CY1124718T1 - Ανθεκτικο στη διασπαση υαλουρονικο χαμηλου μοριακου βαρους με σταυροδεσμους - Google Patents
Ανθεκτικο στη διασπαση υαλουρονικο χαμηλου μοριακου βαρους με σταυροδεσμουςInfo
- Publication number
- CY1124718T1 CY1124718T1 CY20211100969T CY211100969T CY1124718T1 CY 1124718 T1 CY1124718 T1 CY 1124718T1 CY 20211100969 T CY20211100969 T CY 20211100969T CY 211100969 T CY211100969 T CY 211100969T CY 1124718 T1 CY1124718 T1 CY 1124718T1
- Authority
- CY
- Cyprus
- Prior art keywords
- cross
- linked
- molecular weight
- resistant
- low molecular
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
- C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
- C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
- C08B37/0072—Hyaluronic acid, i.e. HA or hyaluronan; Derivatives thereof, e.g. crosslinked hyaluronic acid (hylan) or hyaluronates
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L5/00—Compositions of polysaccharides or of their derivatives not provided for in groups C08L1/00 or C08L3/00
- C08L5/08—Chitin; Chondroitin sulfate; Hyaluronic acid; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/726—Glycosaminoglycans, i.e. mucopolysaccharides
- A61K31/728—Hyaluronic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/738—Cross-linked polysaccharides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/04—Dispersions; Emulsions
- A61K8/042—Gels
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/735—Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/14—Macromolecular materials
- A61L27/20—Polysaccharides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L27/52—Hydrogels or hydrocolloids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
- C08J3/00—Processes of treating or compounding macromolecular substances
- C08J3/02—Making solutions, dispersions, lattices or gels by other methods than by solution, emulsion or suspension polymerisation techniques
- C08J3/03—Making solutions, dispersions, lattices or gels by other methods than by solution, emulsion or suspension polymerisation techniques in aqueous media
- C08J3/075—Macromolecular gels
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
- C08J2305/00—Characterised by the use of polysaccharides or of their derivatives not provided for in groups C08J2301/00 or C08J2303/00
- C08J2305/08—Chitin; Chondroitin sulfate; Hyaluronic acid; Derivatives thereof
Abstract
Περιγράφεται βιοδιασπώμενο αλλά ανθεκτικό στη διάσπαση προϊόν που αποτελείται από ημιστερεά, διαυγή υδρογέλη υαλουρονικού οξέος χαμηλού μοριακού βάρους με σταυροδεσμούς που προέρχεται από υπόστρωμα υαλουρονικού νατρίου που έχει μοριακό βάρος από 50.000 έως 100.000 Da. To προϊόν έχει μεγάλη ανθεκτικότητα στην ενζυμική διάσπαση και προορίζεται για χρήση σε βιοϊατρικές, φαρμακευτικές και καλλυντικές εφαρμογές.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP11006559 | 2011-08-10 | ||
EP12755897.1A EP2742070B1 (en) | 2011-08-10 | 2012-07-31 | Degradation-resistant cross-linked, low-molecular-weight hyaluronate |
PCT/IB2012/001472 WO2013021249A1 (en) | 2011-08-10 | 2012-07-31 | Degradation-resistant cross-linked, low-molecular-weight hyaluronate |
Publications (1)
