CY2021036I1 - Αντισωματα anti-angptl3 και χρησεις αυτων - Google Patents

Αντισωματα anti-angptl3 και χρησεις αυτων

Info

Publication number
CY2021036I1
CY2021036I1 CY2021036C CY2021036C CY2021036I1 CY 2021036 I1 CY2021036 I1 CY 2021036I1 CY 2021036 C CY2021036 C CY 2021036C CY 2021036 C CY2021036 C CY 2021036C CY 2021036 I1 CY2021036 I1 CY 2021036I1
Authority
CY
Cyprus
Prior art keywords
angptl3 antibodies
angptl3
antibodies
Prior art date
Application number
CY2021036C
Other languages
English (en)
Other versions
CY2021036I2 (el
Original Assignee
Regeneron Pharmaceuticals, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=46298728&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CY2021036(I1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Regeneron Pharmaceuticals, Inc. filed Critical Regeneron Pharmaceuticals, Inc.
Publication of CY2021036I1 publication Critical patent/CY2021036I1/el
Publication of CY2021036I2 publication Critical patent/CY2021036I2/el

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/22Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/455Nicotinic acids, e.g. niacin; Derivatives thereof, e.g. esters, amides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/395Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/18Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/04Anorexiants; Antiobesity agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/06Antihyperlipidemics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/505Medicinal preparations containing antigens or antibodies comprising antibodies
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/20Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/30Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/30Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/70Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/90Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Diabetes (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Endocrinology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Cardiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Emergency Medicine (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
CY2021036C 2011-06-17 2021-12-06 Αντισωματα anti-angptl3 και χρησεις αυτων CY2021036I2 (el)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201161498518P 2011-06-17 2011-06-17
US201161578309P 2011-12-21 2011-12-21

Publications (2)

Publication Number Publication Date
CY2021036I1 true CY2021036I1 (el) 2022-03-24
CY2021036I2 CY2021036I2 (el) 2022-05-27

Family

ID=46298728

Family Applications (2)

Application Number Title Priority Date Filing Date
CY181101324T CY1120996T1 (el) 2011-06-17 2018-12-11 Αντισωματα anti-angptl3 και χρησεις αυτων
CY2021036C CY2021036I2 (el) 2011-06-17 2021-12-06 Αντισωματα anti-angptl3 και χρησεις αυτων

Family Applications Before (1)

Application Number Title Priority Date Filing Date
CY181101324T CY1120996T1 (el) 2011-06-17 2018-12-11 Αντισωματα anti-angptl3 και χρησεις αυτων

Country Status (46)

Country Link
US (7) US9018356B2 (el)
EP (2) EP3418301A1 (el)
JP (2) JP6400471B2 (el)
KR (1) KR102031007B1 (el)
CN (1) CN103732624B (el)
AR (1) AR087329A1 (el)
AU (1) AU2012271663B2 (el)
CA (1) CA2838867C (el)
CL (1) CL2013003552A1 (el)
CO (1) CO6821892A2 (el)
CR (1) CR20130621A (el)
CY (2) CY1120996T1 (el)
DK (1) DK2721065T3 (el)
DO (1) DOP2013000299A (el)
EC (1) ECSP13013085A (el)
ES (1) ES2699499T3 (el)
FI (1) FIC20210028I1 (el)
FR (1) FR21C1061I2 (el)
GT (1) GT201300306A (el)
HR (1) HRP20182098T1 (el)
HU (1) HUS2100034I1 (el)
IL (2) IL229612B (el)
JO (1) JO3412B1 (el)
LT (2) LT2721065T (el)
LU (1) LUC00231I2 (el)
MA (1) MA35190B1 (el)
MX (2) MX361859B (el)
MY (1) MY160516A (el)
NI (1) NI201300136A (el)
NL (1) NL301122I2 (el)
NO (2) NO2021037I1 (el)
PE (1) PE20141166A1 (el)
PH (1) PH12013502570B1 (el)
PL (1) PL2721065T3 (el)
PT (1) PT2721065T (el)
RS (1) RS58310B1 (el)
RU (1) RU2620064C2 (el)
SG (1) SG195165A1 (el)
SI (1) SI2721065T1 (el)
SM (1) SMT201800658T1 (el)
TR (1) TR201816591T4 (el)
TW (3) TWI644922B (el)
UA (1) UA114891C2 (el)
UY (2) UY39340A (el)
WO (1) WO2012174178A1 (el)
ZA (1) ZA201308879B (el)

