CY1117805T1 - Αντιμετωπιση οστεοπορωσης - Google Patents

Αντιμετωπιση οστεοπορωσης

Info

Publication number
CY1117805T1
CY1117805T1 CY20161100668T CY161100668T CY1117805T1 CY 1117805 T1 CY1117805 T1 CY 1117805T1 CY 20161100668 T CY20161100668 T CY 20161100668T CY 161100668 T CY161100668 T CY 161100668T CY 1117805 T1 CY1117805 T1 CY 1117805T1
Authority
CY
Cyprus
Prior art keywords
osteoporosis treatment
osteoporosis
treatment
osteopenia
prodrug
Prior art date
Application number
CY20161100668T
Other languages
English (en)
Inventor
Stephen Hodges
Robin Soper
Original Assignee
Haomamedica Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Haomamedica Limited filed Critical Haomamedica Limited
Publication of CY1117805T1 publication Critical patent/CY1117805T1/el

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/12—Ketones
    • A61K31/122—Ketones having the oxygen directly attached to a ring, e.g. quinones, vitamin K1, anthralin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid 
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/20—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/216—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acids having aromatic rings, e.g. benactizyne, clofibrate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Emergency Medicine (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Display Devices Of Pinball Game Machines (AREA)
  • Superconductors And Manufacturing Methods Therefor (AREA)
  • Medicinal Preparation (AREA)

Abstract

Σύμφωνα με την εφεύρεση παρέχεται μία ένωση του τύπου (I): όπου R1, R2, R3 και n έχουν σημασίες οι οποίες δίνονται στην περιγραφή, ή ένα φαρμακευτικώς αποδεκτό επιδιαλύτωμα, άλας ή προφάρμακο αυτής για χρήση στην αντιμετώπιση οστεοπόρωσης και/ή οστεοπενίας.
CY20161100668T 2009-12-23 2016-07-12 Αντιμετωπιση οστεοπορωσης CY1117805T1 (el)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB0922513.7A GB2476644B (en) 2009-12-23 2009-12-23 1,4-Dihydro-1,4-dioxonaphtalene derivatives for the treatment of osteoporosis
PCT/GB2010/052195 WO2011077159A1 (en) 2009-12-23 2010-12-22 Treatment of osteoporosis

Publications (1)

Publication Number Publication Date
CY1117805T1 true CY1117805T1 (el) 2017-05-17

Family

ID=41716867

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20161100668T CY1117805T1 (el) 2009-12-23 2016-07-12 Αντιμετωπιση οστεοπορωσης

Country Status (22)

Country Link
US (2) US8895624B2 (el)
EP (1) EP2536398B1 (el)
JP (1) JP5922033B2 (el)
KR (1) KR101805940B1 (el)
CN (1) CN103002886B (el)
AU (1) AU2010334566B2 (el)
BR (1) BR112012017773B1 (el)
CA (1) CA2785553C (el)
CY (1) CY1117805T1 (el)
DK (1) DK2536398T3 (el)
GB (1) GB2476644B (el)
HK (1) HK1178057A1 (el)
HR (1) HRP20160832T1 (el)
HU (1) HUE028400T2 (el)
IL (1) IL220620A (el)
PL (1) PL2536398T3 (el)
PT (1) PT2536398T (el)
RS (1) RS54987B1 (el)
RU (1) RU2562976C2 (el)
SI (1) SI2536398T1 (el)
SM (1) SMT201600224B (el)
WO (1) WO2011077159A1 (el)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2476643B (en) * 2009-12-23 2012-11-14 Haomamedica Ltd 1,4-Dihydro-1,4-dioxonaphtalene derivatives as anticoagulants
GB2476644B (en) 2009-12-23 2012-11-14 Haomamedica Ltd 1,4-Dihydro-1,4-dioxonaphtalene derivatives for the treatment of osteoporosis

