CY1113530T1 - Εμβολιο εναντι του αναπαραγωγικου και αναπνευστικου συνδρομου των χοιρων, βασισμενο στο απομονωθεν στελεχος ja-142 - Google Patents
Εμβολιο εναντι του αναπαραγωγικου και αναπνευστικου συνδρομου των χοιρων, βασισμενο στο απομονωθεν στελεχος ja-142Info
- Publication number
- CY1113530T1 CY1113530T1 CY20121100590T CY121100590T CY1113530T1 CY 1113530 T1 CY1113530 T1 CY 1113530T1 CY 20121100590 T CY20121100590 T CY 20121100590T CY 121100590 T CY121100590 T CY 121100590T CY 1113530 T1 CY1113530 T1 CY 1113530T1
- Authority
- CY
- Cyprus
- Prior art keywords
- prrs
- virus
- forms
- respiratory syndrome
- pigs
- Prior art date
Links
- 229960005486 vaccine Drugs 0.000 title abstract 3
- 241000282887 Suidae Species 0.000 title 1
- 230000001850 reproductive effect Effects 0.000 title 1
- 230000000241 respiratory effect Effects 0.000 title 1
- 208000011580 syndromic disease Diseases 0.000 title 1
- 241001135989 Porcine reproductive and respiratory syndrome virus Species 0.000 abstract 5
- 208000005342 Porcine Reproductive and Respiratory Syndrome Diseases 0.000 abstract 3
- 241000700605 Viruses Species 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- 230000001717 pathogenic effect Effects 0.000 abstract 2
- 241001465754 Metazoa Species 0.000 abstract 1
- 230000003698 anagen phase Effects 0.000 abstract 1
- 230000005875 antibody response Effects 0.000 abstract 1
- 238000009395 breeding Methods 0.000 abstract 1
- 230000001488 breeding effect Effects 0.000 abstract 1
- 230000036039 immunity Effects 0.000 abstract 1
- 208000015181 infectious disease Diseases 0.000 abstract 1
- 230000002458 infectious effect Effects 0.000 abstract 1
- 230000003612 virological effect Effects 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
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- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
- C12N7/04—Inactivation or attenuation; Producing viral sub-units
- C12N7/08—Inactivation or attenuation by serial passage of virus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/525—Virus
- A61K2039/5254—Virus avirulent or attenuated
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/55—Medicinal preparations containing antigens or antibodies characterised by the host/recipient, e.g. newborn with maternal antibodies
- A61K2039/552—Veterinary vaccine
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
- C12N2770/00011—Details
- C12N2770/10011—Arteriviridae
- C12N2770/10022—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
- C12N2770/00011—Details
- C12N2770/10011—Arteriviridae
- C12N2770/10034—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
- C12N2770/00011—Details
- C12N2770/10011—Arteriviridae
- C12N2770/10061—Methods of inactivation or attenuation
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
- C12N2770/00011—Details
- C12N2770/10011—Arteriviridae
- C12N2770/10061—Methods of inactivation or attenuation
- C12N2770/10064—Methods of inactivation or attenuation by serial passage
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S424/00—Drug, bio-affecting and body treating compositions
- Y10S424/815—Viral vaccine for porcine species, e.g. swine
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Virology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Genetics & Genomics (AREA)
- Public Health (AREA)
