CY1121163T1 - Ανταγωνιστες υποδοχεα σωματοστατινης υποτυπου 5 (sstr5) - Google Patents
Ανταγωνιστες υποδοχεα σωματοστατινης υποτυπου 5 (sstr5)Info
- Publication number
- CY1121163T1 CY1121163T1 CY20181100912T CY181100912T CY1121163T1 CY 1121163 T1 CY1121163 T1 CY 1121163T1 CY 20181100912 T CY20181100912 T CY 20181100912T CY 181100912 T CY181100912 T CY 181100912T CY 1121163 T1 CY1121163 T1 CY 1121163T1
- Authority
- CY
- Cyprus
- Prior art keywords
- sstr5
- competitors
- somatostatin receptor
- compound
- receptor receptors
- Prior art date
Links
- 108050001286 Somatostatin Receptor Proteins 0.000 title 1
- 102000011096 Somatostatin receptor Human genes 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 5
- 239000003814 drug Substances 0.000 abstract 3
- 150000003839 salts Chemical class 0.000 abstract 3
- 101000829153 Homo sapiens Somatostatin receptor type 5 Proteins 0.000 abstract 1
- 102100023806 Somatostatin receptor type 5 Human genes 0.000 abstract 1
- 239000005557 antagonist Substances 0.000 abstract 1
- 206010012601 diabetes mellitus Diseases 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 230000000069 prophylactic effect Effects 0.000 abstract 1
- 229940124597 therapeutic agent Drugs 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Diabetes (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
Μια ένωση που έχει δράση ανταγωνιστή SSTR5 και χρήση της ένωσης ως φάρμακο παρέχονται. Συγκεκριμένα, μια ένωση που αντιπροσωπεύεται από τον παρακάτω τύπο· όπου κάθε σύμβολο ορίζεται στην παρούσα, ή ένα άλας αυτής, ένα φάρμακο που περιέχει την ένωση ή ένα άλας αυτής, και χρήση της ένωσης ή ενός άλατος αυτής ως παράγοντα για την προφύλαξη ή τη θεραπεία του σακχαρώδους διαβήτη παρέχονται.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2013209826 | 2013-10-07 | ||
| PCT/JP2014/005075 WO2015052910A1 (en) | 2013-10-07 | 2014-10-06 | Antagonists of somatostatin receptor subtype 5 (sstr5) |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CY1121163T1 true CY1121163T1 (el) | 2020-05-29 |
Family
ID=51842719
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CY20181100912T CY1121163T1 (el) | 2013-10-07 | 2018-09-04 | Ανταγωνιστες υποδοχεα σωματοστατινης υποτυπου 5 (sstr5) |
Country Status (23)
| Country | Link |
|---|---|
| US (2) | US9353108B2 (el) |
| EP (1) | EP3055309B1 (el) |
| JP (1) | JP6411520B2 (el) |
| CN (1) | CN105612158B (el) |
| AR (1) | AR097932A1 (el) |
| BR (1) | BR112016007620B1 (el) |
| CA (1) | CA2926544C (el) |
| CY (1) | CY1121163T1 (el) |
| DK (1) | DK3055309T3 (el) |
| ES (1) | ES2687102T3 (el) |
| HR (1) | HRP20181372T1 (el) |
| HU (1) | HUE039386T2 (el) |
| JO (1) | JO3442B1 (el) |
| LT (1) | LT3055309T (el) |
| PL (1) | PL3055309T3 (el) |
| PT (1) | PT3055309T (el) |
| RS (1) | RS57743B1 (el) |
| RU (1) | RU2671958C2 (el) |
| SI (1) | SI3055309T1 (el) |
| TR (1) | TR201810506T4 (el) |
| TW (1) | TWI648276B (el) |
| UY (1) | UY35774A (el) |