Families Citing this family (75)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JO3412B1 (ar) 2011-06-17 2019-10-20 Regeneron Pharma أجسام مضادة ل angptl3 واستخداماتها
US9255154B2 (en) 2012-05-08 2016-02-09 Alderbio Holdings, Llc Anti-PCSK9 antibodies and use thereof
AR095196A1 (es) 2013-03-15 2015-09-30 Regeneron Pharma Medio de cultivo celular libre de suero
WO2017011929A1 (zh) * 2015-07-17 2017-01-26 北京大学第一医院 检测血清血管生成素样蛋白2含量的物质在制备检测肝脏炎症和纤维化程度产品中的应用
TW202440903A (zh) 2015-08-04 2024-10-16 美商再生元醫藥公司 補充牛磺酸之細胞培養基及用法(一)
TW201713690A (zh) 2015-08-07 2017-04-16 再生元醫藥公司 抗angptl8抗體及其用途
JP7648335B2 (ja) * 2016-02-17 2025-03-18 リジェネロン・ファーマシューティカルズ・インコーポレイテッド Angptl3の阻害剤を投与することによるアテローム性動脈硬化症の処置又は予防のための方法
MX2018010401A (es) * 2016-03-03 2019-03-06 Regeneron Pharma Metodos para el tratamiento de pacientes con hiperlipidemia administrando un inhibidor de pcsk9 en combinacion con un inhibidor de angptl3.
HRP20212028T1 (hr) * 2016-04-08 2022-04-01 Regeneron Pharmaceuticals, Inc. Postupci za liječenje hiperlipidemije inhibitorom angptl8 i inhibitorom angptl3
DK3448426T3 (da) * 2016-04-28 2025-06-30 Regeneron Pharma Fremgangsmåder til behandling af patienter med familiær hyperkolesterolæmi
WO2018039499A1 (en) 2016-08-24 2018-03-01 Regeneron Pharmaceuticals, Inc. Host cell protein modification
EA201991203A1 (ru) 2016-11-17 2019-10-31 Способы лечения ожирения антителами к angptl8
KR102659791B1 (ko) 2017-07-06 2024-04-23 리제너론 파마슈티칼스 인코포레이티드 당단백질을 만들기 위한 세포 배양 과정
WO2019126194A1 (en) 2017-12-18 2019-06-27 Regeneron Pharmaceuticals, Inc. Angptl8 assay and uses thereof
JP7321159B2 (ja) 2017-12-22 2023-08-04 リジェネロン・ファーマシューティカルズ・インコーポレイテッド 薬剤生成物不純物を特性決定するためのシステム及び方法
BR112020013336A2 (pt) 2018-01-31 2020-12-01 Regeneron Pharmaceuticals, Inc. produto farmacêutico proteico, métodos para caracterizar as impurezas do produto farmacêutico proteico de alto peso molecular intermediário, para produção de um anticorpo, e para caracterizar as impurezas de fármaco com variação de carga, anticorpo, e, sistema para caracterizar impurezas de fármaco de alto peso molecular intermediário.
TWI786265B (zh) 2018-02-02 2022-12-11 美商再生元醫藥公司 用於表徵蛋白質二聚合之系統及方法
AU2019227531B2 (en) 2018-02-28 2025-01-30 Regeneron Pharmaceuticals, Inc. Systems and methods for identifying viral contaminants
US12259355B2 (en) 2018-03-19 2025-03-25 Regeneron Pharmaceuticals, Inc. Microchip capillary electrophoresis assays and reagents
US12253490B2 (en) 2018-03-19 2025-03-18 Regeneron Pharmaceuticals, Inc. Microchip capillary electrophoresis assays and reagents
EP3768709B1 (en) 2018-03-19 2023-12-27 Regeneron Pharmaceuticals, Inc. Microchip capillary electrophoresis assays and reagents
TW202016125A (zh) 2018-05-10 2020-05-01 美商再生元醫藥公司 用於定量及調節蛋白質黏度之系統與方法
EP3774841A1 (en) 2018-08-27 2021-02-17 Regeneron Pharmaceuticals, Inc. Use of raman spectroscopy in downstream purification
US11754569B2 (en) 2018-08-30 2023-09-12 Regeneron Pharmaceuticals, Inc. Methods for characterizing protein complexes
