CY1122632T1 - Μεθοδοι για μελετη πυρηνικων οξεων - Google Patents
Μεθοδοι για μελετη πυρηνικων οξεωνInfo
- Publication number
- CY1122632T1 CY1122632T1 CY20201100053T CY201100053T CY1122632T1 CY 1122632 T1 CY1122632 T1 CY 1122632T1 CY 20201100053 T CY20201100053 T CY 20201100053T CY 201100053 T CY201100053 T CY 201100053T CY 1122632 T1 CY1122632 T1 CY 1122632T1
- Authority
- CY
- Cyprus
- Prior art keywords
- nucleic acid
- chromatin
- isolating
- molecular interactions
- agent
- Prior art date
Links
- 150000007523 nucleic acids Chemical class 0.000 title abstract 9
- 102000039446 nucleic acids Human genes 0.000 title abstract 9
- 108020004707 nucleic acids Proteins 0.000 title abstract 9
- 238000000034 method Methods 0.000 title abstract 6
- 108010077544 Chromatin Proteins 0.000 abstract 8
- 210000003483 chromatin Anatomy 0.000 abstract 8
- 238000012163 sequencing technique Methods 0.000 abstract 4
- 230000004001 molecular interaction Effects 0.000 abstract 3
- 102000008579 Transposases Human genes 0.000 abstract 2
- 108010020764 Transposases Proteins 0.000 abstract 2
- 239000011230 binding agent Substances 0.000 abstract 2
- 239000003795 chemical substances by application Substances 0.000 abstract 2
- 230000003321 amplification Effects 0.000 abstract 1
- 238000002955 isolation Methods 0.000 abstract 1
- 238000013507 mapping Methods 0.000 abstract 1
- 238000003199 nucleic acid amplification method Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C40—COMBINATORIAL TECHNOLOGY
- C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
- C40B50/00—Methods of creating libraries, e.g. combinatorial synthesis
- C40B50/06—Biochemical methods, e.g. using enzymes or whole viable microorganisms
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6806—Preparing nucleic acids for analysis, e.g. for polymerase chain reaction [PCR] assay
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/44—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material not provided for elsewhere, e.g. haptens, metals, DNA, RNA, amino acids
-
- C—CHEMISTRY; METALLURGY
- C40—COMBINATORIAL TECHNOLOGY
- C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
- C40B50/00—Methods of creating libraries, e.g. combinatorial synthesis
- C40B50/04—Methods of creating libraries, e.g. combinatorial synthesis using dynamic combinatorial chemistry techniques
-
- C—CHEMISTRY; METALLURGY
- C40—COMBINATORIAL TECHNOLOGY
- C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
- C40B50/00—Methods of creating libraries, e.g. combinatorial synthesis
- C40B50/08—Liquid phase synthesis, i.e. wherein all library building blocks are in liquid phase or in solution during library creation; Particular methods of cleavage from the liquid support
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2521/00—Reaction characterised by the enzymatic activity
- C12Q2521/30—Phosphoric diester hydrolysing, i.e. nuclease
- C12Q2521/327—RNAse, e.g. RNAseH
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2522/00—Reaction characterised by the use of non-enzymatic proteins
- C12Q2522/10—Nucleic acid binding proteins
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Medicinal Chemistry (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Analytical Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Immunology (AREA)
- Microbiology (AREA)
