DD150457A5 - Verfahren zur herstellung der(r,r)optisch isomeren verbindungen von labetalol - Google Patents

Verfahren zur herstellung der(r,r)optisch isomeren verbindungen von labetalol Download PDF

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Publication number
DD150457A5
DD150457A5 DD79215640A DD21564079A DD150457A5 DD 150457 A5 DD150457 A5 DD 150457A5 DD 79215640 A DD79215640 A DD 79215640A DD 21564079 A DD21564079 A DD 21564079A DD 150457 A5 DD150457 A5 DD 150457A5
Authority
DD
German Democratic Republic
Prior art keywords
methyl
protected
item
phenylpropyl
benzyl
Prior art date
Application number
DD79215640A
Other languages
German (de)
English (en)
Inventor
Elijah H Gold
Wei Chang
Original Assignee
Schering Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Corp filed Critical Schering Corp
Publication of DD150457A5 publication Critical patent/DD150457A5/de

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/12—Preparation of carboxylic acid amides by reactions not involving the formation of carboxamide groups
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/166—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the carbon of a carboxamide group directly attached to the aromatic ring, e.g. procainamide, procarbazine, metoclopramide, labetalol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/64—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings
    • C07C233/65—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biomedical Technology (AREA)
  • Pain & Pain Management (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Vascular Medicine (AREA)
  • Rheumatology (AREA)
  • Urology & Nephrology (AREA)
  • Epidemiology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Epoxy Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
DD79215640A 1978-09-20 1979-09-19 Verfahren zur herstellung der(r,r)optisch isomeren verbindungen von labetalol DD150457A5 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US94451678A 1978-09-20 1978-09-20

Publications (1)

Publication Number Publication Date
DD150457A5 true DD150457A5 (de) 1981-09-02

Family

ID=25481553

Family Applications (1)

Application Number Title Priority Date Filing Date
DD79215640A DD150457A5 (de) 1978-09-20 1979-09-19 Verfahren zur herstellung der(r,r)optisch isomeren verbindungen von labetalol

Country Status (27)

Country Link
EP (1) EP0009702B1 (xx)
JP (3) JPS5555147A (xx)
KR (2) KR830000904A (xx)
AT (1) ATE351T1 (xx)
AU (1) AU528626B2 (xx)
CA (1) CA1151211A (xx)
CY (1) CY1175A (xx)
DD (1) DD150457A5 (xx)
DE (1) DE2961263D1 (xx)
DK (1) DK387579A (xx)
FI (1) FI792884A (xx)
GR (1) GR73179B (xx)
HK (1) HK13383A (xx)
HU (1) HU185523B (xx)
IE (1) IE49301B1 (xx)
IL (1) IL58258A (xx)
KE (1) KE3283A (xx)
MY (1) MY8500042A (xx)
NO (1) NO149660C (xx)
NZ (1) NZ191589A (xx)
OA (1) OA06339A (xx)
PH (1) PH16794A (xx)
PL (1) PL129114B1 (xx)
PT (1) PT70191A (xx)
SG (1) SG283G (xx)
YU (1) YU227379A (xx)
ZA (1) ZA794872B (xx)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4658060A (en) * 1982-04-26 1987-04-14 Schering Corporation Preparation of (-)-5-(beta)-1-hydroxy-2-((beta)-1-methyl-3-phenylpropyl)aminoethyl) salicylamide
IT1194406B (it) * 1983-09-27 1988-09-22 Scharper S P A Procedimento per la preparazione di 2-idrossi-5-01-idrossi-2-((4-fenil-2-butil)ammino) etil benzammide
HU190867B (en) * 1984-01-20 1986-11-28 Egyt Gyogyszervegyeszeti Gyar,Hu Process for preparing 2-hydroxy-5-/1-hydroxy-2-/1-methyl-3-phenyl-propyl/-amino/ethyl/-benzamide and pharmaceutically acceptable salts thereof
US4788183A (en) * 1987-11-30 1988-11-29 Schering Corporation Method for treatment of dyslipidemia in humans
US4879233A (en) * 1989-02-10 1989-11-07 Schering Corporation Novel Aspergillus niveus microorganism used for the chiral reduction of carbonyl groups
US5688938A (en) * 1991-08-23 1997-11-18 The Brigham & Women's Hospital, Inc. Calcium receptor-active molecules
US5763569A (en) * 1991-08-23 1998-06-09 The Brigham And Women's Hospital, Inc Calcium receptor-active molecules
US6011068A (en) * 1991-08-23 2000-01-04 Nps Pharmaceuticals, Inc. Calcium receptor-active molecules
US5858684A (en) * 1991-08-23 1999-01-12 The Brigham And Women's Hospital, Inc. Method of screening calcium receptor-active molecules
US6031003A (en) * 1991-08-23 2000-02-29 Nps Pharmaceuticals, Inc. Calcium receptor-active molecules
US6001884A (en) * 1991-08-23 1999-12-14 Nps Pharmaceuticals, Inc. Calcium receptor-active molecules
US6313146B1 (en) 1991-08-23 2001-11-06 Nps Pharmaceuticals, Inc. Calcium receptor-active molecules
DE69233572T2 (de) * 1991-08-23 2006-08-31 NPS Pharmaceuticals, Inc., Salt Lake City Screening-Verfahren für Kalzium-Rezeptor aktive Verbindungen
US5962314A (en) * 1993-02-23 1999-10-05 Nps Pharmaceuticals, Inc. Calcium receptor-active molecules
HU228150B1 (en) 1994-10-21 2012-12-28 Nps Pharma Inc Calcium receptor-active compounds, medicaments comprising them, and the use of said medicaments
DE69737303T2 (de) 1996-05-01 2007-08-30 NPS Pharmaceuticals, Inc., Salt Lake City Verbindungen, die auf anorganische Ionen-Rezeptoren wirken
IT1313583B1 (it) 1999-07-30 2002-09-09 Chiesi Farma Spa Derivati 2-amminotetralinici per la terapia del glaucoma.
PT1961735E (pt) * 2007-02-22 2009-12-21 Indena Spa Processo para a preparação de sal de acetato de éster metílico de (2r,3s)-3-fenilisoserina
EP2603215A4 (en) 2010-08-11 2015-08-05 Philadelphia Health & Educatio NEW DOPAMINERGIC D3 RECEPTOR AGONISTS FOR TREATING DYSKINESIA IN PARKINSON'S DISEASE

