CZ290383B6 - Racemické a opticky aktivní estery trans-apovinkaminové kyseliny jako léčiva - Google Patents

Racemické a opticky aktivní estery trans-apovinkaminové kyseliny jako léčiva Download PDF

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Publication number
CZ290383B6
CZ290383B6 CZ19981962A CZ196298A CZ290383B6 CZ 290383 B6 CZ290383 B6 CZ 290383B6 CZ 19981962 A CZ19981962 A CZ 19981962A CZ 196298 A CZ196298 A CZ 196298A CZ 290383 B6 CZ290383 B6 CZ 290383B6
Authority
CZ
Czechia
Prior art keywords
trans
formula
racemic
group
acid
Prior art date
Application number
CZ19981962A
Other languages
Czech (cs)
English (en)
Other versions
CZ196298A3 (cs
Inventor
Csaba Szántay
István Moldvai
András Vedres
Mária Incze
János Kreidl
László Czibula
Jenöné Mária Farkas
Juhász Ida Deutschné
Anikó Gere
Paróczai Margit Pellioniszné
Erzsébet Lapis
András Szekeres
Balázs Mária Zájerné
Ádám Sarkadi
Ferenc Auth
Béla Kiss
Egon Kárpáti
Sándor Farkas
Original Assignee
Richter Gedeon Vegyészeti Gyár Rt.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Richter Gedeon Vegyészeti Gyár Rt. filed Critical Richter Gedeon Vegyészeti Gyár Rt.
Publication of CZ196298A3 publication Critical patent/CZ196298A3/cs
Publication of CZ290383B6 publication Critical patent/CZ290383B6/cs

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D461/00—Heterocyclic compounds containing indolo [3,2,1-d,e] pyrido [3,2,1,j] [1,5]-naphthyridine ring systems, e.g. vincamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Hospice & Palliative Care (AREA)
  • Diabetes (AREA)
  • Vascular Medicine (AREA)
  • Psychiatry (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
CZ19981962A 1995-12-22 1996-12-13 Racemické a opticky aktivní estery trans-apovinkaminové kyseliny jako léčiva CZ290383B6 (cs)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
HU9503736A HU214600B (hu) 1995-12-22 1995-12-22 Transz-apovinkaminsav-észter-származékok, az azokat tartalmazó gyógyszerkészítmények és eljárás ezek előállítására

Publications (2)

Publication Number Publication Date
CZ196298A3 CZ196298A3 (cs) 1998-10-14
CZ290383B6 true CZ290383B6 (cs) 2002-07-17

Family

ID=10987512

Family Applications (1)

Application Number Title Priority Date Filing Date
CZ19981962A CZ290383B6 (cs) 1995-12-22 1996-12-13 Racemické a opticky aktivní estery trans-apovinkaminové kyseliny jako léčiva

Country Status (22)

Country Link
US (1) US6093720A (pt)
EP (1) EP0876367B1 (pt)
JP (1) JP2000502676A (pt)
KR (1) KR19990076606A (pt)
CN (1) CN1072670C (pt)
AR (1) AR005182A1 (pt)
AT (1) ATE223914T1 (pt)
AU (1) AU1166997A (pt)
CA (1) CA2238635A1 (pt)
CZ (1) CZ290383B6 (pt)
DE (1) DE69623656T2 (pt)
DK (1) DK0876367T3 (pt)
ES (1) ES2181926T3 (pt)
HU (1) HU214600B (pt)
IL (1) IL124097A (pt)
PL (1) PL186626B1 (pt)
PT (1) PT876367E (pt)
RU (1) RU2161157C2 (pt)
TW (1) TW366348B (pt)
UA (1) UA61062C2 (pt)
WO (1) WO1997023481A1 (pt)
ZA (1) ZA9610646B (pt)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006054536A1 (ja) * 2004-11-16 2006-05-26 Nippon Shinyaku Co., Ltd. 尿路結石症治療剤
JP2008017734A (ja) * 2006-07-11 2008-01-31 Memory Secret Inc 精神的機能を改善するための栄養補助及び栄養摂取食品用の口経投与組成物
CN102485723A (zh) * 2010-12-02 2012-06-06 江苏斯威森生物医药工程研究中心有限公司 一锅法半合成长春西汀及其水溶性盐制备
CN114920743B (zh) * 2022-05-09 2023-08-04 南京中医药大学 一种吲哚生物碱及其制备方法与应用

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2531108A1 (de) * 1975-07-11 1977-02-03 Synthelabo Vincaminderivate, verfahren zu ihrer herstellung und sie enthaltende arzneimittel
HU186891B (en) * 1981-06-12 1985-10-28 Richter Gedeon Vegyeszet Process for producing esters of apovincaminic acid
IT1142026B (it) * 1981-07-21 1986-10-08 Ausonia Farma Srl Nuovo composto ad attivita' eumetabolica cerebrale
HU187733B (en) * 1982-06-30 1986-02-28 Richter Gedeon Vegyeszeti Gyar Rt,Hu Process for preparing apovincaminic acid derivatives
JPS60248688A (ja) * 1984-05-24 1985-12-09 Sanwa Kagaku Kenkyusho:Kk 新規のアポビンカミン酸エステルおよびその酸付加塩並びにその製造方法

Also Published As

Publication number Publication date
US6093720A (en) 2000-07-25
HUT76555A (en) 1997-09-29
CZ196298A3 (cs) 1998-10-14
DK0876367T3 (da) 2002-12-30
DE69623656T2 (de) 2003-05-22
PT876367E (pt) 2003-01-31
CA2238635A1 (en) 1997-07-03
ATE223914T1 (de) 2002-09-15
TW366348B (en) 1999-08-11
UA61062C2 (en) 2003-11-17
IL124097A (en) 2001-12-23
DE69623656D1 (en) 2002-10-17
PL328170A1 (en) 1999-01-18
ZA9610646B (en) 1997-06-24
PL186626B1 (pl) 2004-02-27
HU214600B (hu) 1998-04-28
ES2181926T3 (es) 2003-03-01
EP0876367A1 (en) 1998-11-11
WO1997023481A1 (en) 1997-07-03
EP0876367B1 (en) 2002-09-11
CN1072670C (zh) 2001-10-10
HU9503736D0 (en) 1996-02-28
KR19990076606A (ko) 1999-10-15
JP2000502676A (ja) 2000-03-07
CN1205701A (zh) 1999-01-20
RU2161157C2 (ru) 2000-12-27
AU1166997A (en) 1997-07-17
AR005182A1 (es) 1999-04-14

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Legal Events

Date Code Title Description
PD00 Pending as of 2000-06-30 in czech republic
MM4A Patent lapsed due to non-payment of fee

Effective date: 20041213