DD159327A5 - Substituierte phenoxy-aminopropanolderivate - Google Patents

Substituierte phenoxy-aminopropanolderivate Download PDF

Info

Publication number
DD159327A5
DD159327A5 DD81230464A DD23046481A DD159327A5 DD 159327 A5 DD159327 A5 DD 159327A5 DD 81230464 A DD81230464 A DD 81230464A DD 23046481 A DD23046481 A DD 23046481A DD 159327 A5 DD159327 A5 DD 159327A5
Authority
DD
German Democratic Republic
Prior art keywords
general formula
compound
pharmaceutically acceptable
phenoxy
hydrogen
Prior art date
Application number
DD81230464A
Other languages
German (de)
English (en)
Inventor
Peter J Machin
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of DD159327A5 publication Critical patent/DD159327A5/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C29/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring
    • C07C29/132—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by reduction of an oxygen containing functional group
    • C07C29/136—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by reduction of an oxygen containing functional group of >C=O containing groups, e.g. —COOH
    • C07C29/147—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by reduction of an oxygen containing functional group of >C=O containing groups, e.g. —COOH of carboxylic acids or derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
    • C07C215/02—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C43/00—Ethers; Compounds having groups, groups or groups
    • C07C43/02—Ethers
    • C07C43/03—Ethers having all ether-oxygen atoms bound to acyclic carbon atoms
    • C07C43/14—Unsaturated ethers
    • C07C43/178—Unsaturated ethers containing hydroxy or O-metal groups
    • C07C43/1782—Unsaturated ethers containing hydroxy or O-metal groups containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C43/00—Ethers; Compounds having groups, groups or groups
    • C07C43/02—Ethers
    • C07C43/03—Ethers having all ether-oxygen atoms bound to acyclic carbon atoms
    • C07C43/14—Unsaturated ethers
    • C07C43/178—Unsaturated ethers containing hydroxy or O-metal groups
    • C07C43/1786—Unsaturated ethers containing hydroxy or O-metal groups containing halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C43/00—Ethers; Compounds having groups, groups or groups
    • C07C43/02—Ethers
    • C07C43/20—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring
    • C07C43/23—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring containing hydroxy or O-metal groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
    • C07C45/68—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
    • C07C45/70—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction with functional groups containing oxygen only in singly bound form
    • C07C45/71—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction with functional groups containing oxygen only in singly bound form being hydroxy groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/76—Ketones containing a keto group bound to a six-membered aromatic ring
    • C07C49/84—Ketones containing a keto group bound to a six-membered aromatic ring containing ether groups, groups, groups, or groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40—Unsaturated compounds
    • C07C59/58—Unsaturated compounds containing ether groups, groups, groups, or groups
    • C07C59/64—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings
    • C07C59/66—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings the non-carboxylic part of the ether containing six-membered aromatic rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Cardiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
DD81230464A 1980-06-02 1981-06-01 Substituierte phenoxy-aminopropanolderivate DD159327A5 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB8017983 1980-06-02
GB8108345 1981-03-17

Publications (1)

Publication Number Publication Date
DD159327A5 true DD159327A5 (de) 1983-03-02

Family

ID=26275709

Family Applications (1)

Application Number Title Priority Date Filing Date
DD81230464A DD159327A5 (de) 1980-06-02 1981-06-01 Substituierte phenoxy-aminopropanolderivate

Country Status (27)

