CY1123651T1 - Ολιγοσακχαριτης και διαδικασια παρασκευης αυτου - Google Patents
Ολιγοσακχαριτης και διαδικασια παρασκευης αυτουInfo
- Publication number
- CY1123651T1 CY1123651T1 CY20201101214T CY201101214T CY1123651T1 CY 1123651 T1 CY1123651 T1 CY 1123651T1 CY 20201101214 T CY20201101214 T CY 20201101214T CY 201101214 T CY201101214 T CY 201101214T CY 1123651 T1 CY1123651 T1 CY 1123651T1
- Authority
- CY
- Cyprus
- Prior art keywords
- oligosaccharide
- weight
- less
- molecular weight
- daltons
- Prior art date
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/716—Glucans
- A61K31/721—Dextrans
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- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
- C08B37/0006—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid
- C08B37/0009—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid alpha-D-Glucans, e.g. polydextrose, alternan, glycogen; (alpha-1,4)(alpha-1,6)-D-Glucans; (alpha-1,3)(alpha-1,4)-D-Glucans, e.g. isolichenan or nigeran; (alpha-1,4)-D-Glucans; (alpha-1,3)-D-Glucans, e.g. pseudonigeran; Derivatives thereof
- C08B37/0021—Dextran, i.e. (alpha-1,4)-D-glucan; Derivatives thereof, e.g. Sephadex, i.e. crosslinked dextran
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/02—Nutrients, e.g. vitamins, minerals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/06—Antianaemics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H3/00—Compounds containing only hydrogen atoms and saccharide radicals having only carbon, hydrogen, and oxygen atoms
- C07H3/06—Oligosaccharides, i.e. having three to five saccharide radicals attached to each other by glycosidic linkages
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Organic Chemistry (AREA)
- Biochemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Polymers & Plastics (AREA)
- Materials Engineering (AREA)
- Genetics & Genomics (AREA)
- Biotechnology (AREA)
- Hematology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Diabetes (AREA)
- Dermatology (AREA)
- Obesity (AREA)
- Nutrition Science (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
- Saccharide Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Η εφεύρεση αναφέρεται σε έναν ολιγοσακχαρίτη ο οποίος έχει μέσο μοριακό βάρος κατά βάρος (Mw) μικρότερο από 3.000 Dalton, όπου ο εν λόγω ολιγοσακχαρίτης περιλαμβάνει λειτουργικές ομάδες αλδεΰδης και έχει περιεκτικότητα διμερούς σακχαρίτη 2,9 % κατά βάρος ή μικρότερη, με βάση το ολικό βάρος του υδρογονωμένου ολιγοσακχαρίτη. Η εφεύρεση αναφέρεται επίσης σε μία διαδικασία παρασκευής του ολιγοσακχαρίτη, η οποία διαδικασία περιλαμβάνει τα εξής βήματα: υδρόλυση ενός πολυσακχαρίτη ώστε να μειωθεί το μοριακό του βάρος, όπου ο προκύπτων ολιγοσακχαρίτης περιλαμβάνει λειτουργικές ομάδες αλδεΰδης, και κλασμάτωση του ολιγοσακχαρίτη σύμφωνα με το μοριακό βάρος, ούτως ώστε το καθαρό κλάσμα να έχει μέσο μοριακό βάρος κατά βάρος ίσο προς ή μικρότερο από 3.000 Dalton. Η διαδικασία καθαρισμού πραγματοποιείται μέσω μίας ή περισσότερων διεργασιών μεμβράνης, που έχουν τιμή αποκοπής μεταξύ 340 και 800 Dalton, η οποία διαδικασία συνεχίζεται έως ότου μειωθεί η περιεκτικότητα διμερούς σακχαρίτη στο καθαρό κλάσμα του ολιγοσακχαρίτη σε 2,9 % κατά βάρος ή λιγότερο, με βάση το ολικό βάρος του υδρογονωμένου ολιγοσακχαρίτη.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP16201189.4A EP3156075B1 (en) | 2009-03-25 | 2009-03-25 | An oligosaccharide and a process for preparation thereof |