EP3887393A1 (en) * 2018-11-26 2021-10-06 Novartis AG Lpl-gpihbp1 fusion polypeptides
TWI747098B (zh) 2018-12-21 2021-11-21 美商美國禮來大藥廠 抗angptl3/8複合物抗體及其使用方法
BR112021009543A2 (pt) 2019-01-16 2021-08-17 Regeneron Pharmaceuticals, Inc. métodos para identificar tióis livres em um medicamento de proteína, de identificação de heterogeneidade de dissulfeto em um medicamento de proteína e para selecionar um medicamento de proteína, e, composição farmacêutica
US20220144961A1 (en) * 2019-03-11 2022-05-12 Xyence Therapeutics, Inc. Cd27-binding antibodies and uses thereof
JP7541534B2 (ja) 2019-05-13 2024-08-28 リジェネロン・ファーマシューティカルズ・インコーポレイテッド 改善された競合的リガンド結合アッセイ
US20200369760A1 (en) * 2019-05-24 2020-11-26 Regeneron Pharmaceuticals, Inc. Stabilized formulations containing anti-angptl3 antibodies
CN112062845B (zh) * 2019-06-10 2022-09-02 山东博安生物技术股份有限公司 Angptl3结合片段及其用途
WO2021001804A1 (en) * 2019-07-04 2021-01-07 Cadila Healthcare Limited Angptl3 based vaccine for the treatment of liver disease
KR20220066393A (ko) 2019-09-24 2022-05-24 리제너론 파아마슈티컬스, 인크. 크로마토그래피의 사용 및 재생을 위한 시스템 및 방법
US12297451B1 (en) 2019-10-25 2025-05-13 Regeneron Pharmaceuticals, Inc. Cell culture medium
WO2021108548A1 (en) 2019-11-25 2021-06-03 Regeneron Pharmaceuticals, Inc. Sustained release formulations using non-aqueous emulsions
CN110938144B (zh) * 2019-11-27 2022-07-26 复旦大学附属儿科医院 一种抗angptl3单克隆抗体及其在制备治疗肾病综合征药物中的用途
CN115398236B (zh) 2020-01-21 2024-06-11 瑞泽恩制药公司 用于糖基化的蛋白质的电泳的去糖基化方法
US20230138315A1 (en) * 2020-01-22 2023-05-04 Jiangsu Hengrui Medicine Co., Ltd. Anti-angptl3 antibody and use thereof
KR20230058094A (ko) 2020-08-31 2023-05-02 리제너론 파아마슈티컬스, 인크. 세포 배양 성능을 개선하고 아스파라긴 서열 변이체를 완화하기 위한 아스파라긴 공급 전략
WO2022115588A1 (en) 2020-11-25 2022-06-02 Regeneron Pharmaceuticals, Inc. Sustained release formulations using non-aqueous membrane emulsification
KR20230121854A (ko) 2020-12-17 2023-08-21 리제너론 파아마슈티컬스, 인크. 단백질-캡슐화 마이크로겔의 제작
JP2024503408A (ja) 2021-01-20 2024-01-25 リジェネロン・ファーマシューティカルズ・インコーポレイテッド 細胞培養におけるタンパク質力価の改善方法
TW202246325A (zh) 2021-03-03 2022-12-01 美商再生元醫藥公司 用於定量及修飾蛋白質黏度之系統及方法
WO2022187353A1 (en) * 2021-03-05 2022-09-09 Anji Pharmaceuticals Inc. Methods and compositions for treating sepsis
MX2023010794A (es) 2021-03-26 2023-10-25 Regeneron Pharma Metodos y sistemas para el desarrollo de protocolos de mezcla.
WO2022205021A1 (zh) * 2021-03-30 2022-10-06 复旦大学附属儿科医院 一种抗angptl3抗体或其抗原结合片段及其制备方法和用途
TW202314240A (zh) 2021-06-01 2023-04-01 美商再生元醫藥公司 微晶片毛細管電泳分析及試劑
CA3225970A1 (en) * 2021-07-21 2023-01-26 Jiangsu Hengrui Pharmaceuticals Co., Ltd. Pharmaceutical composition of anti-angptl3 antibody or antigen binding fragment thereof and its application
TW202326138A (zh) 2021-09-08 2023-07-01 美商再生元醫藥公司 用於定量抗體及其他含Fc蛋白之高通量及基於質譜之方法
TW202328179A (zh) 2021-09-20 2023-07-16 美商再生元醫藥公司 控制抗體異質性之方法
WO2023059803A1 (en) 2021-10-07 2023-04-13 Regeneron Pharmaceuticals, Inc. Ph meter calibration and correction
