CY1118406T1 - Μεθοδοι αγωγης συνδρομου down, συνδρομου ευθραυστου χ και αυτισμου - Google Patents

Μεθοδοι αγωγης συνδρομου down, συνδρομου ευθραυστου χ και αυτισμου

Info

Publication number
CY1118406T1
CY1118406T1 CY20171100014T CY171100014T CY1118406T1 CY 1118406 T1 CY1118406 T1 CY 1118406T1 CY 20171100014 T CY20171100014 T CY 20171100014T CY 171100014 T CY171100014 T CY 171100014T CY 1118406 T1 CY1118406 T1 CY 1118406T1
Authority
CY
Cyprus
Prior art keywords
syndrome
autism
treatment methods
gaba
antagonists
Prior art date
Application number
CY20171100014T
Other languages
English (en)
Inventor
Randall L Carpenter
Kathryn Roberts
Mark F Bear
Original Assignee
Clinical Research Associates, Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Clinical Research Associates, Llc filed Critical Clinical Research Associates, Llc
Publication of CY1118406T1 publication Critical patent/CY1118406T1/el

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/428—Thiazoles condensed with carbocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Emergency Medicine (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Ultra Sonic Daignosis Equipment (AREA)
  • Heat Treatment Of Sheet Steel (AREA)
  • Surgical Instruments (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Υποκείμενα τα οποία πάσχουν από τουλάχιστον μία κατάσταση η οποία επιλέγεται από την ομάδα η οποία αποτελείται από νοητική καθυστέρηση, σύνδρομο Down, σύνδρομο εύθραυστου Χ και αυτισμό υποβάλλονται σε αγωγή με μία σύνθεση η οποία περιλαμβάνει αγωνιστές γάμμα-αμινοβουτυρικού οξέος και/ή ανταγωνιστές Μ1 μουσκαρινικού υποδοχέα. Ο αγωνιστής γάμμα-αμινοβουτυρικού οξέος (GABA) μπορεί να είναι ένας αγωνιστής GABA(B) όπως baclofen. Οι αγωνιστές GABA(B) μπορούν να χρησιμοποιούνται σε συνδυασμό με ανταγωνιστές mGluR Ομάδας I και ανταγωνιστές Μ1 μουσκαρινικού υποδοχέα σε μεθόδους αγωγής σε ανθρώπους.
CY20171100014T 2006-11-22 2017-01-05 Μεθοδοι αγωγης συνδρομου down, συνδρομου ευθραυστου χ και αυτισμου CY1118406T1 (el)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US86073306P 2006-11-22 2006-11-22
US156707P 2007-11-02 2007-11-02
PCT/US2007/024311 WO2008066750A1 (en) 2006-11-22 2007-11-21 Methods of treating mental retardation, down's syndrome, fragile x syndrome and autism

Publications (1)

Publication Number Publication Date
CY1118406T1 true CY1118406T1 (el) 2017-06-28

Family

ID=39272866

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20171100014T CY1118406T1 (el) 2006-11-22 2017-01-05 Μεθοδοι αγωγης συνδρομου down, συνδρομου ευθραυστου χ και αυτισμου

Country Status (16)

