NZ577538A - 5-hydroxymethyl-2-oxo-oxazolidine-quinoline and 5-hydroxymethyl-2-oxo-oxazolidine-naphthyridine derivatives - Google Patents

5-hydroxymethyl-2-oxo-oxazolidine-quinoline and 5-hydroxymethyl-2-oxo-oxazolidine-naphthyridine derivatives

Info

Publication number
NZ577538A
NZ577538A NZ577538A NZ57753807A NZ577538A NZ 577538 A NZ577538 A NZ 577538A NZ 577538 A NZ577538 A NZ 577538A NZ 57753807 A NZ57753807 A NZ 57753807A NZ 577538 A NZ577538 A NZ 577538A
Authority
NZ
New Zealand
Prior art keywords
formula
compound
oxo
fluoro
compounds
Prior art date
Application number
NZ577538A
Other languages
English (en)
Inventor
Christian Hubschwerlen
Philippe Panchaud
Jean-Luc Specklin
Original Assignee
Actelion Pharmaceuticals Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=39170372&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=NZ577538(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Actelion Pharmaceuticals Ltd filed Critical Actelion Pharmaceuticals Ltd
Publication of NZ577538A publication Critical patent/NZ577538A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42—Oxazoles
    • A61K31/422—Oxazoles not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C07D215/22—Oxygen atoms attached in position 2 or 4
    • C07D215/233—Oxygen atoms attached in position 2 or 4 only one oxygen atom which is attached in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D263/16—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D263/18—Oxygen atoms
    • C07D263/20—Oxygen atoms attached in position 2
    • C07D263/22—Oxygen atoms attached in position 2 with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to other ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Peptides Or Proteins (AREA)
NZ577538A 2006-11-10 2007-11-09 5-hydroxymethyl-2-oxo-oxazolidine-quinoline and 5-hydroxymethyl-2-oxo-oxazolidine-naphthyridine derivatives NZ577538A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IB2006054189 2006-11-10
PCT/IB2007/054557 WO2008056335A1 (en) 2006-11-10 2007-11-09 5-hydroxymethyl-oxazolidin-2-one derivatives

Publications (1)

Publication Number Publication Date
NZ577538A true NZ577538A (en) 2011-11-25

Family

ID=39170372

Family Applications (1)

Application Number Title Priority Date Filing Date
NZ577538A NZ577538A (en) 2006-11-10 2007-11-09 5-hydroxymethyl-2-oxo-oxazolidine-quinoline and 5-hydroxymethyl-2-oxo-oxazolidine-naphthyridine derivatives

Country Status (27)

Country Link
EP (1) EP2086968B1 (enExample)
JP (2) JP4484965B2 (enExample)
KR (1) KR101118402B1 (enExample)
CN (1) CN101535305B (enExample)
AR (1) AR063788A1 (enExample)
AT (1) ATE544764T1 (enExample)
AU (1) AU2007318901B2 (enExample)
BR (1) BRPI0718862B8 (enExample)
CA (1) CA2668280C (enExample)
CL (1) CL2007003232A1 (enExample)
CY (1) CY1112696T1 (enExample)
DK (1) DK2086968T3 (enExample)
ES (1) ES2380388T3 (enExample)
HR (1) HRP20120385T1 (enExample)
IL (1) IL198645A (enExample)
MA (1) MA30960B1 (enExample)
MX (1) MX2009004764A (enExample)
MY (1) MY148847A (enExample)
NO (1) NO344727B1 (enExample)
NZ (1) NZ577538A (enExample)
PL (1) PL2086968T3 (enExample)
PT (1) PT2086968E (enExample)
RU (1) RU2453546C2 (enExample)
SI (1) SI2086968T1 (enExample)
TW (1) TWI374138B (enExample)
WO (1) WO2008056335A1 (enExample)
ZA (1) ZA200904028B (enExample)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003031443A1 (en) 2001-10-04 2003-04-17 Morphochem Aktiengesellschaft für kombinatorische Chemie Dual actions antibiotics comprising a oxazoldinone and a quinolone or naphthyridinone moiety
BRPI0409955A (pt) 2003-04-30 2006-04-25 Morphochem Ag Komb Chemie uso de antibióticos hìbridos de oxazolidinona - quinolina para o tratamento de antrax e outras infecções
DE10340485B4 (de) 2003-09-03 2015-05-13 Morphochem AG Aktiengesellschaft für kombinatorische Chemie Verfahren zur Herstellung von Oxazolidinon-Chinolon Hybriden
MXPA06006769A (es) 2003-12-18 2006-12-19 Morphochem Ag Komb Chemie Antibioticos hibridos de oxazolidinona-quinolona.
US8158797B2 (en) 2003-12-18 2012-04-17 Morphochem Aktiengesellschaft Fur Kombinatorische Chemie Oxazolidinone-quinolone hybrid antibiotics
US8124623B2 (en) 2006-11-10 2012-02-28 Actelion Pharmaceuticals Ltd. 5-hydroxymethyl-oxazolidin-2-one-derivatives and their uses as antibacterials
BRPI0911991B8 (pt) * 2008-05-09 2021-05-25 Actelion Pharmaceuticals Ltd derivados de 5-hidroximetil-oxazolidin-2-ona para o tratamento de doenças intestinais bacterianas
PL2776431T3 (pl) * 2011-11-08 2016-11-30 Stanowiące antybiotyki pochodne 2-okso-oksazolidyno-3,5-diylu
LT3003289T (lt) 2013-05-28 2019-06-25 Morphochem Gmbh Oksazolidinono-chinolono hibrido kaip antibakterinio preparato įvedimas
CN105246476B (zh) 2013-05-28 2019-11-15 莫弗凯姆联合化学股份公司 含噁唑烷酮-喹诺酮的联合疗法在治疗细菌感染中的应用
WO2016079757A2 (en) * 2014-11-19 2016-05-26 Symed Labs Limited Novel processes for preparing 5-hydroxymethyl-oxazolidin-2-one derivatives
EP3421454B9 (en) * 2016-02-26 2023-08-09 Otsuka Pharmaceutical Co., Ltd. Piperidine derivative
US10087171B2 (en) 2016-12-19 2018-10-02 Actelion Pharmaceuticals Ltd Crystalline forms of cadazolid

