EA201600032A1 - Производные 1-сульфонилпиперидина в качестве модуляторов рецепторов прокинетицина - Google Patents

Производные 1-сульфонилпиперидина в качестве модуляторов рецепторов прокинетицина

Info

Publication number
EA201600032A1
EA201600032A1 EA201600032A EA201600032A EA201600032A1 EA 201600032 A1 EA201600032 A1 EA 201600032A1 EA 201600032 A EA201600032 A EA 201600032A EA 201600032 A EA201600032 A EA 201600032A EA 201600032 A1 EA201600032 A1 EA 201600032A1
Authority
EA
Eurasian Patent Office
Prior art keywords
sulphonylipiperidine
models
derivatives
prokineticin receptors
prokineticin
Prior art date
Application number
EA201600032A
Other languages
English (en)
Other versions
EA029430B1 (ru
Inventor
Мартин Тилл
Original Assignee
Такеда Фармасьютикл Компани Лимитед
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB201311169A external-priority patent/GB201311169D0/en
Priority claimed from GB201314397A external-priority patent/GB201314397D0/en
Application filed by Такеда Фармасьютикл Компани Лимитед filed Critical Такеда Фармасьютикл Компани Лимитед
Publication of EA201600032A1 publication Critical patent/EA201600032A1/ru
Publication of EA029430B1 publication Critical patent/EA029430B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

В настоящем изобретении предложены соединения формулы (I) и их фармацевтически приемлемые соли, в которых m, n, W, X, Y, Z, R, R, R, Rи Rтакие, как определено в настоящем описании, композиции, содержащие указанные соединения, и их применение в терапии.
EA201600032A 2013-06-21 2014-06-20 Производные 1-сульфонилпиперидина в качестве модуляторов рецепторов прокинетицина EA029430B1 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB201311169A GB201311169D0 (en) 2013-06-21 2013-06-21 Therapeutic compounds
GB201314397A GB201314397D0 (en) 2013-08-09 2013-08-09 Therapeutic Compounds
PCT/GB2014/051900 WO2014202999A1 (en) 2013-06-21 2014-06-20 1-sulfonyl piperidine derivatives as modulators of prokineticin receptors

Publications (2)

Publication Number Publication Date
EA201600032A1 true EA201600032A1 (ru) 2016-08-31
EA029430B1 EA029430B1 (ru) 2018-03-30

Family

ID=50982934

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201600032A EA029430B1 (ru) 2013-06-21 2014-06-20 Производные 1-сульфонилпиперидина в качестве модуляторов рецепторов прокинетицина

Country Status (9)

Country Link
US (2) US10208016B2 (ru)
EP (1) EP3010900B1 (ru)
JP (1) JP6401254B2 (ru)
CN (1) CN105324372B (ru)
AU (1) AU2014282977B2 (ru)
CA (1) CA2914263C (ru)
EA (1) EA029430B1 (ru)
HK (1) HK1219722A1 (ru)
WO (1) WO2014202999A1 (ru)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB201420095D0 (en) 2014-11-12 2014-12-24 Takeda Pharmaceutical New use

