CZ297136B6 - Bicyklické heteroaromatické slouceniny - Google Patents

Bicyklické heteroaromatické slouceniny Download PDF

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Publication number
CZ297136B6
CZ297136B6 CZ20030828A CZ2003828A CZ297136B6 CZ 297136 B6 CZ297136 B6 CZ 297136B6 CZ 20030828 A CZ20030828 A CZ 20030828A CZ 2003828 A CZ2003828 A CZ 2003828A CZ 297136 B6 CZ297136 B6 CZ 297136B6
Authority
CZ
Czechia
Prior art keywords
amino
pyrimidine
methylthio
tert
butyl
Prior art date
Application number
CZ20030828A
Other languages
Czech (cs)
English (en)
Other versions
CZ2003828A3 (cs
Inventor
Marius Timmers@Cornelis
Frederik Johan Karstens@Willem
Original Assignee
Akzo Nobel N. V.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Akzo Nobel N. V. filed Critical Akzo Nobel N. V.
Publication of CZ2003828A3 publication Critical patent/CZ2003828A3/cs
Publication of CZ297136B6 publication Critical patent/CZ297136B6/cs

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/06—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/78—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Endocrinology (AREA)
  • Diabetes (AREA)
  • Reproductive Health (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pregnancy & Childbirth (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
CZ20030828A 2000-09-22 2001-09-17 Bicyklické heteroaromatické slouceniny CZ297136B6 (cs)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP00203287 2000-09-22

Publications (2)

Publication Number Publication Date
CZ2003828A3 CZ2003828A3 (cs) 2003-08-13
CZ297136B6 true CZ297136B6 (cs) 2006-09-13

Family

ID=8172046

Family Applications (1)

Application Number Title Priority Date Filing Date
CZ20030828A CZ297136B6 (cs) 2000-09-22 2001-09-17 Bicyklické heteroaromatické slouceniny

Country Status (32)

Country Link
US (2) US7229990B2 (fr)
EP (2) EP1886999A3 (fr)
JP (1) JP4977940B2 (fr)
KR (1) KR100860040B1 (fr)
CN (1) CN1247594C (fr)
AR (1) AR030784A1 (fr)
AT (1) ATE384726T1 (fr)
AU (2) AU1392902A (fr)
BR (1) BR0113987A (fr)
CA (1) CA2422054C (fr)
CY (1) CY1107308T1 (fr)
CZ (1) CZ297136B6 (fr)
DE (1) DE60132607T2 (fr)
DK (1) DK1322651T3 (fr)
EC (1) ECSP034523A (fr)
ES (1) ES2299524T3 (fr)
HK (1) HK1054942A1 (fr)
HR (1) HRP20030220B1 (fr)
HU (1) HU229422B1 (fr)
IL (2) IL154624A0 (fr)
IS (1) IS2531B (fr)
MX (1) MXPA03002478A (fr)
NO (1) NO328683B1 (fr)
NZ (1) NZ524444A (fr)
PE (1) PE20020537A1 (fr)
PL (1) PL207755B1 (fr)
PT (1) PT1322651E (fr)
RU (1) RU2271360C2 (fr)
SK (1) SK287554B6 (fr)
TW (1) TWI290143B (fr)
WO (1) WO2002024703A1 (fr)
ZA (1) ZA200301588B (fr)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT1322651E (pt) * 2000-09-22 2008-02-28 Organon Nv Compostos heteroaromáticos bicíclicos
TW200407127A (en) 2002-08-21 2004-05-16 Astrazeneca Ab Chemical compounds
US7674822B2 (en) 2004-11-24 2010-03-09 Wyeth PTP1b inhibitors
US7737155B2 (en) * 2005-05-17 2010-06-15 Schering Corporation Nitrogen-containing heterocyclic compounds and methods of use thereof
US7723342B2 (en) * 2005-05-17 2010-05-25 Schering Corporation Heterocycles as nicotinic acid receptor agonists for the treatment of dyslipidemia
JP2009537551A (ja) * 2006-05-17 2009-10-29 アメリカ合衆国 ホルモン受容体を調節するためのピリミジン低分子量リガンド
WO2009132980A1 (fr) 2008-04-29 2009-11-05 F. Hoffmann-La Roche Ag Pyrimidinyle pyridones inhibiteurs de jnk
CA2741030A1 (fr) 2008-10-20 2010-04-29 Marvin C. Gershengorn Agonistes de faible poids moleculaire du recepteur de l'hormone stimulatrice de la thyroide (tshr)
EP2563777A4 (fr) 2010-04-08 2013-09-04 Us Health Agonistes inverses et antagonistes neutres pour récepteur du tsh
HUE065564T2 (hu) 2011-08-23 2024-06-28 Libertas Bio Inc Pirimido-piridazinon vegyületek és alkalmazásuk
CN113680386B (zh) * 2021-08-23 2023-08-11 深圳湾实验室坪山生物医药研发转化中心 氮杂环卡宾-方酰胺双功能催化剂及其制备方法

