CA2283172A1 - Method for the propagation of hair - Google Patents
Method for the propagation of hair Download PDFInfo
- Publication number
- CA2283172A1 CA2283172A1 CA002283172A CA2283172A CA2283172A1 CA 2283172 A1 CA2283172 A1 CA 2283172A1 CA 002283172 A CA002283172 A CA 002283172A CA 2283172 A CA2283172 A CA 2283172A CA 2283172 A1 CA2283172 A1 CA 2283172A1
- Authority
- CA
- Canada
- Prior art keywords
- cells
- hair
- cultured
- hair follicle
- autologous
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- 210000004209 hair Anatomy 0.000 title claims abstract description 82
- 238000000034 method Methods 0.000 title claims abstract description 48
- 210000004027 cell Anatomy 0.000 claims abstract description 68
- 210000000442 hair follicle cell Anatomy 0.000 claims abstract description 41
- 102100031573 Hematopoietic progenitor cell antigen CD34 Human genes 0.000 claims abstract description 38
- 101000777663 Homo sapiens Hematopoietic progenitor cell antigen CD34 Proteins 0.000 claims abstract description 38
- 210000003630 histaminocyte Anatomy 0.000 claims abstract description 35
- 230000003698 anagen phase Effects 0.000 claims abstract description 24
- 239000001963 growth medium Substances 0.000 claims abstract description 17
- 239000002269 analeptic agent Substances 0.000 claims abstract description 12
- 238000002513 implantation Methods 0.000 claims abstract description 3
- 239000000284 extract Substances 0.000 claims description 14
- 239000011148 porous material Substances 0.000 claims description 14
- 210000003780 hair follicle Anatomy 0.000 claims description 12
- 239000000725 suspension Substances 0.000 claims description 9
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- 239000002537 cosmetic Substances 0.000 claims description 3
- 229920006395 saturated elastomer Polymers 0.000 claims description 3
- 230000003325 follicular Effects 0.000 claims description 2
- 210000002768 hair cell Anatomy 0.000 claims description 2
- 239000002609 medium Substances 0.000 abstract description 26
- 238000012258 culturing Methods 0.000 abstract description 10
- 210000002510 keratinocyte Anatomy 0.000 abstract description 9
- 238000002360 preparation method Methods 0.000 abstract description 3
- 239000003795 chemical substances by application Substances 0.000 description 12
- 230000012010 growth Effects 0.000 description 12
- 230000003112 degranulating effect Effects 0.000 description 8
- 239000003102 growth factor Substances 0.000 description 7
- 210000004186 follicle cell Anatomy 0.000 description 6
- 210000003491 skin Anatomy 0.000 description 6
- 201000004384 Alopecia Diseases 0.000 description 5
- 230000003779 hair growth Effects 0.000 description 5
- 239000000470 constituent Substances 0.000 description 4
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- 230000003676 hair loss Effects 0.000 description 4
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- 239000003636 conditioned culture medium Substances 0.000 description 2
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- JYGXADMDTFJGBT-VWUMJDOOSA-N hydrocortisone Chemical compound O=C1CC[C@]2(C)[C@H]3[C@@H](O)C[C@](C)([C@@](CC4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 JYGXADMDTFJGBT-VWUMJDOOSA-N 0.000 description 2
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 description 2
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- XINQFOMFQFGGCQ-UHFFFAOYSA-L (2-dodecoxy-2-oxoethyl)-[6-[(2-dodecoxy-2-oxoethyl)-dimethylazaniumyl]hexyl]-dimethylazanium;dichloride Chemical compound [Cl-].[Cl-].CCCCCCCCCCCCOC(=O)C[N+](C)(C)CCCCCC[N+](C)(C)CC(=O)OCCCCCCCCCCCC XINQFOMFQFGGCQ-UHFFFAOYSA-L 0.000 description 1