| PCT/DK2009/050069 WO2010108493A1 (en) | 2009-03-25 | 2009-03-25 | A stable iron oligosaccharide compound |
| EP09776213.2A EP2411053B1 (en) | 2009-03-25 | 2009-03-25 | A stable iron oligosaccharide compound |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CY1123651T1 true CY1123651T1 (el) | 2022-03-24 |
Family
ID=41350678
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CY20171100226T CY1118725T1 (el) | 2009-03-25 | 2017-02-20 | Σταθερη ενωση σιδηρου-ολιγοσακχαριτη |
| CY20201101214T CY1123651T1 (el) | 2009-03-25 | 2020-12-23 | Ολιγοσακχαριτης και διαδικασια παρασκευης αυτου |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CY20171100226T CY1118725T1 (el) | 2009-03-25 | 2017-02-20 | Σταθερη ενωση σιδηρου-ολιγοσακχαριτη |
Country Status (26)
| Country | Link |
|---|---|
| US (7) | US8815301B2 (el) |
| EP (3) | EP3156075B1 (el) |
| JP (1) | JP5426010B2 (el) |
| KR (1) | KR101580348B1 (el) |
| CN (3) | CN102361651A (el) |
| AU (1) | AU2009342799B2 (el) |
| BR (1) | BRPI0924653B8 (el) |
| CA (1) | CA2756580A1 (el) |
| CY (2) | CY1118725T1 (el) |
| DK (2) | DK3156075T3 (el) |
| EA (1) | EA023917B1 (el) |
| ES (2) | ES2840074T3 (el) |
| HK (1) | HK1164138A1 (el) |
| HR (2) | HRP20170230T1 (el) |
| HU (2) | HUE052617T2 (el) |
| LT (2) | LT3156075T (el) |
| MX (1) | MX2011009936A (el) |
| NZ (1) | NZ595597A (el) |
| PH (1) | PH12015500891B1 (el) |
| PL (2) | PL2411053T3 (el) |
| PT (2) | PT3156075T (el) |
| RS (2) | RS55700B1 (el) |
| SI (2) | SI3156075T1 (el) |
| UA (1) | UA103373C2 (el) |
| WO (1) | WO2010108493A1 (el) |
| ZA (1) | ZA201107431B (el) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2626074A1 (en) | 2006-01-06 | 2013-08-14 | Luitpold Pharmaceuticals, Inc. | Methods and compositions for administration of iron |
| EP3156075B1 (en) | 2009-03-25 | 2020-10-14 | Pharmacosmos Holding A/S | An oligosaccharide and a process for preparation thereof |
| CN103626807B (zh) * | 2013-11-20 | 2017-07-07 | 青岛国风药业股份有限公司 | 一种多糖铁复合物的制备方法及其质量检测方法 |
| CZ2014451A3 (cs) * | 2014-06-30 | 2016-01-13 | Contipro Pharma A.S. | Protinádorová kompozice na bázi kyseliny hyaluronové a anorganických nanočástic, způsob její přípravy a použití |
| HUE045092T2 (hu) * | 2014-10-27 | 2019-12-30 | Pharmacosmos Holding As | Vérszegénység kezelése vagy megelõzése vemhes nem-humán emlõsökben és utódaikban |
| EP3310364B1 (en) * | 2015-06-22 | 2021-09-15 | Pharmacosmos Holding A/s | Iron carbohydrate complex for treatment of iron deficiency of a fetus or an infant |
| CA2932075C (en) * | 2015-09-01 | 2020-11-17 | Particle Dynamics International, Llc | Iron-polysaccharide complexes and methods for the preparation thereof |
| US10258647B2 (en) | 2015-09-01 | 2019-04-16 | Particle Dynamics International, Llc | Iron-polysaccharide complexes and methods for the preparation thereof |
| CN105908611A (zh) * | 2016-06-12 | 2016-08-31 | 天津康远工程机械有限公司 | 具有清洗功能的自动找平双层预应力烫平板 |
| EP3450443A1 (en) | 2017-08-29 | 2019-03-06 | Jennewein Biotechnologie GmbH | Process for purifying sialylated oligosaccharides |
| JP7426927B2 (ja) | 2017-09-11 | 2024-02-02 | ファーマコスモス ホールディング エー／エス | 治療的使用のための鉄錯体化合 |
