DD207714A5 - Verfahren zur herstellung von benzimidazolen - Google Patents
Verfahren zur herstellung von benzimidazolen Download PDFInfo
- Publication number
- DD207714A5 DD207714A5 DD83255127A DD25512783A DD207714A5 DD 207714 A5 DD207714 A5 DD 207714A5 DD 83255127 A DD83255127 A DD 83255127A DD 25512783 A DD25512783 A DD 25512783A DD 207714 A5 DD207714 A5 DD 207714A5
- Authority
- DD
- German Democratic Republic
- Prior art keywords
- formula
- low
- benzimidazole
- amino
- compounds
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
- C07D235/12—Radicals substituted by oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
- C07D235/26—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
- C07D235/28—Sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
- C07D235/30—Nitrogen atoms not forming part of a nitro radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Oncology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Virology (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Communicable Diseases (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US06/424,784 US4492708A (en) | 1982-09-27 | 1982-09-27 | Antiviral benzimidazoles |
Publications (1)
Publication Number | Publication Date |
---|---|
DD207714A5 true DD207714A5 (de) | 1984-03-14 |
Family
ID=23683858
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DD83255127A DD207714A5 (de) | 1982-09-27 | 1983-09-27 | Verfahren zur herstellung von benzimidazolen |
Country Status (13)
Country | Link |
---|---|
US (1) | US4492708A (pt) |
EP (1) | EP0111993A3 (pt) |
JP (1) | JPS5980666A (pt) |
KR (1) | KR840006215A (pt) |
AU (1) | AU1956683A (pt) |
DD (1) | DD207714A5 (pt) |
DK (1) | DK438983D0 (pt) |
FI (1) | FI833424A (pt) |
GB (1) | GB2127408B (pt) |
GR (1) | GR79047B (pt) |
PL (1) | PL243905A1 (pt) |
PT (1) | PT77398B (pt) |
ZA (1) | ZA836958B (pt) |
Families Citing this family (45)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4728741A (en) * | 1985-01-08 | 1988-03-01 | Smithkline Beckman Corporation | 1-substituted-2-mercapto benzimidazole compounds and intermediates |
HU193951B (en) * | 1985-03-11 | 1987-12-28 | Richter Gedeon Vegyeszet | Process for producing new sulfur-containing 5-substituted benzimidazol derivatives and pharmaceutical compositions containing them |
FR2593177B1 (fr) * | 1986-01-20 | 1988-04-01 | Novapharme | Nouveaux benzimidazo |
SE8604566D0 (sv) * | 1986-10-27 | 1986-10-27 | Haessle Ab | Novel compunds |
FI91754C (fi) * | 1986-12-02 | 1994-08-10 | Tanabe Seiyaku Co | Analogiamenetelmä lääkeaineena käyttökelpoisen imidatsolijohdannaisen valmistamiseksi |
US4851423A (en) * | 1986-12-10 | 1989-07-25 | Schering Corporation | Pharmaceutically active compounds |
US5272167A (en) * | 1986-12-10 | 1993-12-21 | Schering Corporation | Pharmaceutically active compounds |
US5750532A (en) * | 1986-12-10 | 1998-05-12 | Schering Corporation | Pharmaceutically active compounds |
EP0407217A1 (en) * | 1989-07-07 | 1991-01-09 | Schering Corporation | Pharmaceutically active compounds |
TW203049B (pt) * | 1990-04-13 | 1993-04-01 | Yamanouchi Pharma Co Ltd | |
US5602127A (en) * | 1991-02-06 | 1997-02-11 | Karl Thomae Gmbh | (Alkanesultam-1-yl)-benzimidazol-1-yl)-1yl)-methyl-biphenyls useful as angiotensin-II antagonists |
US5591762A (en) * | 1991-02-06 | 1997-01-07 | Dr. Karl Thomae Gmbh | Benzimidazoles useful as angiotensin-11 antagonists |