AU2022360838A1 (en) 2021-10-07 2024-03-28 Regeneron Pharmaceuticals, Inc. Systems and methods of ph modeling and control
JP2024541952A (ja) 2021-10-26 2024-11-13 リジェネロン・ファーマシューティカルズ・インコーポレイテッド 実験室用水を生成し、実験室用水を異なる温度で分配するためのシステム及び方法
CN116284377A (zh) * 2021-12-21 2023-06-23 复旦大学 抗人血管生成素3纳米抗体及其应用
KR20240119084A (ko) * 2021-12-22 2024-08-06 리제너론 파마슈티칼스 인코포레이티드 안지오포이에틴 유사 3(angptl3) 억제제를 이용한 신장 질환 치료
US20230296559A1 (en) 2022-03-18 2023-09-21 Regeneron Pharmaceuticals, Inc. Methods and systems for analyzing polypeptide variants
TWI833641B (zh) 2022-05-02 2024-02-21 丹麥商諾佛 儂迪克股份有限公司 適於高濃度組成物及皮下投藥之新穎抗angptl3抗體
CN117603361A (zh) * 2022-08-22 2024-02-27 复旦大学附属儿科医院 包含angptl3单抗的融合蛋白
CN116143919B (zh) * 2022-11-01 2025-06-13 中国药科大学 全人源抗人nt-angptl3抗体、其抗原结合片段及其应用
WO2024130165A1 (en) * 2022-12-16 2024-06-20 Regeneron Pharmaceuticals, Inc. Angptl3 inhibitors for triglyceride reduction in multifactorial chylomicronemia syndrome
CN120418653A (zh) 2022-12-16 2025-08-01 里珍纳龙药品有限公司 评估色谱柱完整性的方法和系统
US20240248097A1 (en) 2023-01-25 2024-07-25 Regeneron Pharmaceuticals, Inc. Mass spectrometry-based characterization of antibodies co-expressed in vivo
US20240245779A1 (en) 2023-01-25 2024-07-25 Regeneron Pharmaceuticals, Inc. Methods of modeling liquid protein composition stability
US20240255519A1 (en) 2023-02-01 2024-08-01 Regeneron Pharmaceuticals, Inc. Asymmetrical flow field-flow fractionation with mass spectrometry for biomacromolecule analysis
WO2024178213A2 (en) 2023-02-22 2024-08-29 Regeneron Pharmaceuticals, Inc. System suitability parameters and column aging
US20240366471A1 (en) 2023-05-01 2024-11-07 Regeneron Pharmaceuticals, Inc. Multidose antibody drug products using phenol or benzyl alcohol
CN119192369A (zh) * 2023-06-25 2024-12-27 百奥泰生物制药股份有限公司 抗angptl3抗体及其应用
WO2025054406A1 (en) 2023-09-08 2025-03-13 Regeneron Pharmaceuticals, Inc. Methods and systems for assessing chromatographic column integrity
WO2025064403A2 (en) 2023-09-18 2025-03-27 Regeneron Pharmaceuticals, Inc. Methods and systems for developing chromatography protocols
US20250109905A1 (en) 2023-09-29 2025-04-03 Regeneron Pharmaceuticals, Inc. Lyophilization using controlled nucleation
CN117535353A (zh) * 2023-10-11 2024-02-09 首都医科大学附属北京潞河医院 一种糖尿病视网膜病变模型的建立方法及应用
WO2025085594A1 (en) 2023-10-18 2025-04-24 Regeneron Pharmaceuticals, Inc. Rapid purification of monoclonal antibody from in-process upstream cell culture material
US20250145662A1 (en) 2023-11-02 2025-05-08 Regeneron Pharmaceuticals, Inc. Methods for reducing lipase activity using stress
WO2025166281A1 (en) 2024-02-01 2025-08-07 Regeneron Pharmaceuticals, Inc. Platform for charge-detection mass spectrometry analysis of aavs
WO2025175164A1 (en) 2024-02-16 2025-08-21 Regeneron Pharmaceuticals, Inc. Methods of producing concentrated formulated drug substances comprising proteins, and concentrated formulated drug substance made by the methods

