187184A DK 187184 A DK187184 A DK 187184A DK 187184 A DK187184 A DK 187184A DK 187184 A DK187184 A DK 187184A
- Authority
- DK
- Denmark
- Prior art keywords
- amino
- carboxyly
- 7beta
- cephem
- acetylamino
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D501/14—Compounds having a nitrogen atom directly attached in position 7
- C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
- C07D501/59—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3 with hetero atoms directly attached in position 3
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D501/14—Compounds having a nitrogen atom directly attached in position 7
- C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
- C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Cephalosporin Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Description
R er hydrogen, Cj-C^-alkyl, halogen, nitro, amino, Cj-C^-alkoxy, Cj-C^-alkanoylamino eller C^-C^-alkyl-sulfonylamino; R1 er hydrogen, Cj-C-j-alky 1, halogen, hydroxy eller
Ci-C^-alkoxy; A og B er hydrogen eller betegner sammen en dobbeltbinding; er hydrogen, en amino-beskyttende gruppe, hydroxy, C^_c^-alkoxy eller en carboxy-substitueret alkoxygruppe eller carboxy-substitueret cycloalkoxygruppe med form-1 en
hvori c og d hver for sig er hydrogen eller C^-C^-alkyl, eller hvori c og d sammen med carbonatomet, hvortil de er bundet, danner en C3-C6-cycloalkylring; og n er et tal fra 0 til 3; -i 2 3 R er hydrogen, eller R og R er tilsammen gruppen
hvori M og L hver for sig er C^-C^-alkyl; R5 er hydrogen, methyl, halogen, methoxy, vinyl eller en substitueret methylgruppe med formlen
hvori R^ er methoxy, acetoxy eller carbamoyloxy, og R^ er hydrogen eller en carboxy-beskyttende gruppe, fremstilles ved en række forskellige fremgangsmåder.
Forbindelserne (I) er nyttige antibiotika til oral behandling af bakterielle infektioner fremkaldt af grampositive mikroorganismer.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US48412583 | 1983-04-12 | ||
| US06/484,125 US4501741A (en) | 1983-04-12 | 1983-04-12 | Cephalosporin antibiotics |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DK187184D0 DK187184D0 (da) | 1984-04-11 |
| DK187184A true DK187184A (da) | 1984-10-13 |
Family
ID=23922851
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK187184A DK187184A (da) | 1983-04-12 | 1984-04-11 | Antibiotisk virksomme 7beta-(2-amino-2-(benzothienyl)acetylamino)-3-cephem-4-carboxylsyrer, fremgangsmaade til fremstilling deraf og mellemprodukt til brug ved fremgangsmaaden |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US4501741A (da) |
| EP (1) | EP0122158A3 (da) |
| JP (1) | JPS59199694A (da) |
| KR (1) | KR840008652A (da) |
| AU (1) | AU2673784A (da) |
| CA (1) | CA1210756A (da) |
| DK (1) | DK187184A (da) |
| ES (1) | ES8506029A1 (da) |
| FI (1) | FI841435A (da) |
| GB (1) | GB2137998B (da) |
| HU (1) | HU192004B (da) |
| IL (1) | IL71499A0 (da) |
| NZ (1) | NZ207806A (da) |
| PT (1) | PT78401A (da) |
| ZA (1) | ZA842691B (da) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4581352A (en) * | 1984-12-03 | 1986-04-08 | Eli Lilly And Company | Thienothienylglycyl cephalosporin derivatives |
| DE3508258A1 (de) * | 1985-03-08 | 1986-09-18 | Bayer Ag, 5090 Leverkusen | Ss-lactamantibiotika, verfahren zur herstellung und ihre verwendung als und in arzneimitteln |
| DE3509618A1 (de) * | 1985-03-16 | 1986-09-18 | Bayer Ag, 5090 Leverkusen | Ss-lactam-antibiotika, verfahren zur herstellung und ihre verwendung als arzneimittel |
| US4783443A (en) * | 1986-03-03 | 1988-11-08 | The University Of Chicago | Amino acyl cephalosporin derivatives |
| AR035728A1 (es) * | 2001-01-16 | 2004-07-07 | Merck & Co Inc | Proceso perfeccionado para la sintesis de carbapenem |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3575969A (en) * | 1968-03-04 | 1971-04-20 | Lilly Co Eli | Desacetoxycephalosporin antibiotics |
| US4024133A (en) * | 1971-05-14 | 1977-05-17 | Glaxo Laboratories Limited | 7β-[2-Etherified oximino-2-(thienyl-,furyl- or pyridylacetamido)]cephalosporins |
| US4229575A (en) * | 1978-02-27 | 1980-10-21 | Richardson-Merrell Inc. | 7-(2,3-Dihydrobenzo-5-furanyl)-acetamido cephalosporin derivatives |
| US4219648A (en) * | 1978-03-06 | 1980-08-26 | Richardson-Merrell Inc. | 7-[[Amino(1,3-dihydrobenzo[c]thienyl)acetyl]amino]cephalosporin derivatives |
-
1983
- 1983-04-12 US US06/484,125 patent/US4501741A/en not_active Expired - Lifetime
-
1984
- 1984-04-10 IL IL71499A patent/IL71499A0/xx unknown
- 1984-04-11 DK DK187184A patent/DK187184A/da not_active Application Discontinuation