US5594003A (en) * | 1991-02-06 | 1997-01-14 | Dr. Karl Thomae Gmbh | Tetrahydroimidazo[1,2-a]pyridin-2-yl-(benzimidazol-1-yl)-methyl-biphenyls useful as angiotensin-II antagonists |
DK0520200T3 (da) * | 1991-06-24 | 1998-09-23 | Neurosearch As | Imadazol-forbindelser, deres fremstilling og anvendelse |
US5210091A (en) * | 1991-06-24 | 1993-05-11 | Neurosearch A/S | Imidazole compounds and their use |
CA2085844A1 (en) * | 1991-12-27 | 1993-06-28 | Nobuyuki Hamanaka | Fused benzeneoxyacetic acid derivatives |
DK40192D0 (da) * | 1992-03-26 | 1992-03-26 | Neurosearch As | Imidazolforbindelser, deres fremstilling og anvendelse |
US5399580A (en) * | 1993-03-08 | 1995-03-21 | Burroughs Wellcome Co. | Therapeutic nucleosides-uses |
US5693661A (en) * | 1995-06-07 | 1997-12-02 | Eli Lilly And Company | Anti-viral compounds |
US5545653A (en) * | 1995-06-07 | 1996-08-13 | Eli Lilly And Company | Anti-viral compounds |
GB9600142D0 (en) * | 1996-01-05 | 1996-03-06 | Wellcome Found | Chemical compounds |
US5891874A (en) * | 1996-06-05 | 1999-04-06 | Eli Lilly And Company | Anti-viral compound |
JP2000511899A (ja) * | 1996-06-05 | 2000-09-12 | イーライ・リリー・アンド・カンパニー | 抗―ウイルス性化合物群 |
US5821242A (en) * | 1996-06-06 | 1998-10-13 | Eli Lilly And Company | Anti-viral compounds |
US5929117A (en) * | 1996-08-12 | 1999-07-27 | Celgene Corporation | Immunotherapeutic agents |
AU6031898A (en) * | 1997-01-22 | 1998-08-07 | Eli Lilly And Company | Anti-viral compounds |
EP1001767A4 (en) * | 1997-06-04 | 2001-07-04 | Lilly Co Eli | ANTIVIRAL CONNECTIONS |
US5990146A (en) * | 1997-08-20 | 1999-11-23 | Warner-Lambert Company | Benzimidazoles for inhibiting protein tyrosine kinase mediated cellular proliferation |
CA2458533C (en) * | 2001-10-09 | 2011-01-04 | Tularik Inc. | Imidazole derivates as anti-inflammatory agents |
US7470723B2 (en) * | 2003-03-05 | 2008-12-30 | Celgene Corporation | Diphenylethylene compounds and uses thereof |
NZ542407A (en) * | 2003-03-05 | 2008-08-29 | Celgene Corp | Diphenylethylene compounds and uses thereof |
TWI356055B (en) * | 2003-12-18 | 2012-01-11 | Tibotec Pharm Ltd | Aminobenzimidazoles and benzimidazoles as inhibito |
GB2424882B (en) * | 2004-01-12 | 2008-08-06 | Cytopia Res Pty Ltd | Selective kinase inhibitors |
CA2578789A1 (en) * | 2004-09-03 | 2006-03-16 | Celgene Corporation | Substituted heterocyclic compounds and uses thereof |
EP2308852A1 (de) | 2005-08-21 | 2011-04-13 | Abbott GmbH & Co. KG | 5-Ring-Heteroaromaten-Verbindungen und ihre Verwendung als Bindungspartner für 5-HT5-Rezeptoren |
FR2892719B3 (fr) * | 2005-11-02 | 2008-01-18 | Sep Innovaterm | Barriere physico-chimique anti-termites constituee par du beton dans lequel a ete incorpore dans toute la masse un insecticide contre les termites |
WO2007103111A2 (en) * | 2006-03-02 | 2007-09-13 | Siga Technologies, Inc. | Antiviral drugs for treatment of arenavirus infection |
US7977365B2 (en) * | 2006-03-02 | 2011-07-12 | Siga Technologies, Inc. | Antiviral drugs for treatment of arenavirus infection |
US8871746B2 (en) | 2006-03-02 | 2014-10-28 | Kineta Four, LLC | Antiviral drugs for treatment of arenavirus infection |
WO2009029622A2 (en) | 2007-08-27 | 2009-03-05 | Siga Technologies, Inc. | Antiviral drugs for treatment of arenavirus infection |
US20130303781A1 (en) * | 2010-11-24 | 2013-11-14 | Sequent Scientific Limited | Process for preparation of triclabendazole |