Family Cites Families (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020035058A1 (en) 1996-05-15 2002-03-21 The University Of Sheffield Isopentenyl pyrophosphate isomerase (IPI) and/or prenyl transferase inhibitors
US6030831A (en) 1997-09-19 2000-02-29 Genetech, Inc. Tie ligand homologues
US7070959B1 (en) 1999-06-08 2006-07-04 Regeneron Pharmaceuticals, Inc. Modified chimeric polypeptides with improved pharmacokinetic properties
ATE357216T1 (de) 2001-02-22 2007-04-15 Jagotec Ag Fibrat-statin kombinationen mit verminderten von der nahrungsaufnahme abhängigen auswirkungen
CA2464542C (en) 2001-11-16 2015-01-20 Genentech, Inc. Composition comprising and method of using angiopoietin-like protein 3 angptl3
US20070185017A1 (en) 2002-10-29 2007-08-09 Genentech, Inc. Compositions and methods for the treatment of immune related diseases
US20040101920A1 (en) 2002-11-01 2004-05-27 Czeslaw Radziejewski Modification assisted profiling (MAP) methodology
JP2005080508A (ja) 2003-09-04 2005-03-31 Sankyo Co Ltd 脂質代謝改善剤の試験方法
US7850962B2 (en) 2004-04-20 2010-12-14 Genmab A/S Human monoclonal antibodies against CD20
CA2601677A1 (en) 2005-03-11 2006-09-21 Genentech, Inc. Gene disruptions, compositions and methods relating thereto
PL1962895T3 (pl) 2005-12-16 2013-06-28 Regeneron Pharma Terapeutyczne zastosowanie antagonisty dii4 oraz inhibitora vegf do inhibicji wzrostu nowotworów
BRPI0712224B8 (pt) 2006-06-02 2021-05-25 Regeneron Pharma anticorpos de alta afinidade para o receptor de il-6 humano e composições farmacêuticas
WO2008054606A2 (en) * 2006-10-02 2008-05-08 Regeneron Pharmaceuticals, Inc. High affinity human antibodies to human il-4 receptor
BRPI0720218A2 (pt) * 2006-12-08 2013-12-24 Lexicon Pharmaceuticals Inc Anticorpos monoclonais contra angptl3
NO347649B1 (no) 2006-12-14 2024-02-12 Regeneron Pharma Humant antistoff eller antistoff fragment som spesifikt binder human deltaliknende ligand 4 (hDII4), nukleinsyremolekyl som koder for slike og vektor og vert-vektorsystemer, samt fremgangsmåte for fremstilling, sammensetning og anvendelse.
JO3672B1 (ar) 2008-12-15 2020-08-27 Regeneron Pharma أجسام مضادة بشرية عالية التفاعل الكيماوي بالنسبة لإنزيم سبتيليسين كنفرتيز بروبروتين / كيكسين نوع 9 (pcsk9).
US20130064834A1 (en) 2008-12-15 2013-03-14 Regeneron Pharmaceuticals, Inc. Methods for treating hypercholesterolemia using antibodies to pcsk9
EP2216016A1 (en) 2009-02-06 2010-08-11 LEK Pharmaceuticals d.d. Process for the preparation of a pharmaceutical composition comprising ezetimibe
CN101852805B (zh) 2009-03-31 2015-04-01 浙江大学 Angptl3作为卵巢癌的诊断标记物的用途
PL2453921T3 (pl) 2009-07-14 2015-11-30 Scripps Research Inst Różnicowanie mezenchymalnych komórek macierzystych
WO2011085271A2 (en) 2010-01-08 2011-07-14 Isis Pharmaceuticals, Inc. Modulation of angiopoietin-like 3 expression
JO3412B1 (ar) 2011-06-17 2019-10-20 Regeneron Pharma أجسام مضادة ل angptl3 واستخداماتها
KR102554896B1 (ko) * 2011-06-21 2023-07-12 알닐람 파마슈티칼스 인코포레이티드 안지오포이에틴-유사 3(ANGPTL3) iRNA 조성물 및 그 사용 방법
US10111953B2 (en) 2013-05-30 2018-10-30 Regeneron Pharmaceuticals, Inc. Methods for reducing remnant cholesterol and other lipoprotein fractions by administering an inhibitor of proprotein convertase subtilisin kexin-9 (PCSK9)
PT3087183T (pt) 2013-12-24 2020-10-08 Ionis Pharmaceuticals Inc Modulação da expressão da proteína relacionada com angiopoietina 3
CA2946003A1 (en) 2014-05-01 2015-11-05 Ionis Pharmaceuticals, Inc. Compositions and methods for modulating angiopoietin-like 3 expression
RU2735521C2 (ru) 2014-07-16 2020-11-03 Санофи Байотекнолоджи Способы лечения пациентов с гетерозиготной семейной гиперхолестеринемией (hefh)
TW201713690A (zh) 2015-08-07 2017-04-16 再生元醫藥公司 抗angptl8抗體及其用途
JP7648335B2 (ja) 2016-02-17 2025-03-18 リジェネロン・ファーマシューティカルズ・インコーポレイテッド Angptl3の阻害剤を投与することによるアテローム性動脈硬化症の処置又は予防のための方法
MX2018010401A (es) 2016-03-03 2019-03-06 Regeneron Pharma Metodos para el tratamiento de pacientes con hiperlipidemia administrando un inhibidor de pcsk9 en combinacion con un inhibidor de angptl3.
HRP20212028T1 (hr) 2016-04-08 2022-04-01 Regeneron Pharmaceuticals, Inc. Postupci za liječenje hiperlipidemije inhibitorom angptl8 i inhibitorom angptl3
DK3448426T3 (da) 2016-04-28 2025-06-30 Regeneron Pharma Fremgangsmåder til behandling af patienter med familiær hyperkolesterolæmi
US20200369760A1 (en) * 2019-05-24 2020-11-26 Regeneron Pharmaceuticals, Inc. Stabilized formulations containing anti-angptl3 antibodies