Country Link
US (1) US4649160A (pt)
EP (1) EP0041233B1 (pt)
KR (2) KR840001919B1 (pt)
AR (2) AR227046A1 (pt)
AT (1) ATE6250T1 (pt)
AU (1) AU538634B2 (pt)
BR (1) BR8103439A (pt)
CA (1) CA1220488A (pt)
CS (2) CS221962B2 (pt)
DD (1) DD159327A5 (pt)
DE (1) DE3162256D1 (pt)
DK (1) DK154021C (pt)
ES (2) ES502649A0 (pt)
FI (1) FI811706L (pt)
GR (1) GR75681B (pt)
HU (1) HU182341B (pt)
IE (1) IE51812B1 (pt)
IL (1) IL62970A (pt)
MC (1) MC1387A1 (pt)
NO (1) NO150152C (pt)
NZ (1) NZ197184A (pt)
PH (1) PH16940A (pt)
PL (2) PL135317B1 (pt)
PT (1) PT73113B (pt)
SU (2) SU1194270A3 (pt)
YU (2) YU133581A (pt)
ZW (1) ZW9881A1 (pt)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3125870C2 (de) * 1980-07-09 1994-09-15 William John Louis 3-Aminopropoxyphenyl Derivate, ihre Herstellung und sie enthaltende Arzneimittel
CA1262729A (en) * 1983-10-19 1989-11-07 Leo Alig Phenoxypropanolamines
US5380755A (en) * 1992-07-24 1995-01-10 The Du Pont Merck Pharmaceutical Company Alkyl and alkylbenzyl ethers of substituted hydroquinones
EP1165325B1 (en) * 2000-01-05 2006-02-08 Appleton Papers Inc. Thermally-responsive record material
US6835691B2 (en) 2000-01-05 2004-12-28 Appleton Papers Inc. Thermally-responsive record material
CA2646503C (en) * 2006-04-18 2015-06-30 Emisphere Technologies, Inc. Dialkyl ether delivery agents

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DD8731A (pt) *
SE384853B (sv) * 1972-04-04 1976-05-24 Haessle Ab Forfarande for framstellning av nya aminer
CA956632A (en) * 1969-05-16 1974-10-22 Yoshitomi Pharmaceutical Industries Phenoxy-aminopropanol derivatives
SE372762B (pt) * 1969-05-21 1975-01-13 Haessle Ab
GB1320453A (en) * 1971-03-24 1973-06-13 Biosedra Lab Aromatic diethers
AR204105A1 (es) * 1973-01-17 1975-11-20 Ciba Geigy Ag Procedimiento para la preparacion del 1-(4-(2-metiltioetoxi-fenoxi)-2-hidroxi-3-isipropilaminopropano
FR2330383A1 (fr) * 1975-11-06 1977-06-03 Synthelabo Nouveaux ethers de phenols substitues, leurs sels, leur preparation et les medicaments qui les renferment
GB2079750B (en) * 1980-07-09 1984-08-22 Sandoz Ltd 3 aminopropoxyphenyl derivatives their preparation and pharmaceutical compositions containing them

Also Published As

Publication number Publication date
PL231453A1 (pt) 1982-08-02
DK154021B (da) 1988-10-03
NO150152C (no) 1984-08-29
CS221963B2 (en) 1983-04-29
KR840001919B1 (ko) 1984-10-25
KR830006176A (ko) 1983-09-20
DK231581A (da) 1981-12-03
PH16940A (en) 1984-04-24
NO811852L (no) 1981-12-03
GR75681B (pt) 1984-08-02
PT73113B (en) 1983-05-11
FI811706L (fi) 1981-12-03
YU133581A (en) 1983-12-31
AU538634B2 (en) 1984-08-23
MC1387A1 (fr) 1982-04-27
ES8207505A1 (es) 1982-10-01
IE811212L (en) 1981-12-02
NO150152B (no) 1984-05-21
ES509168A0 (es) 1982-12-16
DE3162256D1 (en) 1984-03-22
IL62970A0 (en) 1981-07-31
CA1220488A (en) 1987-04-14
PL135317B1 (en) 1985-10-31
BR8103439A (pt) 1982-02-24
CS221962B2 (en) 1983-04-29
YU42079B (en) 1988-04-30
HU182341B (en) 1983-12-28
AR226946A1 (es) 1982-08-31
EP0041233B1 (de) 1984-02-15
PL135306B1 (en) 1985-10-31
ES8301888A1 (es) 1982-12-16
US4649160A (en) 1987-03-10
ATE6250T1 (de) 1984-03-15
IL62970A (en) 1985-01-31
KR840001920B1 (ko) 1984-10-25
EP0041233A1 (de) 1981-12-09
DK154021C (da) 1989-02-06
AU7101481A (en) 1981-12-10
SU1155154A3 (ru) 1985-05-07
AR227046A1 (es) 1982-09-15
PT73113A (en) 1981-07-01
ES502649A0 (es) 1982-10-01
IE51812B1 (en) 1987-04-01
ZW9881A1 (en) 1981-12-23
YU156883A (en) 1983-12-31
SU1194270A3 (ru) 1985-11-23
NZ197184A (en) 1984-05-31