Publication Number | Publication Date |
---|---|
CY1124718T1 true CY1124718T1 (el) | 2022-07-22 |
Family
ID=46799277
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CY20211100969T CY1124718T1 (el) | 2011-08-10 | 2021-11-09 | Ανθεκτικο στη διασπαση υαλουρονικο χαμηλου μοριακου βαρους με σταυροδεσμους |
Country Status (13)
Country | Link |
---|---|
EP (1) | EP2742070B1 (el) |
CY (1) | CY1124718T1 (el) |
DK (1) | DK2742070T3 (el) |
ES (1) | ES2899992T3 (el) |
HR (1) | HRP20211659T1 (el) |
HU (1) | HUE056131T2 (el) |
LT (1) | LT2742070T (el) |
PL (1) | PL2742070T3 (el) |
PT (1) | PT2742070T (el) |
RS (1) | RS62488B1 (el) |
RU (1) | RU2613887C2 (el) |
SI (1) | SI2742070T1 (el) |
WO (1) | WO2013021249A1 (el) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP2892564A4 (en) * | 2012-09-06 | 2016-04-27 | Univ Nanyang Tech | HYALURONIC ACID MEDICINE DELIVERY SYSTEMS |
US9908948B2 (en) | 2014-08-29 | 2018-03-06 | Galderma S.A. | Enantiopure or enantioenriched BDDE and its use as crosslinking agent in the manufacture of cross-linked products |
WO2016057607A1 (en) * | 2014-10-08 | 2016-04-14 | Therakine | Micronized hydrophilic cross-linked biopolymer systems and method of making same |
RU2582702C1 (ru) * | 2015-08-19 | 2016-04-27 | федеральное государственное бюджетное учреждение "Федеральный научно-исследовательский центр эпидемиологии и микробиологии имени почетного академика Н.Ф. Гамалеи" Министерства здравоохранения Российской Федерации (ФГБУ "ФНИЦЭМ им. Н.Ф. Гамалеи" Минздрава России) | Способ получения композиции на основе модифицированного гиалуроната натрия, композиция на основе модифицированного гиалуроната натрия и ее применение |
KR101846271B1 (ko) * | 2015-11-13 | 2018-04-06 | 서강대학교산학협력단 | 유착 방지용 하이드로젤 및 이의 제조 방법 |
JP6660469B2 (ja) | 2015-11-24 | 2020-03-11 | ビーエムアイ コリア カンパニー リミテッド | ヒアルロン酸誘導体およびdna分画物が含まれているヒアルロン酸注射用組成物およびその利用 |
PL241064B1 (pl) * | 2018-10-01 | 2022-08-01 | Dolniak Blazej | Sposób wytwarzania lepko-sprężystego żelu uzupełniającego maź stawową i lepko-sprężysty żel uzupełniający maź stawową |
IT202000008299A1 (it) * | 2020-04-17 | 2021-10-17 | Glycores 2000 Srl | Composizione liquida oftalmica comprendente acido ialuronico lineare a basso peso molecolare |
CN113413484B (zh) * | 2021-06-21 | 2023-02-10 | 浙江苏嘉医疗器械股份有限公司 | 可用于人体软组织填充的植入材料 |
Family Cites Families (21)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4716224A (en) | 1984-05-04 | 1987-12-29 | Seikagaku Kogyo Co. Ltd. | Crosslinked hyaluronic acid and its use |
SE442820B (sv) | 1984-06-08 | 1986-02-03 | Pharmacia Ab | Gel av tverbunden hyaluronsyra for anvendning som glaskroppssubstitut |
US4582865A (en) | 1984-12-06 | 1986-04-15 | Biomatrix, Inc. | Cross-linked gels of hyaluronic acid and products containing such gels |
US4713448A (en) | 1985-03-12 | 1987-12-15 | Biomatrix, Inc. | Chemically modified hyaluronic acid preparation and method of recovery thereof from animal tissues |
SE452469B (sv) | 1986-06-18 | 1987-11-30 | Pharmacia Ab | Material bestaende av en tverbunden karboxylgrupphaltig polysackarid och forfarande vid framstellning av detsamma |
