CY1113016T1 - Μεθοδος για παραγωγη δενδριτικων κυτταρων με εφαρμογη μειωμενης θερμοκρασιας - Google Patents

Μεθοδος για παραγωγη δενδριτικων κυτταρων με εφαρμογη μειωμενης θερμοκρασιας

Info

Publication number
CY1113016T1
CY1113016T1 CY20121100452T CY121100452T CY1113016T1 CY 1113016 T1 CY1113016 T1 CY 1113016T1 CY 20121100452 T CY20121100452 T CY 20121100452T CY 121100452 T CY121100452 T CY 121100452T CY 1113016 T1 CY1113016 T1 CY 1113016T1
Authority
CY
Cyprus
Prior art keywords
production
application
reduced temperature
cells
dendric cells
Prior art date
Application number
CY20121100452T
Other languages
English (en)
Inventor
Alexei Kirkin
Karine Djandjougazian
Jesper Zeuthen
Original Assignee
Dandrit Biotech A/S
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dandrit Biotech A/S filed Critical Dandrit Biotech A/S
Publication of CY1113016T1 publication Critical patent/CY1113016T1/el

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0639—Dendritic cells, e.g. Langherhans cells in the epidermis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/515—Animal cells
    • A61K2039/5154—Antigen presenting cells [APCs], e.g. dendritic cells or macrophages
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/20—Cytokines; Chemokines
    • C12N2501/22—Colony stimulating factors (G-CSF, GM-CSF)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/20—Cytokines; Chemokines
    • C12N2501/23—Interleukins [IL]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/20—Cytokines; Chemokines
    • C12N2501/25—Tumour necrosing factors [TNF]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2523/00—Culture process characterised by temperature

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Biotechnology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Virology (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Hematology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Gastroenterology & Hepatology (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Molecular Biology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

Η εφεύρεση σχετίζεται σε ορισμένες υλοποιήσεις με μια μέθοδο για παραγωγή δενδριτικών κυττάρων με εφαρμογή θερμοκρασιών κάτω των 37°C κατά τη διάρκεια της ανάπτυξης προγονικών κυττάρων και ανώριμων δενδριτικών κυττάρων. Σε μερικές υλοποιήσεις η εφεύρεση σχετίζεται με πληθυσμούς δενδριτικών κυττάρων και τη χρήση τους.
CY20121100452T 2005-12-08 2012-05-15 Μεθοδος για παραγωγη δενδριτικων κυτταρων με εφαρμογη μειωμενης θερμοκρασιας CY1113016T1 (el)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DKPA200501742 2005-12-08
EP06818153A EP1971680B1 (en) 2005-12-08 2006-12-07 Method for generating dendritic cells employing decreased temperature

Publications (1)

Publication Number Publication Date
CY1113016T1 true CY1113016T1 (el) 2016-04-13

Family

ID=37745820

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20121100452T CY1113016T1 (el) 2005-12-08 2012-05-15 Μεθοδος για παραγωγη δενδριτικων κυτταρων με εφαρμογη μειωμενης θερμοκρασιας

Country Status (18)

Country Link
US (1) US9771558B2 (el)
EP (1) EP1971680B1 (el)
JP (1) JP2009518017A (el)
CN (1) CN101321861B (el)
AT (1) ATE545698T1 (el)
AU (1) AU2006322451A1 (el)
BR (1) BRPI0619520A2 (el)
CA (1) CA2640836C (el)
CY (1) CY1113016T1 (el)
DK (1) DK1971680T3 (el)
EA (1) EA015266B1 (el)
ES (1) ES2382565T3 (el)
IL (1) IL191782A (el)
MY (1) MY145814A (el)
NO (1) NO20083023L (el)
NZ (1) NZ569343A (el)
PT (1) PT1971680E (el)
WO (1) WO2007065439A1 (el)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009062502A1 (en) * 2007-11-13 2009-05-22 Dandrit Biotech A/S Method for generating tolerogenic dendritic cells employing decreased temperature
RU2486238C1 (ru) * 2011-12-29 2013-06-27 Государственное бюджетное образовательное учреждение высшего профессионального образования "Сибирский государственный медицинский университет" Министерства здравоохранения и социального развития Российской Федерации (ГБОУ ВПО СибГМУ Минздравсоцразвития России) СПОСОБ НАГРУЗКИ ДЕНДРИТНЫХ КЛЕТОК АНТИГЕНОМ ИНФЕКЦИОННОГО ПРОИСХОЖДЕНИЯ Opisthorchis felineus
RU2663468C1 (ru) * 2017-09-25 2018-08-06 Федеральное государственное бюджетное учреждение "Ростовский научно-исследовательский онкологический институт" Министерства здравоохранения Российской Федерации Способ лечения местно-распространенного нерезектабельного рака поджелудочной железы
CN114980930A (zh) * 2019-12-27 2022-08-30 志瑞亚新药工业株式会社 癌症治疗方法及药物