Similar Documents

Publication Publication Date Title
DE2645710C2 (de) Phenoxy-amino-propanole, Verfahren zu ihrer Herstellung und pharmazeutische Zubereitung
US4034009A (en) 4-Ureido-2-acyl phenoxypropanolamine
IE47237B1 (en) Triphenylalkene derivatives, process for their preparation and pharmaceutical compositions containing them
US4081447A (en) 5-[2-Hydroxy-3-(3,4-dimethoxy phenethylamino)]-propoxy-3,4-dihydro carbostyril and pharmaceutically acceptable salts thereof
DE2334404C2 (de) Alkylthiophenyl-2-n-octylaminoalkohole und deren Salze, Verfahren zu deren Herstellung und pharmazeutische Zubereitung
EP0074014B1 (de) 2-(2'-Hydroxy-3'-(1,1-dimethylpropylamino)-propoxy)-beta-phenylpropiophenon, seine Säureadditionssalze, Verfahren zu seiner Herstellung und Arzneimittel
DE2020864B2 (de) p-Substituierte 1-Phenoxy-3-alkylaminopropan-2-ole, Herstellungsverfahren und Arzneimittel
DD159327A5 (de) Substituierte phenoxy-aminopropanolderivate
EP0167121A2 (de) Neue substituierte Phenylpiperazinyl-propanole, Verfahren zu ihrer Herstellung und ihre Vewendung sowei diese Verbindungen enthaltende Zubereitungen
EP0034831B1 (de) Substituierte Phenoxy-aminopropanol-Derivate, Zwischenprodukte und Verfahren zu deren Herstellung sowie diese enthaltende Arzneimittel
US4515814A (en) 3-Phenoxypropan-2-ol derivatives for treating glaucoma
EP0030380A1 (de) 2,3-Indoldionderivate, Verfahren zu ihrer Herstellung, Zwischenprodukte, Arzneimittel enthaltend solche 2,3-Indoldionderivate und ihre pharmazeutische Verwendung
EP0027928B1 (de) Piperidinderivate von 4,5-Dialkyl-3-hydroxy-pyrrol-2-carbonsäureestern, ihre Herstellung und diese enthaltende pharmazeutische Zubereitungen
EP0009683B1 (de) Neue basische Phenyläther, diese enthaltende pharmazeutische Zubereitungen und die Herstellung dieser Äther und Zubereitungen
EP0008108B1 (de) Aminopropanolderivate des 2-(o-Hydroxyphenyl)-pyrrols, Verfahren zu ihrer Herstellung und diese enthaltende pharmazeutische Zubereitungen
EP0037062B1 (de) Substituierte 3-Aryl-2-cycloalken-1-one, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
EP0152556A1 (de) Aminopropanolderivate von substituierten 2-Hydroxy-propiophenonen, Verfahren zu ihrer Herstellung und diese enthaltende therapeutische Mittel
DE2354444A1 (de) Biphenylylaether und verfahren zu ihrer herstellung
EP0401798A2 (de) Substituierte Aminoalkylbenzolderivate
EP0297435B1 (de) Aminopropanolderivate von 3-(3'-Hydroxyphenyl)-1-propanon-Verbindungen, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende Arzneimittel
DE2950064A1 (de) Piperidinderivate von 3-hydroxythiophen-2-carbonsaeure und -estern, ihre herstellung und diese enthaltende pharmazeutische zubereitungen
EP0575361B1 (de) Neue 1-aryl-4-piperazinyl-cyclohexancarbonsäurenitrile, ihre herstellung und verwendung
WO1991009834A1 (de) o-HYDROXY-β-(1-NAPHTHYL)-PROPIOPHENONDERIVATE, VERFAHREN ZU IHRER HERSTELLUNG UND DIESE VERBINDUNGEN ENTHALTENDE ARZNEIMITTEL
EP0158144A1 (de) N-Bicycloheptyl- und N-Bicycloheptenyl-imidazole, Verfahren zu ihrer Herstellung, ihre Verwendung sowie pharmazeutische Präparate
DE3143950A1 (de) Neue n,n'-methylen-bis-oxazolidine