CY1114111T1 - Μεθοδοι χρησης του mirna για την ανιχνευση του in vivo θανατου των κυτταρων - Google Patents
Μεθοδοι χρησης του mirna για την ανιχνευση του in vivo θανατου των κυτταρωνInfo
- Publication number
- CY1114111T1 CY1114111T1 CY20131100546T CY131100546T CY1114111T1 CY 1114111 T1 CY1114111 T1 CY 1114111T1 CY 20131100546 T CY20131100546 T CY 20131100546T CY 131100546 T CY131100546 T CY 131100546T CY 1114111 T1 CY1114111 T1 CY 1114111T1
- Authority
- CY
- Cyprus
- Prior art keywords
- cell death
- methods
- vivo cell
- mirna
- detect
- Prior art date
Links
- 230000030833 cell death Effects 0.000 title abstract 3
- 238000000034 method Methods 0.000 title abstract 3
- 208000035473 Communicable disease Diseases 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 231100000433 cytotoxic Toxicity 0.000 abstract 1
- 230000001472 cytotoxic effect Effects 0.000 abstract 1
- 238000001514 detection method Methods 0.000 abstract 1
- 238000003745 diagnosis Methods 0.000 abstract 1
- 210000003754 fetus Anatomy 0.000 abstract 1
- 238000001727 in vivo Methods 0.000 abstract 1
- 208000015181 infectious disease Diseases 0.000 abstract 1
- 108091070501 miRNA Proteins 0.000 abstract 1
- 239000002679 microRNA Substances 0.000 abstract 1
- 230000007170 pathology Effects 0.000 abstract 1
- 239000000126 substance Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/70—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving virus or bacteriophage
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/70—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving virus or bacteriophage
- C12Q1/701—Specific hybridization probes
- C12Q1/705—Specific hybridization probes for herpetoviridae, e.g. herpes simplex, varicella zoster
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/118—Prognosis of disease development
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/158—Expression markers
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/178—Oligonucleotides characterized by their use miRNA, siRNA or ncRNA
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Analytical Chemistry (AREA)
- Genetics & Genomics (AREA)
- Immunology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Microbiology (AREA)
- Molecular Biology (AREA)
- Physics & Mathematics (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Pathology (AREA)
- Virology (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US96587107P | 2007-08-22 | 2007-08-22 | |
| EP08795523.3A EP2195450B2 (en) | 2007-08-22 | 2008-08-22 | Methods of using mirna for detection of in vivo cell death |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CY1114111T1 true CY1114111T1 (el) | 2016-07-27 |
Family
ID=40378881
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CY20131100546T CY1114111T1 (el) | 2007-08-22 | 2013-07-03 | Μεθοδοι χρησης του mirna για την ανιχνευση του in vivo θανατου των κυτταρων |
Country Status (16)
| Country | Link |
|---|---|
| US (4) | US8486626B2 (https=) |
| EP (2) | EP2195450B2 (https=) |
| JP (1) | JP5416110B2 (https=) |
| CN (2) | CN105400868B (https=) |
| AU (2) | AU2008289447B2 (https=) |
| CA (1) | CA2696403C (https=) |
| CY (1) | CY1114111T1 (https=) |
| DK (2) | DK2612926T3 (https=) |
| ES (2) | ES2660785T3 (https=) |
| HR (1) | HRP20130618T1 (https=) |
| HU (1) | HUE019019T5 (https=) |
| NO (1) | NO2612926T3 (https=) |
| PL (2) | PL2612926T3 (https=) |
| PT (2) | PT2612926T (https=) |
| TR (1) | TR201802758T4 (https=) |
| WO (1) | WO2009025852A2 (https=) |
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| WO2011006119A2 (en) | 2009-07-09 | 2011-01-13 | The Scripps Research Institute | Gene expression profiles associated with chronic allograft nephropathy |
| US8648017B2 (en) * | 2009-11-04 | 2014-02-11 | Diamir, Llc | Methods of using small RNA from bodily fluids for diagnosis and monitoring of neurodegenerative diseases |
| JP2013509883A (ja) | 2009-11-06 | 2013-03-21 | ザ ボード オブ トラスティーズ オブ ザ リーランド スタンフォード ジュニア ユニバーシティ | 臓器移植患者における移植片拒絶反応の非侵襲的診断方法 |
