CY1116824T1 - Ενωσεις πυρουβαμιδιου ως αναστολεις της αλλεργιογονου πεπτιδασης ομαδας 1 των ακαρεων σκονης - Google Patents

Ενωσεις πυρουβαμιδιου ως αναστολεις της αλλεργιογονου πεπτιδασης ομαδας 1 των ακαρεων σκονης

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Publication number
CY1116824T1
CY1116824T1 CY20151100695T CY151100695T CY1116824T1 CY 1116824 T1 CY1116824 T1 CY 1116824T1 CY 20151100695 T CY20151100695 T CY 20151100695T CY 151100695 T CY151100695 T CY 151100695T CY 1116824 T1 CY1116824 T1 CY 1116824T1
Authority
CY
Cyprus
Prior art keywords
compounds
group
peptidase
allergen
powder
Prior art date
Application number
CY20151100695T
Other languages
Greek (el)
English (en)
Inventor
Clive Robinson
Jihui Zhang
David Ronald Garrod
Trevor Robert Perrior
Gary Karl Newton
Kerry Jenkins
Rebekah Elisabeth Beevers
Meriel Ruth Mayor
Mark Richard Stewart
Original Assignee
St. George's Hospital Medical School
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by St. George's Hospital Medical School filed Critical St. George's Hospital Medical School
Publication of CY1116824T1 publication Critical patent/CY1116824T1/el

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    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0802—Tripeptides with the first amino acid being neutral
    • C07K5/0812—Tripeptides with the first amino acid being neutral and aromatic or cycloaliphatic
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    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
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    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0202—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-X-X-C(=0)-, X being an optionally substituted carbon atom or a heteroatom, e.g. beta-amino acids
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GB201001070D0 (en) 2010-01-22 2010-03-10 St George's Hospital Medical School Theraputic compounds and their use
RU2015117578A (ru) * 2012-10-11 2016-11-27 Ф. Хоффманн-Ля Рош Аг Кетоамидные ингибиторы иммунопротеасом
CN103724334A (zh) * 2013-10-02 2014-04-16 张惠琳 新的抗变态反应的苯并环庚并噻吩类化合物
WO2015106240A1 (en) 2014-01-13 2015-07-16 The General Hospital Corporation Heteroaryl disulfide compounds as allosteric effectors for increasing the oxygen-binding affinity of hemoglobin
US20160331783A1 (en) * 2014-01-13 2016-11-17 The General Hospital Corporation Bisamide compounds as allosteric effectors for reducing the oxygen-binding affinity of hemoglobin
GB201908511D0 (en) 2019-06-13 2019-07-31 Adorx Therapeutics Ltd Hydroxamate compounds
US20240317801A1 (en) * 2020-12-17 2024-09-26 Disc Medicine, Inc. Peptidomimetic matriptase 2 inhibitors and uses thereof
WO2023165334A1 (zh) * 2022-03-01 2023-09-07 成都威斯克生物医药有限公司 酮酰胺类衍生物及其制药用途
WO2024028417A1 (en) 2022-08-03 2024-02-08 Institut National de la Santé et de la Recherche Médicale New composition for the treatment and/or prevention of vitiligo

