CZ294587B6 - Pyrazolo[4,3-D]pyrimidin, způsob jeho přípravy, jeho použití a farmaceutický prostředek, který ho obsahuje - Google Patents

Pyrazolo[4,3-D]pyrimidin, způsob jeho přípravy, jeho použití a farmaceutický prostředek, který ho obsahuje Download PDF

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Publication number
CZ294587B6
CZ294587B6 CZ2002736A CZ2002736A CZ294587B6 CZ 294587 B6 CZ294587 B6 CZ 294587B6 CZ 2002736 A CZ2002736 A CZ 2002736A CZ 2002736 A CZ2002736 A CZ 2002736A CZ 294587 B6 CZ294587 B6 CZ 294587B6
Authority
CZ
Czechia
Prior art keywords
pyrazolo
methyl
propyl
pyrimidin
formula
Prior art date
Application number
CZ2002736A
Other languages
Czech (cs)
English (en)
Other versions
CZ2002736A3 (cs
Inventor
Rochus Jonas
Hans-Michael Eggenweiler
Pierre Schelling
Maria Christadler
Norbert Beier
Original Assignee
Merck Patent Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Patent Gmbh filed Critical Merck Patent Gmbh
Publication of CZ2002736A3 publication Critical patent/CZ2002736A3/cs
Publication of CZ294587B6 publication Critical patent/CZ294587B6/cs

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Gynecology & Obstetrics (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
CZ2002736A 1999-09-06 2000-08-24 Pyrazolo[4,3-D]pyrimidin, způsob jeho přípravy, jeho použití a farmaceutický prostředek, který ho obsahuje CZ294587B6 (cs)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19942474A DE19942474A1 (de) 1999-09-06 1999-09-06 Pyrazolo[4,3-d]pyrimidine

Publications (2)

Publication Number Publication Date
CZ2002736A3 CZ2002736A3 (cs) 2002-05-15
CZ294587B6 true CZ294587B6 (cs) 2005-02-16

Family

ID=7920966

Family Applications (1)

Application Number Title Priority Date Filing Date
CZ2002736A CZ294587B6 (cs) 1999-09-06 2000-08-24 Pyrazolo[4,3-D]pyrimidin, způsob jeho přípravy, jeho použití a farmaceutický prostředek, který ho obsahuje

Country Status (23)

Country Link
US (1) US6777419B1 (enExample)
EP (1) EP1210349B1 (enExample)
JP (1) JP4975921B2 (enExample)
KR (1) KR20020025253A (enExample)
CN (1) CN1145627C (enExample)
AR (1) AR025569A1 (enExample)
AT (1) ATE231866T1 (enExample)
AU (1) AU773878B2 (enExample)
BR (1) BR0013781A (enExample)
CA (1) CA2384037C (enExample)
CZ (1) CZ294587B6 (enExample)
DE (2) DE19942474A1 (enExample)
DK (1) DK1210349T3 (enExample)
ES (1) ES2189766T3 (enExample)
HU (1) HUP0202624A3 (enExample)
MX (1) MXPA02002383A (enExample)
NO (1) NO20021083D0 (enExample)
PL (1) PL353366A1 (enExample)
PT (1) PT1210349E (enExample)
RU (1) RU2249594C2 (enExample)
SK (1) SK3132002A3 (enExample)
WO (1) WO2001018004A2 (enExample)
ZA (1) ZA200202653B (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CZ308056B6 (cs) * 2015-07-20 2019-11-27 Ustav Experimentalni Botaniky Av Cr V V I 5-Substituované-7-[4-(substituované)benzyl]amino-3-isopropylpyrazolo[4,3-d]pyrimidiny, jejich použití jako antirevmatika, a farmaceutické přípravky