- General Chemical & Material Sciences (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Physics & Mathematics (AREA)
- Structural Engineering (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP15180705 | 2015-08-12 | ||
| EP15189788 | 2015-10-14 | ||
| PCT/EP2016/069121 WO2017025594A1 (en) | 2015-08-12 | 2016-08-11 | Methods for studying nucleic acids |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CY1122632T1 true CY1122632T1 (el) | 2021-03-12 |
Family
ID=56876995
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CY20201100053T CY1122632T1 (el) | 2015-08-12 | 2020-01-22 | Μεθοδοι για μελετη πυρηνικων οξεων |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US10934636B2 (cg-RX-API-DMAC7.html) |
| EP (2) | EP3674414A1 (cg-RX-API-DMAC7.html) |
| JP (1) | JP6697070B2 (cg-RX-API-DMAC7.html) |
| CN (1) | CN108368540B (cg-RX-API-DMAC7.html) |
| CA (1) | CA2995305A1 (cg-RX-API-DMAC7.html) |
| CY (1) | CY1122632T1 (cg-RX-API-DMAC7.html) |
| DK (1) | DK3334841T3 (cg-RX-API-DMAC7.html) |
| ES (1) | ES2779798T3 (cg-RX-API-DMAC7.html) |
| HR (1) | HRP20200062T1 (cg-RX-API-DMAC7.html) |
| HU (1) | HUE047175T2 (cg-RX-API-DMAC7.html) |
| LT (1) | LT3334841T (cg-RX-API-DMAC7.html) |
| PL (1) | PL3334841T3 (cg-RX-API-DMAC7.html) |
| PT (1) | PT3334841T (cg-RX-API-DMAC7.html) |
| RS (1) | RS59838B1 (cg-RX-API-DMAC7.html) |
| SI (1) | SI3334841T1 (cg-RX-API-DMAC7.html) |
| SM (1) | SMT202000037T1 (cg-RX-API-DMAC7.html) |
| WO (1) | WO2017025594A1 (cg-RX-API-DMAC7.html) |
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| GB0719620D0 (en) | 2007-10-08 | 2007-11-14 | Isis Innovation | Mutant Enzymes |
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| US9938524B2 (en) | 2011-11-22 | 2018-04-10 | Active Motif, Inc. | Multiplex isolation of protein-associated nucleic acids |
| US10584381B2 (en) | 2012-08-14 | 2020-03-10 | 10X Genomics, Inc. | Methods and systems for processing polynucleotides |
| US10221442B2 (en) | 2012-08-14 | 2019-03-05 | 10X Genomics, Inc. | Compositions and methods for sample processing |
| US9701998B2 (en) | 2012-12-14 | 2017-07-11 | 10X Genomics, Inc. | Methods and systems for processing polynucleotides |
| WO2014028537A1 (en) | 2012-08-14 | 2014-02-20 | 10X Technologies, Inc. | Microcapsule compositions and methods |
| US11591637B2 (en) | 2012-08-14 | 2023-02-28 | 10X Genomics, Inc. | Compositions and methods for sample processing |
| US10752949B2 (en) | 2012-08-14 | 2020-08-25 | 10X Genomics, Inc. | Methods and systems for processing polynucleotides |
| US9951386B2 (en) | 2014-06-26 | 2018-04-24 | 10X Genomics, Inc. | Methods and systems for processing polynucleotides |
| US10323279B2 (en) | 2012-08-14 | 2019-06-18 | 10X Genomics, Inc. | Methods and systems for processing polynucleotides |
| US10273541B2 (en) | 2012-08-14 | 2019-04-30 | 10X Genomics, Inc. | Methods and systems for processing polynucleotides |
| EP2931919B1 (en) | 2012-12-14 | 2019-02-20 | 10X Genomics, Inc. | Methods and systems for processing polynucleotides |
| US10533221B2 (en) | 2012-12-14 | 2020-01-14 | 10X Genomics, Inc. | Methods and systems for processing polynucleotides |
| AU2014214682B2 (en) | 2013-02-08 | 2018-07-26 | 10X Genomics, Inc. | Polynucleotide barcode generation |
| CN111394426B (zh) | 2013-05-23 | 2024-05-10 | 斯坦福大学托管董事会 | 用于个人表观基因组学的至天然染色质的转座 |
| MX2016013156A (es) | 2014-04-10 | 2017-02-14 | 10X Genomics Inc | Dispositivos, sistemas y metodos fluidicos, para encapsular y dividir reactivos, y aplicaciones de los mismos. |