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- YJLIKUSWRSEPSM-WGQQHEPDSA-N (2r,3r,4s,5r)-2-[6-amino-8-[(4-phenylphenyl)methylamino]purin-9-yl]-5-(hydroxymethyl)oxolane-3,4-diol Chemical compound C=1C=C(C=2C=CC=CC=2)C=CC=1CNC1=NC=2C(N)=NC=NC=2N1[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O YJLIKUSWRSEPSM-WGQQHEPDSA-N 0.000 description 1
- PZEUTLIKVUEDLB-UHFFFAOYSA-N 2-[[[2-[[6-amino-2-[[2-[[6-amino-2-[[2-[[2-[[2-[[2-[[2-[2-[[1-[2-[[2-[[2-[[2-[[2-[[2-[[6-amino-2-[[2-[[2-[2-[[2-[[2-[(2-aminoacetyl)amino]-3-methylpentanoyl]amino]acetyl]amino]propanoylamino]-3-methylbutanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]amino]-3-methylbutanoyl]amino]-4-methylpentanoyl]amino]-3-hydroxybutanoyl]amino]-3-methylbutanoyl]amino]acetyl]amino]-4-methylpentanoyl]pyrrolidine-2-carbonyl]amino]propanoylamino]-4-methylpentanoyl]amino]-3-methylpentanoyl]amino]-3-hydroxypropanoyl]amino]-3-(1H-indol-3-yl)propanoyl]amino]-3-methylpentanoyl]amino]hexanoyl]amino]-5-carbamimidamidopentanoyl]amino]hexanoyl]amino]-3-(carbamoylamino)propanoyl]-(3-amino-3-oxopropyl)carbamoyl]amino]pentanediamide Chemical compound CCC(C)C(NC(=O)CN)C(=O)NCC(=O)NC(C)C(=O)NC(C(C)C)C(=O)NC(CC(C)C)C(=O)NC(CCCCN)C(=O)NC(C(C)C)C(=O)NC(CC(C)C)C(=O)NC(C(C)O)C(=O)NC(C(C)C)C(=O)NCC(=O)NC(CC(C)C)C(=O)N1CCCC1C(=O)NC(C)C(=O)NC(CC(C)C)C(=O)NC(C(C)CC)C(=O)NC(CO)C(=O)NC(Cc1c[nH]c2ccccc12)C(=O)NC(C(C)CC)C(=O)NC(CCCCN)C(=O)NC(CCCNC(N)=N)C(=O)NC(CCCCN)C(=O)NC(CNC(N)=O)C(=O)N(CCC(N)=O)C(=O)NC(CCC(N)=O)C(N)=O PZEUTLIKVUEDLB-UHFFFAOYSA-N 0.000 description 1
- PWKSKIMOESPYIA-UHFFFAOYSA-N 2-acetamido-3-sulfanylpropanoic acid Chemical compound CC(=O)NC(CS)C(O)=O PWKSKIMOESPYIA-UHFFFAOYSA-N 0.000 description 1
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- HIYAVKIYRIFSCZ-CVXKHCKVSA-N Calcimycin Chemical compound CC([C@H]1OC2([C@@H](C[C@H]1C)C)O[C@H]([C@H](CC2)C)CC=1OC2=CC=C(C(=C2N=1)C(O)=O)NC)C(=O)C1=CC=CN1 HIYAVKIYRIFSCZ-CVXKHCKVSA-N 0.000 description 1
- CEAZRRDELHUEMR-URQXQFDESA-N Gentamicin Chemical compound O1[C@H](C(C)NC)CC[C@@H](N)[C@H]1O[C@H]1[C@H](O)[C@@H](O[C@@H]2[C@@H]([C@@H](NC)[C@@](C)(O)CO2)O)[C@H](N)C[C@@H]1N CEAZRRDELHUEMR-URQXQFDESA-N 0.000 description 1
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- 102000004877 Insulin Human genes 0.000 description 1
- 108090001061 Insulin Proteins 0.000 description 1
- 235000019454 L-leucine Nutrition 0.000 description 1
- 239000004395 L-leucine Substances 0.000 description 1
- 241000286904 Leptothecata Species 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
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- 229910019142 PO4 Inorganic materials 0.000 description 1
- 206010033546 Pallor Diseases 0.000 description 1
- 102400000096 Substance P Human genes 0.000 description 1
- 101800003906 Substance P Proteins 0.000 description 1
- 102000004142 Trypsin Human genes 0.000 description 1
- 108090000631 Trypsin Proteins 0.000 description 1
- 231100000360 alopecia Toxicity 0.000 description 1
- 239000003242 anti bacterial agent Substances 0.000 description 1
- 229940088710 antibiotic agent Drugs 0.000 description 1
- 239000003659 bee venom Substances 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- QXZGBUJJYSLZLT-FDISYFBBSA-N bradykinin Chemical compound NC(=N)NCCC[C@H](N)C(=O)N1CCC[C@H]1C(=O)N1[C@H](C(=O)NCC(=O)N[C@@H](CC=2C=CC=CC=2)C(=O)N[C@@H](CO)C(=O)N2[C@@H](CCC2)C(=O)N[C@@H](CC=2C=CC=CC=2)C(=O)N[C@@H](CCCNC(N)=N)C(O)=O)CCC1 QXZGBUJJYSLZLT-FDISYFBBSA-N 0.000 description 1
- HIYAVKIYRIFSCZ-UHFFFAOYSA-N calcium ionophore A23187 Natural products N=1C2=C(C(O)=O)C(NC)=CC=C2OC=1CC(C(CC1)C)OC1(C(CC1C)C)OC1C(C)C(=O)C1=CC=CN1 HIYAVKIYRIFSCZ-UHFFFAOYSA-N 0.000 description 1
