CY1119895T1 - Εμβολια βιοπροϊοντος συζευξης καψικων gram-θετικων βακτηριδιων - Google Patents

Εμβολια βιοπροϊοντος συζευξης καψικων gram-θετικων βακτηριδιων

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Publication number
CY1119895T1
CY1119895T1 CY20181100148T CY181100148T CY1119895T1 CY 1119895 T1 CY1119895 T1 CY 1119895T1 CY 20181100148 T CY20181100148 T CY 20181100148T CY 181100148 T CY181100148 T CY 181100148T CY 1119895 T1 CY1119895 T1 CY 1119895T1
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Cyprus
Prior art keywords
positive
gram
directed
bioconjugate
vaccines
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CY20181100148T
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English (en)
Inventor
Michael Wacker
Michael Kowarik
Michael Wetter
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Glaxosmithkline Biologicals Sa
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Application filed by Glaxosmithkline Biologicals Sa filed Critical Glaxosmithkline Biologicals Sa
Publication of CY1119895T1 publication Critical patent/CY1119895T1/el

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    • C12N15/70—Vectors or expression systems specially adapted for E. coli
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
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    • C07K16/12—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria
    • C07K16/1267—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-positive bacteria
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
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    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1025—Acyltransferases (2.3)
    • C12N9/1029—Acyltransferases (2.3) transferring groups other than amino-acyl groups (2.3.1)
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    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1048—Glycosyltransferases (2.4)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/57—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2
    • A61K2039/575—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2 humoral response
    • A—HUMAN NECESSITIES
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    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
    • A61K2039/6031—Proteins
    • A61K2039/6037—Bacterial toxins, e.g. diphteria toxoid [DT], tetanus toxoid [TT]
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    • A61K39/00—Medicinal preparations containing antigens or antibodies
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    • A61K2039/6087—Polysaccharides; Lipopolysaccharides [LPS]
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    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C07K2317/734—Complement-dependent cytotoxicity [CDC]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07K2319/00—Fusion polypeptide
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    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/034—Fusion polypeptide containing a localisation/targetting motif containing a motif for targeting to the periplasmic space of Gram negative bacteria as a soluble protein, i.e. signal sequence should be cleaved
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07K2319/00—Fusion polypeptide
    • C07K2319/20—Fusion polypeptide containing a tag with affinity for a non-protein ligand
    • C07K2319/21—Fusion polypeptide containing a tag with affinity for a non-protein ligand containing a His-tag
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Abstract

Μία πραγματοποίηση της παρούσας εφεύρεσης κατευθύνεται σε ένα νέο εμβόλιο βιοπροϊόντος σύζευξης S. aureus. Γενικότερα, η εφεύρεση απευθύνεται σε Gram-θετικά και άλλου βιοπροϊόντος σύζευξης εμβόλια που περιλαμβάνουν: μία πρωτεΐνη φορέα που περιλαμβάνει εισαχθείσα αλληλουχία νουκλεϊνικού οξέος κοινής ομολογίας, τουλάχιστον ένα πολυσακχαρίδιο όπως καψικό Gram-θετικό πολυσακχαρίδιο που συνδέεται προς την συναινετική αλληλουχία και, προαιρετικώς, ανοσοενισχυτικό ή φαρμακευτικώς αποδεκτό φορέα. Σε μια περαιτέρω άποψη, η παρούσα εφεύρεση κατευθύνεται σε μεθόδους παραγωγής Gram-θετικών και άλλου βιοπροϊόντος σύζευξης εμβόλια. Σε άλλη άποψη, παρέχεται Ν-γλυκοζυλιωμένη πρωτεΐνη που περιλαμβάνει ένα ή περισσότερα πολυσακχαρίδιο όπως Gram-θετικά πολυσακχαρίδια. Η παρούσα εφεύρεση επιπροσθέτως κατευθύνεται σε γενετικά κατασκευασμένους προκαρυωτικούς οργανισμούς που περιλαμβάνουν αλληλουχίες νουκλεοτιδίου που κωδικοποιούν γλυκοζυλτρανσφεράση ενός πρώτου προκαρυωτικού οργανισμού και γλυκοζυλτρανσφεράση ενός δεύτερου προκαρυωτικού οργανισμού. Η εφεύρεση περαιτέρω περιλαμβάνει πλασμίδια και προκαρυωτικά κύτταρα μετασχηματισμένα με πλασμίδια που κωδικοποιούν πολυσακχαρίδια και ένζυμα τα οποία παράγουν N-γλυκοζυλιωμένη πρωτεΐνη ή/και εμβόλιο βιοπροϊόντος σύζευξης. Περαιτέρω, η εφεύρεση απευθύνεται σε μεθόδους διέγερσης ανοσοαπόκρισης σε ένα θηλαστικό που περιλαμβάνει χορήγηση των εν λόγω βιοπροϊόντος σύζευξης.
CY20181100148T 2010-05-06 2018-02-06 Εμβολια βιοπροϊοντος συζευξης καψικων gram-θετικων βακτηριδιων CY1119895T1 (el)

Applications Claiming Priority (2)

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US33217010P 2010-05-06 2010-05-06
PCT/EP2011/057111 WO2011138361A1 (en) 2010-05-06 2011-05-04 Capsular gram-positive bacteria bioconjugate vaccines

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EP (2) EP2566507B1 (el)
JP (2) JP6339366B2 (el)
KR (2) KR101916290B1 (el)
CN (1) CN103079591B (el)
AU (2) AU2011249839B2 (el)
CA (1) CA2798381C (el)
CY (1) CY1119895T1 (el)
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HR (1) HRP20180064T1 (el)
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SG185433A1 (en) 2012-12-28
DK2566507T3 (da) 2018-01-29
IL222711B (en) 2018-10-31
EP2566507B1 (en) 2017-11-22
AU2011249839B2 (en) 2016-05-26
PL2566507T3 (pl) 2018-05-30
EP2566507A1 (en) 2013-03-13
US20110274720A1 (en) 2011-11-10
ES2844596T3 (es) 2021-07-22
SI2566507T1 (en) 2018-04-30
JP2013524844A (ja) 2013-06-20
US10307473B2 (en) 2019-06-04
KR20180021219A (ko) 2018-02-28
KR20130063510A (ko) 2013-06-14
HUE037956T2 (hu) 2018-09-28
EP3281639B1 (en) 2020-11-11
WO2011138361A1 (en) 2011-11-10
US9585950B2 (en) 2017-03-07
JP6339366B2 (ja) 2018-06-06
KR101916290B1 (ko) 2018-11-09
ES2657588T3 (es) 2018-03-06
US20150010592A1 (en) 2015-01-08
AU2016208265A1 (en) 2016-08-11
LT2566507T (lt) 2018-02-12
NO2566507T3 (el) 2018-04-21
IL222711A0 (en) 2012-12-31
HRP20180064T1 (hr) 2018-02-23
US20170128559A1 (en) 2017-05-11
JP2017036303A (ja) 2017-02-16
PT2566507T (pt) 2018-02-06
US8871491B2 (en) 2014-10-28
CN103079591A (zh) 2013-05-01
CA2798381A1 (en) 2011-11-10
CN103079591B (zh) 2017-07-28
AU2011249839A1 (en) 2012-11-29
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EP3281639A1 (en) 2018-02-14

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