| WO2015200869A1 (en) | 2014-06-26 | 2015-12-30 | 10X Genomics, Inc. | Analysis of nucleic acid sequences |
| MX2016016902A (es) | 2014-06-26 | 2017-03-27 | 10X Genomics Inc | Metodos para analizar acidos nucleicos de celulas individuales o poblaciones de celulas. |
| US12312640B2 (en) | 2014-06-26 | 2025-05-27 | 10X Genomics, Inc. | Analysis of nucleic acid sequences |
| BR112017008877A2 (pt) | 2014-10-29 | 2018-07-03 | 10X Genomics Inc | métodos e composições para sequenciamento de ácido nucleico-alvo |
| US9975122B2 (en) | 2014-11-05 | 2018-05-22 | 10X Genomics, Inc. | Instrument systems for integrated sample processing |
| MX367432B (es) | 2015-01-12 | 2019-08-08 | 10X Genomics Inc | Procesos y sistemas para la preparación de bibliotecas de secuenciación de ácido nucleico y bibliotecas preparadas con estos. |
| BR112017018054A2 (pt) | 2015-02-24 | 2018-07-24 | 10X Genomics Inc | métodos para a cobertura de sequências de ácidos nucleicos direcionadas |
| WO2016137973A1 (en) | 2015-02-24 | 2016-09-01 | 10X Genomics Inc | Partition processing methods and systems |
| KR102723865B1 (ko) | 2015-12-04 | 2024-10-29 | 10엑스 제노믹스, 인크. | 핵산 분석을 위한 방법 및 조성물 |
| WO2017197343A2 (en) | 2016-05-12 | 2017-11-16 | 10X Genomics, Inc. | Microfluidic on-chip filters |
| WO2017197338A1 (en) | 2016-05-13 | 2017-11-16 | 10X Genomics, Inc. | Microfluidic systems and methods of use |
| US10815525B2 (en) | 2016-12-22 | 2020-10-27 | 10X Genomics, Inc. | Methods and systems for processing polynucleotides |
| US10011872B1 (en) | 2016-12-22 | 2018-07-03 | 10X Genomics, Inc. | Methods and systems for processing polynucleotides |
| US10550429B2 (en) | 2016-12-22 | 2020-02-04 | 10X Genomics, Inc. | Methods and systems for processing polynucleotides |
| EP4310183B1 (en) | 2017-01-30 | 2025-07-09 | 10X Genomics, Inc. | Methods and systems for droplet-based single cell barcoding |
| US12264411B2 (en) | 2017-01-30 | 2025-04-01 | 10X Genomics, Inc. | Methods and systems for analysis |
| US10914729B2 (en) | 2017-05-22 | 2021-02-09 | The Trustees Of Princeton University | Methods for detecting protein binding sequences and tagging nucleic acids |
| CN116064732A (zh) | 2017-05-26 | 2023-05-05 | 10X基因组学有限公司 | 转座酶可接近性染色质的单细胞分析 |
| US20180340169A1 (en) | 2017-05-26 | 2018-11-29 | 10X Genomics, Inc. | Single cell analysis of transposase accessible chromatin |
| US20200123591A1 (en) * | 2017-07-17 | 2020-04-23 | The Board Of Trustees Of The Leland Stanford Junior University | Epigenetic profiling using targeted chromatin ligation |
| AU2018335575B2 (en) | 2017-09-25 | 2024-07-04 | Fred Hutchinson Cancer Center | High efficiency targeted in situ genome-wide profiling |
| WO2019076768A1 (en) * | 2017-10-16 | 2019-04-25 | Tervisetehnoloogiate Arenduskeskus As | METHOD AND KIT FOR PREPARING DNA BANK |
| WO2019084043A1 (en) | 2017-10-26 | 2019-05-02 | 10X Genomics, Inc. | METHODS AND SYSTEMS FOR NUCLEIC ACID PREPARATION AND CHROMATIN ANALYSIS |
| CN107841533B (zh) * | 2017-11-13 | 2021-11-05 | 深圳先进技术研究院 | 一种染色质破碎方法及其应用 |
| SG11201913654QA (en) | 2017-11-15 | 2020-01-30 | 10X Genomics Inc | Functionalized gel beads |
| US10829815B2 (en) | 2017-11-17 | 2020-11-10 | 10X Genomics, Inc. | Methods and systems for associating physical and genetic properties of biological particles |
| CN108300774A (zh) * | 2017-12-01 | 2018-07-20 | 苏州睿迈英基因检测科技有限公司 | 一种改进的开放染色质检测方法及其试剂盒和应用 |