- Immunology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Zoology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Wood Science & Technology (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Biotechnology (AREA)
- Oncology (AREA)
- General Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Communicable Diseases (AREA)
- Gastroenterology & Hepatology (AREA)
- Epidemiology (AREA)
- Mycology (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Pulmonology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Abstract
Παρέχονται ουσιαστικά μη παθογόνες μορφές άτυπου ιού του αναπαραγωγικού και αναπνευστικού συνδρόμου των χοίρων (ΡRRS) και αντίστοιχα εμβόλια που προκύπτουν από ανακαλλιέργεια κυτταρικών καλλιεργειών λοιμογόνων μορφών του ΡRRS. Ο μη παθογόνος άτυπος ιός ΡRRS που προκύπτει είναι χρήσιμος ως εμβόλιο στο ότι προκαλείται ειδική ανταπόκριση αντισώματος έναντι του ΡRRS δια του ενοφθαλμισμού των ζώων ξενιστών, αποδίδοντας τοιουτοτρόπως αποτελεσματική ανοσία έναντι τόσο προγενέστερα γνωστών στελεχών του ιού ΡRRS όσο και προσφάτως απομονωθέντων άτυπων στελεχών του ιού ΡRRS. Η προτιμώμενη τεχνική ανακαλλιέργειας εξασφαλίζει ότι ο ιός παραμένει σε λογαριθμική φάση αναπτύξεως ουσιαστικά σε όλη τη διάρκεια της διεργασίας, που ελαχιστοποιεί το χρόνο τον απαιτούμενο για την επίτευξη της εξασθενήσεως.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US29811099A | 1999-04-22 | 1999-04-22 | |
US46187999A | 1999-12-15 | 1999-12-15 | |
EP10169336A EP2251419B1 (en) | 1999-04-22 | 2000-04-21 | Porcine reproductive and respiratory syndrome vaccine, based on isolate JA-142 |
Publications (1)
Publication Number | Publication Date |
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CY1113530T1 true CY1113530T1 (el) | 2016-06-22 |
Family
ID=26970484
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CY20121100590T CY1113530T1 (el) | 1999-04-22 | 2012-06-29 | Εμβολιο εναντι του αναπαραγωγικου και αναπνευστικου συνδρομου των χοιρων, βασισμενο στο απομονωθεν στελεχος ja-142 |
Country Status (14)
Country | Link |
---|---|
US (5) | US6641819B2 (el) |
EP (2) | EP2251419B1 (el) |
JP (2) | JP4778620B2 (el) |
KR (1) | KR100900370B1 (el) |
AT (1) | ATE474041T1 (el) |
AU (1) | AU4482200A (el) |
CA (2) | CA2650236C (el) |
CY (1) | CY1113530T1 (el) |
DE (1) | DE60044672D1 (el) |
DK (2) | DK1183332T3 (el) |
ES (2) | ES2388909T3 (el) |
MX (1) | MXPA01010681A (el) |
PT (1) | PT2251419E (el) |
WO (1) | WO2000065032A1 (el) |
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US20040224327A1 (en) * | 1996-10-30 | 2004-11-11 | Meulenberg Johanna Jacoba Maria | Infectious clones of RNA viruses and vaccines and diagnostic assays derived thereof |
EP0839912A1 (en) | 1996-10-30 | 1998-05-06 | Instituut Voor Dierhouderij En Diergezondheid (Id-Dlo) | Infectious clones of RNA viruses and vaccines and diagnostic assays derived thereof |
US7618797B2 (en) * | 1998-12-22 | 2009-11-17 | Pfizer Inc | Infectious cDNA clone of North American porcine reproductive and respiratory syndrome (PRRS) virus and uses thereof |
CA2650236C (en) | 1999-04-22 | 2016-01-12 | United States Of America, As Represented By The Secretary Of Agriculture | Porcine reproductive and respiratory syndrome vaccine, based on isolate ja-142 |
TW200604526A (en) | 2004-06-18 | 2006-02-01 | Unviersity Of Minnesota | Identifying virally infected and vaccinated organisms |
US7632636B2 (en) * | 2004-09-21 | 2009-12-15 | Boehringer Ingelheim Vetmedica, Inc. | Porcine reproductive and respiratory syndrome isolates and methods of use |