Country Link
US (6) US8143311B2 (el)
EP (3) EP2578216A1 (el)
JP (1) JP2010510314A (el)
AU (1) AU2007325836B2 (el)
CA (1) CA2670116C (el)
CY (1) CY1118406T1 (el)
DK (1) DK2083811T3 (el)
ES (1) ES2610508T3 (el)
HR (1) HRP20170027T1 (el)
HU (1) HUE032743T2 (el)
LT (1) LT2083811T (el)
PL (1) PL2083811T3 (el)
PT (1) PT2083811T (el)
RS (1) RS55585B1 (el)
SI (1) SI2083811T1 (el)
WO (1) WO2008066750A1 (el)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20100144863A1 (en) * 2008-12-08 2010-06-10 Bernard Hublot Compounds and methods for treating autism spectrum disorders
PT2395990E (pt) 2009-02-12 2015-02-09 Univ Indiana Res & Tech Corp Material e métodos de tratamento de transtornos do desenvolvimento incluindo autismo comórbido e idiopático
US8334287B2 (en) 2009-07-17 2012-12-18 Hoffmann-La Roche Inc. Imidazoles
WO2011053636A1 (en) * 2009-10-27 2011-05-05 Mount Sinai School Of Medicine Methods of treating psychiatric or neurological disorders with mglur antagonists
EP2544688B1 (en) * 2010-03-02 2016-09-07 President and Fellows of Harvard College Methods and compositions for treatment of angelman syndrome
WO2012009646A1 (en) * 2010-07-15 2012-01-19 Xenoport, Inc. Methods of treating fragile x syndrome, down's syndrome, autism and related disorders
US8946206B2 (en) 2010-12-17 2015-02-03 The Board Of Trustees Of The Leland Stanford Junior University Methods for improving cognitive function
CA2874737A1 (en) * 2012-06-01 2013-12-05 Lynn Health Science Institute, Inc. Use of baclofen to treat insomnia
EP2928300A4 (en) * 2012-11-28 2016-07-13 Neuren Pharmaceuticals Ltd TREATMENT OF AUTISTIC SPECTRUM DISORDERS USING GLYCYL-L-2-METHYLPROLYL-L-GLUTAMIC ACID
US9265458B2 (en) 2012-12-04 2016-02-23 Sync-Think, Inc. Application of smooth pursuit cognitive testing paradigms to clinical drug development
JPWO2014128882A1 (ja) * 2013-02-21 2017-02-02 医療法人 和楽会 不安うつ病の治療薬
US9380976B2 (en) 2013-03-11 2016-07-05 Sync-Think, Inc. Optical neuroinformatics
PL3058371T3 (pl) * 2013-10-14 2021-11-08 Indiana University Research And Technology Corporation Zastosowanie akamprozatu do modulowania aktywacji erk 1-2 w modelach zwierzęcych dla fxs i asd oraz u osób z rozpoznaniem fxs i asd
US10350183B2 (en) 2015-01-15 2019-07-16 Allaysis, Llc Intravenous baclofen formulations and treatment methods
BR112017017729A2 (pt) 2015-02-20 2018-04-10 Osmotica Kereskedelmi Es Szolgaltato Kft forma de dosagem oral de liberação controlada de agonista de receptor gaba
US10300032B2 (en) 2015-02-20 2019-05-28 Osmotica Kereskedelmi Es Szolgaltato Kft Controlled release dosage form
US10172800B2 (en) 2015-02-20 2019-01-08 Osmotica Kereskedelmi Es Szolgaltato Kft Controlled release dosage form with enhanced pharmacokinetics
US10987328B2 (en) 2015-02-20 2021-04-27 Osmotica Kereskedelmi Es Szolgaltato Kft Controlled release dosage form
PE20190338A1 (es) * 2015-07-17 2019-03-07 Ovid Therapeutics Inc Metodos de tratamiento de trastornos del desarrollo con gaboxadol
MX2019001669A (es) 2016-08-11 2019-09-27 Ovid Therapeutics Inc Metodos y composiciones para el tratamiento de trastornos epilepticos.
US10535243B2 (en) * 2016-10-28 2020-01-14 HBH Development LLC Target behavior monitoring system
US10071083B2 (en) 2017-02-03 2018-09-11 Ovid Therapeutics Inc Use of gaboxadol in the treatment of tinnitus
AU2018309049A1 (en) 2017-08-04 2020-02-27 Ovid Therapeutics Inc. Use of gaboxadol in the treatment of diabetes and related conditions
US20210057078A1 (en) * 2018-01-18 2021-02-25 Cureapp, Inc. System, device, method, and program for treating disorder treatable by behavior modification
US11911351B2 (en) 2018-01-30 2024-02-27 Apnimed, Inc. (Delaware) Methods for treating sleep apnea with combinations of atomoxetine and (R)-oxybutynin
US10765666B2 (en) 2018-09-20 2020-09-08 Ovid Therapeutics Inc Use of gaboxadol for the treatment of Tourette syndrome, tics and stuttering
USD967184S1 (en) * 2021-02-26 2022-10-18 Oracle International Corporation Display screen or portion thereof with icon, or paper product with surface ornamentation
USD970544S1 (en) * 2021-02-26 2022-11-22 Oracle International Corporation Display screen or portion thereof with icon or paper product with surface ornamentation
US11523984B1 (en) * 2021-11-12 2022-12-13 Amneal Pharmaceuticals Llc Compositions and methods of administering baclofen
WO2023178183A1 (en) * 2022-03-16 2023-09-21 University Of Florida Research Foundation, Incorporated Combinatorial activation of gaba(b) and alpha-2 adrenergic receptors for treatment of stress induced depression