| WO2019116306A1 (en) | 2017-12-13 | 2019-06-20 | Ecole Polytechnique Federale De Lausanne (Epfl) | System for capture or immunoprecipitation of a protein-dna complex |
| CN108220394B (zh) * | 2018-01-05 | 2021-03-23 | 清华大学 | 基因调控性染色质相互作用的鉴定方法、系统及其应用 |
| EP3749740B1 (en) | 2018-02-05 | 2023-08-30 | The Board Of Trustees Of The Leland Stanford Junior University | Systems and methods for multiplexed measurements in single and ensemble cells |
| CN108285494B (zh) * | 2018-02-11 | 2021-09-07 | 北京大学 | 一种融合蛋白、试剂盒以及CHIP-seq检测方法 |
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| CN108913712B (zh) * | 2018-07-17 | 2021-04-02 | 厦门生命互联科技有限公司 | 一种重组Tn5转座酶的表达纯化方法 |
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| CN109880887A (zh) * | 2019-03-20 | 2019-06-14 | 嘉兴菲沙基因信息有限公司 | 一种适用于植物ATAC-seq测序技术的文库构建方法 |
| WO2020198664A1 (en) * | 2019-03-28 | 2020-10-01 | The Regents Of The University Of California | Methods and systems for sequencing cell-free microbiome dna |
| KR102192455B1 (ko) * | 2019-04-05 | 2020-12-17 | 한국과학기술원 | 개인의 전이효소-접근가능한 염색질 시퀀싱 정보를 이용한 암 진단 마커 및 이의 용도 |
| US20220267759A1 (en) * | 2019-07-12 | 2022-08-25 | New York Genome Center, Inc. | Methods and compositions for scalable pooled rna screens with single cell chromatin accessibility profiling |
| BR112022000722A2 (pt) * | 2019-07-16 | 2022-03-08 | Meliolabs Inc | Métodos e dispositivos para curva de melting digital baseada em célula única |
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| JP2022547106A (ja) | 2019-09-06 | 2022-11-10 | チェム－フォルシュングスツェントルン フュル モレクラーレ メディツィン ゲゼルシャフト ミット ベシュレンクテル ハフツング | Ｒｎａオリゴヌクレオチドをシークエンシングする方法 |
| US12241890B2 (en) * | 2019-12-23 | 2025-03-04 | 10X Genomics, Inc. | Methods for generating barcoded nucleic acid molecules using fixed cells |
| CN115279917B (zh) * | 2020-09-16 | 2025-10-10 | 深圳华大生命科学研究院 | 多维度解析细胞表观基因组学的方法 |
| TW202242130A (zh) * | 2020-12-29 | 2022-11-01 | 比利時商比利時意志有限公司 | 循環轉錄因子分析 |
| WO2022167665A1 (en) * | 2021-02-05 | 2022-08-11 | Ospedale San Raffaele S.R.L. | Engineered transposase and uses thereof |
| CN112795563A (zh) * | 2021-03-23 | 2021-05-14 | 上海欣百诺生物科技有限公司 | 生物素化的转座体在回收CUT&Tag或ATAC-seq产物中的用途及方法 |
| CN113186174B (zh) * | 2021-04-23 | 2022-04-15 | 江南大学 | 一种Tn5突变酶的制备和应用 |
| CN113774052A (zh) * | 2021-09-30 | 2021-12-10 | 首都医科大学附属北京安贞医院 | mtDNA的提取和建库试剂 |
| JP2025523739A (ja) * | 2022-07-27 | 2025-07-25 | イルミナ インコーポレイテッド | タグメンテーションワークフロー |
| CN115948363B (zh) * | 2022-08-26 | 2024-02-27 | 武汉影子基因科技有限公司 | Tn5转座酶突变体及其制备方法和应用 |
| CN116590283B (zh) * | 2023-07-17 | 2023-11-07 | 北京微岩医疗器械有限公司 | 一种细胞结合增强剂和去除人源游离核酸的方法 |
| CN117106857B (zh) * | 2023-10-24 | 2024-02-09 | 北京大学 | 一种血浆游离染色质的检测方法、试剂盒及其应用 |
| WO2025151541A1 (en) * | 2024-01-08 | 2025-07-17 | Massachusetts Eye And Ear Infirmary | Extraction of genomic dna from fixed cells |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| US5677170A (en) | 1994-03-02 | 1997-10-14 | The Johns Hopkins University | In vitro transposition of artificial transposons |
| US5925545A (en) | 1996-09-09 | 1999-07-20 | Wisconsin Alumni Research Foundation | System for in vitro transposition |
| US5965443A (en) | 1996-09-09 | 1999-10-12 | Wisconsin Alumni Research Foundation | System for in vitro transposition |
| US6159736A (en) | 1998-09-23 | 2000-12-12 | Wisconsin Alumni Research Foundation | Method for making insertional mutations using a Tn5 synaptic complex |
