CY1112696T1 - Παραγωγα 5-υδροξυμεθυλ-οξαζολιδιν-2-ονης - Google Patents
Παραγωγα 5-υδροξυμεθυλ-οξαζολιδιν-2-ονηςInfo
- Publication number
- CY1112696T1 CY1112696T1 CY20121100383T CY121100383T CY1112696T1 CY 1112696 T1 CY1112696 T1 CY 1112696T1 CY 20121100383 T CY20121100383 T CY 20121100383T CY 121100383 T CY121100383 T CY 121100383T CY 1112696 T1 CY1112696 T1 CY 1112696T1
- Authority
- CY
- Cyprus
- Prior art keywords
- oxazolidin
- hydroxymethyl
- product
- amino acid
- formula
- Prior art date
Links
- LSYOFPBORRARMF-UHFFFAOYSA-N 5-(hydroxymethyl)-1,3-oxazolidin-2-one Chemical compound OCC1CNC(=O)O1 LSYOFPBORRARMF-UHFFFAOYSA-N 0.000 title 1
- 150000001413 amino acids Chemical class 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- 125000006273 (C1-C3) alkyl group Chemical group 0.000 abstract 1
- DRLPWCAENQZXJT-UHFFFAOYSA-N 2-[(dimethylazaniumyl)amino]acetate Chemical compound CN(C)NCC(O)=O DRLPWCAENQZXJT-UHFFFAOYSA-N 0.000 abstract 1
- 208000035143 Bacterial infection Diseases 0.000 abstract 1
- PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical compound FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 239000003242 anti bacterial agent Substances 0.000 abstract 1
- 229940088710 antibiotic agent Drugs 0.000 abstract 1
- 208000022362 bacterial infectious disease Diseases 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 229910052731 fluorine Inorganic materials 0.000 abstract 1
- 239000011737 fluorine Substances 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 208000015181 infectious disease Diseases 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 239000000825 pharmaceutical preparation Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/42—Oxazoles
- A61K31/422—Oxazoles not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/20—Oxygen atoms
- C07D215/22—Oxygen atoms attached in position 2 or 4
- C07D215/233—Oxygen atoms attached in position 2 or 4 only one oxygen atom which is attached in position 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
- C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D263/16—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D263/18—Oxygen atoms
- C07D263/20—Oxygen atoms attached in position 2
- C07D263/22—Oxygen atoms attached in position 2 with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to other ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IB2006054189 | 2006-11-10 | ||
| EP07827038A EP2086968B1 (en) | 2006-11-10 | 2007-11-09 | 5-hydroxymethyl-oxazolidin-2-one derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CY1112696T1 true CY1112696T1 (el) | 2016-02-10 |
Family
ID=39170372
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CY20121100383T CY1112696T1 (el) | 2006-11-10 | 2012-04-24 | Παραγωγα 5-υδροξυμεθυλ-οξαζολιδιν-2-ονης |
Country Status (27)
| Country | Link |
|---|---|
| EP (1) | EP2086968B1 (enExample) |
| JP (2) | JP4484965B2 (enExample) |
| KR (1) | KR101118402B1 (enExample) |
| CN (1) | CN101535305B (enExample) |
| AR (1) | AR063788A1 (enExample) |
| AT (1) | ATE544764T1 (enExample) |
| AU (1) | AU2007318901B2 (enExample) |
| BR (1) | BRPI0718862B8 (enExample) |
| CA (1) | CA2668280C (enExample) |
| CL (1) | CL2007003232A1 (enExample) |
| CY (1) | CY1112696T1 (enExample) |
| DK (1) | DK2086968T3 (enExample) |
