CY1680A - (s)-(-)-1-propyl-2',6'-pipecoloxylidide hydrochloride monohydrate,process for its preparation and pharmaceutical preparation containing it - Google Patents
(s)-(-)-1-propyl-2',6'-pipecoloxylidide hydrochloride monohydrate,process for its preparation and pharmaceutical preparation containing itInfo
- Publication number
- CY1680A CY1680A CY1680A CY168093A CY1680A CY 1680 A CY1680 A CY 1680A CY 1680 A CY1680 A CY 1680A CY 168093 A CY168093 A CY 168093A CY 1680 A CY1680 A CY 1680A
- Authority
- CY
- Cyprus
- Prior art keywords
- propyl
- preparation
- hydrochloride monohydrate
- pharmaceutical preparation
- pipecoloxylidide hydrochloride
- Prior art date
Links
- ZKMNUMMKYBVTFN-HNNXBMFYSA-N (S)-ropivacaine Chemical compound CCCN1CCCC[C@H]1C(=O)NC1=C(C)C=CC=C1C ZKMNUMMKYBVTFN-HNNXBMFYSA-N 0.000 title 1
- DKAGJZJALZXOOV-UHFFFAOYSA-N hydrate;hydrochloride Chemical compound O.Cl DKAGJZJALZXOOV-UHFFFAOYSA-N 0.000 title 1
- 238000000034 method Methods 0.000 title 1
- 239000000825 pharmaceutical preparation Substances 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/60—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Neurology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
SE8600017A SE451840B (sv) | 1986-01-03 | 1986-01-03 | Optiskt rent monohydrat av s-(-)-1-propyl-2',6'-pipekoloxylididhydroklorid, sett att framstella denna och farmaceutiska beredningar for lokalbedovning |
Publications (1)
Publication Number | Publication Date |
---|---|
CY1680A true CY1680A (en) | 1993-10-10 |
Family
ID=20363001
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CY1680A CY1680A (en) | 1986-01-03 | 1993-10-10 | (s)-(-)-1-propyl-2',6'-pipecoloxylidide hydrochloride monohydrate,process for its preparation and pharmaceutical preparation containing it |
Country Status (29)
Country | Link |
---|---|
US (1) | US4870086A (da) |
EP (1) | EP0239710B1 (da) |
JP (1) | JPH07598B2 (da) |
KR (1) | KR940008302B1 (da) |
AR (1) | AR242561A1 (da) |
AT (1) | ATE56956T1 (da) |
AU (1) | AU592392B2 (da) |
BG (1) | BG62066B2 (da) |
CA (1) | CA1276154C (da) |
CY (1) | CY1680A (da) |
DE (1) | DE3674582D1 (da) |
DK (1) | DK171378B1 (da) |
EG (1) | EG17867A (da) |
ES (1) | ES2036179T3 (da) |
FI (1) | FI83075C (da) |
GR (1) | GR3002516T3 (da) |
HK (1) | HK5493A (da) |
IE (1) | IE59061B1 (da) |
LU (1) | LU88843I2 (da) |
LV (1) | LV5765B4 (da) |
MY (1) | MY101132A (da) |
NL (1) | NL960005I2 (da) |
NO (2) | NO170330C (da) |
NZ (1) | NZ218615A (da) |
PH (1) | PH22924A (da) |
PT (1) | PT84041B (da) |
SE (1) | SE451840B (da) |
SG (1) | SG117292G (da) |
ZA (1) | ZA868600B (da) |
Families Citing this family (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
NZ238424A (en) * | 1990-06-07 | 1993-12-23 | Wellcome Found | 3,5-substituted indole derivatives; medicaments and preparatory processes. |
ES2082703B1 (es) * | 1993-11-04 | 1996-12-16 | Inst Investigacion Desarrollo | Nuevos derivados de ciclopropilo, procedimientos para su preparacion y aplicaciones. |
US5834490A (en) * | 1993-11-04 | 1998-11-10 | Instituto De Investigacion Y Desarrolo Quimico Biologico, S.A. | Cyclopropyl derivatives, preparation method there-of and applications |