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10031584A1 (de) 2000-06-29 2002-01-10 Merck Patent Gmbh 5-Aminoalkyl-pyrazolo[4,3-d]pyrimidine
DE10058662A1 (de) * 2000-11-25 2002-05-29 Merck Patent Gmbh Verwendung von Pyrazolo[4,3-d]pyrimidinen
PL362513A1 (en) * 2000-12-19 2004-11-02 Merck Patent Gmbh Pharmaceutical formulation containing pyrazolo[4,3-d]pyrimidines and antithrombotic agents, calcium-antagonists, prostaglandins or prostaglandin derivatives
DE10103647A1 (de) * 2001-01-27 2002-08-01 Merck Patent Gmbh Verfahren zur Herstellung eines Pyrazolo (4,3-d) pyrimidinderivates
DE10148883A1 (de) * 2001-10-04 2003-04-10 Merck Patent Gmbh Pyrimidinderivate
EP1620437B1 (en) 2003-04-29 2009-06-17 Pfizer Limited 5,7-diaminopyrazolo¬4,3-d pyrimidines useful in the traetment of hypertension
US7572799B2 (en) * 2003-11-24 2009-08-11 Pfizer Inc Pyrazolo[4,3-d]pyrimidines as Phosphodiesterase Inhibitors
GB0327323D0 (en) * 2003-11-24 2003-12-31 Pfizer Ltd Novel pharmaceuticals
ATE417849T1 (de) * 2004-04-07 2009-01-15 Pfizer Pyrazoloä4,3-düpyrimidine
EP1881985B1 (en) 2005-05-12 2010-12-29 Pfizer, Inc. Anhydrous crystalline forms of n-ý1-(2-ethoxyethyl)-5-(n-ethyl-n-methylamino)-7-(4-methylpyridin-2-yl-amino)-1h-pyrazolo[4,3-d]pyrimidine-3-carbonyl¨methanesulfonamide
NL2000291C2 (nl) 2005-11-10 2009-02-17 Pfizer Prod Inc 1-(1-(2-ethoxyethyl)-3-ethyl-7-(4-methylpyridin-2-ylamino)-1H- pyrazool(4,3-d)pyrimidine-5-yl)piperidine-4-carbonzuur en zouten daarvan.
CA2831634C (en) * 2011-04-21 2019-11-12 Origenis Gmbh Pyrazolo [4,3-d] pyrimidines useful as kinase inhibitors
US10034861B2 (en) 2016-07-04 2018-07-31 H. Lundbeck A/S 1H-pyrazolo[4,3-b]pyridines as PDE1 inhibitors
AR113926A1 (es) 2017-12-14 2020-07-01 H Lundbeck As Derivados de 1h-pirazolo[4,3-b]piridinas
RU2020118913A (ru) 2017-12-14 2022-01-14 Х. Лундбекк А/С (H. Lundbeck A/S) Виды комбинированного лечения, предусматривающего введение 1h-пиразолo[4,3-b]пиридинов
US11535611B2 (en) 2017-12-20 2022-12-27 H. Lundbeck A/S Pyrazolo[3,4-B]pyridines and imidazo[1,5-B]pyridazines as PDE1 inhibitors
US10766893B2 (en) * 2017-12-20 2020-09-08 H. Lundbeck A/S 1H-pyrazolo[4,3-b]pyridines as PDE1 inhibitors

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5256650A (en) * 1989-03-29 1993-10-26 Merrell Dow Pharmaceuticals Inc. Selective adenosine receptor agents
GB9114760D0 (en) * 1991-07-09 1991-08-28 Pfizer Ltd Therapeutic agents
DE19644228A1 (de) * 1996-10-24 1998-04-30 Merck Patent Gmbh Thienopyrimidine
AU730670B2 (en) * 1997-04-25 2001-03-08 Pfizer Limited Pyrazolopyrimidinones which inhibit type 5 cyclic guanosine 3',5'-monophosphate phosphodiesterase (cGMP PDE5) for the treatment of sexual dysfunction
DE19752952A1 (de) * 1997-11-28 1999-06-02 Merck Patent Gmbh Thienopyrimidine
DE10031584A1 (de) * 2000-06-29 2002-01-10 Merck Patent Gmbh 5-Aminoalkyl-pyrazolo[4,3-d]pyrimidine
DE10058662A1 (de) * 2000-11-25 2002-05-29 Merck Patent Gmbh Verwendung von Pyrazolo[4,3-d]pyrimidinen
DE10060388A1 (de) * 2000-12-05 2002-06-06 Merck Patent Gmbh Verwendung von Pyrazolo [4,3-d]pyrimidinen
DE10103647A1 (de) * 2001-01-27 2002-08-01 Merck Patent Gmbh Verfahren zur Herstellung eines Pyrazolo (4,3-d) pyrimidinderivates

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CZ308056B6 (cs) * 2015-07-20 2019-11-27 Ustav Experimentalni Botaniky Av Cr V V I 5-Substituované-7-[4-(substituované)benzyl]amino-3-isopropylpyrazolo[4,3-d]pyrimidiny, jejich použití jako antirevmatika, a farmaceutické přípravky

Also Published As

Publication number Publication date
CN1377357A (zh) 2002-10-30
RU2249594C2 (ru) 2005-04-10
DE50001191D1 (de) 2003-03-06
AR025569A1 (es) 2002-12-04
BR0013781A (pt) 2002-05-14
DE19942474A1 (de) 2001-03-15
PT1210349E (pt) 2003-06-30
PL353366A1 (en) 2003-11-17
HUP0202624A3 (en) 2004-11-29
JP2003508534A (ja) 2003-03-04
HUP0202624A2 (hu) 2002-12-28
ZA200202653B (en) 2003-09-23
DK1210349T3 (da) 2003-05-19
EP1210349B1 (de) 2003-01-29
CA2384037C (en) 2009-10-13
CN1145627C (zh) 2004-04-14
MXPA02002383A (es) 2002-09-02
KR20020025253A (ko) 2002-04-03
AU7279300A (en) 2001-04-10
WO2001018004A2 (de) 2001-03-15
EP1210349A2 (de) 2002-06-05
CA2384037A1 (en) 2001-03-15
ATE231866T1 (de) 2003-02-15
NO20021083L (no) 2002-03-05
WO2001018004A3 (de) 2001-08-09
AU773878B2 (en) 2004-06-10
NO20021083D0 (no) 2002-03-05
CZ2002736A3 (cs) 2002-05-15
JP4975921B2 (ja) 2012-07-11
ES2189766T3 (es) 2003-07-16
US6777419B1 (en) 2004-08-17
SK3132002A3 (en) 2002-07-02

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Legal Events

Date Code Title Description
MM4A Patent lapsed due to non-payment of fee

Effective date: 20050824