| CN109646454A (zh) * | 2018-12-29 | 2019-04-19 | 博瑞生物医药（苏州）股份有限公司 | 异麦芽糖酐铁1000的制备方法 |
| US20220062331A1 (en) | 2019-01-10 | 2022-03-03 | Pharmacosmos Holding A/S | Treating iron deficiency in subjects at risk of cardiovascular adverse events and iron for the management of atrial fibrillation |
| EA202191858A1 (ru) | 2019-06-12 | 2021-11-12 | Фармакосмос Холдинг А/С | Лечение дефицита железа у субъектов с риском нежелательных явлений со стороны сердечно-сосудистой системы и железо для лечения фибрилляции предсердий |
| US11447513B2 (en) * | 2020-02-12 | 2022-09-20 | Rk Pharma Inc. | Purification process of ferric carboxymaltose |
| BR112024002150A2 (pt) | 2021-08-03 | 2024-04-30 | Pharmacosmos Holding As | Compostos de complexo de ferro para uso subcutâneo na terapia de deficiência de ferro em animais de companhia |
| WO2024069644A1 (en) * | 2022-09-30 | 2024-04-04 | West Bengal Chemical Industries Limited | A pharmaceutically acceptable ferric carboxymaltose and preparation thereof |
| CN116672360B (zh) * | 2023-06-30 | 2024-05-14 | 重庆汉佩生物科技有限公司 | 一种妥曲珠利与葡庚糖酐铁的组合物 |
| CN116726045B (zh) * | 2023-06-30 | 2024-03-19 | 重庆汉佩生物科技有限公司 | 一种氟雷拉纳组合物 |
Family Cites Families (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA623412A (en) | 1961-07-04 | Muller Arthur | Iron polyisomaltose complexes for therapeutical application | |
| CA623411A (en) | 1961-07-04 | Muller Arthur | Process for the manufacture of iron-polyisomaltose complex for therapeutical purposes | |
| US2807610A (en) * | 1952-02-15 | 1957-09-24 | Baker Chem Co J T | Hydrogenated dextran |
| US3100202A (en) | 1960-06-17 | 1963-08-06 | Muller Arthur | Process for preparing an iron hydroxide polyisomaltose complex and the resulting product |
| US3076798A (en) | 1961-02-23 | 1963-02-05 | Hausmann Lab Ltd | Process for preparing a ferric hydroxide polymaltose complex |
| DE1293144B (de) | 1964-11-04 | 1969-04-24 | Hausmann Ag Labor | Verfahren zur Herstellung von Komplexverbindungen des Eisens mit Sorbit, Gluconsaeure und einem Oligosaccharid |
| US3639588A (en) | 1966-10-22 | 1972-02-01 | Fisons Pharmaceuticals Ltd | Pharmaceutical compositions containing ferric hydroxide complexed with dextran or dextrin heptonic acids |
| GB1594697A (en) * | 1977-04-19 | 1981-08-05 | Pharmacia Ab | Oligosaccharide compositions for parenteral use |
| DE3026868C2 (de) | 1980-07-16 | 1986-03-13 | Laboratorien Hausmann AG, St. Gallen | Verfahren zur Herstellung von Eisen(III)hydroxid-Dextran-Komplexen und sie enthaltende pharmazeutische sterile wäßrige Lösung |
| US4518581A (en) * | 1981-11-02 | 1985-05-21 | Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo | Imparting low- or anti-cariogenic property to orally-usable products |
| DE3422249A1 (de) | 1984-06-15 | 1985-12-19 | Pfeifer & Langen, 5000 Köln | Wasserloesliches eisendextran und verfahren zu seiner herstellung |
| US5624668A (en) | 1995-09-29 | 1997-04-29 | Luitpold Pharmaceuticals, Inc. | Iron dextran formulations |
| US6219440B1 (en) | 1997-01-17 | 2001-04-17 | The University Of Connecticut | Method and apparatus for modeling cellular structure and function |
| DK172860B1 (da) * | 1998-03-25 | 1999-08-16 | Pharmacosmos Holding As | Jerndextranforbindelse til anvendelse som komponent i et terapeutisk middel til forebyggelse af eller behandling af jernman |