- 230000003778 catagen phase Effects 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 230000001143 conditioned effect Effects 0.000 description 1
- 125000004122 cyclic group Chemical group 0.000 description 1
- 210000000805 cytoplasm Anatomy 0.000 description 1
- 210000004207 dermis Anatomy 0.000 description 1
- 239000003797 essential amino acid Substances 0.000 description 1
- 235000020776 essential amino acid Nutrition 0.000 description 1
- 239000000262 estrogen Substances 0.000 description 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 description 1
- 239000012737 fresh medium Substances 0.000 description 1
- 229960002518 gentamicin Drugs 0.000 description 1
- 210000003128 head Anatomy 0.000 description 1
- 229940088597 hormone Drugs 0.000 description 1
- 239000005556 hormone Substances 0.000 description 1
- 229960000890 hydrocortisone Drugs 0.000 description 1
- 238000000338 in vitro Methods 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 229940125396 insulin Drugs 0.000 description 1
- 229940127560 insulin pen Drugs 0.000 description 1
- 229960003136 leucine Drugs 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 235000013372 meat Nutrition 0.000 description 1
- 239000002858 neurotransmitter agent Substances 0.000 description 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 1
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- 238000002054 transplantation Methods 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/98—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin
- A61K8/981—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin of mammals or bird
- A61K8/985—Skin or skin outgrowth, e.g. hair, nails
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q7/00—Preparations for affecting hair growth
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0625—Epidermal cells, skin cells; Cells of the oral mucosa
- C12N5/0627—Hair cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2500/00—Specific components of cell culture medium
- C12N2500/05—Inorganic components
- C12N2500/10—Metals; Metal chelators
- C12N2500/12—Light metals, i.e. alkali, alkaline earth, Be, Al, Mg
- C12N2500/14—Calcium; Ca chelators; Calcitonin
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2500/00—Specific components of cell culture medium
- C12N2500/90—Serum-free medium, which may still contain naturally-sourced components
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2502/00—Coculture with; Conditioned medium produced by
- C12N2502/11—Coculture with; Conditioned medium produced by blood or immune system cells
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Dermatology (AREA)
- Zoology (AREA)
- Biomedical Technology (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Biotechnology (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Genetics & Genomics (AREA)
- Microbiology (AREA)
- Epidemiology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Birds (AREA)
- Cell Biology (AREA)
- Cosmetics (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Eye Examination Apparatus (AREA)
- Diaphragms For Electromechanical Transducers (AREA)
- Crystals, And After-Treatments Of Crystals (AREA)
- Prostheses (AREA)
- Indexing, Searching, Synchronizing, And The Amount Of Synchronization Travel Of Record Carriers (AREA)
- Toys (AREA)
- Magnetic Resonance Imaging Apparatus (AREA)
- Farming Of Fish And Shellfish (AREA)
- Massaging Devices (AREA)
- Measurement And Recording Of Electrical Phenomena And Electrical Characteristics Of The Living Body (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| NL1005445 | 1997-03-05 | ||