| WO (1) | WO2015052910A1 (el) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP6247697B2 (ja) * | 2013-03-14 | 2017-12-13 | 武田薬品工業株式会社 | スピロアゼチジンイソキサゾール誘導体及びそのｓｓｔｒ５アンタゴニストとしての使用 |
| EP3227282B1 (en) * | 2014-12-02 | 2019-04-03 | F.Hoffmann-La Roche Ag | Novel piperidine derivatives |
| TW201712012A (zh) | 2015-06-16 | 2017-04-01 | 美國禮來大藥廠 | ２－側氧基－１，３，８－三氮雜螺［４．５］癸－３－基羧酸衍生物 |
| BR112022006546A2 (pt) | 2019-10-07 | 2022-08-30 | Kallyope Inc | Agonistas de gpr119 |
| TW202207929A (zh) * | 2020-05-13 | 2022-03-01 | 日商思可海雅藥品股份有限公司 | 膽道系疾病的診斷輔助、預防或治療劑 |
| BR112022023359A2 (pt) | 2020-05-19 | 2023-04-18 | Kallyope Inc | Ativadores de ampk |
| EP4172162A1 (en) | 2020-06-26 | 2023-05-03 | Kallyope, Inc. | Ampk activators |
| CN116354961A (zh) * | 2021-12-27 | 2023-06-30 | 中国科学院上海药物研究所 | 生长抑素受体5拮抗剂及其药物组合物及用途 |
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| US5356906A (en) | 1989-10-27 | 1994-10-18 | The Du Pont Merck Pharmaceutical Company | (N-phthalimidoalkyl) piperidines useful as treatments for psychosis |
| EP0862562B1 (en) | 1995-09-13 | 2001-07-04 | Takeda Chemical Industries, Ltd. | Benzoxazepine compounds, their production and use as lipid lowering agents |
| CA2416384A1 (en) | 2000-07-17 | 2003-01-16 | Takeda Chemical Industries, Ltd. | Sulfone derivatives, their production and use |
| EP1432708B1 (en) | 2001-09-24 | 2005-11-30 | Bayer Pharmaceuticals Corporation | Preparation and use of 1,5,6,7-tetrahydropyrrolo 3,2-c]pyridine derivatives for treatment of obesity |
| RU2004112771A (ru) * | 2001-09-26 | 2005-10-10 | Байер Фармасьютикалс Корпорейшн (US) | Производные 1, 8-нафтиридина как противодиабетические средства |
| TW200302225A (en) | 2001-12-04 | 2003-08-01 | Bristol Myers Squibb Co | Substituted amino methyl factor Xa inhibitors |
| NZ540381A (en) | 2002-11-01 | 2007-11-30 | Takeda Pharmaceutical | 5-membered aromatic heterocycle derivatives as prophylactic and therapeutic agents for treating neuropathy |
| WO2004041266A1 (ja) | 2002-11-08 | 2004-05-21 | Takeda Pharmaceutical Company Limited | 受容体機能調節剤 |
| WO2004048363A1 (ja) | 2002-11-22 | 2004-06-10 | Takeda Pharmaceutical Company Limited | イミダゾール誘導体、その製造法および用途 |
| WO2004080966A1 (ja) | 2003-03-14 | 2004-09-23 | Ono Pharmaceutical Co., Ltd. | 含窒素複素環誘導体およびそれらを有効成分とする薬剤 |
| EP1630152A4 (en) | 2003-05-30 | 2009-09-23 | Takeda Pharmaceutical | CONNECTION WITH CONDENSED RING |
| US7534887B2 (en) | 2003-09-30 | 2009-05-19 | Takeda Pharmaceutical Company Limited | Thiazoline derivative and use of the same |
| JP2007513082A (ja) | 2003-11-10 | 2007-05-24 | シエーリング アクチエンゲゼルシャフト | Ｃｃｒ−５アンタゴニストとして有用なベンジルエーテルアミン化合物 |
| CA2550012A1 (en) | 2003-12-17 | 2005-06-30 | Takeda Pharmaceutical Company Limited | Urea derivative, process for producing the same and use |
| BRPI0418148A (pt) | 2003-12-25 | 2007-04-17 | Takeda Pharmaceutical | composto, prodroga de um composto, modulador da função do receptor gpr40, agente farmacêutico, uso de um composto e métodos de modificação de uma função do receptor gpr40 em um mamìfero, de profilaxia ou tratamento de diabetes em um mamìfero e de produção de um composto |
