CY1123674T1 - Συνθεσεις και μεθοδοι για τη θεραπεια δερματικου τ κυτταρικου λεμφωματος - Google Patents

Συνθεσεις και μεθοδοι για τη θεραπεια δερματικου τ κυτταρικου λεμφωματος

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Publication number
CY1123674T1
CY1123674T1 CY20201101178T CY201101178T CY1123674T1 CY 1123674 T1 CY1123674 T1 CY 1123674T1 CY 20201101178 T CY20201101178 T CY 20201101178T CY 201101178 T CY201101178 T CY 201101178T CY 1123674 T1 CY1123674 T1 CY 1123674T1
Authority
CY
Cyprus
Prior art keywords
cutaneous
cell lymphoma
compositions
treatment
methods
Prior art date
Application number
CY20201101178T
Other languages
English (en)
Inventor
Alain H. Rook
Joel M. GELFAND
Maria M. WYSOCKA
Bernice M. Benoit
Andrea Beth Troxel
Original Assignee
The Trustees Of The University Of Pennsylvania
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by The Trustees Of The University Of Pennsylvania filed Critical The Trustees Of The University Of Pennsylvania
Publication of CY1123674T1 publication Critical patent/CY1123674T1/el

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0021—Intradermal administration, e.g. through microneedle arrays, needleless injectors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue

Landscapes

  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Dermatology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Η παρούσα εφεύρεση παρέχει μεθόδους για τη θεραπεία ενός ατόμου με δερματικό Τ κυτταρικό λέμφωμα (CTCL). Σε μια εκδοχή, σε ένα άτομο χορηγείται μια δραστική ποσότητα μιας ένωσης IRM όπου τουλάχιστον ένα σύμπτωμα ή ένα κλινικό σημείο του CTCL αμβλύνεται. Η παρούσα εφεύρεση περιλαμβάνει επιπλέον μια μέθοδο αύξησης μιας κυτταρικής ανοσολογικής απόκρισης ενός κυτταρικού πληθυσμού που περιλαμβάνει κύτταρα τα οποία έχουν προσβληθεί από CTCL. Σε μια εκδοχή, μια αποτελεσματική ποσότητα του κυτταρικού πληθυσμού έρχεται σε επαφή με μια ένωση IRM όπου τουλάχιστον μια κυτταρική ανοσολογική απόκριση του κυτταρικού πληθυσμού αυξάνεται.
CY20201101178T 2013-01-07 2020-12-14 Συνθεσεις και μεθοδοι για τη θεραπεια δερματικου τ κυτταρικου λεμφωματος CY1123674T1 (el)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201361749739P 2013-01-07 2013-01-07
PCT/US2014/010339 WO2014107663A2 (en) 2013-01-07 2014-01-06 Compositions and methods for treating cutaneous t cell lymphoma

Publications (1)

Publication Number Publication Date
CY1123674T1 true CY1123674T1 (el) 2022-03-24

Family

ID=51062559

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20201101178T CY1123674T1 (el) 2013-01-07 2020-12-14 Συνθεσεις και μεθοδοι για τη θεραπεια δερματικου τ κυτταρικου λεμφωματος

Country Status (21)

Country Link
US (1) US20150335637A1 (el)
EP (2) EP2941233B1 (el)
JP (3) JP6457401B2 (el)
KR (1) KR20150103718A (el)
CN (1) CN105025854A (el)
AU (1) AU2014203896B2 (el)
CA (1) CA2896966C (el)
CY (1) CY1123674T1 (el)
DK (1) DK2941233T3 (el)
ES (1) ES2828735T3 (el)
HK (1) HK1217165A1 (el)
HR (1) HRP20201630T1 (el)
HU (1) HUE051988T2 (el)
LT (1) LT2941233T (el)
MX (1) MX2015008773A (el)
PL (1) PL2941233T3 (el)
PT (1) PT2941233T (el)
RS (1) RS61101B1 (el)
RU (1) RU2669941C2 (el)
SI (1) SI2941233T1 (el)
WO (1) WO2014107663A2 (el)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT2941233T (pt) * 2013-01-07 2020-11-13 Univ Pennsylvania Composições e métodos para tratar linfoma cutâneo de células t
US11179385B2 (en) 2015-06-30 2021-11-23 The Trustees Of The University Of Pennsylvania Resiquimod topical and injectable compositions for the treatment of neoplastic skin conditions

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