Family Cites Families (79)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3539573A (en) 1967-03-22 1970-11-10 Jean Schmutz 11-basic substituted dibenzodiazepines and dibenzothiazepines
NO129043B (el) 1968-02-16 1974-02-18 Fujisawa Pharmaceutical Co
FR2492258A1 (fr) 1980-10-17 1982-04-23 Pharmindustrie Nouveau medicament a base d'amino-2 trifluoromethoxy-6 benzothiazole
US4411901A (en) 1981-12-23 1983-10-25 Mead Johnson & Company Benzisothiazole and benzisoxazole piperazine derivatives
JPH0625181B2 (ja) 1985-03-27 1994-04-06 住友製薬株式会社 新規なイミド誘導体
US4804663A (en) 1985-03-27 1989-02-14 Janssen Pharmaceutica N.V. 3-piperidinyl-substituted 1,2-benzisoxazoles and 1,2-benzisothiazoles
IE58370B1 (en) 1985-04-10 1993-09-08 Lundbeck & Co As H Indole derivatives
GB8607684D0 (en) 1986-03-27 1986-04-30 Ici America Inc Thiazepine compounds
US4831031A (en) 1988-01-22 1989-05-16 Pfizer Inc. Aryl piperazinyl-(C2 or C4) alkylene heterocyclic compounds having neuroleptic activity
DE69010232T2 (de) 1989-03-03 1994-12-01 Dainippon Pharmaceutical Co 2-(1-Piperazinyl)-4-phenylcycloalkanpyridin-Derivate, Verfahren zu deren Herstellung und pharmazeutische Zusammensetzungen, die sie enthalten.
GB8908085D0 (en) 1989-04-11 1989-05-24 Lundbeck & Co As H New therapeutic use
US5238945A (en) 1989-04-11 1993-08-24 H. Lundbeck A/S Method of treating psychoses
ES2076253T3 (es) 1989-05-19 1995-11-01 Hoechst Roussel Pharma N-(ariloxialquil)-heteroarilpiperidinas y -heteroarilpiperazinas, un procedimiento para su preparacion y su uso como medicamentos.
US5229382A (en) 1990-04-25 1993-07-20 Lilly Industries Limited 2-methyl-thieno-benzodiazepine
US6107025A (en) 1991-05-24 2000-08-22 Baylor College Of Medicine Diagnosis of the fragile X syndrome
US6180337B1 (en) 1991-05-24 2001-01-30 Baylor College Of Medicine Diagnosis of the fragile X syndrome
DE4243287A1 (de) 1992-06-19 1993-12-23 Basf Ag N-Substituierte Azabicycloheptan-Derivate, ihre Herstellung und Verwendung
DE4339702A1 (de) 1993-11-22 1995-05-24 Bayer Ag Verfahren zur Herstellung von harten Polyurethanschaumstoffen
CZ265096A3 (en) 1994-03-14 1997-06-11 Novo Nordisk As Thienoindole derivatives, their use, process of their preparation and pharmaceutical composition containing thereof
US6309853B1 (en) 1994-08-17 2001-10-30 The Rockfeller University Modulators of body weight, corresponding nucleic acids and proteins, and diagnostic and therapeutic uses thereof
WO1996015099A1 (en) 1994-11-09 1996-05-23 Novo Nordisk A/S Heterocyclic compounds, their preparation and use
US6011021A (en) 1996-06-17 2000-01-04 Guilford Pharmaceuticals Inc. Methods of cancer treatment using naaladase inhibitors
WO1997005109A1 (en) 1995-07-31 1997-02-13 Novo Nordisk A/S Heterocyclic compounds, their preparation and use
JPH11509846A (ja) 1995-07-31 1999-08-31 ノボ ノルディスク アクティーゼルスカブ ヘテロ環式化合物、それらの調製及び使用
GB9609976D0 (en) 1996-05-13 1996-07-17 Lilly Industries Ltd Pharmaceutical compounds
US5795877A (en) 1996-12-31 1998-08-18 Guilford Pharmaceuticals Inc. Inhibitors of NAALADase enzyme activity
US5863536A (en) 1996-12-31 1999-01-26 Guilford Pharmaceuticals Inc. Phosphoramidate derivatives