| ES (1) | ES2380388T3 (enExample) |
| HR (1) | HRP20120385T1 (enExample) |
| IL (1) | IL198645A (enExample) |
| MA (1) | MA30960B1 (enExample) |
| MX (1) | MX2009004764A (enExample) |
| MY (1) | MY148847A (enExample) |
| NO (1) | NO344727B1 (enExample) |
| NZ (1) | NZ577538A (enExample) |
| PL (1) | PL2086968T3 (enExample) |
| PT (1) | PT2086968E (enExample) |
| RU (1) | RU2453546C2 (enExample) |
| SI (1) | SI2086968T1 (enExample) |
| TW (1) | TWI374138B (enExample) |
| WO (1) | WO2008056335A1 (enExample) |
| ZA (1) | ZA200904028B (enExample) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2003031443A1 (en) | 2001-10-04 | 2003-04-17 | Morphochem Aktiengesellschaft für kombinatorische Chemie | Dual actions antibiotics comprising a oxazoldinone and a quinolone or naphthyridinone moiety |
| EP1620098B1 (en) | 2003-04-30 | 2008-06-11 | Morphochem Aktiengesellschaft Für Kombinatorische Chemie | Use of oxazolidinone-quinoline hybrid antibiotics for the treatment of anthrax and other infections |
| DE10340485B4 (de) | 2003-09-03 | 2015-05-13 | Morphochem AG Aktiengesellschaft für kombinatorische Chemie | Verfahren zur Herstellung von Oxazolidinon-Chinolon Hybriden |
| US8158797B2 (en) | 2003-12-18 | 2012-04-17 | Morphochem Aktiengesellschaft Fur Kombinatorische Chemie | Oxazolidinone-quinolone hybrid antibiotics |
| AU2004299278C9 (en) | 2003-12-18 | 2013-10-24 | Morphochem Aktiengesellschaft Fuer Kombinatorische Chemie | Oxazolidinone-quinolone hybrid antibiotics |
| US8124623B2 (en) | 2006-11-10 | 2012-02-28 | Actelion Pharmaceuticals Ltd. | 5-hydroxymethyl-oxazolidin-2-one-derivatives and their uses as antibacterials |
| JP4819980B2 (ja) * | 2008-05-09 | 2011-11-24 | アクテリオン ファーマシューティカルズ リミテッド | 細菌性腸管疾患の治療のための５−ヒドロキシメチル−オキサゾリジン−２−オン誘導体 |
| EP2776431B1 (en) * | 2011-11-08 | 2016-05-04 | Actelion Pharmaceuticals Ltd. | 2-oxo-oxazolidin-3,5-diyl antibiotic derivatives |
| PT3003289T (pt) | 2013-05-28 | 2019-06-04 | Morphochem Gmbh | Administração de antibacterianos híbridos de oxazolidinona-quinolona |
| AU2014273471B2 (en) | 2013-05-28 | 2019-10-03 | Morphochem Aktiengesellschaft Fur Kombinatorische Chemie | Combination therapy comprising oxazolidinone-quinolones for use in treating bacterial infections |
| WO2016079757A2 (en) * | 2014-11-19 | 2016-05-26 | Symed Labs Limited | Novel processes for preparing 5-hydroxymethyl-oxazolidin-2-one derivatives |
| JP6905506B2 (ja) * | 2016-02-26 | 2021-07-21 | 大塚製薬株式会社 | ピペリジン誘導体 |
| US10087171B2 (en) | 2016-12-19 | 2018-10-02 | Actelion Pharmaceuticals Ltd | Crystalline forms of cadazolid |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SU1156597A3 (ru) * | 1982-04-28 | 1985-05-15 | Е.И.Дюпон Де Немур Энд Компани (Фирма) | Способ получени производных 3-( @ -алкилсульфонилфенил)оксазолидинона или их фармацевтически приемлемых кислотно-аддитивных солей |
| US4461773A (en) * | 1982-09-15 | 1984-07-24 | E. I. Dupont De Nemours And Company | P-Oxooxazolidinylbenzene compounds as antibacterial agents |
| US6608081B2 (en) * | 1999-08-12 | 2003-08-19 | Ortho-Mcneil Pharmaceutical, Inc. | Bicyclic heterocyclic substituted phenyl oxazolidinone antibacterials, and related compositions and methods |