Also Published As

Publication number Publication date
EP2721065A1 (en) 2014-04-23
TW201920261A (zh) 2019-06-01
AU2012271663A1 (en) 2014-01-16
FIC20210028I1 (fi) 2021-09-09
JP2018166516A (ja) 2018-11-01
CO6821892A2 (es) 2013-12-31
PH12013502570A1 (en) 2014-01-27
CY2021036I2 (el) 2022-05-27
PL2721065T3 (pl) 2019-02-28
PT2721065T (pt) 2018-12-06
US20190315851A1 (en) 2019-10-17
US20220153825A1 (en) 2022-05-19
NL301122I2 (nl) 2021-12-30
RS58310B1 (sr) 2019-03-29
US20190092845A1 (en) 2019-03-28
MX2013014345A (es) 2014-01-31
LTPA2021009I1 (el) 2021-09-27
EP3418301A1 (en) 2018-12-26
CR20130621A (es) 2014-02-12
PE20141166A1 (es) 2014-09-16
MX337644B (es) 2016-03-14
TR201816591T4 (tr) 2018-11-21
KR102031007B1 (ko) 2019-11-08
MA35190B1 (fr) 2014-06-02
FR21C1061I2 (fr) 2022-11-18
US20130171149A1 (en) 2013-07-04
ZA201308879B (en) 2014-07-30
NO2021037I1 (no) 2021-09-15
UY39340A (es) 2021-08-31
FR21C1061I1 (fr) 2022-01-21
CA2838867A1 (en) 2012-12-20
SMT201800658T1 (it) 2019-01-11
JP2014523739A (ja) 2014-09-18
DOP2013000299A (es) 2014-04-15
CL2013003552A1 (es) 2014-07-25
CN103732624B (zh) 2016-08-17
TW201815822A (zh) 2018-05-01
MY160516A (en) 2017-03-15
JO3412B1 (ar) 2019-10-20
TWI644922B (zh) 2018-12-21
IL259436A (en) 2018-07-31
RU2620064C2 (ru) 2017-05-22
US9018356B2 (en) 2015-04-28
RU2013155906A (ru) 2015-07-27
HRP20182098T1 (hr) 2019-02-08
ES2699499T3 (es) 2019-02-11
UY34137A (es) 2013-01-03
SG195165A1 (en) 2013-12-30
AR087329A1 (es) 2014-03-19
NZ619092A (en) 2016-03-31
WO2012174178A1 (en) 2012-12-20
IL229612B (en) 2019-06-30
US20220403016A1 (en) 2022-12-22
KR20140037218A (ko) 2014-03-26
US10358487B2 (en) 2019-07-23
EP2721065B1 (en) 2018-09-12
NL301122I1 (el) 2021-09-01
CA2838867C (en) 2020-07-14
MX361859B (es) 2018-12-18
UA114891C2 (uk) 2017-08-28
LT2721065T (lt) 2018-12-10
US20150197564A1 (en) 2015-07-16
CY1120996T1 (el) 2019-12-11
DK2721065T3 (en) 2018-12-03
LTC2721065I2 (el) 2022-10-25
GT201300306A (es) 2015-03-09
NO2025028I1 (no) 2025-06-13
AU2012271663B2 (en) 2017-04-20
IL229612A0 (en) 2014-01-30
JP6400471B2 (ja) 2018-10-03
SI2721065T1 (sl) 2018-12-31
PH12013502570B1 (en) 2019-01-16
HUS2100034I1 (hu) 2021-10-28
ECSP13013085A (es) 2014-01-31
TW201313738A (zh) 2013-04-01
CN103732624A (zh) 2014-04-16
US9951127B2 (en) 2018-04-24
NI201300136A (es) 2014-05-15
US20250136675A1 (en) 2025-05-01
LUC00231I2 (el) 2025-02-03

