CY1119492T1 - Παραγωγα καρβαμικα/ουριας - Google Patents

Παραγωγα καρβαμικα/ουριας

Info

Publication number
CY1119492T1
CY1119492T1 CY20171101112T CY171101112T CY1119492T1 CY 1119492 T1 CY1119492 T1 CY 1119492T1 CY 20171101112 T CY20171101112 T CY 20171101112T CY 171101112 T CY171101112 T CY 171101112T CY 1119492 T1 CY1119492 T1 CY 1119492T1
Authority
CY
Cyprus
Prior art keywords
carbamic
producers
urine
compound
formula
Prior art date
Application number
CY20171101112T
Other languages
English (en)
Inventor
Yves Auberson
Mark Gary Bock
Dario Braga
Marco Curzi
Stephanie Kay Dodd
Stefano Luca Giaffreda
Haiyang Jiang
Piotr Karpinski
Thomas J. Troxler
Tielin Wang
Xiaoyang Wang
Xuechun Zhang
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=49263333&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CY1119492(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of CY1119492T1 publication Critical patent/CY1119492T1/el

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445Non condensed piperidines, e.g. piperocaine
    • A61K31/4523Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4545Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50Pyridazines; Hydrogenated pyridazines
    • A61K31/501Pyridazines; Hydrogenated pyridazines not condensed and containing further heterocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/04Immunostimulants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C57/00Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
    • C07C57/02Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms with only carbon-to-carbon double bonds as unsaturation
    • C07C57/13Dicarboxylic acids
    • C07C57/15Fumaric acid
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/235Saturated compounds containing more than one carboxyl group
    • C07C59/245Saturated compounds containing more than one carboxyl group containing hydroxy or O-metal groups
    • C07C59/265Citric acid
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D403/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D403/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07BGENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13Crystalline forms, e.g. polymorphs

Abstract

Η εφεύρεση σχετίζεται με μία ένωση με τον τύπο I
CY20171101112T 2012-07-20 2017-10-25 Παραγωγα καρβαμικα/ουριας CY1119492T1 (el)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CN2012078933 2012-07-20
CN2013078309 2013-06-28
PCT/IB2013/055916 WO2014013469A1 (en) 2012-07-20 2013-07-18 Carbamate/urea derivatives

Publications (1)

Publication Number Publication Date
CY1119492T1 true CY1119492T1 (el) 2018-03-07

Family

ID=49263333

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20171101112T CY1119492T1 (el) 2012-07-20 2017-10-25 Παραγωγα καρβαμικα/ουριας

Country Status (42)

