BRPI0720991A8 - Preparação da romidepsina - Google Patents

Preparação da romidepsina

Info

Publication number
BRPI0720991A8
BRPI0720991A8 BRPI0720991A BRPI0720991A BRPI0720991A8 BR PI0720991 A8 BRPI0720991 A8 BR PI0720991A8 BR PI0720991 A BRPI0720991 A BR PI0720991A BR PI0720991 A BRPI0720991 A BR PI0720991A BR PI0720991 A8 BRPI0720991 A8 BR PI0720991A8
Authority
BR
Brazil
Prior art keywords
romidepsin
preparation
adducts
oligomerized
dimerized
Prior art date
Application number
BRPI0720991A
Other languages
English (en)
Inventor
L Verdine Gregory
H Vrolijk Nicholas
Bertel Stephan
Original Assignee
Gloucester Pharmaceuticals Inc
Celgene Corp
Sandoz Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gloucester Pharmaceuticals Inc, Celgene Corp, Sandoz Ag filed Critical Gloucester Pharmaceuticals Inc
Publication of BRPI0720991A2 publication Critical patent/BRPI0720991A2/pt
Publication of BRPI0720991A8 publication Critical patent/BRPI0720991A8/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1002—Tetrapeptides with the first amino acid being neutral
    • C07K5/1005—Tetrapeptides with the first amino acid being neutral and aliphatic
    • C07K5/101—Tetrapeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms, e.g. Val, Ile, Leu
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Abstract

PREPARAÇÃO DA ROMIDEPSINA. A presente invenção proporciona um processo aperfeiçoado para a preparação de romidepsina. O processo envolve a produção, purificação ou a armazenagem da romidepsina sob condições que impeçam a formação de adutos indesejáveis. A purificação de romidepsina em pH aparente mais baixo do que aproximadamente 6,0 (por exemplo, entre um pH aparente do 4,0 e 6,0) foi descoberta como impedindo a redução da ligação de dissulfeto da romidepsina e a formação subsequente de adutos dimerizados, oligomerizados, ou polimerizados. A invenção também proporciona composições farmacêuticas de romidepsina monomérica isenta de adutos dimerizados, oligomerizados, ou polimerizados.
BRPI0720991A 2006-12-29 2007-12-28 Preparação da romidepsina BRPI0720991A8 (pt)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US88269806P 2006-12-29 2006-12-29
US88270406P 2006-12-29 2006-12-29
US60/882,704 2006-12-29
US60/882,698 2006-12-29
PCT/US2007/089067 WO2008083288A2 (en) 2006-12-29 2007-12-28 Purifiction of romidepsin

Publications (2)

Publication Number Publication Date
BRPI0720991A2 BRPI0720991A2 (pt) 2014-03-18
BRPI0720991A8 true BRPI0720991A8 (pt) 2016-03-15

Family

ID=39493420

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0720991A BRPI0720991A8 (pt) 2006-12-29 2007-12-28 Preparação da romidepsina

Country Status (10)

Country Link
US (2) US8691534B2 (pt)
EP (1) EP2102230A2 (pt)
JP (1) JP2010514801A (pt)
CN (2) CN101801994A (pt)
AU (1) AU2007342028B2 (pt)
BR (1) BRPI0720991A8 (pt)
CA (1) CA2674309A1 (pt)
IL (1) IL199547A (pt)
MX (1) MX2009006969A (pt)
WO (1) WO2008083288A2 (pt)

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AU2013202506B2 (en) 2012-09-07 2015-06-18 Celgene Corporation Resistance biomarkers for hdac inhibitors
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CN103173390B (zh) * 2013-03-16 2014-09-10 浙江海正药业股份有限公司 一种紫色杆菌菌株及其应用
CN104072589B (zh) * 2013-03-29 2017-09-22 浙江海正药业股份有限公司 抗肿瘤三硫化合物及其制备方法与应用
CN104450837B (zh) * 2013-09-18 2019-01-01 上海医药工业研究院 一种用于生产罗米地辛的方法及发酵培养基
CN104447950A (zh) * 2013-09-18 2015-03-25 上海医药工业研究院 一种罗米地辛的分离纯化方法
NZ630311A (en) 2013-12-27 2016-03-31 Celgene Corp Romidepsin formulations and uses thereof
CN104262456B (zh) * 2014-09-11 2018-01-09 浙江海正药业股份有限公司 一种罗米地辛的新晶型及其制备方法和用途
CN109796521B (zh) * 2017-11-17 2022-04-19 上海医药工业研究院 一种罗米地辛醋酸盐晶型及其制备方法
US20220049213A1 (en) * 2018-12-24 2022-02-17 Marrone Bio Innovations, Inc. A method for increasing romidepsin production from fermentation broth
CN113549131B (zh) * 2021-08-05 2023-01-17 台州科技职业学院 一种合成罗米地辛二聚合物romipeptide A的制备方法

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Also Published As

Publication number Publication date
WO2008083288A3 (en) 2008-10-02
IL199547A (en) 2017-09-28
WO2008083288A2 (en) 2008-07-10
EP2102230A2 (en) 2009-09-23
JP2010514801A (ja) 2010-05-06
CA2674309A1 (en) 2008-07-10
BRPI0720991A2 (pt) 2014-03-18
US8691534B2 (en) 2014-04-08
CN101801994A (zh) 2010-08-11
CN107090482A (zh) 2017-08-25
AU2007342028B2 (en) 2013-06-13
AU2007342028A1 (en) 2008-07-10
US20090209616A1 (en) 2009-08-20
MX2009006969A (es) 2010-04-07
US20090186382A1 (en) 2009-07-23

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