WO2012070069A2 (en) * | 2010-11-24 | 2012-05-31 | Sequent Scientific Limited | A process for preparation of albendazole |
EP3180004B1 (en) * | 2014-08-13 | 2021-01-06 | University Of Virginia Patent Foundation | Cancer therapeutics |
WO2019031990A1 (ru) * | 2017-08-07 | 2019-02-14 | Закрытое Акционерное Общество "Биокад" | Новые гетероциклические соединения как ингибиторы cdk8/19 |
WO2021189080A1 (en) * | 2020-03-18 | 2021-09-23 | The Board Of Regents Of The University Of Texas System | Methods and compositions for the treatment of influenza |
Family Cites Families (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR1384313A (fr) * | 1963-02-09 | 1965-01-04 | Schering Ag | Nouveaux dérivés du benzimidazole et leur préparation |
GB1045534A (en) * | 1963-02-09 | 1966-10-12 | Schering Ag | New 1-benzyl-5,6-dialkoxy benzimidazoles and a process for their manufacture |
US3336191A (en) * | 1966-03-11 | 1967-08-15 | Smith Kline French Lab | Anthelmintic 2-amidobenzimidazoles |
FR1513160A (fr) * | 1966-03-24 | 1968-02-09 | Alfa Laval Ab | Centrifugeuse |
US3936702A (en) * | 1972-02-24 | 1976-02-03 | Micro Devices Corporation | Electrical protection means |
US3825537A (en) * | 1972-02-28 | 1974-07-23 | Squibb & Sons Inc | 1-thiazolin-2-yl(or thiazin-2-yl)-2-aminobenzimidazoles and derivatives thereof |
US3813409A (en) * | 1972-07-31 | 1974-05-28 | Squibb & Sons Inc | Benzimidazolinone compounds |
US4026936A (en) * | 1975-08-07 | 1977-05-31 | Hoffmann-La Roche Inc. | Anthelmintic pyridine and thiazole substituted benzimidazole carbamates |
GR61627B (en) * | 1975-08-28 | 1978-12-04 | Lilly Co Eli | Preparation process of carbonyl-substituted 1-sulfonylbenzimidazoles |
US4174454A (en) * | 1975-08-28 | 1979-11-13 | Eli Lilly And Company | Alkylidenylmethyl-substituted 1-sulfonylbenzimidazoles |
CA1076582A (en) * | 1975-10-28 | 1980-04-29 | Charles J. Paget | Antiviral thiazolinyl or thiazinyl ketobenzimidazoles |
US4008243A (en) * | 1975-11-19 | 1977-02-15 | Eli Lilly And Company | Antiviral thiazolinyl or thiazinyl benzimidazole esters |
LU75684A1 (pt) * | 1976-08-27 | 1978-04-13 | ||
US4191832A (en) * | 1979-03-12 | 1980-03-04 | Eli Lilly And Company | Separation of syn and anti oximes of 1-sulfonyl-2-aminobenzimidazoles |
US4230868A (en) * | 1979-04-17 | 1980-10-28 | Eli Lilly And Company | α-Alkyl-α-hydroxybenzyl-substituted 1-sulfonylbenzimidazoles |
US4316021A (en) * | 1979-08-13 | 1982-02-16 | Eli Lilly And Company | Substituted 1-sulfonylbenzimidazoles |
US4338329A (en) * | 1979-11-14 | 1982-07-06 | Eli Lilly And Company | Antiviral method employing 1-sulfonylbenzimidazoles |
US4338315A (en) * | 1979-11-14 | 1982-07-06 | Eli Lilly And Company | Antiviral method employing thiazinyl benzimidazole derivatives |
-
1982
- 1982-09-27 US US06/424,784 patent/US4492708A/en not_active Expired - Fee Related
-
1983
- 1983-09-19 ZA ZA836958A patent/ZA836958B/xx unknown
- 1983-09-19 GR GR72474A patent/GR79047B/el unknown
- 1983-09-22 EP EP83305611A patent/EP0111993A3/en not_active Ceased
- 1983-09-22 GB GB08325360A patent/GB2127408B/en not_active Expired
- 1983-09-23 FI FI833424A patent/FI833424A/fi not_active Application Discontinuation
- 1983-09-26 PL PL24390583A patent/PL243905A1/xx unknown
- 1983-09-26 DK DK4389/83A patent/DK438983D0/da not_active Application Discontinuation
- 1983-09-26 PT PT77398A patent/PT77398B/pt unknown
- 1983-09-26 AU AU19566/83A patent/AU1956683A/en not_active Abandoned