| DK173138B1 (da) | 1998-11-20 | 2000-02-07 | Pharmacosmos Holding As | Fremgangsmåde til fremstilling af en jerndextranforbindelse, jerndextranforbindelse fremstillet efter fremgangsmåden, farma |
| US7871597B2 (en) | 1999-04-09 | 2011-01-18 | Amag Pharmaceuticals, Inc. | Polyol and polyether iron oxide complexes as pharmacological and/or MRI contrast agents |
| DE60043188D1 (de) | 1999-04-09 | 2009-12-03 | Amag Pharmaceuticals Inc | Hitzebeständige umhüllte kolloidale eisenoxide |
| KR20020096284A (ko) * | 2001-06-19 | 2002-12-31 | 현대자동차주식회사 | 자동차의 연료 누유 진단장치 |
| BR0308773A (pt) * | 2002-04-09 | 2005-02-09 | Pharmacosmos Holding As | Compostos de dextrina de ferro para tratamento de anemia por deficiência de ferro |
| DE10249552A1 (de) | 2002-10-23 | 2004-05-13 | Vifor (International) Ag | Wasserlösliche Eisen-Kohlenhydrat-Komplexe, deren Herstellung und diese enthaltende Arzneimittel |
| US20060116349A1 (en) | 2003-03-14 | 2006-06-01 | Luitpold Pharmaceuticals, Inc. | Methods and compositions for administration of iron for the treatment of restless leg syndrome |
| US6960571B2 (en) | 2003-03-14 | 2005-11-01 | Luitpold Pharmaceuticals, Inc. | Methods and compositions for administration of iron for the treatment of restless leg syndrome |
| US7964568B2 (en) * | 2003-05-30 | 2011-06-21 | Chromaceutical Advanced Technologies, Inc. | Synthesis of high molecular weight iron-saccharidic complexes |
| EP1848446B1 (de) * | 2005-02-09 | 2009-10-14 | Vifor (International) Ag | Verwendung von eisen(iii)-komplexverbindungen |
| ITMO20050056A1 (it) | 2005-03-15 | 2006-09-16 | Biofer Spa | Processo per la preparazione di complessi del ferro trivalente con zuccheri mono-, di- e polisaccaridi. |
| CN100528237C (zh) * | 2005-04-26 | 2009-08-19 | 重庆医药工业研究院有限责任公司 | 多核的氢氧化铁-糖复合物的制备方法 |
| EP1757299A1 (de) | 2005-08-25 | 2007-02-28 | Vifor (International) Ag | Eisen(III)-Komplexverbindungen zur Behandlung von Eisenmangel-Zuständen bei Patienten mit chronisch-entzündlicher Darmerkrankung |
| EP2626074A1 (en) | 2006-01-06 | 2013-08-14 | Luitpold Pharmaceuticals, Inc. | Methods and compositions for administration of iron |
| EP1997833A1 (de) | 2007-05-29 | 2008-12-03 | Vifor (International) Ag | Wasserlösliche Eisen-Kohlenhydratderivat-Komplexe, deren Herstellung und diese enthaltende Arzneimittel |
| EP3156075B1 (en) | 2009-03-25 | 2020-10-14 | Pharmacosmos Holding A/S | An oligosaccharide and a process for preparation thereof |
| WO2014058516A1 (en) | 2012-07-27 | 2014-04-17 | Luitpold Pharmaceuticals, Inc. | Method of treating iron deficiency anemia |
| US20140121193A1 (en) | 2012-11-01 | 2014-05-01 | Robert S. Katz | Methods for treating fibromyalgia |
| SG11201504116SA (en) | 2012-11-30 | 2015-06-29 | Pharmacosmos As | Cryoprotecting agent, cryoprotecting and cryopreserved compositions, uses thereof, and methods of cryopreservation |
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2009
- 2009-03-25 EP EP16201189.4A patent/EP3156075B1/en active Active
- 2009-03-25 PT PT162011894T patent/PT3156075T/pt unknown
- 2009-03-25 EA EA201190214A patent/EA023917B1/ru not_active IP Right Cessation
- 2009-03-25 DK DK16201189.4T patent/DK3156075T3/da active
