EA200801385A1 - Способ образования дендритных клеток с применением пониженной температуры - Google Patents

Способ образования дендритных клеток с применением пониженной температуры

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Publication number
EA200801385A1
EA200801385A1 EA200801385A EA200801385A EA200801385A1 EA 200801385 A1 EA200801385 A1 EA 200801385A1 EA 200801385 A EA200801385 A EA 200801385A EA 200801385 A EA200801385 A EA 200801385A EA 200801385 A1 EA200801385 A1 EA 200801385A1
Authority
EA
Eurasian Patent Office
Prior art keywords
dendritic cells
formation
application
reduced temperature
cells
Prior art date
Application number
EA200801385A
Other languages
English (en)
Other versions
EA015266B1 (ru
Inventor
Алексей Киркин
Каринэ Джанджоугазиан
Джаспер Цеутен
Original Assignee
Дандрит Биотек А/С
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by Дандрит Биотек А/С filed Critical Дандрит Биотек А/С
Publication of EA200801385A1 publication Critical patent/EA200801385A1/ru
Publication of EA015266B1 publication Critical patent/EA015266B1/ru

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0639—Dendritic cells, e.g. Langherhans cells in the epidermis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/515—Animal cells
    • A61K2039/5154—Antigen presenting cells [APCs], e.g. dendritic cells or macrophages
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/20—Cytokines; Chemokines
    • C12N2501/22—Colony stimulating factors (G-CSF, GM-CSF)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/20—Cytokines; Chemokines
    • C12N2501/23—Interleukins [IL]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/20—Cytokines; Chemokines
    • C12N2501/25—Tumour necrosing factors [TNF]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2523/00—Culture process characterised by temperature

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Biotechnology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Virology (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Hematology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Gastroenterology & Hepatology (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Molecular Biology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

Данное изобретение касается в определенных вариантах осуществления способа образования дендритных клеток путем применения температур ниже 37°С во время развития клеток-предшественников и незрелых дендритных клеток. В некоторых вариантах осуществления данное изобретение касается популяций дендритных клеток и их применения.
EA200801385A 2005-12-08 2006-12-07 Способ получения зрелых дендритных клеток для индуцирования иммунного ответа и применение полученных клеток EA015266B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DKPA200501742 2005-12-08
PCT/DK2006/000694 WO2007065439A1 (en) 2005-12-08 2006-12-07 Method for generating dendritic cells employing decreased temperature

Publications (2)

Publication Number Publication Date
EA200801385A1 true EA200801385A1 (ru) 2008-10-30
EA015266B1 EA015266B1 (ru) 2011-06-30

Family

ID=37745820

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200801385A EA015266B1 (ru) 2005-12-08 2006-12-07 Способ получения зрелых дендритных клеток для индуцирования иммунного ответа и применение полученных клеток

Country Status (18)

Country Link
US (1) US9771558B2 (ru)
EP (1) EP1971680B1 (ru)
JP (1) JP2009518017A (ru)
CN (1) CN101321861B (ru)
AT (1) ATE545698T1 (ru)
AU (1) AU2006322451A1 (ru)
BR (1) BRPI0619520A2 (ru)
CA (1) CA2640836C (ru)
CY (1) CY1113016T1 (ru)
DK (1) DK1971680T3 (ru)
EA (1) EA015266B1 (ru)
ES (1) ES2382565T3 (ru)
IL (1) IL191782A (ru)
MY (1) MY145814A (ru)
NO (1) NO20083023L (ru)
NZ (1) NZ569343A (ru)
PT (1) PT1971680E (ru)
WO (1) WO2007065439A1 (ru)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2486238C1 (ru) * 2011-12-29 2013-06-27 Государственное бюджетное образовательное учреждение высшего профессионального образования "Сибирский государственный медицинский университет" Министерства здравоохранения и социального развития Российской Федерации (ГБОУ ВПО СибГМУ Минздравсоцразвития России) СПОСОБ НАГРУЗКИ ДЕНДРИТНЫХ КЛЕТОК АНТИГЕНОМ ИНФЕКЦИОННОГО ПРОИСХОЖДЕНИЯ Opisthorchis felineus