Similar Documents

Publication Publication Date Title
CY2021036I1 (el) Αντισωματα anti-angptl3 και χρησεις αυτων
CY2020045I2 (el) Anti-pd-l1 αντισωματα και χρησεις αυτων
CY2022019I2 (el) Συνθεσεις αντι-cgrp και χρησεις αυτων
HUS2300021I1 (hu) Anti-IL-36R antitestek
CY2024011I1 (el) Αντισωματα anti-fcrn
CY2024022I2 (el) Αντιμυκητιασικοι παραγοντες και χρησεις αυτων
BR112014012137A2 (pt) anticorpos anti-fgfr2 e suas utilizações
IL231777B (en) Antibodies against tl1a and uses thereof
IL249650A0 (en) Antibodies directed against icos and uses thereof
DK2914291T3 (da) Anti-komplement-c1s-antistoffer og anvendelser deraf
CO6811812A2 (es) Anticuerpo anti-b7-h3
CO7071096A2 (es) Anticuerpos anti-lgr5 e inmunoconjugados
LT2794654T (lt) Anti-phf-tau antikūnai ir jų panaudojimas
BR112012030311A2 (pt) anticorpo
DK3381943T3 (da) Anti-kit-antistoffer og anvendelser deraf
BR112015002193A2 (pt) anticorpos anti-etbr e imunoconjugados
EP2714735A4 (en) SPECIFIC ANTIBODIES OF TGF BETA
CR20140127A (es) Anticuerpo anti-abtcr
BR112014009050A2 (pt) pirrolbenzodiazepinas e conjugados destas
DK2668210T3 (da) Anti-kit antistoffer og anvendelser deraf
HUE056313T2 (hu) Anti-DLL3 antitest
HRP20181457T1 (hr) Anti-htra1 protutijela i postupci uporabe
DK2683406T3 (da) Anti-cd40-antistoffer og anvendelser deraf
BR112014025037A2 (pt) anticorpo ou um fragmento funcional do mesmo, nucleotídeo, vetor recombinante, célula, métodos para a produção de um anticorpo ou fragmento funcional, para detecção ou ensaio de fgfr2 humano iiib, para a identificação de um indivíduo receptor de uma composição farmacêutica, e, para identificar e para produzir uma substância, forma modificada, composição, e, reagente
CO6791565A2 (es) Anticuerpos anti-notch1