CN1104416C (zh) * | 1994-09-23 | 2003-04-02 | 达尔文发现有限公司 | 制左旋布比卡因及类似物中所用的外消旋及不对称转变方法 |
SE9501808D0 (sv) * | 1995-05-16 | 1995-05-16 | Astra Ab | New process |
US7799337B2 (en) | 1997-07-21 | 2010-09-21 | Levin Bruce H | Method for directed intranasal administration of a composition |
SE9800139D0 (sv) | 1998-01-21 | 1998-01-21 | Astra Ab | New use |
BRPI0104491B8 (pt) * | 2001-10-10 | 2021-05-25 | Cristalia Produtos Quim Farmaceuticos Ltda | n-(2,6-dimetilfenil)-1-propil-2-piperidinocarboxamida; processo de obtenção dos enantiômeros; mistura não racêmica dos anantiômeros e seu processo de obtenção e composição farmacêutica. |
US20060270708A1 (en) * | 2005-05-25 | 2006-11-30 | Navinta Llc | Novel process for preparation of isotonic aqueous injection of ropivacaine |
US7683175B2 (en) * | 2005-06-06 | 2010-03-23 | Navinta, Llc | Process of making optically pure L-pipecolic acid and process of making anesthetics and intermediates therefrom |
WO2007123405A1 (en) * | 2006-04-25 | 2007-11-01 | Dishman Pharmaceuticals And Chemicals Ltd. | Ropivacaine hydrochloride anhydrate and the preparation thereof |
ATE555093T1 (de) * | 2008-01-15 | 2012-05-15 | Pharmathen Sa | Verfahren zur herstellung einer (s)-1-alkyl-2i,6i-pipecoloxylididverbindung |
US8473062B2 (en) | 2008-05-01 | 2013-06-25 | Autonomic Technologies, Inc. | Method and device for the treatment of headache |
US8412336B2 (en) | 2008-12-29 | 2013-04-02 | Autonomic Technologies, Inc. | Integrated delivery and visualization tool for a neuromodulation system |
US9320908B2 (en) | 2009-01-15 | 2016-04-26 | Autonomic Technologies, Inc. | Approval per use implanted neurostimulator |
US8494641B2 (en) | 2009-04-22 | 2013-07-23 | Autonomic Technologies, Inc. | Implantable neurostimulator with integral hermetic electronic enclosure, circuit substrate, monolithic feed-through, lead assembly and anchoring mechanism |
CN102093284B (zh) * | 2010-12-29 | 2013-05-08 | 宜昌人福药业有限责任公司 | 富集哌啶-2-甲酰苯胺类旋光化合物的方法 |
Family Cites Families (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2248018A (en) * | 1939-03-30 | 1941-07-01 | Winthrop Chem Co Inc | 4-aryl-piperidine-ketones and a process of preparing them |
GB775749A (en) * | 1955-04-06 | 1957-05-29 | Bofors Ab | Method of preparing amides of n-alkyl piperidine monocarboxylic acid and n-alkyl pyrrolidine -a-monocarboxylic acid |
US2799679A (en) * | 1955-04-28 | 1957-07-16 | Bofors Ab | Process of preparing amides of heterocyclic carboxylic acids |
GB775750A (en) * | 1955-04-28 | 1957-05-29 | Bofors Ab | Method of preparing amides of n-alkyl piperidine mono-carboxylic acid and n-alkyl pyrrolidine -a-monocarboxylic acid |
GB800565A (en) * | 1956-01-23 | 1958-08-27 | Bofors Ab | Method of producing n-alkyl-piperidine-ª‡-monocarboxylic acid amides and n-alkyl-pyrrolidine-ª‡-monocarboxylic acid amides |
GB824542A (en) * | 1957-05-15 | 1959-12-02 | Bofors Ab | Method of producing n-alkyl-piperidine-alpha-monocarboxylic acid amides |
GB869978A (en) * | 1958-03-13 | 1961-06-07 | Bofors Ab | Method of producing n-alkyl-and-cycloalkyl-piperidine carboxylic acid amides |
