ES8600307A1 - Un procedimiento para la preparacion de nuevas cefalosporinas. - Google Patents

Un procedimiento para la preparacion de nuevas cefalosporinas.

Info

Publication number
ES8600307A1
ES8600307A1 ES531530A ES531530A ES8600307A1 ES 8600307 A1 ES8600307 A1 ES 8600307A1 ES 531530 A ES531530 A ES 531530A ES 531530 A ES531530 A ES 531530A ES 8600307 A1 ES8600307 A1 ES 8600307A1
Authority
ES
Spain
Prior art keywords
formula
translation
procedure
machine
legally binding
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES531530A
Other languages
English (en)
Other versions
ES531530A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eli Lilly and Co
Original Assignee
Eli Lilly and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US06/484,128 external-priority patent/US4490370A/en
Priority claimed from US06/516,220 external-priority patent/US4474780A/en
Application filed by Eli Lilly and Co filed Critical Eli Lilly and Co
Publication of ES8600307A1 publication Critical patent/ES8600307A1/es
Publication of ES531530A0 publication Critical patent/ES531530A0/es
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/22—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with radicals containing only hydrogen and carbon atoms, attached in position 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
    • C07D501/26—Methylene radicals, substituted by oxygen atoms; Lactones thereof with the 2-carboxyl group
    • C07D501/28—Methylene radicals, substituted by oxygen atoms; Lactones thereof with the 2-carboxyl group with the 7-amino radical acylated by an aliphatic carboxylic acid, which is substituted by hetero atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/59—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3 with hetero atoms directly attached in position 3

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Cephalosporin Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

PROCEDIMIENTO PARA LA OBTENCION DE CEFALOSPORINAS Y DE SUS SALES FISIOLOGICAMENTE COMPATIBLES, DE FORMULA (I), EN LA QUE A Y B SON HIDROGENO O JUNTOS FORMAN UN DOBLE ENLACE; R1-R6 PUEDEN SER VARIOS TIPOS DE RADICALES.CONSISTE EN LA REACCION DE ACILACION DE UN COMPUESTO DE FORMULA (II) CON UN AGENTE ACILANTE DE FORMULA (III), O UN DERIVADO ACTIVO DEL MISMO, EN LAS QUE TODOS LOS SIMBOLOS TIENEN EL MISMO SIGNIFICADO QUE EN LA FORMULA (I). LA ACILACION SE LLEVA A CABO EN UN DISOLVENTE ORGANICO COMUN, INERTE, EN PRESENCIA DE UNA BASE, A UNA TEMPERATURA COMPRENDIDA ENTRE C20JC Y 60JC.ESTOS COMPUESTOS TIENEN APLICACIONES FARMACOLOGICAS PARA EL TRATAMIENTO DE ENFERMEDADES BACTERIANAS.
ES531530A 1983-04-12 1984-04-11 Un procedimiento para la preparacion de nuevas cefalosporinas. Granted ES531530A0 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US06/484,128 US4490370A (en) 1983-04-12 1983-04-12 Naphthylglycyl cephalosporin derivatives
US06/516,220 US4474780A (en) 1983-07-22 1983-07-22 Crystalline cephalosporin
US53805083A 1983-09-30 1983-09-30

Publications (2)

Publication Number Publication Date
ES8600307A1 true ES8600307A1 (es) 1985-10-01
ES531530A0 ES531530A0 (es) 1985-10-01

Family

ID=27413675

Family Applications (1)

Application Number Title Priority Date Filing Date
ES531530A Granted ES531530A0 (es) 1983-04-12 1984-04-11 Un procedimiento para la preparacion de nuevas cefalosporinas.

Country Status (12)

Country Link
DD (1) DD216240A5 (es)
DK (1) DK187484A (es)
ES (1) ES531530A0 (es)
FI (1) FI841438A (es)
GR (1) GR79909B (es)
HU (1) HUT34497A (es)
IL (1) IL71500A0 (es)
MA (1) MA20094A1 (es)
NO (1) NO841442L (es)
OA (1) OA07702A (es)
PT (1) PT78405A (es)
ZW (1) ZW4484A1 (es)

Also Published As

Publication number Publication date
DD216240A5 (de) 1984-12-05
MA20094A1 (fr) 1984-12-31
DK187484A (da) 1984-11-23
HUT34497A (en) 1985-03-28
ZW4484A1 (en) 1984-10-03
PT78405A (en) 1984-05-01
FI841438A0 (fi) 1984-04-11
IL71500A0 (en) 1984-07-31
OA07702A (fr) 1985-08-30
ES531530A0 (es) 1985-10-01
NO841442L (no) 1984-10-15
FI841438A (fi) 1984-10-13
DK187484D0 (da) 1984-04-11
GR79909B (es) 1984-10-31

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