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009062502A1 (en) * 2007-11-13 2009-05-22 Dandrit Biotech A/S Method for generating tolerogenic dendritic cells employing decreased temperature
RU2663468C1 (ru) * 2017-09-25 2018-08-06 Федеральное государственное бюджетное учреждение "Ростовский научно-исследовательский онкологический институт" Министерства здравоохранения Российской Федерации Способ лечения местно-распространенного нерезектабельного рака поджелудочной железы
CN114980930A (zh) * 2019-12-27 2022-08-30 志瑞亚新药工业株式会社 癌症治疗方法及药物

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4306813B2 (ja) * 1995-09-19 2009-08-05 アスビオファーマ株式会社 動物細胞の新規培養方法
US5849589A (en) * 1996-03-11 1998-12-15 Duke University Culturing monocytes with IL-4, TNF-α and GM-CSF TO induce differentiation to dendric cells
US20050084966A1 (en) * 1999-04-20 2005-04-21 Edelson Richard L. Methods for inducing the differentiation of blood monocytes into functional dendritic cells
EP1259592A1 (en) * 2000-01-11 2002-11-27 Maxygen, Inc. Monocyte-derived dendritic cell subsets
CN1168740C (zh) * 2001-04-04 2004-09-29 上海美恩生物技术有限公司 细胞因子基因修饰的抗原提呈细胞/肿瘤细胞偶联物、其制法和用途
US20040009596A1 (en) * 2002-03-28 2004-01-15 Rao Kanury V. S. Extract from an Indian green mussel (perna viridis) for differentiation and maturation of dendric cells
JP4219789B2 (ja) * 2002-10-30 2009-02-04 独立行政法人科学技術振興機構 骨髄由来の不死化樹状細胞株
WO2004092220A1 (en) * 2003-04-14 2004-10-28 Board Of Regents, The University Of Texas System Methods for ex vivo hybridoma-free production of polyclonal and monoclonal antibodies and generation of immortalized cell populations
US20050003533A1 (en) * 2003-05-08 2005-01-06 Pawel Kalinski Mature type-1 polarized dendritic cells with enhanced IL-12 production and methods of serum-free production and use
WO2006127150A2 (en) * 2005-04-08 2006-11-30 Argos Therapeutics, Inc. Dendritic cell compositions and methods

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2486238C1 (ru) * 2011-12-29 2013-06-27 Государственное бюджетное образовательное учреждение высшего профессионального образования "Сибирский государственный медицинский университет" Министерства здравоохранения и социального развития Российской Федерации (ГБОУ ВПО СибГМУ Минздравсоцразвития России) СПОСОБ НАГРУЗКИ ДЕНДРИТНЫХ КЛЕТОК АНТИГЕНОМ ИНФЕКЦИОННОГО ПРОИСХОЖДЕНИЯ Opisthorchis felineus

Also Published As

Publication number Publication date
BRPI0619520A2 (pt) 2011-10-04
ES2382565T3 (es) 2012-06-11
JP2009518017A (ja) 2009-05-07
IL191782A (en) 2012-05-31
CN101321861B (zh) 2012-10-24
NO20083023L (no) 2008-08-28
CN101321861A (zh) 2008-12-10
EP1971680A1 (en) 2008-09-24
MY145814A (en) 2012-04-30
AU2006322451A1 (en) 2007-06-14
ATE545698T1 (de) 2012-03-15
US9771558B2 (en) 2017-09-26
WO2007065439A1 (en) 2007-06-14
IL191782A0 (en) 2008-12-29
CA2640836A1 (en) 2007-06-14
EA015266B1 (ru) 2011-06-30
EP1971680B1 (en) 2012-02-15
PT1971680E (pt) 2012-05-23
US20090196856A1 (en) 2009-08-06
DK1971680T3 (da) 2012-06-11
CY1113016T1 (el) 2016-04-13
NZ569343A (en) 2011-11-25
CA2640836C (en) 2018-05-15

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MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ BY KZ KG MD TJ TM RU