| NL1005445A NL1005445C2 (nl) | 1997-03-05 | 1997-03-05 | Werkwijze voor het vermenigvuldigen van haar. |
| PCT/NL1998/000129 WO1998047471A1 (en) | 1997-03-05 | 1998-03-05 | Method for the propagation of hair |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2283172A1 true CA2283172A1 (en) | 1998-10-29 |
Family
ID=19764538
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002283172A Abandoned CA2283172A1 (en) | 1997-03-05 | 1998-03-05 | Method for the propagation of hair |
Country Status (22)
| Country | Link |
|---|---|
| US (1) | US6399057B1 (OSRAM) |
| EP (1) | EP0971679B1 (OSRAM) |
| JP (1) | JP2001526560A (OSRAM) |
| CN (1) | CN1254277A (OSRAM) |
| AT (1) | ATE219654T1 (OSRAM) |
| AU (1) | AU732729B2 (OSRAM) |
| BR (1) | BR9808190A (OSRAM) |
| CA (1) | CA2283172A1 (OSRAM) |
| CZ (1) | CZ298118B6 (OSRAM) |
| DE (1) | DE69806232T2 (OSRAM) |
| DK (1) | DK0971679T3 (OSRAM) |
| EA (1) | EA199900799A1 (OSRAM) |
| ES (1) | ES2176977T3 (OSRAM) |
| ID (1) | ID22700A (OSRAM) |
| IL (1) | IL131740A (OSRAM) |
| NL (1) | NL1005445C2 (OSRAM) |
| NO (1) | NO312805B1 (OSRAM) |
| NZ (1) | NZ337640A (OSRAM) |
| PL (1) | PL335723A1 (OSRAM) |
| PT (1) | PT971679E (OSRAM) |
| TR (1) | TR199902184T2 (OSRAM) |
| WO (1) | WO1998047471A1 (OSRAM) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU1472501A (en) * | 1999-11-05 | 2001-05-14 | Gerigene Medical Corporation | Augmentation and repair of age-related soft tissue defects |
| KR20020005331A (ko) * | 2000-07-10 | 2002-01-17 | 정상훈 | 모낭 세포의 배양 방법 및 모발 이식용 키트 |
| KR20030043928A (ko) | 2000-08-08 | 2003-06-02 | 바이오아미드 인코포레이티드 | 조직 조작된 모발용 지지체 |
| KR100371274B1 (ko) * | 2000-08-09 | 2003-02-06 | 정상훈 | 모발 이식용 키트 |
| US20030161815A1 (en) * | 2002-02-12 | 2003-08-28 | Intercytex Limited | Cell delivery system |
| CA2505409C (en) * | 2002-11-14 | 2017-04-04 | Intercytex Limited | Cultivation of hair inductive cells |
| US7597885B2 (en) | 2004-03-26 | 2009-10-06 | Aderans Research Institute, Inc. | Tissue engineered biomimetic hair follicle graft |
| WO2006031313A2 (en) * | 2004-08-05 | 2006-03-23 | The Board Of Trustees Of The Leland Stanford Junior University | Methods and compositions for cell activation |
| US20060073117A1 (en) * | 2004-10-01 | 2006-04-06 | Stowers Institute For Medical Research | Methods and compositions for controlling hair follicle stem cell fate |
| KR100616752B1 (ko) * | 2004-11-29 | 2006-08-31 | 박정극 | 모낭 유도 능력이 있는 모유두 조직의 제조방법 |
| NL1030484C1 (nl) | 2005-11-22 | 2007-05-23 | Hair Science Inst | Werkwijze voor in vivo haarvermenigvuldiging. |
| TW200800240A (en) | 2005-11-22 | 2008-01-01 | Aderans Res Inst Inc | Hair follicle graft from tissue engineered skin |
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| EP2007877B1 (en) | 2006-02-28 | 2013-04-17 | The Trustees of Columbia University in the City of New York | Methods for compact aggregation of dermal cells |
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| EP1964519B1 (en) | 2007-03-01 | 2009-09-02 | Sony Corporation | Method for extracting a biosubstance from hair and hair sampling device useful in the method |
| US20110086007A1 (en) * | 2007-09-21 | 2011-04-14 | Aderans Research Institute, Inc. | Epidermal stimulation to enhance hair follicle formation |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| GB8604360D0 (en) * | 1986-02-21 | 1986-03-26 | Univ Dundee | Stimulation of hair growth |
| US5635387A (en) * | 1990-04-23 | 1997-06-03 | Cellpro, Inc. | Methods and device for culturing human hematopoietic cells and their precursors |
| WO1992000376A1 (en) * | 1990-06-25 | 1992-01-09 | Immunex Corporation | Mast cell growth factor |