- 1984-04-11 HU HU841415A patent/HU192004B/hu unknown
- 1984-04-11 ES ES531528A patent/ES8506029A1/es not_active Expired
- 1984-04-11 GB GB08409384A patent/GB2137998B/en not_active Expired
- 1984-04-11 ZA ZA842691A patent/ZA842691B/xx unknown
- 1984-04-11 EP EP84302460A patent/EP0122158A3/en not_active Withdrawn
- 1984-04-11 FI FI841435A patent/FI841435A/fi not_active Application Discontinuation
- 1984-04-11 KR KR1019840001912A patent/KR840008652A/ko not_active Application Discontinuation
- 1984-04-11 CA CA000451710A patent/CA1210756A/en not_active Expired
- 1984-04-11 JP JP59074843A patent/JPS59199694A/ja active Pending
- 1984-04-11 AU AU26737/84A patent/AU2673784A/en not_active Abandoned
- 1984-04-11 PT PT78401A patent/PT78401A/pt unknown
- 1984-04-11 NZ NZ207806A patent/NZ207806A/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| IL71499A0 (en) | 1984-07-31 |
| US4501741A (en) | 1985-02-26 |
| AU2673784A (en) | 1984-10-18 |
| NZ207806A (en) | 1986-11-12 |
| GB2137998B (en) | 1986-12-03 |
| HUT34495A (en) | 1985-03-28 |
| GB8409384D0 (en) | 1984-05-23 |
| PT78401A (en) | 1984-05-01 |
| FI841435A0 (fi) | 1984-04-11 |
| EP0122158A3 (en) | 1985-08-28 |
| HU192004B (en) | 1987-04-28 |
| KR840008652A (ko) | 1984-12-17 |
| ES531528A0 (es) | 1985-06-16 |
| GB2137998A (en) | 1984-10-17 |
| FI841435A (fi) | 1984-10-13 |
| JPS59199694A (ja) | 1984-11-12 |
| CA1210756A (en) | 1986-09-02 |
| DK187184D0 (da) | 1984-04-11 |
| EP0122158A2 (en) | 1984-10-17 |
| ZA842691B (en) | 1985-11-27 |
| ES8506029A1 (es) | 1985-06-16 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ES443627A1 (es) | Un procedimiento para preparar un compuesto de cefem. | |
| AU538928B2 (en) | Substituted propenylamine derivatives | |
| HUP9701048A2 (hu) | Új eljárás sildenafil előállítására és a felhasznált új köztitermékek | |
| HUP9603389A2 (hu) | Eljárás 2-acil-amino-alkohol-származékok előállítására és köztitermékeik | |
| DK518683A (da) | Fremgangsmaade til fremstilling af 4aeepi-9-deoxo-9a-methyl-9a-aza-9a-homoerythromycin a eller farmaceutisk acceptable syreadditionssalte deraf og mellemprodukter ved fremgangsmaaden | |
| DK187184A (da) | Antibiotisk virksomme 7beta-(2-amino-2-(benzothienyl)acetylamino)-3-cephem-4-carboxylsyrer, fremgangsmaade til fremstilling deraf og mellemprodukt til brug ved fremgangsmaaden | |
| HUP0001741A2 (hu) | Antibakteriális hatású aza-biciklo-karbamoil-oxi-mutilin-származékok, eljárás ezek előállítására, ezeket tartalmazó készítmények és alkalmazásuk | |
| EP0136830A3 (en) | Azahomoerythromycin d derivative and intermediates therefor | |
| YU214378A (en) | Process for the purification of nucleotide sequences suitable for bacterial manifestation | |
| ATE200492T1 (de) | 7-acyl-3-(substituierte carbamoyloxy) cephem verbindungen, verfahren zu ihrer herstellung und anwendung | |
| HUP9702368A2 (hu) | 3-(1-/2-Hidroxi-fenil/-1-alkoximino-metil)-dioxazin-származékok és intermedierjeik és eljárás ezek előállítására | |
| JPS6485A (en) | Novel cephalosporin derivative | |
| DK187284A (da) | 7-(3-indolyl)glycylamido-cephalosporin-antibiotika og fremgangsmaade til fremstilling deraf | |
| DK187484A (da) | Naphthylglycyl- og tetrahydronaphthylglycyl-cephalosporin-antibiotika og fremgangsmaade til fremstilling heraf | |
| JPS5746990A (en) | Novel cephalexin derivative and its preparation | |
| JPS5781415A (en) | Single strain vaccine for infectious disease by some strains of cilia bacteria | |
| DK187384A (da) | 7-(3-benzothienyl)glycylamido-cephalosporin-antibiotika og fremgangsmaade til fremstilling heraf | |
| ATE18559T1 (de) | Vinyl-3-cephalosporinverbindungen und ihre herstellung. | |
| EP0076452A3 (de) | Cephalosporinverbindungen, Verfahren zu ihrer Herstellung und sie enthaltende pharmazeutische Präparate | |
| HUP0105049A2 (hu) | Az oleandomicinek osztályába tartozó új származékok, eljárás az előállításukra és az intermedierjeik | |
| DK187084A (da) | 7-(2-benzothienyl)glycylamido-cephalosporin-antibiotika og fremgangsmaade til fremstilling deraf | |
| WO2001060832A3 (en) | Pluraflavins and derivatives thereof, process for their preparation and use thereof | |
| HUP9903880A2 (hu) | Naftokinonszármazékok, eljárás az előállításukra, valamint hatóanyagként e vegyületeket tartalmazó fungicid, inszekticid és akaricid készítmények, eljárás az alkalmazásukra | |
| SE7709646L (sv) | Antibakteriella medel | |
| JPS56115788A (en) | Azetidinone derivative and its preparation |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| AHB | Application shelved due to non-payment |