| WO2011143659A2 (en) * | 2010-05-14 | 2011-11-17 | Fluidigm Corporation | Nucleic acid isolation methods |
| RU2626540C2 (ru) | 2011-04-18 | 2017-07-28 | Диамир, Ллс | Способы обнаружения патологических изменений в органе или системе органов |
| CN102188719B (zh) * | 2011-05-12 | 2012-12-19 | 南方医科大学 | EB病毒miR-BART3反义寡聚核苷酸在制备治疗鼻咽癌的药物中的应用 |
| RU2639509C2 (ru) | 2011-06-27 | 2017-12-21 | Эйсай Ар Энд Ди Менеджмент Ко., Лтд. | МикроРНК - БИОМАРКЕРЫ, УКАЗЫВАЮЩИЕ НА БОЛЕЗНЬ АЛЬЦГЕЙМЕРА |
| CA2838562A1 (en) * | 2011-08-08 | 2013-02-14 | Eugenia Wang | Biomarker for alzheimer's disease and/or mild cognitively impairment, and use thereof |
| CA3069089A1 (en) * | 2011-09-22 | 2013-03-28 | Lineage Biosciences, Inc. | Compositions and methods for analyzing heterogeneous samples |
| ITRM20110685A1 (it) | 2011-12-23 | 2013-06-24 | Internat Ct For Genetic En Gineering And | Microrna per la rigenerazione cardiaca attraverso l induzione della proliferazione dei miociti cardiaci |
| US20160289762A1 (en) | 2012-01-27 | 2016-10-06 | The Board Of Trustees Of The Leland Stanford Junior University | Methods for profiliing and quantitating cell-free rna |
| HK1211624A1 (en) | 2012-01-27 | 2016-05-27 | The Board Of Trustees Of The University Of The Leland Stanford Junior University | Methods for profiling and quantitating cell-free rna |
| US20140087964A1 (en) * | 2012-09-24 | 2014-03-27 | University Of Virginia Patent Foundation | Compositions and methods for detecting aberrant regulation, expression, and levels of hgh |
| EP2733220B1 (en) * | 2012-11-16 | 2017-10-18 | Siemens Aktiengesellschaft | Novel miRNA as a diagnostic marker for Alzheimer's Disease |
| WO2014075822A1 (en) * | 2012-11-16 | 2014-05-22 | Siemens Aktiengesellschaft | New diagnostic mirna markers for parkinson disease |
| EP2733219B1 (en) | 2012-11-16 | 2017-09-20 | Siemens Aktiengesellschaft | Diagnostic miRNA markers for Alzheimer |
| CN103045736B (zh) * | 2012-12-20 | 2014-09-17 | 徐勇 | 唐氏综合征21号染色体miRNA差异表达图谱模型、构建方法及应用 |
| CN103045596A (zh) * | 2012-12-20 | 2013-04-17 | 徐勇 | 唐氏综合征21号染色体相关miRNA、基因、筛选方法和应用 |
| EP2759602A1 (en) * | 2013-01-25 | 2014-07-30 | Charité - Universitätsmedizin Berlin | Non-invasive prenatal genetic diagnostic methods |
| EP3611262B1 (en) | 2013-03-15 | 2020-11-11 | Lineage Biosciences, Inc. | Methods of sequencing the immune repertoire |
| CN105917005B (zh) | 2013-11-18 | 2020-09-11 | 迪阿米尔有限责任公司 | 使用来自体液的miRNA检测和监控帕金森病(PD)的方法 |
| US10443100B2 (en) | 2014-05-22 | 2019-10-15 | The Scripps Research Institute | Gene expression profiles associated with sub-clinical kidney transplant rejection |
| US11104951B2 (en) | 2014-05-22 | 2021-08-31 | The Scripps Research Institute | Molecular signatures for distinguishing liver transplant rejections or injuries |
| TWI813141B (zh) | 2014-07-18 | 2023-08-21 | 香港中文大學 | Ｄｎａ混合物中之組織甲基化模式分析 |
| JP6873921B2 (ja) | 2015-05-18 | 2021-05-19 | カリウス・インコーポレイテッド | 核酸の集団を濃縮するための組成物および方法 |
| WO2017019751A1 (en) | 2015-07-27 | 2017-02-02 | The Johns Hopkins University | Method to use viral and host methylation markers for cervical cancer screening and triage in liquid prep, serum/plasma, and urine: pcr and sequencing based process methods |
| JP2018526021A (ja) * | 2015-09-11 | 2018-09-13 | コーニング インコーポレイテッド | 血液試料からの核酸精製のための組成物及び方法 |
| US10975436B2 (en) | 2016-01-05 | 2021-04-13 | Diamir, Llc | Methods of using miRNA from bodily fluids for diagnosis and monitoring of neurodevelopmental disorders |
| US11149313B2 (en) | 2016-03-21 | 2021-10-19 | Diamir, Llc | Methods of using miRNAs from bodily fluids for detection and differentiation of neurodegenerative diseases |
| WO2018045359A1 (en) * | 2016-09-02 | 2018-03-08 | Karius, Inc. | Detection and treatment of infection during pregnancy |
| WO2018090054A1 (en) | 2016-11-14 | 2018-05-17 | Berg Llc | Methods for treating parkinson's disease |
| KR20260032575A (ko) | 2016-11-30 | 2026-03-09 | 더 차이니즈 유니버시티 오브 홍콩 | 소변 및 기타 샘플에서의 무세포 dna의 분석 |
