CZ117392A3 - Rapamycin derivatives and pharmaceutical preparations containing thereof - Google Patents

Rapamycin derivatives and pharmaceutical preparations containing thereof Download PDF

Info

Publication number
CZ117392A3
CZ117392A3 CS921173A CS117392A CZ117392A3 CZ 117392 A3 CZ117392 A3 CZ 117392A3 CS 921173 A CS921173 A CS 921173A CS 117392 A CS117392 A CS 117392A CZ 117392 A3 CZ117392 A3 CZ 117392A3
Authority
CZ
Czechia
Prior art keywords
rapamycin
carbon atoms
acid
alkyl
compound according
Prior art date
Application number
CS921173A
Other languages
Czech (cs)
English (en)
Inventor
Wenling Kao
Robert Lewis Vogel
John Henry Musser
Original Assignee
American Home Prod
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US07/686,728 external-priority patent/US5118678A/en
Priority claimed from US07/837,048 external-priority patent/US5194447A/en
Application filed by American Home Prod filed Critical American Home Prod
Publication of CZ117392A3 publication Critical patent/CZ117392A3/cs

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D498/18—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/08—Plasma substitutes; Perfusion solutions; Dialytics or haemodialytics; Drugs for electrolytic or acid-base disorders, e.g. hypovolemic shock
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Immunology (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Transplantation (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
CS921173A 1991-04-17 1992-04-16 Rapamycin derivatives and pharmaceutical preparations containing thereof CZ117392A3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US07/686,728 US5118678A (en) 1991-04-17 1991-04-17 Carbamates of rapamycin
US07/837,048 US5194447A (en) 1992-02-18 1992-02-18 Sulfonylcarbamates of rapamycin

Publications (1)

Publication Number Publication Date
CZ117392A3 true CZ117392A3 (en) 1993-09-15

Family

ID=27103855

Family Applications (1)

Application Number Title Priority Date Filing Date
CS921173A CZ117392A3 (en) 1991-04-17 1992-04-16 Rapamycin derivatives and pharmaceutical preparations containing thereof

Country Status (12)

Country Link
EP (1) EP0509795A2 (Direct)
JP (1) JPH05112573A (Direct)
KR (1) KR920019798A (Direct)
AU (1) AU642592B2 (Direct)
CZ (1) CZ117392A3 (Direct)
FI (1) FI921595L (Direct)
HU (1) HU9201254D0 (Direct)
IE (1) IE921249A1 (Direct)
MX (1) MX9201710A (Direct)
NO (1) NO921449L (Direct)
NZ (1) NZ242367A (Direct)
SK (1) SK117392A3 (Direct)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5776943A (en) * 1991-05-14 1998-07-07 American Home Products Corporation Rapamycin metabolites
US5118677A (en) * 1991-05-20 1992-06-02 American Home Products Corporation Amide esters of rapamycin
MX9301188A (es) * 1992-03-05 1994-07-29 American Home Prod Nuevos sulfonatos y 42-(n-carboalcoxi)sulfamatos en posicion 42 de la rapamicina, procedimiento para su preparacion y composicion farmaceutica que los comprende.
GB9307491D0 (en) * 1993-04-08 1993-06-02 Sandoz Ltd Organic compounds
CH686761A5 (de) 1993-05-27 1996-06-28 Sandoz Ag Galenische Formulierungen.
US5527907A (en) * 1993-11-19 1996-06-18 Abbott Laboratories Macrolide immunomodulators
CA2175215C (en) * 1993-11-19 2008-06-03 Yat Sun Or Semisynthetic analogs of rapamycin (macrolides) being immunomodulators
US5362718A (en) 1994-04-18 1994-11-08 American Home Products Corporation Rapamycin hydroxyesters
JP2002534468A (ja) 1999-01-13 2002-10-15 バイエル コーポレイション ｐ３８キナーゼ阻害剤としてのω−カルボキシアリール置換ジフェニル尿素
US8124630B2 (en) 1999-01-13 2012-02-28 Bayer Healthcare Llc ω-carboxyaryl substituted diphenyl ureas as raf kinase inhibitors
EP1210350B1 (en) * 1999-08-18 2004-07-14 Wyeth Water soluble sdz-rad esters
DK1478358T3 (da) 2002-02-11 2013-10-07 Bayer Healthcare Llc Sorafenibtosylat til behandling af sygdomme kendetegnet ved unormal angiogenese
UY28213A1 (es) 2003-02-28 2004-09-30 Bayer Pharmaceuticals Corp Nuevos derivados de cianopiridina útiles en el tratamiento de cáncer y otros trastornos.
DE602004011340T2 (de) 2003-05-20 2008-11-06 Bayer Healthcare Llc Diaryl-harnstoffe mit kinasehemmender wirkung
JP4777887B2 (ja) 2003-07-23 2011-09-21 バイエル、ファーマシューテイカルズ、コーポレイション 病気および状態の処置および防止のためのフロロ置換オメガカルボキシアリールジフェニル尿素
US7659244B2 (en) 2003-11-03 2010-02-09 Quest Pharmatech, Inc. Rapamycin peptides conjugates: synthesis and uses thereof
US8021849B2 (en) 2004-11-05 2011-09-20 Siemens Healthcare Diagnostics Inc. Methods and kits for the determination of sirolimus in a sample
CN101137659A (zh) 2005-03-07 2008-03-05 惠氏公司 42-o-（2-羟基）乙基-雷帕霉素的氧杂环庚烷异构体
US7189582B2 (en) 2005-04-27 2007-03-13 Dade Behring Inc. Compositions and methods for detection of sirolimus
US20220098159A1 (en) * 2019-01-25 2022-03-31 NodThera Limited Carbamate derivatives and uses thereof