Family Cites Families (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3149159A (en) 1962-04-16 1964-09-15 Smith Kline French Lab Substituted 7-aminoalkylbicyclo-[4. 2. 0] octa-1, 3, 5-trienes
EP0100673A2 (en) 1982-08-02 1984-02-15 The Research Foundation Of State University Of New York A method of enhancing neurofiber regrowth
US5066785A (en) 1988-11-15 1991-11-19 City Of Hope Carboxyl terminal peptide and protein sequencing
WO1990012805A1 (fr) 1989-04-15 1990-11-01 Zaidan Hojin Biseibutsu Kagaku Kenkyu Kai Postostatine et son compose connexe, ou leurs sels
US6235929B1 (en) * 1991-12-27 2001-05-22 Georgia Tech Research Corporation Tripeptide α-ketoamides
DE4331135A1 (de) 1993-09-14 1995-03-16 Bayer Ag Neue antiviral wirksame valinhaltige Pseudopeptide
US5580854A (en) 1994-03-04 1996-12-03 Mount Sinai School Of Medicine Of The City University Of New York Substrate-related peptidyl-aldehyde inhibitors of the proteolytic activity of the multicatalytic proteinase complex
JPH08208462A (ja) * 1994-11-24 1996-08-13 Takeda Chem Ind Ltd カテプシンｌ阻害剤
AU3935895A (en) 1994-11-24 1996-06-17 Takeda Chemical Industries Ltd. Alpha-ketoamide derivatives as cathepsin l inhibitor
EP0820464A2 (en) 1995-03-31 1998-01-28 Takeda Chemical Industries, Ltd. Cysteine protease inhibitor
AU716716B2 (en) 1995-07-17 2000-03-02 Medivir Uk Ltd Cysteine protease inhibitors for use in treatment of IgE mediated allergic diseases
AU728373B2 (en) 1995-12-07 2001-01-11 Scripps Research Institute, The HIV protease inhibitors
AU1599497A (en) 1996-02-16 1997-09-02 Bayer Aktiengesellschaft Oxime- and nitron-substituted pseudopeptides with an anti-viral action
CA2225325A1 (en) 1997-12-19 1999-06-19 The University Of British Columbia Hemiasterlin analogs
TR200103406T2 (tr) 1998-03-19 2002-06-21 Vertex Pharmaceuticals Incorporated Kaspaz inhibitörleri.
US7521068B2 (en) 1998-11-12 2009-04-21 Elan Pharma International Ltd. Dry powder aerosols of nanoparticulate drugs
WO2001040262A1 (en) 1999-12-03 2001-06-07 Bristol-Myers Squibb Pharma Company Alpha-ketoamide inhibitors of hepatitis c virus ns3 protease
JP2002030053A (ja) * 2000-07-13 2002-01-29 Senju Pharmaceut Co Ltd α−ケトアミド誘導体の製造法
CZ2003195A3 (cs) 2000-07-21 2003-04-16 Schering Corporation Peptidové inhibitory serinové proteázy NS3 a farmaceutický prostředek
EP1553964A4 (en) * 2002-09-25 2009-08-12 Georgia Tech Res Inst INHIBITORS OF CETOAMIDES IN CHRONIC NERVOUS DISEASES
US20080108593A1 (en) 2003-11-12 2008-05-08 Shinshu Tlo Co., Ltd Allergen Decomposer and Antiallergenic Feathers
CA2617294A1 (en) 2005-08-03 2007-02-08 Boehringer Ingelheim International Gmbh Substituted ethane-1,2-diamines for the treatment of alzheimer's disease ii
WO2007041775A1 (en) 2005-10-10 2007-04-19 The University Of Queensland Cysteine protease inhibitors incorporating azide groups
GB201001070D0 (en) 2010-01-22 2010-03-10 St George's Hospital Medical School Theraputic compounds and their use
GB201011411D0 (en) 2010-07-06 2010-08-18 St Georges Hosp Medical School Therapeutic compounds and their use

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KR101798676B1 (ko) 2017-11-16
EP2526116A2 (en) 2012-11-28
RU2586215C2 (ru) 2016-06-10
PL2526116T3 (pl) 2015-10-30
US20130217617A1 (en) 2013-08-22
BR112012017476B8 (pt) 2021-05-25
JP2013518040A (ja) 2013-05-20
RS54148B1 (sr) 2015-12-31
IL220665A (en) 2016-05-31
DK2526116T3 (en) 2015-08-10
KR20120120306A (ko) 2012-11-01
CA2786690C (en) 2019-05-07
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WO2011089396A2 (en) 2011-07-28
BR112012017476A2 (pt) 2016-04-19
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ME02218B (me) 2016-02-20
MX2012007711A (es) 2013-01-29
SMT201500215B (it) 2015-10-30
IL220665A0 (en) 2012-08-30
NZ601155A (en) 2013-08-30
RU2012127709A (ru) 2014-02-27
AU2011208510A1 (en) 2012-07-19
CA2786690A1 (en) 2011-07-28
HK1173735A1 (en) 2013-05-24
US8637453B2 (en) 2014-01-28
CN102822192A (zh) 2012-12-12
SI2526116T1 (sl) 2015-09-30
US8541363B2 (en) 2013-09-24
GB201001070D0 (en) 2010-03-10
BR112012017476B1 (pt) 2021-03-16
US20120322722A1 (en) 2012-12-20
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