CZ20033256A3 - Process for preparing a thiazole ppar-ligand and polymorphs thereof - Google Patents
Process for preparing a thiazole ppar-ligand and polymorphs thereof Download PDFInfo
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- CZ20033256A3 CZ20033256A3 CZ20033256A CZ20033256A CZ20033256A3 CZ 20033256 A3 CZ20033256 A3 CZ 20033256A3 CZ 20033256 A CZ20033256 A CZ 20033256A CZ 20033256 A CZ20033256 A CZ 20033256A CZ 20033256 A3 CZ20033256 A3 CZ 20033256A3
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- Prior art keywords
- compound
- methyl
- formula
- compounds
- pharmaceutically acceptable
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- 238000004519 manufacturing process Methods 0.000 title claims description 4
- 239000003446 ligand Substances 0.000 title abstract description 3
- FZWLAAWBMGSTSO-UHFFFAOYSA-N Thiazole Chemical compound C1=CSC=N1 FZWLAAWBMGSTSO-UHFFFAOYSA-N 0.000 title 1
- 150000001875 compounds Chemical class 0.000 claims abstract description 105
- 238000000034 method Methods 0.000 claims abstract description 27
- 150000003839 salts Chemical class 0.000 claims abstract description 16
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- RAXXELZNTBOGNW-UHFFFAOYSA-N imidazole Natural products C1=CNC=N1 RAXXELZNTBOGNW-UHFFFAOYSA-N 0.000 claims description 20
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 18
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 12
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- 230000001404 mediated effect Effects 0.000 claims description 8
- -1 thiazole compound Chemical class 0.000 claims description 8
- 238000002360 preparation method Methods 0.000 claims description 7
- 230000008569 process Effects 0.000 claims description 5
- ILUPZUOBHCUBKB-UHFFFAOYSA-N 2-methyl-2-(4-{[({4-methyl-2-[4-(trifluoromethyl)phenyl]-1,3-thiazol-5-yl}carbonyl)amino]methyl}phenoxy)propanoic acid Chemical group CC=1N=C(C=2C=CC(=CC=2)C(F)(F)F)SC=1C(=O)NCC1=CC=C(OC(C)(C)C(O)=O)C=C1 ILUPZUOBHCUBKB-UHFFFAOYSA-N 0.000 claims description 4
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- XBDQKXXYIPTUBI-UHFFFAOYSA-N dimethylselenoniopropionate Natural products CCC(O)=O XBDQKXXYIPTUBI-UHFFFAOYSA-N 0.000 claims 2
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- IUVKMZGDUIUOCP-BTNSXGMBSA-N quinbolone Chemical compound O([C@H]1CC[C@H]2[C@H]3[C@@H]([C@]4(C=CC(=O)C=C4CC3)C)CC[C@@]21C)C1=CCCC1 IUVKMZGDUIUOCP-BTNSXGMBSA-N 0.000 claims 1
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- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 description 5
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- FYSNRJHAOHDILO-UHFFFAOYSA-N thionyl chloride Chemical compound ClS(Cl)=O FYSNRJHAOHDILO-UHFFFAOYSA-N 0.000 description 4
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Diabetes (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Hospice & Palliative Care (AREA)
- Child & Adolescent Psychology (AREA)
- Nutrition Science (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Steroid Compounds (AREA)
- Physical Or Chemical Processes And Apparatus (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0113232.3A GB0113232D0 (en) | 2001-05-31 | 2001-05-31 | Chemical process |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CZ20033256A3 true CZ20033256A3 (en) | 2004-04-14 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CZ20033256A CZ20033256A3 (en) | 2001-05-31 | 2002-05-29 | Process for preparing a thiazole ppar-ligand and polymorphs thereof |
Country Status (22)
| Country | Link |
|---|---|
| US (1) | US7244849B2 (enExample) |
| EP (1) | EP1395572B1 (enExample) |
| JP (1) | JP2004532265A (enExample) |
| KR (1) | KR20040007631A (enExample) |
| CN (1) | CN1551871A (enExample) |
| AT (1) | ATE315556T1 (enExample) |
| AU (1) | AU2002317764B2 (enExample) |
| BR (1) | BR0209892A (enExample) |
| CA (1) | CA2448101A1 (enExample) |
| CO (1) | CO5540298A2 (enExample) |
| CZ (1) | CZ20033256A3 (enExample) |
| DE (1) | DE60208682T2 (enExample) |
| ES (1) | ES2256493T3 (enExample) |
| GB (1) | GB0113232D0 (enExample) |
| HU (1) | HUP0400117A3 (enExample) |
| IL (1) | IL158641A0 (enExample) |
| MX (1) | MXPA03010943A (enExample) |
| NO (1) | NO20035313L (enExample) |
| NZ (1) | NZ529486A (enExample) |
| PL (1) | PL367114A1 (enExample) |
| WO (1) | WO2002096893A1 (enExample) |