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4885171A (en) * 1978-11-03 1989-12-05 American Home Products Corporation Use of rapamycin in treatment of certain tumors
US4316885A (en) * 1980-08-25 1982-02-23 Ayerst, Mckenna And Harrison, Inc. Acyl derivatives of rapamycin
US4650803A (en) * 1985-12-06 1987-03-17 University Of Kansas Prodrugs of rapamycin
WO1991002736A1 (en) * 1989-08-18 1991-03-07 Fisons Plc Macrocyclic compounds
PT98990A (pt) * 1990-09-19 1992-08-31 American Home Prod Processo para a preparacao de esteres de acidos carboxilicos de rapamicina
US5118677A (en) * 1991-05-20 1992-06-02 American Home Products Corporation Amide esters of rapamycin

Also Published As

Publication number Publication date
SK117392A3 (en) 1995-04-12
JPH05112573A (ja) 1993-05-07
MX9201710A (es) 1993-01-01
KR920019798A (ko) 1992-11-20
FI921595A0 (fi) 1992-04-10
EP0509795A2 (en) 1992-10-21
EP0509795A3 (Direct) 1994-03-23
FI921595A7 (fi) 1992-10-18
AU642592B2 (en) 1993-10-21
NO921449L (no) 1992-10-19
HU9201254D0 (en) 1992-07-28
NZ242367A (en) 1994-07-26
IE921249A1 (en) 1992-10-21
FI921595L (fi) 1992-10-18
NO921449D0 (no) 1992-04-10
AU1488092A (en) 1992-10-22

Similar Documents

Publication Publication Date Title
CZ117392A3 (en) Rapamycin derivatives and pharmaceutical preparations containing thereof
US5194447A (en) Sulfonylcarbamates of rapamycin
JP3710140B2 (ja) ラパマイシンのヒンダードエステルおよびそれらの医薬品としての使用
US5411967A (en) Carbamates of rapamycin
DE69426831T2 (de) Heterocyclische ester von rapamycin und sie enthaltende pharmazeutische zusammensetzungen
ES2461967T3 (es) Compuestos de pirrolo[2,3-d]pirimidina
IE921728A1 (en) Use of rapamycin prodrugs as immunosuppressant agents
CA2065790A1 (en) Carbamates of rapamycin
HUT74675A (en) C-22-ring stabilized rapamycin derivatives and pharmaceutical compositions containing them
JPH10509977A (ja) ラパマイシンのヒンダードｎ−オキシドエステルおよびそれらの医薬品としての使用
JPH10501268A (ja) ラパマイシンアミジノカルバメートおよびそれらを含有する医薬組成物
JPH09512018A (ja) ラパマイシンヒドロキシエステル、それらの製造方法、および、それらを含有する医薬組成物
HUT70765A (en) Immunregulator rapamycin derivatives of activity, pharmaceutical compositions containing them and process for preparing them
JPH08502748A (ja) 免疫抑制剤および抗真菌薬としてのラパマイシンのアリールカルボニルおよびアルコキシカルボニルカルバミン酸エステル
MXPA97003893A (en) Un-oxido-impaired esters of rapamycin and its uses as a medicine
NZ242778A (en) Amide esters of rapamycin and pharmaceutical compositions thereof
US5262424A (en) Composition of sulfonylcarbamates of rapamycin and method of treating diseases requiring immunosuppression therewith
HU222575B1 (hu) Rapamicin-karbamát-származékok, eljárás előállításukra és az ezeket tartalmazó gyógyszerkészítmények
WO1997017973A1 (en) Hemoregulatory compounds
US6197793B1 (en) Hemoregulatory compounds
NO176103B (no) Analogifremgangsmåte for fremstilling av mitomycinfosfatderivat
JPH0242052A (ja) カルバモイル化ヒドロキサミン酸誘導体及びその製造方法
KR100304327B1 (ko) 라파마이신의카밤산염및이를포함하는약제학적조성물
US6114357A (en) Hemoregulatory compounds
EP0861077B1 (en) Hemoregulatory compounds