| US6413981B1 (en) * | 1999-08-12 | 2002-07-02 | Ortho-Mcneil Pharamceutical, Inc. | Bicyclic heterocyclic substituted phenyl oxazolidinone antibacterials, and related compositions and methods |
| EP1349853B1 (en) * | 2000-12-21 | 2006-03-08 | Pharmacia & Upjohn Company LLC | Antimicrobial quinolone derivatives and use of the same to treat bacterial infections |
| CA2405532A1 (en) * | 2001-02-07 | 2002-08-22 | Ortho-Mcneil Pharmaceutical, Inc. | Pyridoarylphenyl oxazolidinone antibacterials, and related compositions and methods |
| WO2003031443A1 (en) * | 2001-10-04 | 2003-04-17 | Morphochem Aktiengesellschaft für kombinatorische Chemie | Dual actions antibiotics comprising a oxazoldinone and a quinolone or naphthyridinone moiety |
| ZA200509147B (en) * | 2003-04-30 | 2007-03-28 | Morphochem Ag | Use of oxazolidinone-quinoline hybrid antibiotics for the treatment of anthrax and other infections |
| EP1620098B1 (en) * | 2003-04-30 | 2008-06-11 | Morphochem Aktiengesellschaft Für Kombinatorische Chemie | Use of oxazolidinone-quinoline hybrid antibiotics for the treatment of anthrax and other infections |
| KR100854211B1 (ko) * | 2003-12-18 | 2008-08-26 | 동아제약주식회사 | 신규한 옥사졸리디논 유도체, 그의 제조방법 및 이를유효성분으로 하는 항생제용 약학 조성물 |
| AU2004299278C9 (en) * | 2003-12-18 | 2013-10-24 | Morphochem Aktiengesellschaft Fuer Kombinatorische Chemie | Oxazolidinone-quinolone hybrid antibiotics |
-
2007
- 2007-11-09 EP EP07827038A patent/EP2086968B1/en active Active
- 2007-11-09 CA CA2668280A patent/CA2668280C/en active Active
- 2007-11-09 WO PCT/IB2007/054557 patent/WO2008056335A1/en not_active Ceased
- 2007-11-09 PL PL07827038T patent/PL2086968T3/pl unknown
- 2007-11-09 CL CL200703232A patent/CL2007003232A1/es unknown
- 2007-11-09 KR KR1020097010924A patent/KR101118402B1/ko not_active Expired - Fee Related
- 2007-11-09 NZ NZ577538A patent/NZ577538A/en not_active IP Right Cessation
- 2007-11-09 BR BRPI0718862A patent/BRPI0718862B8/pt not_active IP Right Cessation
- 2007-11-09 AT AT07827038T patent/ATE544764T1/de active
- 2007-11-09 JP JP2009535864A patent/JP4484965B2/ja not_active Expired - Fee Related
- 2007-11-09 MY MYPI20091893A patent/MY148847A/en unknown
- 2007-11-09 DK DK07827038.6T patent/DK2086968T3/da active
- 2007-11-09 CN CN2007800418985A patent/CN101535305B/zh not_active Expired - Fee Related
- 2007-11-09 HR HRP20120385TT patent/HRP20120385T1/hr unknown
- 2007-11-09 PT PT07827038T patent/PT2086968E/pt unknown
- 2007-11-09 SI SI200730902T patent/SI2086968T1/sl unknown
- 2007-11-09 RU RU2009121812/04A patent/RU2453546C2/ru active
- 2007-11-09 AU AU2007318901A patent/AU2007318901B2/en not_active Ceased
- 2007-11-09 TW TW096142564A patent/TWI374138B/zh not_active IP Right Cessation
- 2007-11-09 ES ES07827038T patent/ES2380388T3/es active Active
- 2007-11-09 MX MX2009004764A patent/MX2009004764A/es active IP Right Grant
- 2007-11-12 AR ARP070105031A patent/AR063788A1/es active IP Right Grant
-
2009
- 2009-05-07 IL IL198645A patent/IL198645A/en active IP Right Grant
- 2009-06-01 MA MA31939A patent/MA30960B1/fr unknown
- 2009-06-09 NO NO20092209A patent/NO344727B1/no unknown
- 2009-06-09 ZA ZA200904028A patent/ZA200904028B/xx unknown
-
2010
- 2010-01-27 JP JP2010016076A patent/JP5490553B2/ja not_active Expired - Fee Related
-
2012
- 2012-04-24 CY CY20121100383T patent/CY1112696T1/el unknown
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