US6046180A (en) 1996-06-17 2000-04-04 Guilford Pharmaceuticals Inc. NAALADase inhibitors
US6025344A (en) 1996-06-17 2000-02-15 Guilford Pharmaceuticals Inc. Certain dioic acid derivatives useful as NAALADase inhibitors
US5672592A (en) 1996-06-17 1997-09-30 Guilford Pharmaceuticals Inc. Certain phosphonomethyl-pentanedioic acid derivatives thereof
US5902817A (en) 1997-04-09 1999-05-11 Guilford Pharmaceuticals Inc. Certain sulfoxide and sulfone derivatives
AU3783497A (en) 1996-08-09 1998-03-06 Yamanouchi Pharmaceutical Co., Ltd. Metabotropic glutamate receptor agonists
FR2759366B1 (fr) 1997-02-11 1999-04-16 Centre Nat Rech Scient Composes constituant notamment des effecteurs de recepteurs du systeme nerveux central sensibles aux amino acides neuroexcitateurs, leur preparation et leurs applications biologiques
CA2285192A1 (en) 1997-04-07 1998-10-15 Smriti Iyengar Pharmacological agents
EP0994707A4 (en) 1997-05-27 2001-11-14 Guilford Pharm Inc INHIBITORS OF NAALADASE ENZYMATIC ACTIVITY
TW544448B (en) 1997-07-11 2003-08-01 Novartis Ag Pyridine derivatives
TR200000405T2 (tr) 1997-08-14 2000-08-21 F.Hoffmann-La Roche Ag Nörolojik rahatsızlıklara karşı heterosiklik vinileterler.
PL338783A1 (en) * 1997-08-25 2000-11-20 Neurogen Corp Substituted 4-oxo-naphtyridin-3-carboxamides as ligands of cerebral gaba receptors
CN1158264C (zh) 1997-11-21 2004-07-21 Nps药物有限公司 用于治疗中枢神经系统疾病的代谢性谷氨酸受体拮抗剂
WO1999044639A1 (fr) 1998-03-03 1999-09-10 Yamanouchi Pharmaceutical Co., Ltd. Medicaments contre l'infarcissement du cerveau
JP2002512214A (ja) 1998-04-17 2002-04-23 ケネス カリー， 代謝生成物産生グルタミン酸レセプターアンタゴニストとしてのキュバン誘導体およびそれらの調製プロセス
SE511005C2 (sv) 1998-07-07 1999-07-19 Laekartjaenster I Vaestsverige Användning av komposition omfattande minst ett ämne inom gruppen GnRH-analoger för framställning av ett läkemedel för behandling av tvångstanke-tvångshandlingssjukdom
US20030216293A1 (en) 1998-07-07 2003-11-20 Tomas Eriksson Use of composition comprising at least one substance within the group GnRH-analogues for treatment of obsessive -compulsive disorder (OCD)
ID29095A (id) 1998-10-02 2001-07-26 Novartis Ag Cs Antagonis mglur5 untuk pengobatan rasa sakit dan kegelisahan
GB9823847D0 (en) 1998-11-02 1998-12-23 Lilly Co Eli Pharmaceutical compounds
GB9823845D0 (en) 1998-11-02 1998-12-23 Lilly Co Eli Pharmaceutical compounds
TW593241B (en) 1999-04-20 2004-06-21 Hoffmann La Roche Carbamic acid derivatives
AU4797400A (en) 1999-05-17 2000-12-05 Eli Lilly And Company Metabotropic glutamate receptor antagonists
CH1196397H1 (de) 1999-06-02 2007-05-31 Nps Pharma Inc Metabotrope Glutamatrezeptorantagonisten zur Behandlung von Krankheiten des zentralen Nervensystems.
WO2001002342A1 (en) 1999-06-30 2001-01-11 Igt Pharma Inc. 2-aminoindane analogs
MXPA02000261A (es) 1999-07-02 2003-08-20 Prescient Nerupharma Inc Aminoindanos novedosos.
AU5591900A (en) 1999-07-06 2001-01-22 Eli Lilly And Company Diester prodrugs of a decahydroisoquinoline-3-carboxylic acid
AU5959900A (en) 1999-07-15 2001-02-05 Mcgill University Oligonucleotides for metabotropic glutamate receptor type 1 (mglur1)
AU6182000A (en) 1999-08-02 2001-02-19 Yamanouchi Pharmaceutical Co., Ltd. Remedies for neurogenic pains