| US6406896B1 (en) | 1999-08-02 | 2002-06-18 | Wisconsin Alumni Research Foundation | Transposase enzyme and method for use |
| US7067644B2 (en) | 2000-12-05 | 2006-06-27 | Wisconsin Alumni Research Foundation | Double transposition methods for manipulating nucleic acids |
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| US7316903B2 (en) | 2003-03-28 | 2008-01-08 | United States Of America As Represented By The Department Of Health And Human Services | Detection of nucleic acid sequence variations using phase Mu transposase |
| WO2004093645A2 (en) | 2003-04-17 | 2004-11-04 | Wisconsin Alumni Research Foundation | Tn5 transposase mutants and the use thereof |
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| ES2568910T3 (es) | 2011-01-28 | 2016-05-05 | Illumina, Inc. | Reemplazo de oligonucleótidos para bibliotecas etiquetadas en dos extremos y direccionadas |
| WO2013078470A2 (en) | 2011-11-22 | 2013-05-30 | MOTIF, Active | Multiplex isolation of protein-associated nucleic acids |
| CN102703426A (zh) * | 2012-05-21 | 2012-10-03 | 吴江汇杰生物科技有限公司 | 构建核酸库的方法、试剂及试剂盒 |
| EP2999784B2 (en) | 2013-05-22 | 2022-11-23 | Active Motif, Inc. | Targeted transposition for use in epigenetic studies |
| WO2014205296A1 (en) | 2013-06-21 | 2014-12-24 | The Broad Institute, Inc. | Methods for shearing and tagging dna for chromatin immunoprecipitation and sequencing |
-
2016
- 2016-08-11 CA CA2995305A patent/CA2995305A1/en active Pending
- 2016-08-11 EP EP19205821.2A patent/EP3674414A1/en not_active Withdrawn
- 2016-08-11 HU HUE16760659A patent/HUE047175T2/hu unknown
- 2016-08-11 SI SI201630614T patent/SI3334841T1/sl unknown
- 2016-08-11 JP JP2018506840A patent/JP6697070B2/ja active Active
- 2016-08-11 DK DK16760659.9T patent/DK3334841T3/da active
- 2016-08-11 ES ES16760659T patent/ES2779798T3/es active Active
- 2016-08-11 CN CN201680058837.9A patent/CN108368540B/zh not_active Expired - Fee Related
- 2016-08-11 RS RS20200057A patent/RS59838B1/sr unknown
- 2016-08-11 PT PT167606599T patent/PT3334841T/pt unknown
- 2016-08-11 PL PL16760659T patent/PL3334841T3/pl unknown
- 2016-08-11 US US15/751,918 patent/US10934636B2/en active Active
- 2016-08-11 EP EP16760659.9A patent/EP3334841B1/en active Active
- 2016-08-11 WO PCT/EP2016/069121 patent/WO2017025594A1/en not_active Ceased
- 2016-08-11 LT LTEP16760659.9T patent/LT3334841T/lt unknown
- 2016-08-11 HR HRP20200062TT patent/HRP20200062T1/hr unknown
- 2016-08-11 SM SM20200037T patent/SMT202000037T1/it unknown
-
2020
- 2020-01-22 CY CY20201100053T patent/CY1122632T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| HUE047175T2 (hu) | 2020-04-28 |
| EP3334841B1 (en) | 2019-10-30 |
| US20180237951A1 (en) | 2018-08-23 |
| CN108368540B (zh) | 2022-10-11 |
| CA2995305A1 (en) | 2017-02-16 |
| EP3334841A1 (en) | 2018-06-20 |
| US10934636B2 (en) | 2021-03-02 |
| HRP20200062T1 (hr) | 2020-04-03 |
| SMT202000037T1 (it) | 2020-03-13 |
| CN108368540A (zh) | 2018-08-03 |
| JP6697070B2 (ja) | 2020-05-20 |
| JP2018532373A (ja) | 2018-11-08 |
| SI3334841T1 (sl) | 2020-03-31 |
| WO2017025594A1 (en) | 2017-02-16 |
| PL3334841T3 (pl) | 2020-05-18 |
| EP3674414A1 (en) | 2020-07-01 |
| LT3334841T (lt) | 2020-02-10 |
| ES2779798T3 (es) | 2020-08-19 |
| DK3334841T3 (da) | 2020-01-20 |
| RS59838B1 (sr) | 2020-02-28 |
| PT3334841T (pt) | 2020-01-30 |
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