CZ298118B6 - Zpusob kosmetické reprodukce vlasu a pouzití vlasových folikulových bunek - Google Patents
Zpusob kosmetické reprodukce vlasu a pouzití vlasových folikulových bunek Download PDFInfo
- Publication number
- CZ298118B6 CZ298118B6 CZ0313499A CZ313499A CZ298118B6 CZ 298118 B6 CZ298118 B6 CZ 298118B6 CZ 0313499 A CZ0313499 A CZ 0313499A CZ 313499 A CZ313499 A CZ 313499A CZ 298118 B6 CZ298118 B6 CZ 298118B6
- Authority
- CZ
- Czechia
- Prior art keywords
- hair
- cells
- cultured
- hair follicle
- cell line
- Prior art date
Links
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/98—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin
- A61K8/981—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin of mammals or bird
- A61K8/985—Skin or skin outgrowth, e.g. hair, nails
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q7/00—Preparations for affecting hair growth
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0625—Epidermal cells, skin cells; Cells of the oral mucosa
- C12N5/0627—Hair cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2500/00—Specific components of cell culture medium
- C12N2500/05—Inorganic components
- C12N2500/10—Metals; Metal chelators
- C12N2500/12—Light metals, i.e. alkali, alkaline earth, Be, Al, Mg
- C12N2500/14—Calcium; Ca chelators; Calcitonin
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2500/00—Specific components of cell culture medium
- C12N2500/90—Serum-free medium, which may still contain naturally-sourced components
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2502/00—Coculture with; Conditioned medium produced by
- C12N2502/11—Coculture with; Conditioned medium produced by blood or immune system cells
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Dermatology (AREA)
- Zoology (AREA)
- Biomedical Technology (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Biotechnology (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Genetics & Genomics (AREA)
- Microbiology (AREA)
- Epidemiology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Birds (AREA)
- Cell Biology (AREA)
- Cosmetics (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Eye Examination Apparatus (AREA)
- Diaphragms For Electromechanical Transducers (AREA)
- Crystals, And After-Treatments Of Crystals (AREA)
- Prostheses (AREA)
- Indexing, Searching, Synchronizing, And The Amount Of Synchronization Travel Of Record Carriers (AREA)
- Toys (AREA)
- Magnetic Resonance Imaging Apparatus (AREA)
- Farming Of Fish And Shellfish (AREA)
- Massaging Devices (AREA)
- Measurement And Recording Of Electrical Phenomena And Electrical Characteristics Of The Living Body (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| NL1005445A NL1005445C2 (nl) | 1997-03-05 | 1997-03-05 | Werkwijze voor het vermenigvuldigen van haar. |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CZ313499A3 CZ313499A3 (cs) | 2000-02-16 |
| CZ298118B6 true CZ298118B6 (cs) | 2007-06-27 |
Family
ID=19764538
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CZ0313499A CZ298118B6 (cs) | 1997-03-05 | 1998-03-05 | Zpusob kosmetické reprodukce vlasu a pouzití vlasových folikulových bunek |
Country Status (22)
| Country | Link |
|---|---|
| US (1) | US6399057B1 (OSRAM) |
| EP (1) | EP0971679B1 (OSRAM) |
| JP (1) | JP2001526560A (OSRAM) |
| CN (1) | CN1254277A (OSRAM) |
| AT (1) | ATE219654T1 (OSRAM) |
| AU (1) | AU732729B2 (OSRAM) |
| BR (1) | BR9808190A (OSRAM) |
| CA (1) | CA2283172A1 (OSRAM) |
| CZ (1) | CZ298118B6 (OSRAM) |
| DE (1) | DE69806232T2 (OSRAM) |
| DK (1) | DK0971679T3 (OSRAM) |
| EA (1) | EA199900799A1 (OSRAM) |
| ES (1) | ES2176977T3 (OSRAM) |
| ID (1) | ID22700A (OSRAM) |
| IL (1) | IL131740A (OSRAM) |
| NL (1) | NL1005445C2 (OSRAM) |
| NO (1) | NO312805B1 (OSRAM) |
| NZ (1) | NZ337640A (OSRAM) |