GB949729A (en) * | 1960-11-15 | 1964-02-19 | Bofors Ab | Substituted-piperidine carboxylic acid amide salts and their preparation |
SE341404B (da) * | 1967-05-18 | 1971-12-27 | Sterling Drug Inc | |
CH491915A (de) * | 1967-06-28 | 1970-06-15 | Geigy Ag J R | Verfahren zur Herstellung von neuen Piperidinderivaten |
US3879382A (en) * | 1971-08-27 | 1975-04-22 | Teijin Ltd | Process for the recovery of D- or L-{60 -amino-{68 -caprolactam hydrochloride of enhanced optical purity from mixtures of D- and L-{60 -amino-{68 -caprolactam hydrochloride |
SE7607114L (sv) * | 1976-06-22 | 1977-12-23 | Bofors Ab | Sett att framstella hydrokloriden av n-metylpiperidin-2-karbonsyra-2,6-xyllidid |
SE431092B (sv) * | 1979-07-10 | 1984-01-16 | Thuresson Af Ekenstam Bo | Terapeutiskt aktiva, substituerade piperidinkarboxianilider |
DE3379266D1 (en) * | 1983-08-01 | 1989-04-06 | Astra Laekemedel Ab | L-n-n-propylpipecolic acid-2,6-xylidide and method for preparing the same |
-
1986
- 1986-01-03 SE SE8600017A patent/SE451840B/sv not_active IP Right Cessation
- 1986-11-12 ZA ZA868600A patent/ZA868600B/xx unknown
- 1986-11-24 US US06/934,114 patent/US4870086A/en not_active Expired - Lifetime
- 1986-12-02 EG EG747/86A patent/EG17867A/xx active
- 1986-12-03 NO NO864858A patent/NO170330C/no not_active IP Right Cessation
- 1986-12-12 AU AU66449/86A patent/AU592392B2/en not_active Expired
- 1986-12-12 NZ NZ218615A patent/NZ218615A/xx unknown
- 1986-12-15 AT AT86850440T patent/ATE56956T1/de active
- 1986-12-15 DE DE8686850440T patent/DE3674582D1/de not_active Expired - Lifetime
- 1986-12-15 EP EP86850440A patent/EP0239710B1/en not_active Expired - Lifetime
- 1986-12-15 ES ES198686850440T patent/ES2036179T3/es not_active Expired - Lifetime
- 1986-12-15 PH PH34593A patent/PH22924A/en unknown
- 1986-12-26 JP JP61308983A patent/JPH07598B2/ja not_active Expired - Lifetime
- 1986-12-30 MY MYPI86000260A patent/MY101132A/en unknown
- 1986-12-30 CA CA000526453A patent/CA1276154C/en not_active Expired - Lifetime
- 1986-12-31 PT PT84041A patent/PT84041B/pt unknown
- 1986-12-31 KR KR1019860011720A patent/KR940008302B1/ko not_active IP Right Cessation
-
1987
- 1987-01-02 IE IE487A patent/IE59061B1/en not_active IP Right Cessation
- 1987-01-02 DK DK000287A patent/DK171378B1/da not_active IP Right Cessation
- 1987-01-02 FI FI870003A patent/FI83075C/fi not_active IP Right Cessation
-
1988
- 1988-12-17 AR AR88306211A patent/AR242561A1/es active
-
1990
- 1990-11-08 GR GR90400889T patent/GR3002516T3/el unknown
-
1992
- 1992-11-06 SG SG1172/92A patent/SG117292G/en unknown
-
1993
- 1993-01-21 HK HK54/93A patent/HK5493A/xx not_active IP Right Cessation
- 1993-10-10 CY CY1680A patent/CY1680A/xx unknown
-
1994
- 1994-02-18 BG BG098494A patent/BG62066B2/bg unknown
-
1996
- 1996-03-26 NL NL960005C patent/NL960005I2/nl unknown
- 1996-07-17 LV LV960261A patent/LV5765B4/xx unknown
- 1996-11-27 LU LU88843C patent/LU88843I2/fr unknown
-
1997
- 1997-07-31 NO NO1997009C patent/NO1997009I1/no unknown
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