AR005182A1 - Derivados de esteres del acido trans-apovincaminico, composicion que los contiene y procesos para preparar dichos derivados y composicion. - Google Patents

Derivados de esteres del acido trans-apovincaminico, composicion que los contiene y procesos para preparar dichos derivados y composicion.

Info

Publication number
AR005182A1
AR005182A1 ARP960105829A ARP960105829A AR005182A1 AR 005182 A1 AR005182 A1 AR 005182A1 AR P960105829 A ARP960105829 A AR P960105829A AR P960105829 A ARP960105829 A AR P960105829A AR 005182 A1 AR005182 A1 AR 005182A1
Authority
AR
Argentina
Prior art keywords
derivatives
composition
esters
acid
compounds
Prior art date
Application number
ARP960105829A
Other languages
English (en)
Original Assignee
Richter Gedeon Vegyeszet
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Richter Gedeon Vegyeszet filed Critical Richter Gedeon Vegyeszet
Publication of AR005182A1 publication Critical patent/AR005182A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D461/00—Heterocyclic compounds containing indolo [3,2,1-d,e] pyrido [3,2,1,j] [1,5]-naphthyridine ring systems, e.g. vincamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Abstract

Derivados de esteres del acido trans apovincaminico racemico y opcionalmente activo con la formula (I), donde: R es un hidrogeno o un grupoZ---C = O, donde Z es un alquilo de C1-4, sustituido optativamente por un grupo arilo,aralq uilo, heteroarilo o 14-eburnameninil; y n es un numero enteroque puede ser 2, 3 o 4; asi como una sal aceptable terapeuticamente del mismo, composiciones farmaceuticas que contienen estos compuestos, con un proceso parapreparar los compuestosy las composiciones mencionados. Los nuevos compuestos de formula (I) muestran efectos particularmente antioxidantes, antiisquemicosy son utiles para inhibir la peroxidacion lipidica y para proteger contra o tratar una isquemia o amnesia, asicomo par a tratar enfermedadesneurodegenerativas como por ejemplo el mal de Alzheimer.
ARP960105829A 1995-12-22 1996-12-20 Derivados de esteres del acido trans-apovincaminico, composicion que los contiene y procesos para preparar dichos derivados y composicion. AR005182A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
HU9503736A HU214600B (hu) 1995-12-22 1995-12-22 Transz-apovinkaminsav-észter-származékok, az azokat tartalmazó gyógyszerkészítmények és eljárás ezek előállítására

Publications (1)

Publication Number Publication Date
AR005182A1 true AR005182A1 (es) 1999-04-14

Family

ID=10987512

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP960105829A AR005182A1 (es) 1995-12-22 1996-12-20 Derivados de esteres del acido trans-apovincaminico, composicion que los contiene y procesos para preparar dichos derivados y composicion.

Country Status (22)

Country Link
US (1) US6093720A (es)
EP (1) EP0876367B1 (es)
JP (1) JP2000502676A (es)
KR (1) KR19990076606A (es)
CN (1) CN1072670C (es)
AR (1) AR005182A1 (es)
AT (1) ATE223914T1 (es)
AU (1) AU1166997A (es)
CA (1) CA2238635A1 (es)
CZ (1) CZ290383B6 (es)
DE (1) DE69623656T2 (es)
DK (1) DK0876367T3 (es)
ES (1) ES2181926T3 (es)
HU (1) HU214600B (es)
IL (1) IL124097A (es)
PL (1) PL186626B1 (es)
PT (1) PT876367E (es)
RU (1) RU2161157C2 (es)
TW (1) TW366348B (es)
UA (1) UA61062C2 (es)
WO (1) WO1997023481A1 (es)
ZA (1) ZA9610646B (es)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006054536A1 (ja) * 2004-11-16 2006-05-26 Nippon Shinyaku Co., Ltd. 尿路結石症治療剤
JP2008017734A (ja) * 2006-07-11 2008-01-31 Memory Secret Inc 精神的機能を改善するための栄養補助及び栄養摂取食品用の口経投与組成物
CN102485723A (zh) * 2010-12-02 2012-06-06 江苏斯威森生物医药工程研究中心有限公司 一锅法半合成长春西汀及其水溶性盐制备
CN114920743B (zh) * 2022-05-09 2023-08-04 南京中医药大学 一种吲哚生物碱及其制备方法与应用

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2531108A1 (de) * 1975-07-11 1977-02-03 Synthelabo Vincaminderivate, verfahren zu ihrer herstellung und sie enthaltende arzneimittel
HU186891B (en) * 1981-06-12 1985-10-28 Richter Gedeon Vegyeszet Process for producing esters of apovincaminic acid
IT1142026B (it) * 1981-07-21 1986-10-08 Ausonia Farma Srl Nuovo composto ad attivita' eumetabolica cerebrale
HU187733B (en) * 1982-06-30 1986-02-28 Richter Gedeon Vegyeszeti Gyar Rt,Hu Process for preparing apovincaminic acid derivatives
JPS60248688A (ja) * 1984-05-24 1985-12-09 Sanwa Kagaku Kenkyusho:Kk 新規のアポビンカミン酸エステルおよびその酸付加塩並びにその製造方法

Also Published As

Publication number Publication date
KR19990076606A (ko) 1999-10-15
CZ290383B6 (cs) 2002-07-17
CN1205701A (zh) 1999-01-20
TW366348B (en) 1999-08-11
WO1997023481A1 (en) 1997-07-03
HU214600B (hu) 1998-04-28
US6093720A (en) 2000-07-25
CA2238635A1 (en) 1997-07-03
CZ196298A3 (cs) 1998-10-14
IL124097A (en) 2001-12-23
HU9503736D0 (en) 1996-02-28
ES2181926T3 (es) 2003-03-01
DE69623656T2 (de) 2003-05-22
EP0876367B1 (en) 2002-09-11
PL328170A1 (en) 1999-01-18
EP0876367A1 (en) 1998-11-11
PL186626B1 (pl) 2004-02-27
UA61062C2 (en) 2003-11-17
DE69623656D1 (en) 2002-10-17
HUT76555A (en) 1997-09-29
JP2000502676A (ja) 2000-03-07
ZA9610646B (en) 1997-06-24
CN1072670C (zh) 2001-10-10
AU1166997A (en) 1997-07-17
RU2161157C2 (ru) 2000-12-27
ATE223914T1 (de) 2002-09-15
PT876367E (pt) 2003-01-31
DK0876367T3 (da) 2002-12-30

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Date Code Title Description
FA Abandonment or withdrawal