US5017229A (en) | 1990-06-25 | 1991-05-21 | Genzyme Corporation | Water insoluble derivatives of hyaluronic acid |
SE8900422D0 (sv) | 1989-02-08 | 1989-02-08 | Pharmacia Ab | Tvaerbundna hyaluronatgeler samt foerfarande foer framstaellning av dessa |
US5356883A (en) | 1989-08-01 | 1994-10-18 | Research Foundation Of State University Of N.Y. | Water-insoluble derivatives of hyaluronic acid and their methods of preparation and use |
TWI251596B (en) * | 2002-12-31 | 2006-03-21 | Ind Tech Res Inst | Method for producing a double-crosslinked hyaluronate material |
JP2004323454A (ja) | 2003-04-25 | 2004-11-18 | Chisso Corp | 薬剤 |
JP5016926B2 (ja) | 2003-12-30 | 2012-09-05 | ジェンザイム・コーポレーション | 架橋したヒアルロナンおよび/またはハイランに由来する粘着性ゲル、その調製および使用法 |
US20050281880A1 (en) | 2004-05-20 | 2005-12-22 | Wei Wang | Methods for making injectable polymer hydrogels |
EP1817347B1 (en) | 2004-11-24 | 2017-05-17 | Albumedix A/S | Method of cross-linking hyaluronic acid with divinylsulfone |
EP2037874A1 (en) * | 2006-06-28 | 2009-03-25 | Novozymes Biopolymer A/S | Compositions with several hyaluronic acid fractions for cosmetic and medical uses |
KR20080062092A (ko) * | 2006-12-29 | 2008-07-03 | 주식회사 핸슨바이오텍 | 세포전달체로서의 히알루론산 유도체 및 이의 제조 방법 |
KR20080073419A (ko) * | 2007-02-06 | 2008-08-11 | 주식회사 핸슨바이오텍 | 의료용 히알루론산 유도체 마이크로비드 및 이의 제조 방법 |
JP2008255061A (ja) * | 2007-04-06 | 2008-10-23 | Shiseido Co Ltd | 可溶性架橋ヒアルロン酸含有眼用組成物 |
US8357795B2 (en) * | 2008-08-04 | 2013-01-22 | Allergan, Inc. | Hyaluronic acid-based gels including lidocaine |
GB0816496D0 (en) | 2008-09-10 | 2008-10-15 | Zhao Xiaobin | Hyaluronic acid cryogel |
CN101721349B (zh) * | 2008-10-16 | 2011-07-20 | 常州百瑞吉生物医药有限公司 | 可注射原位交联水凝胶及其制备方法和用途 |
IT1395392B1 (it) * | 2009-08-27 | 2012-09-14 | Fidia Farmaceutici | Geli viscoelastici come nuovi filler |
-
2012
- 2012-07-31 HU HUE12755897A patent/HUE056131T2/hu unknown
- 2012-07-31 EP EP12755897.1A patent/EP2742070B1/en active Active
- 2012-07-31 WO PCT/IB2012/001472 patent/WO2013021249A1/en active Application Filing
- 2012-07-31 DK DK12755897.1T patent/DK2742070T3/da active
- 2012-07-31 PT PT127558971T patent/PT2742070T/pt unknown
- 2012-07-31 LT LTEPPCT/IB2012/001472T patent/LT2742070T/lt unknown
- 2012-07-31 SI SI201231951T patent/SI2742070T1/sl unknown
- 2012-07-31 RS RS20211234A patent/RS62488B1/sr unknown
- 2012-07-31 ES ES12755897T patent/ES2899992T3/es active Active
- 2012-07-31 RU RU2014108821A patent/RU2613887C2/ru active
- 2012-07-31 HR HRP20211659TT patent/HRP20211659T1/hr unknown
- 2012-07-31 PL PL12755897T patent/PL2742070T3/pl unknown
-
2021
- 2021-11-09 CY CY20211100969T patent/CY1124718T1/el unknown
Also Published As
Publication number | Publication date |
---|---|
RS62488B1 (sr) | 2021-11-30 |
RU2613887C2 (ru) | 2017-03-21 |
ES2899992T3 (es) | 2022-03-15 |
RU2014108821A (ru) | 2015-09-20 |
HRP20211659T1 (hr) | 2022-02-04 |
HUE056131T2 (hu) | 2022-01-28 |
DK2742070T3 (da) | 2021-11-08 |
EP2742070A1 (en) | 2014-06-18 |
LT2742070T (lt) | 2021-10-25 |
PL2742070T3 (pl) | 2022-01-31 |
SI2742070T1 (sl) | 2021-11-30 |
WO2013021249A1 (en) | 2013-02-14 |
EP2742070B1 (en) | 2021-09-15 |
PT2742070T (pt) | 2021-11-22 |
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