CY1116043T1 - Κρυσταλλικες μορφες υδροχλωρικου αλατος (4α-r,9α-s)-1-(1η-βενζοϊμιδαζολο-5-καρβονυλ)2,3,4,4α,9,9α-εξαϋδρο-1η-ινδενο[2,1-β]πυριδινο-6-καρβονιτριλιου και χρηση τους ως αναστολεις της hsd 1 - Google Patents
Κρυσταλλικες μορφες υδροχλωρικου αλατος (4α-r,9α-s)-1-(1η-βενζοϊμιδαζολο-5-καρβονυλ)2,3,4,4α,9,9α-εξαϋδρο-1η-ινδενο[2,1-β]πυριδινο-6-καρβονιτριλιου και χρηση τους ως αναστολεις της hsd 1Info
- Publication number
- CY1116043T1 CY1116043T1 CY20151100195T CY151100195T CY1116043T1 CY 1116043 T1 CY1116043 T1 CY 1116043T1 CY 20151100195 T CY20151100195 T CY 20151100195T CY 151100195 T CY151100195 T CY 151100195T CY 1116043 T1 CY1116043 T1 CY 1116043T1
- Authority
- CY
- Cyprus
- Prior art keywords
- benzoimidazolo
- indo
- indeno
- carbonitrile
- hydro
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Abstract
Η παρούσα εφεύρεση αναφέρεται σε κρυσταλλικές ενώσεις του ακόλουθου δομικού τύπου (II) που κατέχουν πολύτιμη φαρμακολογική δραστικότητα. Συγκεκριμένα, οι ενώσεις είναι αναστολείς της 11 β-υδροξυστεροειδικής αφυδρογονάσης (HSD) 1 και όθεν είναι κατάλληλες για τη θεραπεία και πρόληψη νόσων οι οποίες μπορούν να επηρεαστούν από την αναστολή αυτού του ενζύμου, όπως μεταβολικές νόσοι, ιδιαίτερα διαβήτης τύπου 2, παχυσαρκία, και δυσλιπιδαιμία.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201161484995P | 2011-05-11 | 2011-05-11 | |
EP11785232.7A EP2635563B1 (en) | 2010-11-05 | 2011-11-04 | Crystalline forms of hydrochloride salt of (4a-r,9a-s)-1-(1h-benzoimidazole-5-carbonyl)-2,3,4,4a,9,9a-hexahydro-1h-indeno [2,1-b]pyridine-6-carbonitrile and their use as hsd 1 inhibitors |
Publications (1)
Publication Number | Publication Date |
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CY1116043T1 true CY1116043T1 (el) | 2017-01-25 |
Family
ID=44999935
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CY20151100195T CY1116043T1 (el) | 2011-05-11 | 2015-02-25 | Κρυσταλλικες μορφες υδροχλωρικου αλατος (4α-r,9α-s)-1-(1η-βενζοϊμιδαζολο-5-καρβονυλ)2,3,4,4α,9,9α-εξαϋδρο-1η-ινδενο[2,1-β]πυριδινο-6-καρβονιτριλιου και χρηση τους ως αναστολεις της hsd 1 |
Country Status (36)
Country | Link |
---|---|
US (2) | US8686149B2 (el) |
EP (1) | EP2635563B1 (el) |
JP (1) | JP2013541592A (el) |
KR (1) | KR20130119939A (el) |
CN (1) | CN103228642B (el) |
AP (1) | AP3521A (el) |
AR (1) | AR083678A1 (el) |
AU (1) | AU2011323164B2 (el) |
BR (1) | BR112013011095A2 (el) |
CA (1) | CA2816136A1 (el) |
CL (1) | CL2013001221A1 (el) |
CO (1) | CO6781480A2 (el) |
CY (1) | CY1116043T1 (el) |
DK (1) | DK2635563T3 (el) |
EA (1) | EA022406B1 (el) |
EC (2) | ECSP12011788A (el) |
ES (1) | ES2533833T3 (el) |
GE (1) | GEP20166481B (el) |
HK (1) | HK1184144A1 (el) |
HR (1) | HRP20150327T1 (el) |
IL (1) | IL225647A0 (el) |
ME (1) | ME02066B (el) |
MX (1) | MX2013005069A (el) |
NZ (1) | NZ609281A (el) |
PE (1) | PE20140123A1 (el) |
PL (1) | PL2635563T3 (el) |
PT (1) | PT2635563E (el) |
RS (1) | RS53900B1 (el) |
SG (1) | SG189859A1 (el) |
SI (1) | SI2635563T1 (el) |
SM (1) | SMT201500095B (el) |
TN (1) | TN2012000117A1 (el) |
TW (1) | TWI537258B (el) |
UA (1) | UA110807C2 (el) |
UY (1) | UY33701A (el) |
WO (1) | WO2012061708A1 (el) |
Families Citing this family (11)
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WO2009063061A2 (en) | 2007-11-16 | 2009-05-22 | Boehringer Ingelheim International Gmbh | Aryl- and heteroarylcarbonyl derivatives of benzomorphanes and related scaffolds, medicaments containing such compounds and their use |
AR071719A1 (es) | 2008-05-13 | 2010-07-07 | Boehringer Ingelheim Int | Derivados aliciclicos de acido carboxilico de benzomorfanos y estructuras relacionadas, medicamentos que contienen dichos compuestos y su uso.procesos de obtencion |
WO2010139673A1 (en) | 2009-06-02 | 2010-12-09 | Boehringer Ingelheim International Gmbh | Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1 |