Country Link
US (4) US9034874B2 (el)
EP (1) EP2875016B1 (el)
JP (1) JP6203841B2 (el)
KR (1) KR102150739B1 (el)
CN (1) CN104470911B (el)
AP (1) AP3710A (el)
AR (1) AR092354A1 (el)
AU (1) AU2013291617B2 (el)
BR (1) BR112015001207B1 (el)
CA (1) CA2878006C (el)
CL (1) CL2015000056A1 (el)
CO (1) CO7170173A2 (el)
CR (1) CR20150019A (el)
CU (1) CU24248B1 (el)
CY (1) CY1119492T1 (el)
DK (1) DK2875016T3 (el)
EA (1) EA026091B1 (el)
ES (1) ES2648512T3 (el)
GT (1) GT201500012A (el)
HK (1) HK1204609A1 (el)
HR (1) HRP20171692T1 (el)
HU (1) HUE035592T2 (el)
IL (1) IL236656A (el)
IN (1) IN2014DN10449A (el)
JO (1) JO3439B1 (el)
LT (1) LT2875016T (el)
MX (1) MX362059B (el)
MY (1) MY168752A (el)
NO (1) NO2875016T3 (el)
NZ (1) NZ702346A (el)
PE (1) PE20151155A1 (el)
PH (1) PH12014502743B1 (el)
PL (1) PL2875016T3 (el)
PT (1) PT2875016T (el)
RS (1) RS56479B1 (el)
SG (2) SG11201408020RA (el)
SI (1) SI2875016T1 (el)
TN (1) TN2014000497A1 (el)
TW (1) TWI597276B (el)
UY (1) UY34921A (el)
WO (1) WO2014013469A1 (el)
ZA (1) ZA201408805B (el)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR088256A1 (es) 2011-10-08 2014-05-21 Novartis Ag Derivados de carbamato / urea como antagonistas del receptor h3
US9034874B2 (en) 2012-07-20 2015-05-19 Novartis Ag Carbamate/urea derivatives
EP3391886A1 (en) * 2017-04-19 2018-10-24 Novartis AG The use of a h3r inverse agonist for the treatment of shift work disorder
US20190381056A1 (en) 2018-06-17 2019-12-19 Axsome Therapeutics, Inc. Compositions for delivery of reboxetine
JP2022504364A (ja) 2018-10-11 2022-01-13 ノバルティス アーゲー パーキンソン病(pd)に伴う日中の過度の眠気の治療のためのh3r逆作動薬の使用
US20200147093A1 (en) 2018-10-15 2020-05-14 Axsome Therapeutics, Inc. Use of esreboxetine to treat nervous system disorders such as fibromyalgia
US11020402B2 (en) 2018-10-15 2021-06-01 Axsome Therapeutics, Inc. Use of reboxetine to treat narcolepsy
EP4251148A1 (en) 2020-11-27 2023-10-04 Richter Gedeon Nyrt. Histamine h3 receptor antagonists/inverse agonists for the treatment of autism spectrum disorder

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Publication number Priority date Publication date Assignee Title
FR2567518B1 (fr) 1984-07-11 1987-11-13 Sanofi Sa Nouveaux composes a noyau heterocyclique azote, leur preparation et les medicaments qui en contiennent
TW301607B (el) 1993-03-09 1997-04-01 Takeda Pharm Industry Co Ltd
AU779442B2 (en) 2000-01-20 2005-01-27 Eisai Co. Ltd. Novel piperidine compounds and drugs containing the same
JP4522651B2 (ja) 2001-03-13 2010-08-11 シェーリング コーポレイション 新規非イミダゾール化合物
JP2007524596A (ja) 2003-02-28 2007-08-30 トランスフォーム・ファーマシューティカルズ・インコーポレイテッド 共結晶医薬組成物
DK1615909T3 (da) 2003-04-23 2008-11-17 Glaxo Group Ltd Piperazin-derivater og deres anvendelse til behandling af neurologiske og psykiatriske sygdomme
CA2555824C (en) 2004-02-13 2011-06-07 Banyu Pharmaceutical Co., Ltd. Fused-ring 4-oxopyrimidine derivative
SE0401971D0 (sv) * 2004-08-02 2004-08-02 Astrazeneca Ab Piperidne derivatives
KR20090102883A (ko) 2004-09-02 2009-09-30 테바 파마슈티컬 인더스트리즈 리미티드 올메살탄 메독소밀의 정제
CA2573800A1 (en) 2004-09-02 2006-03-16 Teva Pharmaceutical Industries Ltd. Preparation of olmesartan medoxomil
EP1909797A4 (en) * 2005-08-02 2013-02-27 Neurogen Corp DIPIPERAZINYL KETONE AND RELATED ANALOG
WO2007052124A1 (en) 2005-11-04 2007-05-10 Pfizer Limited Tetrahydronaphthyridine derivative
EP1970373A1 (en) 2005-12-02 2008-09-17 Mitsubishi Tanabe Pharma Corporation Alicyclic heterocyclic compound
CN102015668A (zh) * 2007-12-05 2011-04-13 阿斯利康(瑞典)有限公司 用作瘦蛋白受体调节剂的哌嗪衍生物及其用途
TWI498115B (zh) * 2007-12-27 2015-09-01 Daiichi Sankyo Co Ltd 咪唑羰基化合物
EP2328586A2 (en) 2008-05-20 2011-06-08 Cephalon, Inc. Substituted pyridazinone derivatives as histamine-3 (h3) receptor ligands
WO2011090062A1 (ja) 2010-01-22 2011-07-28 大鵬薬品工業株式会社 Pgds阻害作用を有するピペラジン化合物
TW201217312A (en) * 2010-09-22 2012-05-01 Gruenenthal Gmbh Substituted benzamide compounds
AR088256A1 (es) * 2011-10-08 2014-05-21 Novartis Ag Derivados de carbamato / urea como antagonistas del receptor h3
US9034874B2 (en) 2012-07-20 2015-05-19 Novartis Ag Carbamate/urea derivatives