| US5130142A (en) * | 1990-10-31 | 1992-07-14 | The Practer & Gamble Company | Hair growth regulating composition comprising epithelium cell supernatant-derived growth factor |
| US5556783A (en) * | 1991-03-27 | 1996-09-17 | Trustees Of Univ. Of Penna | Methods of culturing and modulating the growth of hair follicular stem cells |
| FR2707876B1 (fr) * | 1993-07-23 | 1995-09-08 | Oreal | Compositions cosmétiques pour le maintien de la coiffure présentant un pouvoir fixant amélioré. |
| TW382595B (en) * | 1993-10-15 | 2000-02-21 | Merck & Co Inc | Pharmaceutical composition for use in arresting and reversing androgenic alopecia |
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| EP0821592A4 (en) * | 1995-04-20 | 2000-03-01 | Univ Pennsylvania | COMPOSITIONS AND METHODS FOR REGULATING HAIR GROWTH |
| US6162211A (en) * | 1996-12-05 | 2000-12-19 | Thermolase Corporation | Skin enhancement using laser light |
-
1997
- 1997-03-05 NL NL1005445A patent/NL1005445C2/nl not_active IP Right Cessation
-
1998
- 1998-03-05 AU AU66388/98A patent/AU732729B2/en not_active Ceased
- 1998-03-05 AT AT98908329T patent/ATE219654T1/de not_active IP Right Cessation
- 1998-03-05 PL PL98335723A patent/PL335723A1/xx not_active Application Discontinuation
- 1998-03-05 CA CA002283172A patent/CA2283172A1/en not_active Abandoned
- 1998-03-05 EA EA199900799A patent/EA199900799A1/ru unknown
- 1998-03-05 NZ NZ337640A patent/NZ337640A/en unknown
- 1998-03-05 ES ES98908329T patent/ES2176977T3/es not_active Expired - Lifetime
- 1998-03-05 CN CN98804712A patent/CN1254277A/zh active Pending
- 1998-03-05 US US09/380,580 patent/US6399057B1/en not_active Expired - Lifetime
- 1998-03-05 IL IL13174098A patent/IL131740A/xx not_active IP Right Cessation
- 1998-03-05 PT PT98908329T patent/PT971679E/pt unknown
- 1998-03-05 ID IDW990962A patent/ID22700A/id unknown
- 1998-03-05 BR BR9808190-0A patent/BR9808190A/pt not_active IP Right Cessation
- 1998-03-05 WO PCT/NL1998/000129 patent/WO1998047471A1/en not_active Ceased
- 1998-03-05 DK DK98908329T patent/DK0971679T3/da active
- 1998-03-05 CZ CZ0313499A patent/CZ298118B6/cs not_active IP Right Cessation
- 1998-03-05 DE DE69806232T patent/DE69806232T2/de not_active Expired - Fee Related
- 1998-03-05 JP JP53894298A patent/JP2001526560A/ja not_active Ceased
- 1998-03-05 TR TR1999/02184T patent/TR199902184T2/xx unknown
- 1998-03-05 EP EP98908329A patent/EP0971679B1/en not_active Expired - Lifetime
-
1999
- 1999-09-06 NO NO19994311A patent/NO312805B1/no unknown
Also Published As
| Publication number | Publication date |
|---|---|
| JP2001526560A (ja) | 2001-12-18 |
| AU6638898A (en) | 1998-11-13 |
| DE69806232D1 (de) | 2002-08-01 |
| EP0971679A1 (en) | 2000-01-19 |
| ATE219654T1 (de) | 2002-07-15 |
| US6399057B1 (en) | 2002-06-04 |
| NO994311L (no) | 1999-11-03 |
| CZ313499A3 (cs) | 2000-02-16 |
| DK0971679T3 (da) | 2002-07-22 |
| PT971679E (pt) | 2002-11-29 |
| AU732729B2 (en) | 2001-04-26 |
| IL131740A0 (en) | 2001-03-19 |
| EA199900799A1 (ru) | 2000-02-28 |
| IL131740A (en) | 2003-12-10 |
| CN1254277A (zh) | 2000-05-24 |
| EP0971679B1 (en) | 2002-06-26 |
| HK1025052A1 (en) | 2000-11-03 |
| NZ337640A (en) | 2001-02-23 |
| PL335723A1 (en) | 2000-05-08 |
| BR9808190A (pt) | 2000-05-16 |
| DE69806232T2 (de) | 2003-02-06 |
| ID22700A (id) | 1999-12-09 |
| NO312805B1 (no) | 2002-07-08 |
| ES2176977T3 (es) | 2002-12-01 |
| CZ298118B6 (cs) | 2007-06-27 |
| NL1005445C2 (nl) | 1998-09-21 |
| NO994311D0 (no) | 1999-09-06 |
| WO1998047471A1 (en) | 1998-10-29 |
| TR199902184T2 (xx) | 1999-12-21 |
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