WO2011011123A1 (en) | 2009-06-11 | 2011-01-27 | Vitae Pharmaceuticals, Inc. | Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1 based on the 1,3 -oxazinan- 2 -one structure |
WO2011159760A1 (en) | 2010-06-16 | 2011-12-22 | Vitae Pharmaceuticals, Inc. | Substituted 5-,6- and 7-membered heterocycles, medicaments containing such compounds, and their use |
TWI537258B (zh) | 2010-11-05 | 2016-06-11 | 百靈佳殷格翰國際股份有限公司 | 六氫茚并吡啶及八氫苯并喹啉之芳基-及雜環芳基羰基衍生物 |
EP2744783A1 (en) | 2011-08-17 | 2014-06-25 | Boehringer Ingelheim International GmbH | Indenopyridine derivatives |
IN2014DN08582A (el) * | 2012-05-09 | 2015-05-22 | Boehringer Ingelheim Int | |
EP3235813A1 (en) | 2016-04-19 | 2017-10-25 | Cidqo 2012, S.L. | Aza-tetra-cyclo derivatives |
CN111315735B (zh) | 2017-09-04 | 2024-03-08 | C4医药公司 | 二氢苯并咪唑酮 |
EP3935050A4 (en) | 2019-03-06 | 2023-01-04 | C4 Therapeutics, Inc. | HETEROCYCLIC COMPOUNDS FOR MEDICAL TREATMENT |
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2011
- 2011-10-18 TW TW100137675A patent/TWI537258B/zh not_active IP Right Cessation
- 2011-11-01 UY UY0001033701A patent/UY33701A/es not_active Application Discontinuation
- 2011-11-01 AR ARP110104053A patent/AR083678A1/es unknown
- 2011-11-04 AU AU2011323164A patent/AU2011323164B2/en not_active Ceased
- 2011-11-04 PE PE2013000949A patent/PE20140123A1/es not_active Application Discontinuation
- 2011-11-04 MX MX2013005069A patent/MX2013005069A/es unknown
- 2011-11-04 PL PL11785232T patent/PL2635563T3/pl unknown
- 2011-11-04 ES ES11785232.7T patent/ES2533833T3/es active Active
- 2011-11-04 KR KR1020137014295A patent/KR20130119939A/ko not_active Application Discontinuation
- 2011-11-04 SG SG2013026430A patent/SG189859A1/en unknown
- 2011-11-04 BR BR112013011095A patent/BR112013011095A2/pt not_active IP Right Cessation
- 2011-11-04 RS RS20150205A patent/RS53900B1/en unknown
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- 2011-11-04 EA EA201390643A patent/EA022406B1/ru not_active IP Right Cessation
- 2011-11-04 NZ NZ609281A patent/NZ609281A/en not_active IP Right Cessation
- 2011-11-04 SI SI201130449T patent/SI2635563T1/sl unknown
- 2011-11-04 ME MEP-2015-42A patent/ME02066B/me unknown
- 2011-11-04 US US13/289,418 patent/US8686149B2/en active Active
- 2011-11-04 WO PCT/US2011/059331 patent/WO2012061708A1/en active Application Filing
- 2011-11-04 CA CA2816136A patent/CA2816136A1/en not_active Abandoned
- 2011-11-04 DK DK11785232.7T patent/DK2635563T3/en active
- 2011-11-04 UA UAA201307042A patent/UA110807C2/uk unknown
- 2011-11-04 CN CN201180053044.5A patent/CN103228642B/zh not_active Expired - Fee Related
- 2011-11-04 EP EP11785232.7A patent/EP2635563B1/en active Active
- 2011-11-04 GE GEAP201113105A patent/GEP20166481B/en unknown
- 2011-11-04 JP JP2013537864A patent/JP2013541592A/ja active Pending
- 2011-11-04 PT PT117852327T patent/PT2635563E/pt unknown
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2012
- 2012-03-16 TN TNP2012000117A patent/TN2012000117A1/en unknown
- 2012-04-05 EC ECSP12011788 patent/ECSP12011788A/es unknown
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2013
- 2013-04-09 IL IL225647A patent/IL225647A0/en unknown
- 2013-05-03 CL CL2013001221A patent/CL2013001221A1/es unknown
- 2013-05-30 CO CO13132839A patent/CO6781480A2/es active IP Right Grant
- 2013-06-05 EC ECSP13012664 patent/ECSP13012664A/es unknown
- 2013-10-15 HK HK13111568.4A patent/HK1184144A1/xx not_active IP Right Cessation
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2014
- 2014-02-26 US US14/190,899 patent/US9120769B2/en active Active
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2015
- 2015-02-25 CY CY20151100195T patent/CY1116043T1/el unknown
- 2015-03-23 HR HRP20150327TT patent/HRP20150327T1/hr unknown
- 2015-04-16 SM SM201500095T patent/SMT201500095B/xx unknown
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