US7879337B2 (en) * | 2004-11-11 | 2011-02-01 | Pfizer Inc. | Mutant porcine reproductive and respiratory syndrome virus |
CN101084011B (zh) * | 2004-11-19 | 2010-06-16 | 英特威国际有限公司 | 猪繁殖与呼吸综合征病毒株及组合物 |
WO2007002321A2 (en) | 2005-06-24 | 2007-01-04 | Regents Of The University Of Minnesota | Prrs viruses, infectious clones, mutants thereof, and methods of use |
CA2675139C (en) | 2007-01-12 | 2019-02-19 | The Board Of Trustees Of The University Of Illinois | Non-simian cells for growth of porcine reproductive and respiratory syndrome (prrs) virus |
JP2010531143A (ja) * | 2007-06-25 | 2010-09-24 | サウス ダコタ ステート ユニバーシティー | 組換え北アメリカ1型ブタ生殖器呼吸器症候群ウイルス及び使用方法 |
KR101653177B1 (ko) * | 2008-08-25 | 2016-09-01 | 베링거잉겔하임베트메디카인코퍼레이티드 | 고병원성 돼지 생식기 및 호흡기 증후군(hp prrs)에 대한 백신 |
JP5306943B2 (ja) * | 2009-08-24 | 2013-10-02 | 全国農業協同組合連合会 | 弱毒ウイルスの作出方法 |
TWI627281B (zh) | 2009-09-02 | 2018-06-21 | 百靈佳殷格翰家畜藥品公司 | 降低pcv-2組合物殺病毒活性之方法及具有改良免疫原性之pcv-2組合物 |
CA2827337C (en) | 2011-02-17 | 2019-07-09 | Boehringer Ingelheim Vetmedica Gmbh | Commercial scale process for production of prrsv |
EA038012B1 (ru) | 2011-02-17 | 2021-06-23 | Бёрингер Ингельхайм Ветмедика Гмбх | Композиция на основе нового штамма prrsv или его белков, продукт, их применение, вирус prrsv, выделенная нк и рекомбинантный вектор экспрессии для получения этого вируса |
CN102305859B (zh) * | 2011-07-27 | 2014-04-23 | 吉林大学 | 检测猪繁殖与呼吸综合征病毒的活毒抗体试剂盒 |
WO2013017568A1 (en) | 2011-07-29 | 2013-02-07 | Boehringer Ingelheim Vetmedica Gmbh | INFECTIOUS cDNA CLONE OF EUROPEAN PRRS VIRUS AND USES THEREOF |
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US8906385B2 (en) | 2011-12-01 | 2014-12-09 | University Of Maryland, College Park | Interferon-inducing porcine reproductive and respiratory syndrome virus isolate |
MX366051B (es) | 2012-12-07 | 2019-06-26 | Univ Illinois | Composiciones del virus del síndrome reproductor y respiratorio de porcino y sus usos. |
WO2014150822A2 (en) | 2013-03-15 | 2014-09-25 | Boehringer Ingelheim Vetmedica, Inc. | Porcine reproductive and respiratory syndrome virus, compositions, vaccine and methods of use |
ES2940691T3 (es) | 2013-12-20 | 2023-05-10 | Boehringer Ingelheim Vetmedica Gmbh | Variante de virus PRRS, clon de ADNc de virus PRRS europeo y usos de los mismos |
RU2687150C2 (ru) | 2014-03-21 | 2019-05-07 | Нютек Венчерз | Не встречающийся в природе вирус репродуктивно-респираторного синдрома свиней (bppcc) и способы применения |
CN105176915A (zh) * | 2015-10-15 | 2015-12-23 | 南京三生生物技术有限公司 | 一种适于Marc-145细胞生长的低血清无蛋白培养基及其制备方法 |
KR101642727B1 (ko) * | 2015-12-31 | 2016-07-27 | 대한민국 | 약독화된 돼지열병 바이러스 생마커백신주 및 이를 이용한 경구투여용 백신 조성물 |
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2000
- 2000-04-21 CA CA2650236A patent/CA2650236C/en not_active Expired - Lifetime
- 2000-04-21 PT PT10169336T patent/PT2251419E/pt unknown
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- 2000-04-21 KR KR1020017013690A patent/KR100900370B1/ko active IP Right Grant
- 2000-04-21 EP EP10169336A patent/EP2251419B1/en not_active Expired - Lifetime
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- 2000-04-21 MX MXPA01010681A patent/MXPA01010681A/es active IP Right Grant
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- 2001-10-18 US US09/981,282 patent/US6641819B2/en not_active Expired - Lifetime
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2002
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