| US10907211B1 (en) | 2017-02-16 | 2021-02-02 | Quantgene Inc. | Methods and compositions for detecting cancer biomarkers in bodily fluids |
| US10781487B2 (en) | 2017-07-24 | 2020-09-22 | Diamir, Llc | miRNA-based methods for detecting and monitoring aging |
| GB2615975B (en) | 2019-02-14 | 2023-11-29 | Mirvie Inc | Methods and systems for determining a pregnancy-related state of a subject |
| KR102802718B1 (ko) * | 2019-10-29 | 2025-04-30 | 고쿠리츠켄큐카이하츠호진 고쿠리츠쥰칸키뵤 겐큐센터 | 뇌경색 치료 지원 시스템 |
| US11475981B2 (en) | 2020-02-18 | 2022-10-18 | Tempus Labs, Inc. | Methods and systems for dynamic variant thresholding in a liquid biopsy assay |
| US11211147B2 (en) | 2020-02-18 | 2021-12-28 | Tempus Labs, Inc. | Estimation of circulating tumor fraction using off-target reads of targeted-panel sequencing |
| US11211144B2 (en) | 2020-02-18 | 2021-12-28 | Tempus Labs, Inc. | Methods and systems for refining copy number variation in a liquid biopsy assay |
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| ITRM20050067A1 (it) * | 2005-02-17 | 2006-08-18 | Istituto Naz Per Le Malattie I | Metodo per la rivelazione di acidi nucleici virali o di origine virale nelle urine. |
| EP2351857B1 (en) | 2005-02-17 | 2014-10-29 | TrovaGene, Inc. | Compositions and methods for detecting pathogen specific nucleic acids in urine |
| ITRM20050068A1 (it) * | 2005-02-17 | 2006-08-18 | Istituto Naz Per Le Malattie I | Metodo per la rivelazione di acidi nucleici di agenti patogeni batterici o di parassiti nelle urine. |
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| US20060292616A1 (en) * | 2005-06-23 | 2006-12-28 | U.S. Genomics, Inc. | Single molecule miRNA-based disease diagnostic methods |
| DE102005059315A1 (de) * | 2005-12-09 | 2007-06-14 | Qiagen Gmbh | Verfahren zur Anreicherung von kurzkettigen Nukleinsäuren |
| US20070202511A1 (en) * | 2006-02-28 | 2007-08-30 | Sigma-Aldrich Co. | Methods and compositions for the rapid isolation of small RNA molecules |
| EP2853601B1 (en) * | 2008-07-18 | 2016-09-21 | TrovaGene, Inc. | Methods for PCR-based detection of "ultra short" nucleic acid sequences |
-
2008
- 2008-08-22 HU HUE08795523A patent/HUE019019T5/en unknown
- 2008-08-22 HR HRP20130618AT patent/HRP20130618T1/hr unknown
- 2008-08-22 TR TR2018/02758T patent/TR201802758T4/tr unknown
- 2008-08-22 CA CA2696403A patent/CA2696403C/en not_active Expired - Fee Related
- 2008-08-22 AU AU2008289447A patent/AU2008289447B2/en not_active Ceased
- 2008-08-22 CN CN201510649676.8A patent/CN105400868B/zh not_active Expired - Fee Related
- 2008-08-22 PT PT131619850T patent/PT2612926T/pt unknown
- 2008-08-22 EP EP08795523.3A patent/EP2195450B2/en not_active Not-in-force
- 2008-08-22 PT PT87955233T patent/PT2195450E/pt unknown
- 2008-08-22 US US12/229,378 patent/US8486626B2/en not_active Expired - Fee Related
- 2008-08-22 WO PCT/US2008/009991 patent/WO2009025852A2/en not_active Ceased
- 2008-08-22 ES ES13161985.0T patent/ES2660785T3/es active Active
- 2008-08-22 PL PL13161985T patent/PL2612926T3/pl unknown
- 2008-08-22 JP JP2010521887A patent/JP5416110B2/ja not_active Expired - Fee Related
- 2008-08-22 PL PL08795523T patent/PL2195450T3/pl unknown
- 2008-08-22 EP EP13161985.0A patent/EP2612926B1/en not_active Not-in-force
- 2008-08-22 DK DK13161985.0T patent/DK2612926T3/en active
- 2008-08-22 NO NO13161985A patent/NO2612926T3/no unknown
- 2008-08-22 ES ES08795523.3T patent/ES2415245T5/es active Active
- 2008-08-22 CN CN200880113585.0A patent/CN101861399B/zh not_active Expired - Fee Related
- 2008-08-22 DK DK08795523.3T patent/DK2195450T4/en active
-
2013
- 2013-07-03 CY CY20131100546T patent/CY1114111T1/el unknown
- 2013-07-16 US US13/942,706 patent/US20150197805A1/en not_active Abandoned
-
2014
- 2014-08-11 AU AU2014210676A patent/AU2014210676B2/en not_active Ceased
-
2017
- 2017-01-06 US US15/400,157 patent/US20180135126A1/en not_active Abandoned
-
2018
- 2018-09-21 US US16/138,338 patent/US20200283851A1/en not_active Abandoned
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