- 1983-09-26 KR KR1019830004492A patent/KR840006215A/ko not_active IP Right Cessation
- 1983-09-27 DD DD83255127A patent/DD207714A5/de unknown
- 1983-09-27 JP JP58181743A patent/JPS5980666A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
EP0111993A3 (en) | 1984-07-25 |
FI833424A (fi) | 1984-03-28 |
GB8325360D0 (en) | 1983-10-26 |
KR840006215A (ko) | 1984-11-22 |
PT77398B (en) | 1986-03-20 |
GR79047B (pt) | 1984-10-02 |
AU1956683A (en) | 1984-04-05 |
GB2127408A (en) | 1984-04-11 |
ZA836958B (en) | 1985-04-24 |
JPS5980666A (ja) | 1984-05-10 |
PL243905A1 (en) | 1985-01-30 |
FI833424A0 (fi) | 1983-09-23 |
DK438983D0 (da) | 1983-09-26 |
EP0111993A2 (en) | 1984-06-27 |
PT77398A (en) | 1983-10-01 |
GB2127408B (en) | 1986-05-14 |
US4492708A (en) | 1985-01-08 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
DD207714A5 (de) | Verfahren zur herstellung von benzimidazolen | |
EP0004279B1 (de) | Verfahren zur Herstellung von 4-Pyridon-3-carbonsäuren, 1-Cyclopropyl-4-Pyridon-3-Carbonsäurederivate und diese enthaltende Arzneimittel | |
DE3033157A1 (de) | 7-amino-1-cyclopropyl-4-oxo-1,4-dihydro-naphthyridin-3-carbonsaeuren, verfahren zu ihrer herstellung sowie diese enthaltende antibakterielle mittel | |
DE2458965A1 (de) | 3-amino-indazolcarbonsaeure-derivate, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel | |
DD139844A5 (de) | Verfahren zur herstellung eines azylanilids | |
DE1795613B2 (de) | Indolylessigsaeuren, verfahren zu ihrer herstellung und arzneimittel | |
DD150002A5 (de) | Verfahren zur herstellung einer pyranon-verbindung | |
EP0185909B1 (de) | 5-Alkyl-1-phenyl-2-piperazinoalkylpyrazolin-3-on-Verbindungen sowie Verfahren und Zwischenprodukte zu ihrer Herstellung und diese Verbindungen enthaltende Arzneimittel | |
DE2633905A1 (de) | 2-substituierte oxazolopyridine | |
DE2931418A1 (de) | Neue imidazochinoxaline und deren salze, verfahren zu deren herstellung, deren verwendung als arzneimittel und die sie enthaltenden pharmazeutischen zusammensetzungen | |
DE2645865C2 (pt) | ||
EP0072960A2 (de) | 1,5-Diphenylpyrazolin-3-on-Verbindungen sowie Verfahren und Zwischenprodukte zu ihrer Herstellung und diese Verbindungen enthaltende Arzneimittel | |
DE2440734C2 (de) | Amphetaminderivate, Verfahren zu deren Herstellung und diese enthaltende Arzneimittel | |
DE2329745A1 (de) | Therapeutisches mittel und verwendung desselben | |
DE2642877A1 (de) | Substituierte 2-nitro-3-phenylbenzofuranverbindungen | |
EP0004322B1 (de) | Isochinolinderivate, Verfahren zu ihrer Herstellung und ihre Verwendung zur Herstellung von Arzneimitteln | |
DE1944759B2 (de) | 3-Indolylacetamide, ihre Salze und Verfahren zu ihrer Herstellung | |
CH619213A5 (en) | Process for the preparation of carbazole derivatives | |
CH623042A5 (en) | Process for the preparation of novel quinoxaline-1,4-dioxide derivatives | |
DE2149825A1 (de) | Substituierte 2,2'-Biimidazole,Verfahren zu ihrer Herstellung und diese enthaltende pharmazeutische Praeparate | |
DE1252204B (de) | Verfahren zur Herstellung von 2,4-Dinitropyrrolderivaten | |
DE2245363A1 (de) | Pyridopyrimidone, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel | |
DE2021747A1 (de) | Verfahren zur Herstellung neuer heterocyclischer Verbindungen | |
AT328458B (de) | Verfahren zur herstellung neuer diazepinderivate sowie deren 5-oxide und saureadditionssalze | |
DE2948885C2 (pt) |