| ZA (1) | ZA200308570B (enExample) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7105551B2 (en) * | 2000-12-20 | 2006-09-12 | Smithkline Beecham Corporation | Thiazole derivatives for treating PPAR related disorders |
| BR0311834A (pt) | 2002-06-19 | 2005-04-12 | Lilly Co Eli | Composto, composição farmacêutica, métodos para mudular um receptor ativado por proliferador de peroxisoma, para tratar e prevenir diabetes mellitus em um mamìfero e para tratar sìndrome x em um mamìfero, e, uso de um composto ou seu sal farmaceuticamente aceitável |
| TW200400816A (en) | 2002-06-26 | 2004-01-16 | Lilly Co Eli | Tricyclic steroid hormone nuclear receptor modulators |
| US7553867B2 (en) | 2002-09-06 | 2009-06-30 | Takeda Pharmaceutical Company Limited | Furan or thiophene derivative and medicinal use thereof |
| EP1680131A4 (en) | 2003-08-01 | 2009-05-27 | Janssen Pharmaceutica Nv | SUBSTITUTED INDOLE-O-GLUCOSIDES |
| EP1734930A2 (en) * | 2004-04-09 | 2006-12-27 | Smithkline Beecham Corporation | Low dose pharmaceutical products |
| JP2009523132A (ja) * | 2006-01-10 | 2009-06-18 | スミスクライン ビーチャム コーポレーション | ｛２−メチル−４−［４−メチル−２−（４−トリフルオロメチルフェニル）チアゾール−５−イルメチルチオ］フェノキシ｝−酢酸の多形体形態 |
| WO2012168948A2 (en) * | 2011-06-06 | 2012-12-13 | Hetero Research Foundation | Process for febuxostat |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR100620337B1 (ko) * | 1998-03-10 | 2006-09-13 | 오노 야꾸힝 고교 가부시키가이샤 | 카르복실산 유도체와 그 유도체를 유효 성분으로서함유하는 약제 |
| PE20011010A1 (es) * | 1999-12-02 | 2001-10-18 | Glaxo Group Ltd | Oxazoles y tiazoles sustituidos como agonista del receptor activado por el proliferador de peroxisomas humano |
| AU2002233271A1 (en) * | 2000-12-20 | 2002-07-01 | Glaxo Group Limited | Substitued oxazoles and thiazoles as hppar alpha agonists |
| GB0111523D0 (en) * | 2001-05-11 | 2001-07-04 | Glaxo Group Ltd | Chemical compounds |
| GB0113233D0 (en) * | 2001-05-31 | 2001-07-25 | Glaxo Group Ltd | Chemical compounds |
-
2001
- 2001-05-31 GB GBGB0113232.3A patent/GB0113232D0/en not_active Ceased
-
2002
- 2002-05-29 AU AU2002317764A patent/AU2002317764B2/en not_active Ceased
- 2002-05-29 ES ES02747330T patent/ES2256493T3/es not_active Expired - Lifetime
- 2002-05-29 US US10/478,260 patent/US7244849B2/en not_active Expired - Fee Related
- 2002-05-29 CZ CZ20033256A patent/CZ20033256A3/cs unknown
- 2002-05-29 KR KR10-2003-7015677A patent/KR20040007631A/ko not_active Ceased
- 2002-05-29 BR BR0209892-0A patent/BR0209892A/pt not_active IP Right Cessation
- 2002-05-29 HU HU0400117A patent/HUP0400117A3/hu unknown
- 2002-05-29 CA CA002448101A patent/CA2448101A1/en not_active Abandoned
- 2002-05-29 AT AT02747330T patent/ATE315556T1/de not_active IP Right Cessation
- 2002-05-29 PL PL02367114A patent/PL367114A1/xx not_active Application Discontinuation
- 2002-05-29 IL IL15864102A patent/IL158641A0/xx unknown
- 2002-05-29 JP JP2003500072A patent/JP2004532265A/ja active Pending
- 2002-05-29 DE DE60208682T patent/DE60208682T2/de not_active Expired - Fee Related
- 2002-05-29 MX MXPA03010943A patent/MXPA03010943A/es unknown
- 2002-05-29 NZ NZ529486A patent/NZ529486A/en unknown
- 2002-05-29 WO PCT/EP2002/005884 patent/WO2002096893A1/en not_active Ceased
- 2002-05-29 EP EP02747330A patent/EP1395572B1/en not_active Expired - Lifetime
- 2002-05-29 CN CNA02810885XA patent/CN1551871A/zh active Pending
-
2003
- 2003-11-03 ZA ZA200308570A patent/ZA200308570B/en unknown
- 2003-11-26 CO CO03104438A patent/CO5540298A2/es not_active Application Discontinuation
- 2003-11-28 NO NO20035313A patent/NO20035313L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| KR20040007631A (ko) | 2004-01-24 |
| NO20035313D0 (no) | 2003-11-28 |
| CO5540298A2 (es) | 2005-07-29 |
| BR0209892A (pt) | 2004-06-08 |
| CA2448101A1 (en) | 2002-12-05 |
| HUP0400117A3 (en) | 2005-09-28 |
| US7244849B2 (en) | 2007-07-17 |
| EP1395572B1 (en) | 2006-01-11 |
| DE60208682T2 (de) | 2006-08-24 |
| US20040242657A1 (en) | 2004-12-02 |
| ES2256493T3 (es) | 2006-07-16 |
| AU2002317764B2 (en) | 2005-01-06 |
| JP2004532265A (ja) | 2004-10-21 |
| WO2002096893A1 (en) | 2002-12-05 |
| HUP0400117A2 (hu) | 2005-03-29 |
| PL367114A1 (en) | 2005-02-21 |
| MXPA03010943A (es) | 2004-02-27 |
| NO20035313L (no) | 2003-12-09 |
| ATE315556T1 (de) | 2006-02-15 |
| CN1551871A (zh) | 2004-12-01 |
| EP1395572A1 (en) | 2004-03-10 |
| GB0113232D0 (en) | 2001-07-25 |
| DE60208682D1 (de) | 2006-04-06 |
| ZA200308570B (en) | 2005-02-03 |
| NZ529486A (en) | 2005-12-23 |
| IL158641A0 (en) | 2004-05-12 |
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