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5640651A (en) * 1979-09-12 1981-04-16 Takeda Chem Ind Ltd Quinone compound and its preparation
JPS55153739A (en) 1979-05-18 1980-11-29 Takeda Chem Ind Ltd Quinone compound and its preparation
GB8310141D0 (en) 1983-04-14 1983-05-18 Wellcome Found Naphthoquinone derivatives
WO1986000887A1 (en) 1984-08-01 1986-02-13 Takeda Chemical Industries, Ltd. Quinone derivatives, process for their preparation, and medicinal composition containing the same
MX9203040A (es) 1984-08-01 1992-07-31 Takeda Chemical Industries Ltd Derivados de quinona y composicion farmaceutica que los contiene.
US4734282A (en) 1986-04-23 1988-03-29 Duke University Rodenticidal compositions containing 1,4-naphthoquinone derivatives
JP2756941B2 (ja) 1996-01-26 1998-05-25 東國製薬株式会社 ２−クロロ−３−アリールアミノ−１，４−ナフトキノン誘導体の血小板凝集抑制剤としての用途
GB9613309D0 (en) * 1996-06-25 1996-08-28 Univ Sheffield Quinone bacterial inhibitors
US5849793A (en) * 1997-08-15 1998-12-15 The Picower Institute For Medical Research HIV matrix protein tyrosine position 29 pocket binders
AU780598B2 (en) * 1999-10-19 2005-04-07 Meiji Dairies Corporation Food materials useful in preventing and ameliorating metabolic bone diseases and preventives/remedies for metabolic bone diseases comprising these materials
AU2002333378A1 (en) * 2001-08-03 2003-02-24 Vitak Bv Isoprenyl derivatives and their use in the treatment and prevention of osteoporosis and cardiovascular calcification
US20050222258A1 (en) * 2003-02-21 2005-10-06 Feixin Wang Pharmaceuticals comprising shikonins as active constituent
EP1889613A4 (en) * 2005-05-27 2010-11-24 Shionogi & Co PHARMACEUTICAL COMPOSITION COMPRISING VITAMIN K
JP5827784B2 (ja) 2006-07-14 2015-12-02 ナットファルマ エーエスエー ビタミンｋ２を含む医薬及び栄養補助製品
GB2476643B (en) * 2009-12-23 2012-11-14 Haomamedica Ltd 1,4-Dihydro-1,4-dioxonaphtalene derivatives as anticoagulants
GB2476644B (en) 2009-12-23 2012-11-14 Haomamedica Ltd 1,4-Dihydro-1,4-dioxonaphtalene derivatives for the treatment of osteoporosis

Also Published As

Publication number Publication date
GB2476644A (en) 2011-07-06
HRP20160832T1 (hr) 2016-09-23
PL2536398T3 (pl) 2016-12-30
JP2013515712A (ja) 2013-05-09
GB2476644B (en) 2012-11-14
BR112012017773A2 (pt) 2016-04-19
PT2536398T (pt) 2016-07-15
SI2536398T1 (sl) 2016-10-28
SMT201600224B (it) 2016-08-31
RS54987B1 (sr) 2016-11-30
JP5922033B2 (ja) 2016-05-24
DK2536398T3 (en) 2016-08-01
KR101805940B1 (ko) 2017-12-06
AU2010334566B2 (en) 2016-12-01
US8895624B2 (en) 2014-11-25
CN103002886A (zh) 2013-03-27
EP2536398B1 (en) 2016-04-13
RU2012130936A (ru) 2014-01-27
CA2785553C (en) 2017-09-05
BR112012017773B1 (pt) 2021-10-26
HK1178057A1 (zh) 2013-09-06
RU2562976C2 (ru) 2015-09-10
CA2785553A1 (en) 2011-06-30
US9622989B2 (en) 2017-04-18
WO2011077159A1 (en) 2011-06-30
US20150141339A1 (en) 2015-05-21
HUE028400T2 (en) 2016-12-28
AU2010334566A1 (en) 2012-07-19
EP2536398A1 (en) 2012-12-26
CN103002886B (zh) 2016-10-26
KR20120123667A (ko) 2012-11-09
IL220620A (en) 2016-02-29
US20130030050A1 (en) 2013-01-31
GB0922513D0 (en) 2010-02-10

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