- 2009-03-25 US US13/138,669 patent/US8815301B2/en active Active
- 2009-03-25 EP EP20200455.2A patent/EP3821910A1/en active Pending
- 2009-03-25 AU AU2009342799A patent/AU2009342799B2/en active Active
- 2009-03-25 RS RS20170157A patent/RS55700B1/sr unknown
- 2009-03-25 BR BRPI0924653A patent/BRPI0924653B8/pt active IP Right Grant
- 2009-03-25 ES ES16201189T patent/ES2840074T3/es active Active
- 2009-03-25 MX MX2011009936A patent/MX2011009936A/es active IP Right Grant
- 2009-03-25 WO PCT/DK2009/050069 patent/WO2010108493A1/en active Application Filing
- 2009-03-25 LT LTEP16201189.4T patent/LT3156075T/lt unknown
- 2009-03-25 CN CN2009801582967A patent/CN102361651A/zh active Pending
- 2009-03-25 ES ES09776213.2T patent/ES2617658T3/es active Active
- 2009-03-25 LT LTEP09776213.2T patent/LT2411053T/lt unknown
- 2009-03-25 PL PL09776213T patent/PL2411053T3/pl unknown
- 2009-03-25 HU HUE16201189A patent/HUE052617T2/hu unknown
- 2009-03-25 SI SI200932104T patent/SI3156075T1/sl unknown
- 2009-03-25 PL PL16201189T patent/PL3156075T3/pl unknown
- 2009-03-25 UA UAA201111767A patent/UA103373C2/ru unknown
- 2009-03-25 RS RS20201417A patent/RS61104B1/sr unknown
- 2009-03-25 HU HUE09776213A patent/HUE030866T2/en unknown
- 2009-03-25 KR KR1020117025035A patent/KR101580348B1/ko active IP Right Grant
- 2009-03-25 CA CA2756580A patent/CA2756580A1/en not_active Abandoned
- 2009-03-25 CN CN201810292732.0A patent/CN108752395A/zh active Pending
- 2009-03-25 JP JP2012501133A patent/JP5426010B2/ja active Active
- 2009-03-25 EP EP09776213.2A patent/EP2411053B1/en active Active
- 2009-03-25 DK DK09776213.2T patent/DK2411053T3/en active
- 2009-03-25 NZ NZ595597A patent/NZ595597A/xx unknown
- 2009-03-25 CN CN201810296939.5A patent/CN109700828A/zh active Pending
- 2009-03-25 SI SI200931621A patent/SI2411053T1/sl unknown
- 2009-03-25 PT PT97762132T patent/PT2411053T/pt unknown
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2011
- 2011-10-11 ZA ZA2011/07431A patent/ZA201107431B/en unknown
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2012
- 2012-05-18 HK HK12104882.9A patent/HK1164138A1/zh unknown
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2014
- 2014-06-18 US US14/308,198 patent/US20140364598A1/en not_active Abandoned
- 2014-06-18 US US14/307,957 patent/US9439969B2/en active Active
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2015
- 2015-04-21 PH PH12015500891A patent/PH12015500891B1/en unknown
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2016
- 2016-07-28 US US15/222,306 patent/US10865255B2/en active Active
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2017
- 2017-02-13 HR HRP20170230TT patent/HRP20170230T1/hr unknown
- 2017-02-20 CY CY20171100226T patent/CY1118725T1/el unknown
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2018
- 2018-11-02 US US16/178,943 patent/US10414831B2/en active Active
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2020
- 2020-10-29 US US17/083,366 patent/US20210108004A1/en active Pending
- 2020-11-30 HR HRP20201903TT patent/HRP20201903T1/hr unknown
- 2020-12-23 CY CY20201101214T patent/CY1123651T1/el unknown
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2021
- 2021-01-06 US US17/142,442 patent/US11851504B2/en active Active
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