Also Published As

Publication number Publication date
UY34921A (es) 2014-02-28
WO2014013469A1 (en) 2014-01-23
ZA201408805B (en) 2016-08-31
AR092354A1 (es) 2015-04-15
PL2875016T3 (pl) 2018-01-31
PH12014502743A1 (en) 2015-02-02
US20150218127A1 (en) 2015-08-06
CN104470911A (zh) 2015-03-25
US9273026B2 (en) 2016-03-01
CN104470911B (zh) 2018-04-06
RS56479B1 (sr) 2018-01-31
US20140163036A1 (en) 2014-06-12
IN2014DN10449A (el) 2015-08-21
DK2875016T3 (da) 2017-11-27
JP6203841B2 (ja) 2017-09-27
AU2013291617B2 (en) 2015-10-01
CL2015000056A1 (es) 2015-03-20
SI2875016T1 (sl) 2017-11-30
US9034874B2 (en) 2015-05-19
PH12014502743B1 (en) 2015-02-02
KR20150036081A (ko) 2015-04-07
CU24248B1 (es) 2017-02-02
BR112015001207A8 (pt) 2018-01-16
EA201590250A1 (ru) 2015-05-29
HRP20171692T1 (hr) 2017-12-15
MY168752A (en) 2018-11-30
CA2878006A1 (en) 2014-01-23
IL236656A (en) 2017-12-31
CU20150006A7 (es) 2016-02-29
NO2875016T3 (el) 2018-01-20
ES2648512T3 (es) 2018-01-03
TW201408656A (zh) 2014-03-01
TWI597276B (zh) 2017-09-01
SG10201700188PA (en) 2017-02-27
CA2878006C (en) 2020-10-27
LT2875016T (lt) 2017-11-10
AP2014008109A0 (en) 2014-12-31
HUE035592T2 (en) 2018-05-28
US20160244426A1 (en) 2016-08-25
PE20151155A1 (es) 2015-08-05
JP2015522606A (ja) 2015-08-06
JO3439B1 (ar) 2019-10-20
NZ702346A (en) 2017-06-30
AU2013291617A1 (en) 2015-01-15
PT2875016T (pt) 2017-11-30
MX362059B (es) 2019-01-07
GT201500012A (es) 2017-11-09
MX2015000903A (es) 2015-04-10
EP2875016A1 (en) 2015-05-27
EP2875016B1 (en) 2017-08-23
CR20150019A (es) 2015-05-04
IL236656A0 (en) 2015-02-26
KR102150739B1 (ko) 2020-09-02
US9624192B2 (en) 2017-04-18
US20170275264A1 (en) 2017-09-28
BR112015001207A2 (pt) 2017-08-01
HK1204609A1 (en) 2015-11-27
EA026091B1 (ru) 2017-02-28
CO7170173A2 (es) 2015-01-28
SG11201408020RA (en) 2015-03-30
TN2014000497A1 (en) 2016-03-30
AP3710A (en) 2016-05-31
BR112015001207B1 (pt) 2022-08-09

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