| JP4855777B2 (ja) | 2003-12-26 | 2012-01-18 | 武田薬品工業株式会社 | フェニルプロパン酸誘導体 |
| JP4875978B2 (ja) | 2004-03-15 | 2012-02-15 | 武田薬品工業株式会社 | アミノフェニルプロパン酸誘導体 |
| WO2005095338A1 (ja) | 2004-03-30 | 2005-10-13 | Takeda Pharmaceutical Company Limited | アルコキシフェニルプロパン酸誘導体 |
| TWI396686B (zh) | 2004-05-21 | 2013-05-21 | Takeda Pharmaceutical | 環狀醯胺衍生物、以及其製品和用法 |
| EP2308839B1 (en) | 2005-04-20 | 2017-03-01 | Takeda Pharmaceutical Company Limited | Fused heterocyclic compounds |
| JPWO2007013694A1 (ja) | 2005-07-29 | 2009-02-12 | 武田薬品工業株式会社 | フェノキシアルカン酸化合物 |
| EP1916234B1 (en) | 2005-07-29 | 2014-11-12 | Takeda Pharmaceutical Company Limited | Cyclopropanecarboxylic acid compound |
| CA2617969A1 (en) | 2005-08-10 | 2007-02-15 | Takeda Pharmaceutical Company Limited | Therapeutic agent for diabetes |
| JP2007063225A (ja) | 2005-09-01 | 2007-03-15 | Takeda Chem Ind Ltd | イミダゾピリジン化合物 |
| ME00535B (me) | 2006-06-27 | 2011-10-10 | Takeda Pharmaceuticals Co | Fuzionisana ciklična jedinjenja |
| WO2008019967A2 (en) * | 2006-08-15 | 2008-02-21 | F. Hoffmann-La Roche Ag | Phenyl, pyridine and quinoline derivatives |
| US8492405B2 (en) | 2006-10-18 | 2013-07-23 | Takeda Pharmaceutical Company Limited | Glucokinase-activating fused heterocyclic compounds and methods of treating diabetes and obesity |
| NZ576570A (en) | 2006-10-19 | 2010-11-26 | Takeda Pharmaceutical | 7-sulfonylamino-2-thiazol and 2-thiadiazol -indole compounds |
| WO2008093639A1 (ja) | 2007-01-29 | 2008-08-07 | Takeda Pharmaceutical Company Limited | ピラゾール化合物 |
| WO2008099794A1 (en) | 2007-02-09 | 2008-08-21 | Takeda Pharmaceutical Company Limited | Fused ring compounds as partial agonists of ppar-gamma |
| US7862825B2 (en) | 2007-02-21 | 2011-01-04 | Mladen Vranic | Method of controlling tight blood glucose by somatostatin receptor antagonists |
| US7799806B2 (en) * | 2007-04-04 | 2010-09-21 | Hoffmann-La Roche Inc. | Substituted n-benzyl piperidines as somatostatin receptor modulators |
| JPWO2008136428A1 (ja) | 2007-04-27 | 2010-07-29 | 武田薬品工業株式会社 | 含窒素５員複素環化合物 |
| US20080306116A1 (en) | 2007-06-08 | 2008-12-11 | Christ Andreas D | Aryloxazole, aryloxadiazole and benzimidazole derivatives |
| WO2008156757A1 (en) | 2007-06-19 | 2008-12-24 | Takeda Pharmaceutical Company Limited | Indazole compounds for activating glucokinase |
| TW200918062A (en) * | 2007-09-12 | 2009-05-01 | Wyeth Corp | Azacyclylisoquinolinone and-isoindolinone derivatives as histamine-3 antagonists |
| EP2427465A1 (en) | 2009-05-07 | 2012-03-14 | Merck Sharp & Dohme Corp. | Substituted spirocyclic amines useful as antidiabetic compounds |
| US8742110B2 (en) | 2010-08-18 | 2014-06-03 | Merck Sharp & Dohme Corp. | Spiroxazolidinone compounds |
| AU2011333472A1 (en) | 2010-11-26 | 2013-06-06 | Lupin Limited | Bicyclic GPR119 modulators |