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4306813B2 (ja) * 1995-09-19 2009-08-05 アスビオファーマ株式会社 動物細胞の新規培養方法
US5849589A (en) * 1996-03-11 1998-12-15 Duke University Culturing monocytes with IL-4, TNF-α and GM-CSF TO induce differentiation to dendric cells
US20050084966A1 (en) * 1999-04-20 2005-04-21 Edelson Richard L. Methods for inducing the differentiation of blood monocytes into functional dendritic cells
EP1259592A1 (en) * 2000-01-11 2002-11-27 Maxygen, Inc. Monocyte-derived dendritic cell subsets
CN1168740C (zh) * 2001-04-04 2004-09-29 上海美恩生物技术有限公司 细胞因子基因修饰的抗原提呈细胞/肿瘤细胞偶联物、其制法和用途
US20040009596A1 (en) * 2002-03-28 2004-01-15 Rao Kanury V. S. Extract from an Indian green mussel (perna viridis) for differentiation and maturation of dendric cells
JP4219789B2 (ja) * 2002-10-30 2009-02-04 独立行政法人科学技術振興機構 骨髄由来の不死化樹状細胞株
WO2004092220A1 (en) * 2003-04-14 2004-10-28 Board Of Regents, The University Of Texas System Methods for ex vivo hybridoma-free production of polyclonal and monoclonal antibodies and generation of immortalized cell populations
US20050003533A1 (en) * 2003-05-08 2005-01-06 Pawel Kalinski Mature type-1 polarized dendritic cells with enhanced IL-12 production and methods of serum-free production and use
WO2006127150A2 (en) * 2005-04-08 2006-11-30 Argos Therapeutics, Inc. Dendritic cell compositions and methods

Also Published As

Publication number Publication date
BRPI0619520A2 (pt) 2011-10-04
ES2382565T3 (es) 2012-06-11
JP2009518017A (ja) 2009-05-07
IL191782A (en) 2012-05-31
CN101321861B (zh) 2012-10-24
NO20083023L (no) 2008-08-28
CN101321861A (zh) 2008-12-10
EP1971680A1 (en) 2008-09-24
MY145814A (en) 2012-04-30
AU2006322451A1 (en) 2007-06-14
ATE545698T1 (de) 2012-03-15
US9771558B2 (en) 2017-09-26
WO2007065439A1 (en) 2007-06-14
IL191782A0 (en) 2008-12-29
CA2640836A1 (en) 2007-06-14
EA015266B1 (ru) 2011-06-30
EP1971680B1 (en) 2012-02-15
PT1971680E (pt) 2012-05-23
US20090196856A1 (en) 2009-08-06
DK1971680T3 (da) 2012-06-11
EA200801385A1 (ru) 2008-10-30
NZ569343A (en) 2011-11-25
CA2640836C (en) 2018-05-15

Similar Documents

Publication Publication Date Title
CY1123480T1 (el) Μεθοδος για την παραγωγη μεταβλητων περιοχων
CY1119173T1 (el) Νεα μορια αναστολεα jnk
BR112012026379A2 (pt) métodos para gerar proteína endogenamente marcada
CY1113321T1 (el) Παραγωγη ενος πληθυσμου κυτταρων in vitro χρησιμοποιωντας κυτταρα τροφοδοτη
CY1113016T1 (el) Μεθοδος για παραγωγη δενδριτικων κυτταρων με εφαρμογη μειωμενης θερμοκρασιας
ATE536192T1 (de) Vernetzte hyaluronsäure und kollagen und ihre verwendungen
CL2012000063A1 (es) Polipéptido factor ix (fix) o un fragmento del mismo porque comprende la modificación de un aminoácido; vector; célula; método para expresar el polipéptido fix; composición farmacéutica; uso de la composición para tratar enfermedades trombóticas, hemorrágicas y coagulación intravascular diseminada (cid) (div. sol. 1796-07).
BRPI0511318A (pt) processo para a produção de 4-(benzimidazolilmetilamino)-benzamidinas
BRPI0911747A2 (pt) "artigo produzido a partir de aglomerado de pedra revestido em pelo menos uma porção de suas faces com uma película delgada transparente, processo para obter um artigo produzido a partir de aglomerado de pedra, e, uso de um artigo produzido a partir de aglomerado de pedra"
ATE459985T1 (de) Verfahren und struktur für einen peltier- gesteuerten phasenwechselspeicher
SMT201300046B (it) Modelli animali e molecole terapeutiche
BRPI0817154A2 (pt) "método de modificar uma célula de levedura para a produção de etanol, célula de levedura modificada, uso de uma célula de levedura modificada e método para a produção de etanol"
ATE520131T1 (de) Aluminiumpasten und ihre verwendung bei der herstellung von silicium-solarzellen
CY1112874T1 (el) Φαρμακευτικες μορφες με βελτιωμενες φαρμακοκινητικες ιδιοτητες
CL2008001159A1 (es) Metodo para producir una proteina en un cultivo de celulas que comprende cultivar celulas a una temperatura reducida y/o cultivar celulas a un ph reducido para minimizar la produccion de proteinas mal plegadas y/o proteinas agregadas.
BR112012023015A2 (pt) imunoensaios para lenalidomida e talidomida
DK2185686T3 (da) Dendritceller
BRPI0510015B8 (pt) método e aparelho de dobramento de uma pluralidade de elementos flexíveis com relação a um elemento de armazenamento de fluido central
CY1116000T1 (el) Υποκατεστημενες πυραζολες, συνθεσεις που τις περιεχουν, μεθοδος παραγωγης και χρηση
CY1116266T1 (el) Σταθερα αλατα της s-αδενοσυλμεθειονινης και μεθοδος παρασκευης τους
DE602005022586D1 (de) Kristallisiertes zirkoniumphosphat mit hohem formfaktor, verfahren zu dessen herstellung sowie verwendung für ein makromolekulares material
MX2009007823A (es) Colorantes dispersos, su preparacion y su uso.
ATE491688T1 (de) Verfahren zur herstellung von 2-substituierten 5- (1-alkylthio)alkylpyridinen
MX2014007360A (es) Organizacion de vector de expresion, metodos novedosos de generacion de celulas de produccion y su uso para la produccion recombinante de polipeptidos.
ATE466003T1 (de) Herstellung von 2-aminothiazol-5- carbonsäurederivaten