| PL (1) | PL335723A1 (OSRAM) |
| PT (1) | PT971679E (OSRAM) |
| TR (1) | TR199902184T2 (OSRAM) |
| WO (1) | WO1998047471A1 (OSRAM) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU1472501A (en) * | 1999-11-05 | 2001-05-14 | Gerigene Medical Corporation | Augmentation and repair of age-related soft tissue defects |
| KR20020005331A (ko) * | 2000-07-10 | 2002-01-17 | 정상훈 | 모낭 세포의 배양 방법 및 모발 이식용 키트 |
| KR20030043928A (ko) | 2000-08-08 | 2003-06-02 | 바이오아미드 인코포레이티드 | 조직 조작된 모발용 지지체 |
| KR100371274B1 (ko) * | 2000-08-09 | 2003-02-06 | 정상훈 | 모발 이식용 키트 |
| US20030161815A1 (en) * | 2002-02-12 | 2003-08-28 | Intercytex Limited | Cell delivery system |
| CA2505409C (en) * | 2002-11-14 | 2017-04-04 | Intercytex Limited | Cultivation of hair inductive cells |
| US7597885B2 (en) | 2004-03-26 | 2009-10-06 | Aderans Research Institute, Inc. | Tissue engineered biomimetic hair follicle graft |
| WO2006031313A2 (en) * | 2004-08-05 | 2006-03-23 | The Board Of Trustees Of The Leland Stanford Junior University | Methods and compositions for cell activation |
| US20060073117A1 (en) * | 2004-10-01 | 2006-04-06 | Stowers Institute For Medical Research | Methods and compositions for controlling hair follicle stem cell fate |
| KR100616752B1 (ko) * | 2004-11-29 | 2006-08-31 | 박정극 | 모낭 유도 능력이 있는 모유두 조직의 제조방법 |
| NL1030484C1 (nl) | 2005-11-22 | 2007-05-23 | Hair Science Inst | Werkwijze voor in vivo haarvermenigvuldiging. |
| TW200800240A (en) | 2005-11-22 | 2008-01-01 | Aderans Res Inst Inc | Hair follicle graft from tissue engineered skin |
| EP2520324A2 (en) | 2006-02-09 | 2012-11-07 | Aderans Research Institute, Inc. | Micrometer assisted fluid delivery device |
| EP2007877B1 (en) | 2006-02-28 | 2013-04-17 | The Trustees of Columbia University in the City of New York | Methods for compact aggregation of dermal cells |
| GB0605450D0 (en) | 2006-03-17 | 2006-04-26 | Intercytex Ltd | Cell co-culture |
| KR100771171B1 (ko) | 2006-07-05 | 2007-10-29 | 재단법인서울대학교산학협력재단 | 모낭 줄기세포의 분리, 증식 및 분화 방법 및 대머리치료용 조성물 |
| EP1964519B1 (en) | 2007-03-01 | 2009-09-02 | Sony Corporation | Method for extracting a biosubstance from hair and hair sampling device useful in the method |
| US20110086007A1 (en) * | 2007-09-21 | 2011-04-14 | Aderans Research Institute, Inc. | Epidermal stimulation to enhance hair follicle formation |
| CN103476360B (zh) * | 2011-04-26 | 2015-09-23 | 李喜永 | 毛发移植材料 |
| NL2009971C2 (en) | 2012-12-12 | 2014-06-16 | Hair Science Inst | Method for in vivo hair multiplication. |
| NL2010222C2 (en) * | 2013-02-01 | 2014-08-04 | Conradus Ghosal Gho | Composition and method for generating a desired cell type and/or tissue type from hair follicular stem cells. |
| NL2010225C2 (en) * | 2013-02-01 | 2014-08-04 | Conradus Ghosal Gho | Composition and method for preserving, transporting and storing living biological materials. |
| GB201816902D0 (en) * | 2018-10-17 | 2018-11-28 | Hairclone Ltd | Hair Rejuvenation |
| CN112245454A (zh) * | 2020-10-16 | 2021-01-22 | 潍坊卡多娜生物科技有限公司 | 一种细胞疤痕修复方法 |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CZ281802B6 (cs) * | 1993-07-23 | 1997-02-12 | L'oreal | Kosmetické prostředky pro udržování účesu, které mají zlepšenou fixační sílu |
| CZ287104B6 (en) * | 1993-10-15 | 2000-09-13 | Merck & Co Inc | Pharmaceutical preparation for treating androgenic alopecia |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8604360D0 (en) * | 1986-02-21 | 1986-03-26 | Univ Dundee | Stimulation of hair growth |
| US5635387A (en) * | 1990-04-23 | 1997-06-03 | Cellpro, Inc. | Methods and device for culturing human hematopoietic cells and their precursors |
| WO1992000376A1 (en) * | 1990-06-25 | 1992-01-09 | Immunex Corporation | Mast cell growth factor |