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995034563A1 (fr) * 1994-06-16 1995-12-21 Pfizer Inc. Pyrazolo et pyrrolopyridines
WO2000061586A1 (fr) * 1999-04-08 2000-10-19 Akzo Nobel N.V. Composes heteroaromatiques bicycliques utiles en tant qu'agonistes de l'hormone luteinisante (lh)

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU712019B2 (en) * 1996-05-20 1999-10-28 Merck & Co., Inc. Antagonists of gonadotropin releasing hormone
PT1322651E (pt) * 2000-09-22 2008-02-28 Organon Nv Compostos heteroaromáticos bicíclicos

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995034563A1 (fr) * 1994-06-16 1995-12-21 Pfizer Inc. Pyrazolo et pyrrolopyridines
WO2000061586A1 (fr) * 1999-04-08 2000-10-19 Akzo Nobel N.V. Composes heteroaromatiques bicycliques utiles en tant qu'agonistes de l'hormone luteinisante (lh)

Also Published As

Publication number Publication date
JP4977940B2 (ja) 2012-07-18
CY1107308T1 (el) 2012-11-21
KR20030040483A (ko) 2003-05-22
US7229990B2 (en) 2007-06-12
CA2422054C (fr) 2011-01-11
DK1322651T3 (da) 2008-06-02
IS6732A (is) 2003-02-28
US20030225113A1 (en) 2003-12-04
HK1054942A1 (en) 2003-12-19
EP1886999A3 (fr) 2008-03-12
DE60132607T2 (de) 2009-01-29
TWI290143B (en) 2007-11-21
AU2002213929B2 (en) 2006-04-13
CN1247594C (zh) 2006-03-29
CZ2003828A3 (cs) 2003-08-13
ZA200301588B (en) 2004-06-22
AU1392902A (en) 2002-04-02
ECSP034523A (es) 2003-04-25
IL154624A0 (en) 2003-09-17
HRP20030220A2 (en) 2003-06-30
BR0113987A (pt) 2003-08-12
EP1886999A8 (fr) 2010-08-04
NO328683B1 (no) 2010-04-26
US7618963B2 (en) 2009-11-17
NO20031314L (no) 2003-03-21
PT1322651E (pt) 2008-02-28
EP1886999A2 (fr) 2008-02-13
DE60132607D1 (de) 2008-03-13
IL154624A (en) 2009-09-01
KR100860040B1 (ko) 2008-09-25
ATE384726T1 (de) 2008-02-15
ES2299524T3 (es) 2008-06-01
IS2531B (is) 2009-07-15
SK3312003A3 (en) 2003-08-05
NZ524444A (en) 2004-03-26
PE20020537A1 (es) 2002-06-20
HU229422B1 (hu) 2013-12-30
PL207755B1 (pl) 2011-01-31
HUP0302648A3 (en) 2004-11-29
HUP0302648A2 (hu) 2003-11-28
EP1322651B1 (fr) 2008-01-23
US20070197527A1 (en) 2007-08-23
JP2004509896A (ja) 2004-04-02
NO20031314D0 (no) 2003-03-21
CA2422054A1 (fr) 2002-03-28
WO2002024703A1 (fr) 2002-03-28
PL360675A1 (en) 2004-09-20
CN1462273A (zh) 2003-12-17
RU2271360C2 (ru) 2006-03-10
HRP20030220B1 (en) 2011-10-31
MXPA03002478A (es) 2004-05-05
SK287554B6 (sk) 2011-01-04
EP1322651A1 (fr) 2003-07-02
AR030784A1 (es) 2003-09-03

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Legal Events

Date Code Title Description
MM4A Patent lapsed due to non-payment of fee

Effective date: 20150917