Family Cites Families (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
UA54375C2 (ru) 1994-08-24 2003-03-17 Астра Актієболаг Спиро-азабициклические соединения, способы их получения и фармацевтическая композиция
SE9504661D0 (sv) 1995-12-22 1995-12-22 Astra Pharma Inc New compounds
SE9600683D0 (sv) 1996-02-23 1996-02-23 Astra Ab Azabicyclic esters of carbamic acids useful in therapy
AR013184A1 (es) 1997-07-18 2000-12-13 Astrazeneca Ab Aminas heterociclicas espiroazobiciclicas, composicion farmaceutica, uso de dichas aminas para preparar medicamentos y metodo de tratamiento o profilaxis
SE9702799D0 (sv) 1997-07-25 1997-07-25 Astra Ab New compounds
SE9900100D0 (sv) 1999-01-15 1999-01-15 Astra Ab New compounds
SE9903760D0 (sv) 1999-10-18 1999-10-18 Astra Ab New compounds
SE9904176D0 (sv) 1999-11-18 1999-11-18 Astra Ab New use
SE0000540D0 (sv) 2000-02-18 2000-02-18 Astrazeneca Ab New compounds
SE0002729D0 (sv) 2000-07-20 2000-07-20 Astrazeneca Ab Novel compound form
AR035974A1 (es) 2001-05-18 2004-07-28 Astrazeneca Ab Derivados de diarilmetil piperazina, procesos para su preparacion, uso de estos derivados para la elaboracion de medicamentos y composicion farmaceutica
KR20040003021A (ko) 2001-06-01 2004-01-07 아스트라제네카 아베 치료에 유용한 니코틴성 아세틸콜린 수용체에 대한 신규리간드
EP1676844A1 (en) * 2004-12-28 2006-07-05 Laboratorios Del Dr. Esteve, S.A. 5-HT7 receptor antagonists
CN1325499C (zh) 2002-04-18 2007-07-11 阿斯特拉曾尼卡有限公司 噻吩基化合物
WO2003087102A1 (en) 2002-04-18 2003-10-23 Astrazeneca Ab Furyl compounds
AU2003224546B2 (en) 2002-04-18 2008-11-06 Astrazeneca Ab Heterocyclic compounds
SE0202430D0 (sv) 2002-08-14 2002-08-14 Astrazeneca Ab New Compounds
SE0202465D0 (sv) 2002-08-14 2002-08-14 Astrazeneca Ab New compounds
SE0202598D0 (sv) 2002-09-02 2002-09-02 Astrazeneca Ab Alpha-7 Nicotinic receptor agonists and statins in combination
BR0315166A (pt) 2002-10-11 2005-08-16 Astrazeneca Ab Uso de um composto ou de um sal farmaceuticamente aceitável do mesmo, composto ou um sal farmaceuticamente aceitável do mesmo, composição farmacêutica, e, método para produzir um efeito inibidor de 11betahsd1 em um animal de sangue quente, tal como o homem, que necessita de tratamento
RS52883B (en) * 2003-12-15 2014-02-28 Merck Sharp & Dohme Corp. HETEROCYCLIC ASPARTYL PROTEASE INHIBITORS
US7829712B2 (en) 2004-09-20 2010-11-09 Xenon Pharmaceuticals Inc. Pyridazine derivatives for inhibiting human stearoyl-CoA-desaturase
US7855201B2 (en) 2005-12-06 2010-12-21 Merck Sharp & Dohme. Corp. Morpholine carboxamide prokineticin receptor antagonists
WO2007079214A2 (en) 2005-12-29 2007-07-12 Janssen Pharmaceutica N.V. Prokineticin 2 receptor antagonists
WO2010077976A2 (en) * 2008-12-17 2010-07-08 The Regents Of The University Of California Prokineticin receptor antagonists and uses thereof
WO2010080864A1 (en) 2009-01-12 2010-07-15 Array Biopharma Inc. Piperidine-containing compounds and use thereof
GB201209587D0 (en) * 2012-05-30 2012-07-11 Takeda Pharmaceutical Therapeutic compounds
JP6343541B2 (ja) 2014-10-09 2018-06-13 株式会社ケーヒン・サーマル・テクノロジー エバポレータおよびこれを用いた車両用空調装置
GB201420095D0 (en) * 2014-11-12 2014-12-24 Takeda Pharmaceutical New use

Also Published As

Publication number Publication date
EP3010900A1 (en) 2016-04-27
EP3010900B1 (en) 2018-01-03
EA029430B1 (ru) 2018-03-30
CA2914263C (en) 2021-05-18
AU2014282977A1 (en) 2015-12-24
US10308635B2 (en) 2019-06-04
US20180251445A1 (en) 2018-09-06
CN105324372B (zh) 2018-03-06
CN105324372A (zh) 2016-02-10
CA2914263A1 (en) 2014-12-24
JP2016522244A (ja) 2016-07-28
AU2014282977B2 (en) 2018-06-14
BR112015031827A2 (pt) 2017-07-25
US20160122317A1 (en) 2016-05-05
HK1219722A1 (zh) 2017-04-13
US10208016B2 (en) 2019-02-19
JP6401254B2 (ja) 2018-10-10
WO2014202999A1 (en) 2014-12-24

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Designated state(s): AM AZ BY KZ KG TJ TM