CY2045B1 - N-isoxazole-naphthylsulfonamide derivatives and their use as endothelin antagonists - Google Patents

N-isoxazole-naphthylsulfonamide derivatives and their use as endothelin antagonists

Info

Publication number
CY2045B1
CY2045B1 CY9802045A CY9802045A CY2045B1 CY 2045 B1 CY2045 B1 CY 2045B1 CY 9802045 A CY9802045 A CY 9802045A CY 9802045 A CY9802045 A CY 9802045A CY 2045 B1 CY2045 B1 CY 2045B1
Authority
CY
Cyprus
Prior art keywords
substituted
naphthylsulfonamide
isoxazole
derivatives
endothelin antagonists
Prior art date
Application number
CY9802045A
Other languages
English (en)
Original Assignee
Squibb & Sons Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Squibb & Sons Inc filed Critical Squibb & Sons Inc
Publication of CY2045B1 publication Critical patent/CY2045B1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
    • C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
    • C07D261/06—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members
    • C07D261/10—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D261/14—Nitrogen atoms

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
  • Diabetes (AREA)
  • Immunology (AREA)
  • Vascular Medicine (AREA)
  • Hematology (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Optical Fibers, Optical Fiber Cores, And Optical Fiber Bundles (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Glass Compositions (AREA)
  • Indole Compounds (AREA)
  • Steroid Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
CY9802045A 1992-02-24 1998-04-30 N-isoxazole-naphthylsulfonamide derivatives and their use as endothelin antagonists CY2045B1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US84049692A 1992-02-24 1992-02-24

Publications (1)

Publication Number Publication Date
CY2045B1 true CY2045B1 (en) 1998-04-30

Family

ID=25282528

Family Applications (1)

Application Number Title Priority Date Filing Date
CY9802045A CY2045B1 (en) 1992-02-24 1998-04-30 N-isoxazole-naphthylsulfonamide derivatives and their use as endothelin antagonists

Country Status (26)

Country Link
EP (1) EP0558258B1 (fi)
JP (1) JP3273818B2 (fi)
KR (1) KR100257134B1 (fi)
CN (1) CN1044235C (fi)
AT (1) ATE152713T1 (fi)
AU (1) AU651922B2 (fi)
CA (1) CA2089184A1 (fi)
CY (1) CY2045B1 (fi)
DE (1) DE69310414T2 (fi)
DK (1) DK0558258T3 (fi)
EG (1) EG20143A (fi)
ES (1) ES2103061T3 (fi)
FI (1) FI930774A (fi)
GR (1) GR3024203T3 (fi)
HK (1) HK121597A (fi)
HU (1) HU219455B (fi)
IL (1) IL104748A (fi)
MX (1) MX9300842A (fi)
MY (1) MY109004A (fi)
NO (1) NO303012B1 (fi)
NZ (1) NZ245905A (fi)
PH (1) PH30795A (fi)
PL (1) PL172035B1 (fi)
RU (1) RU2116301C1 (fi)
TW (1) TW224462B (fi)
ZA (1) ZA93780B (fi)

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US6541498B2 (en) 1993-05-20 2003-04-01 Texas Biotechnology Benzenesulfonamides and the use thereof to modulate the activity of endothelin
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UA58494C2 (uk) * 1995-06-07 2003-08-15 Зенека Лімітед Похідні n-гетероарилпіридинсульфонаміду, фармацевтична композиція, спосіб одержання та спосіб протидії впливам ендотеліну
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US5846990A (en) * 1995-07-24 1998-12-08 Bristol-Myers Squibb Co. Substituted biphenyl isoxazole sulfonamides
JPH09124620A (ja) 1995-10-11 1997-05-13 Bristol Myers Squibb Co 置換ビフェニルスルホンアミドエンドセリン拮抗剤
US5977117A (en) 1996-01-05 1999-11-02 Texas Biotechnology Corporation Substituted phenyl compounds and derivatives thereof that modulate the activity of endothelin
US5856507A (en) * 1997-01-21 1999-01-05 Bristol-Myers Squibb Co. Methods for the preparation of biphenyl isoxazole sulfonamides
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US5958905A (en) 1996-03-26 1999-09-28 Texas Biotechnology Corporation Phosphoramidates, phosphinic amides and related compounds and the use thereof to modulate the activity of endothelin
US5939446A (en) * 1996-04-09 1999-08-17 Bristol-Myers Squibb Co. Heteroaryl substituted phenyl isoxazole sulfonamide endothelin antagonists
US5804585A (en) * 1996-04-15 1998-09-08 Texas Biotechnology Corporation Thieno-pyridine sulfonamides derivatives thereof and related compounds that modulate the activity of endothelin
TW536540B (en) * 1997-01-30 2003-06-11 Bristol Myers Squibb Co Endothelin antagonists: N-[[2'-[[(4,5-dimethyl-3-isoxazolyl)amino]sulfonyl]-4-(2-oxazolyl)[1,1'-biphenyl]-2-yl]methyl]-N,3,3-trimethylbutanamide and N-(4,5-dimethyl-3-isoxazolyl)-2'-[(3,3-dimethyl-2-oxo-1-pyrrolidinyl)methyl]-4'-(2-oxazolyl)[1,1'-biphe
WO1998033781A1 (en) * 1997-01-30 1998-08-06 Bristol-Myers Squibb Company Method for preventing or treating low renin hypertension by administering an endothelin antagonist
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US5783705A (en) 1997-04-28 1998-07-21 Texas Biotechnology Corporation Process of preparing alkali metal salys of hydrophobic sulfonamides
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Also Published As

Publication number Publication date
MX9300842A (es) 1993-08-01
NO930633D0 (no) 1993-02-23
IL104748A (en) 1996-10-16
CN1044235C (zh) 1999-07-21
FI930774A (fi) 1993-08-25
CA2089184A1 (en) 1993-08-25
RU2116301C1 (ru) 1998-07-27
TW224462B (fi) 1994-06-01
MY109004A (en) 1996-11-30
FI930774A0 (fi) 1993-02-22
EP0558258A1 (en) 1993-09-01
CN1079468A (zh) 1993-12-15
JPH069585A (ja) 1994-01-18
PH30795A (en) 1997-10-17
NZ245905A (en) 1995-07-26
GR3024203T3 (en) 1997-10-31
KR100257134B1 (ko) 2000-05-15
DE69310414T2 (de) 1997-12-11
KR930017881A (ko) 1993-09-20
AU3319293A (en) 1993-08-26
NO303012B1 (no) 1998-05-18
JP3273818B2 (ja) 2002-04-15
HU9300491D0 (en) 1993-05-28
DE69310414D1 (de) 1997-06-12
HUT65762A (en) 1994-07-28
AU651922B2 (en) 1994-08-04
EG20143A (en) 1997-07-31
ES2103061T3 (es) 1997-08-16
EP0558258B1 (en) 1997-05-07
HK121597A (en) 1997-09-12
NO930633L (no) 1993-08-25
DK0558258T3 (da) 1997-05-26
HU219455B (hu) 2001-04-28
ZA93780B (en) 1993-09-08
ATE152713T1 (de) 1997-05-15
PL297820A1 (en) 1993-09-06
IL104748A0 (en) 1993-06-10
PL172035B1 (pl) 1997-07-31

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