| US5130142A (en) * | 1990-10-31 | 1992-07-14 | The Practer & Gamble Company | Hair growth regulating composition comprising epithelium cell supernatant-derived growth factor |
| US5556783A (en) * | 1991-03-27 | 1996-09-17 | Trustees Of Univ. Of Penna | Methods of culturing and modulating the growth of hair follicular stem cells |
| JP3573488B2 (ja) * | 1994-04-11 | 2004-10-06 | 独立行政法人 科学技術振興機構 | 毛乳頭細胞の長期継代培養法 |
| EP0821592A4 (en) * | 1995-04-20 | 2000-03-01 | Univ Pennsylvania | COMPOSITIONS AND METHODS FOR REGULATING HAIR GROWTH |
| US6162211A (en) * | 1996-12-05 | 2000-12-19 | Thermolase Corporation | Skin enhancement using laser light |
-
1997
- 1997-03-05 NL NL1005445A patent/NL1005445C2/nl not_active IP Right Cessation
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1998
- 1998-03-05 AU AU66388/98A patent/AU732729B2/en not_active Ceased
- 1998-03-05 AT AT98908329T patent/ATE219654T1/de not_active IP Right Cessation
- 1998-03-05 PL PL98335723A patent/PL335723A1/xx not_active Application Discontinuation
- 1998-03-05 CA CA002283172A patent/CA2283172A1/en not_active Abandoned
- 1998-03-05 EA EA199900799A patent/EA199900799A1/ru unknown
- 1998-03-05 NZ NZ337640A patent/NZ337640A/en unknown
- 1998-03-05 ES ES98908329T patent/ES2176977T3/es not_active Expired - Lifetime
- 1998-03-05 CN CN98804712A patent/CN1254277A/zh active Pending
- 1998-03-05 US US09/380,580 patent/US6399057B1/en not_active Expired - Lifetime
- 1998-03-05 IL IL13174098A patent/IL131740A/xx not_active IP Right Cessation
- 1998-03-05 PT PT98908329T patent/PT971679E/pt unknown
- 1998-03-05 ID IDW990962A patent/ID22700A/id unknown
- 1998-03-05 BR BR9808190-0A patent/BR9808190A/pt not_active IP Right Cessation
- 1998-03-05 WO PCT/NL1998/000129 patent/WO1998047471A1/en not_active Ceased
- 1998-03-05 DK DK98908329T patent/DK0971679T3/da active
- 1998-03-05 CZ CZ0313499A patent/CZ298118B6/cs not_active IP Right Cessation
- 1998-03-05 DE DE69806232T patent/DE69806232T2/de not_active Expired - Fee Related
- 1998-03-05 JP JP53894298A patent/JP2001526560A/ja not_active Ceased
- 1998-03-05 TR TR1999/02184T patent/TR199902184T2/xx unknown
- 1998-03-05 EP EP98908329A patent/EP0971679B1/en not_active Expired - Lifetime
-
1999
- 1999-09-06 NO NO19994311A patent/NO312805B1/no unknown
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CZ281802B6 (cs) * | 1993-07-23 | 1997-02-12 | L'oreal | Kosmetické prostředky pro udržování účesu, které mají zlepšenou fixační sílu |
| CZ287104B6 (en) * | 1993-10-15 | 2000-09-13 | Merck & Co Inc | Pharmaceutical preparation for treating androgenic alopecia |
Also Published As
| Publication number | Publication date |
|---|---|
| JP2001526560A (ja) | 2001-12-18 |
| AU6638898A (en) | 1998-11-13 |
| DE69806232D1 (de) | 2002-08-01 |
| EP0971679A1 (en) | 2000-01-19 |
| ATE219654T1 (de) | 2002-07-15 |
| US6399057B1 (en) | 2002-06-04 |
| NO994311L (no) | 1999-11-03 |
| CZ313499A3 (cs) | 2000-02-16 |
| DK0971679T3 (da) | 2002-07-22 |
| PT971679E (pt) | 2002-11-29 |
| AU732729B2 (en) | 2001-04-26 |
| IL131740A0 (en) | 2001-03-19 |
| EA199900799A1 (ru) | 2000-02-28 |
| IL131740A (en) | 2003-12-10 |
| CN1254277A (zh) | 2000-05-24 |
| EP0971679B1 (en) | 2002-06-26 |
| HK1025052A1 (en) | 2000-11-03 |
| NZ337640A (en) | 2001-02-23 |
| PL335723A1 (en) | 2000-05-08 |
| BR9808190A (pt) | 2000-05-16 |
| DE69806232T2 (de) | 2003-02-06 |
| CA2283172A1 (en) | 1998-10-29 |
| ID22700A (id) | 1999-12-09 |
| NO312805B1 (no) | 2002-07-08 |
| ES2176977T3 (es) | 2002-12-01 |
| NL1005445C2 (nl) | 1998-09-21 |
| NO994311D0 (no) | 1999-09-06 |
| WO1998047471A1 (en) | 1998-10-29 |
| TR199902184T2 (xx) | 1999-12-21 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PD00 | Pending as of 2000-06-30 in czech republic | ||
| MM4A | Patent lapsed due to non-payment of fee |
Effective date: 19980305 |