DE60006618T2 (de) 1999-08-06 2004-09-23 F. Hoffmann-La Roche Ag Tetrahydro-benzo(d)azepine und deren Verwendung als metabotrope Glutamatrezeptor-Antagonisten
NZ517407A (en) * 1999-08-10 2003-10-31 Uab Research Foundation Use of GABA agonists for treatment of spastic disorders, convulsions, and epilepsy
US6313159B1 (en) 1999-08-20 2001-11-06 Guilford Pharmaceuticals Inc. Metabotropic glutamate receptor ligand derivatives as naaladase inhibitors
WO2001032632A2 (en) 1999-11-01 2001-05-10 Eli Lilly And Company Pharmaceutically active 4-substituted pyrimidine derivatives
GB0005700D0 (en) 2000-03-09 2000-05-03 Glaxo Group Ltd Therapy
US20030008897A1 (en) 2000-03-17 2003-01-09 Mendel Carl M. Method of controlling weight gain associated with therapeutic drugs
US6455553B1 (en) * 2000-10-03 2002-09-24 Albert Einstein College Of Medicine Of Yeshiva University Method for treating a demyelinating condition
US20020123490A1 (en) 2001-03-01 2002-09-05 Pfizer Inc. Combination treatment for anxiety, depression, obsessive compulsive disorder and psychosis
US6916821B2 (en) * 2001-04-02 2005-07-12 Brown University Methods of treating disorders with Group I mGluR antagonists
JP2005500260A (ja) * 2001-04-02 2005-01-06 ブラウン ユニバーシティ リサーチ ファウンデイション ｍＧｌｕＲ５アンタゴニストの組成物および使用方法
US6831077B2 (en) 2002-07-25 2004-12-14 Comprehensive Neuroscience, Inc. Augmentation of atypical antipsychotic agent pharmacotherapy with chromium supplementation
US6656172B1 (en) * 2002-09-27 2003-12-02 Medtronic, Inc. Method for treating severe tinnitus
CA2529318C (en) 2003-06-24 2013-09-17 University Of Connecticut Methods of inhibiting vascular permeability and apoptosis
KR20110097942A (ko) * 2003-08-20 2011-08-31 제노포트 인코포레이티드 아실옥시알킬 카르바메이트 프로드러그, 합성 및 사용 방법
US20050090554A1 (en) * 2003-09-12 2005-04-28 John Devane Treatment of gastroparesis and nonulcer dyspepsia with GABAB agonists
WO2006012403A1 (en) * 2004-07-20 2006-02-02 Massachusetts Institute Of Technology Methods of treatment: cell signaling and glutamate release
US20070254314A1 (en) 2004-09-16 2007-11-01 Geier Mark R Methods of treating autism and autism spectrum disorders
US20060058271A1 (en) 2004-09-16 2006-03-16 Geier Mark R Methods for screening, studying, and treating dissorders with a component of mercurial toxicity
US9095713B2 (en) * 2004-12-21 2015-08-04 Allison M. Foster Methods and systems for treating autism by decreasing neural activity within the brain
WO2006121919A2 (en) * 2005-05-05 2006-11-16 Massachusetts Institute Of Technology Methods of treating obsessive compulsive disorder
WO2007029063A2 (en) * 2005-07-29 2007-03-15 Ecole Polytechnique Federale De Lausanne (Epfl) Treatment and/or prevention of pervasive developmental disorders
US20080312279A1 (en) * 2005-10-26 2008-12-18 Warren Stephen T Compositions for Treating Fragile X and Other Disorders Methods of Use Thereof, and Screening for Compounds for Fragile X and Other Disorders
US20070112017A1 (en) * 2005-10-31 2007-05-17 Braincells, Inc. Gaba receptor mediated modulation of neurogenesis
US20070191440A1 (en) * 2006-01-25 2007-08-16 Solomon Michael E Methods of treating autism and fragile X syndrome
JP2013510088A (ja) 2009-11-05 2013-03-21 ブラウン ユニバーシティ ｍＴＯＲのシグナル伝達の増強を処置する方法