| JP6247697B2 (ja) | 2013-03-14 | 2017-12-13 | 武田薬品工業株式会社 | スピロアゼチジンイソキサゾール誘導体及びそのｓｓｔｒ５アンタゴニストとしての使用 |
| AR098215A1 (es) | 2013-10-29 | 2016-05-18 | Takeda Pharmaceuticals Co | Compuesto heterocíclico |
-
2014
- 2014-10-02 JO JOP/2014/0283A patent/JO3442B1/ar active
- 2014-10-03 US US14/505,907 patent/US9353108B2/en active Active
- 2014-10-06 PT PT14790746T patent/PT3055309T/pt unknown
- 2014-10-06 AR ARP140103713A patent/AR097932A1/es active IP Right Grant
- 2014-10-06 WO PCT/JP2014/005075 patent/WO2015052910A1/en active Application Filing
- 2014-10-06 BR BR112016007620-6A patent/BR112016007620B1/pt active IP Right Grant
- 2014-10-06 LT LTEP14790746.3T patent/LT3055309T/lt unknown
- 2014-10-06 TW TW103134715A patent/TWI648276B/zh active
- 2014-10-06 CA CA2926544A patent/CA2926544C/en active Active
- 2014-10-06 TR TR2018/10506T patent/TR201810506T4/tr unknown
- 2014-10-06 EP EP14790746.3A patent/EP3055309B1/en active Active
- 2014-10-06 ES ES14790746.3T patent/ES2687102T3/es active Active
- 2014-10-06 HU HUE14790746A patent/HUE039386T2/hu unknown
- 2014-10-06 RU RU2016117732A patent/RU2671958C2/ru active
- 2014-10-06 UY UY0001035774A patent/UY35774A/es not_active Application Discontinuation
- 2014-10-06 CN CN201480055324.3A patent/CN105612158B/zh active Active
- 2014-10-06 PL PL14790746T patent/PL3055309T3/pl unknown
- 2014-10-06 RS RS20181007A patent/RS57743B1/sr unknown
- 2014-10-06 JP JP2016546198A patent/JP6411520B2/ja active Active
- 2014-10-06 DK DK14790746.3T patent/DK3055309T3/en active
- 2014-10-06 SI SI201430838T patent/SI3055309T1/sl unknown
-
2016
- 2016-04-27 US US15/139,531 patent/US9751878B2/en active Active
-
2018
- 2018-08-27 HR HRP20181372TT patent/HRP20181372T1/hr unknown
- 2018-09-04 CY CY20181100912T patent/CY1121163T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CN105612158A (zh) | 2016-05-25 |
| BR112016007620B1 (pt) | 2020-05-26 |
| RS57743B1 (sr) | 2018-12-31 |
| TWI648276B (zh) | 2019-01-21 |
| JP6411520B2 (ja) | 2018-10-24 |
| EP3055309A1 (en) | 2016-08-17 |
| DK3055309T3 (en) | 2018-08-27 |
| PT3055309T (pt) | 2018-10-01 |
| US20150099777A1 (en) | 2015-04-09 |
| RU2671958C2 (ru) | 2018-11-08 |
| EP3055309B1 (en) | 2018-06-13 |
| TW201536784A (zh) | 2015-10-01 |
| US9353108B2 (en) | 2016-05-31 |
| AR097932A1 (es) | 2016-04-20 |
| WO2015052910A1 (en) | 2015-04-16 |
| ES2687102T3 (es) | 2018-10-23 |
| CA2926544A1 (en) | 2015-04-16 |
| HUE039386T2 (hu) | 2018-12-28 |
| US20160237087A1 (en) | 2016-08-18 |
| US9751878B2 (en) | 2017-09-05 |
| UY35774A (es) | 2015-05-29 |
| JP2016531950A (ja) | 2016-10-13 |
| BR112016007620A2 (pt) | 2017-08-01 |
| TR201810506T4 (tr) | 2018-08-27 |
| JO3442B1 (ar) | 2019-10-20 |
| PL3055309T3 (pl) | 2018-10-31 |
| CN105612158B (zh) | 2017-06-30 |
| RU2016117732A (ru) | 2017-11-15 |
| SI3055309T1 (sl) | 2018-10-30 |
| HRP20181372T1 (hr) | 2018-10-19 |
| LT3055309T (lt) | 2018-08-27 |
| CA2926544C (en) | 2021-07-06 |
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