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SU1156597A3 (ru) * 1982-04-28 1985-05-15 Е.И.Дюпон Де Немур Энд Компани (Фирма) Способ получени производных 3-( @ -алкилсульфонилфенил)оксазолидинона или их фармацевтически приемлемых кислотно-аддитивных солей
US4461773A (en) * 1982-09-15 1984-07-24 E. I. Dupont De Nemours And Company P-Oxooxazolidinylbenzene compounds as antibacterial agents
US6413981B1 (en) * 1999-08-12 2002-07-02 Ortho-Mcneil Pharamceutical, Inc. Bicyclic heterocyclic substituted phenyl oxazolidinone antibacterials, and related compositions and methods
US6608081B2 (en) * 1999-08-12 2003-08-19 Ortho-Mcneil Pharmaceutical, Inc. Bicyclic heterocyclic substituted phenyl oxazolidinone antibacterials, and related compositions and methods
US6689769B2 (en) * 2000-12-21 2004-02-10 Pharmacia & Upjohn Company Antimicrobial quinolone derivatives and use of the same to treat bacterial infections
AU2002256995A1 (en) * 2001-02-07 2002-08-28 Ortho-Mcneil Pharmaceutical, Inc. Pyridoarylphenyl oxazolidinone antibacterials, and related compositions and methods
WO2003031443A1 (en) * 2001-10-04 2003-04-17 Morphochem Aktiengesellschaft für kombinatorische Chemie Dual actions antibiotics comprising a oxazoldinone and a quinolone or naphthyridinone moiety
CN100544719C (zh) * 2003-04-30 2009-09-30 莫弗凯姆联合化学股份公司 噁唑烷酮-喹啉杂化物抗生素用于制备治疗炭疽和其它感染的药物中的用途
BRPI0409955A (pt) * 2003-04-30 2006-04-25 Morphochem Ag Komb Chemie uso de antibióticos hìbridos de oxazolidinona - quinolina para o tratamento de antrax e outras infecções
MXPA06006769A (es) * 2003-12-18 2006-12-19 Morphochem Ag Komb Chemie Antibioticos hibridos de oxazolidinona-quinolona.
KR100854211B1 (ko) * 2003-12-18 2008-08-26 동아제약주식회사 신규한 옥사졸리디논 유도체, 그의 제조방법 및 이를유효성분으로 하는 항생제용 약학 조성물

Also Published As

Publication number Publication date
AU2007318901A1 (en) 2008-05-15
PL2086968T3 (pl) 2012-07-31
JP4484965B2 (ja) 2010-06-16
ATE544764T1 (de) 2012-02-15
PT2086968E (pt) 2012-04-13
JP2010509314A (ja) 2010-03-25
JP5490553B2 (ja) 2014-05-14
MA30960B1 (fr) 2009-12-01
EP2086968A1 (en) 2009-08-12
KR101118402B1 (ko) 2012-03-07
HRP20120385T1 (hr) 2012-06-30
BRPI0718862B8 (pt) 2021-05-25
ZA200904028B (en) 2010-08-25
KR20090075875A (ko) 2009-07-09
CA2668280A1 (en) 2008-05-15
MY148847A (en) 2013-06-14
MX2009004764A (es) 2009-05-21
SI2086968T1 (sl) 2012-06-29
RU2453546C2 (ru) 2012-06-20
TWI374138B (en) 2012-10-11
AU2007318901B2 (en) 2013-03-14
NO344727B1 (no) 2020-03-23
HK1136276A1 (en) 2010-06-25
AR063788A1 (es) 2009-02-18
NO20092209L (no) 2009-06-09
CY1112696T1 (el) 2016-02-10
CN101535305B (zh) 2013-09-18
CL2007003232A1 (es) 2008-06-27
CA2668280C (en) 2015-02-10
IL198645A0 (en) 2010-02-17
ES2380388T3 (es) 2012-05-11
IL198645A (en) 2014-05-28
BRPI0718862A2 (pt) 2013-12-17
RU2009121812A (ru) 2010-12-20
EP2086968B1 (en) 2012-02-08
TW200829580A (en) 2008-07-16
WO2008056335A1 (en) 2008-05-15
DK2086968T3 (da) 2012-03-19
BRPI0718862B1 (pt) 2020-10-13
CN101535305A (zh) 2009-09-16
JP2010132677A (ja) 2010-06-17

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