Also Published As

Publication number Publication date
WO2008066750A1 (en) 2008-06-05
US20130012587A1 (en) 2013-01-10
CA2670116A1 (en) 2008-06-05
JP2010510314A (ja) 2010-04-02
CA2670116C (en) 2015-03-10
HRP20170027T1 (hr) 2017-03-10
ES2610508T3 (es) 2017-04-27
US8278276B2 (en) 2012-10-02
US20100029770A1 (en) 2010-02-04
AU2007325836A1 (en) 2008-06-05
EP2083811A1 (en) 2009-08-05
RS55585B1 (sr) 2017-06-30
PT2083811T (pt) 2017-01-23
LT2083811T (lt) 2017-01-25
EP2567696A1 (en) 2013-03-13
US20130012586A1 (en) 2013-01-10
US20120122986A1 (en) 2012-05-17
SI2083811T1 (sl) 2017-02-28
PL2083811T3 (pl) 2017-05-31
US9044443B2 (en) 2015-06-02
EP2578216A1 (en) 2013-04-10
HUE032743T2 (en) 2017-10-30
US20130261186A1 (en) 2013-10-03
US8273715B2 (en) 2012-09-25
EP2083811B1 (en) 2016-10-26
DK2083811T3 (en) 2017-01-30
US20120129940A1 (en) 2012-05-24
AU2007325836B2 (en) 2011-07-21
US8143311B2 (en) 2012-03-27

Similar Documents

Publication Publication Date Title
CY1118406T1 (el) Μεθοδοι αγωγης συνδρομου down, συνδρομου ευθραυστου χ και αυτισμου
CY1120961T1 (el) Δοσολογικες μορφες απο του στοματος που περιλαμβανουν αντιαιμοπεταλιακο παραγοντα και αναστολεα οξεος
CY1118760T1 (el) Τροποποιημενα αντισωματα εναντι il-23
CY1119339T1 (el) Μεθοδοι για θεραπεια καταστασεων που συνδυαζονται με εξαρτωμενη απο masp-2 ενεργοποιηση συμπληρωματος
EA200802184A1 (ru) Фармацевтические композиции с ингибиторами dpp iv
CY1113651T1 (el) Αντιφλεγμονωδη σκευασματα
BRPI1013688A8 (pt) Proteínas de ligação de il-17.
DE602006003990D1 (de) Medizinisches Instrument mit Greiforgan welches eine Elektrode zur medizinischen Behandlung aufweist
BR112012031071A2 (pt) 8-proteínas de ligação à il-1
CY1121465T1 (el) Μεθοδοι και συνθεσεις για τη θεραπεια της φλεγμονωδους νοσου του εντερου
CL2010001426A1 (es) Compuestos derivados de triciclos, inhibidores de la proteina quinasa; composicion farmaceutica que los comprende; utiles en el tratamiento de enfermedades oncologicas e inmunologicas.
CO6300826A2 (es) Metodos y composiciones que utilizan polipeptidos de fusion de klotho-fgf
CY1115437T1 (el) Υδροξυμεθυλοκυκλοεξυλαμινες
ATE423114T1 (de) Aminocyclopropancarbonsäureamidderivate als bradykininantagonisten
MX2009013645A (es) Deteccion de coproantigeno de ascaride.
EE200800063A (et) N-karbamoüülmetüül-4-(R)-fenüül-2-pürrolidinoon, selle valmistamise meetod ja farmatseutiline kasutamine
CY1114735T1 (el) Θεραπευτικες συνθεσεις οι οποιες περιεχουν εναν ειδικο ανταγωνιστη του υποδοχεα της ενδοθηλινης και εναν αναστολεα της pde5
CY1114307T1 (el) Συνθεσεις που περιεχουν αικουορινη και μεθοδοι που τις χρησιμοποιουν
ATE504833T1 (de) Verfahren zur bestimmung des phänotyps von zellen
CY1114366T1 (el) Συνθεσεις που περιεχουν αποαικoυορiνη και μεθοδοι χρησης τους
GB2442365A (en) Methods of determining compounds useful in the treatment of bipolar disorder and methods of treating such disorders
CY1116166T1 (el) Νεα μεθοδος για την αντιμετωπιση λοιμωξεων απο η.pylori
DE602006014462D1 (de) Elektrodensubstrat, Vorrichtung zur Detektion und Testkit
WO2010042685A3 (en) Inhibitors of the atb(0,+) transporter and uses thereof
EA201000063A1 (ru) Новые соединения, обладающие функцией ингибиторов тромбина, и фармацевтические композиции на их основе