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4012444A (en) * 1969-07-08 1977-03-15 Allen & Hanburys Limited 5-[1-Hydroxy-2-(1-methyl-3-phenylpropyl)aminoethyl] salicylamide and physiologically acceptable acid addition salts thereof
GB1266058A (xx) * 1969-07-08 1972-03-08
FR2313074A1 (fr) * 1975-04-17 1976-12-31 Scherico Ltd Diastereoisomeres de derives phenylaminoethanol

Also Published As

Publication number Publication date
IL58258A (en) 1984-01-31
DE2961263D1 (en) 1982-01-14
OA06339A (fr) 1981-06-30
AU528626B2 (en) 1983-05-05
KR840005307A (ko) 1984-11-05
NO149660B (no) 1984-02-20
HU185523B (en) 1985-02-28
EP0009702B1 (en) 1981-11-04
YU227379A (en) 1983-06-30
NO792993L (no) 1980-03-21
SG283G (en) 1983-09-16
PL218408A1 (xx) 1980-09-08
HK13383A (en) 1983-04-29
NZ191589A (en) 1984-03-30
KR830000904A (ko) 1983-04-28
CY1175A (en) 1983-06-10
MY8500042A (en) 1985-12-31
KE3283A (en) 1983-05-13
EP0009702A1 (en) 1980-04-16
CA1151211A (en) 1983-08-02
DK387579A (da) 1980-03-21
AU5088179A (en) 1980-03-27
FI792884A (fi) 1980-03-21
JPH02167253A (ja) 1990-06-27
GR73179B (xx) 1984-02-14
KR890001998B1 (ko) 1989-06-07
JPS5555147A (en) 1980-04-22
JPH0210128B2 (xx) 1990-03-06
PT70191A (en) 1979-10-01
ATE351T1 (de) 1981-11-15
NO149660C (no) 1984-05-30
PL129114B1 (en) 1984-03-31
IE49301B1 (en) 1985-09-18
JPS59108749A (ja) 1984-06-23
IE791770L (en) 1980-03-20
IL58258A0 (en) 1979-12-30
PH16794A (en) 1984-02-28
ZA794872B (en) 1980-11-26

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