CY1112082T1 - Υγρη φαρμακοτεχνικη μορφη fsh - Google Patents

Υγρη φαρμακοτεχνικη μορφη fsh

Info

Publication number
CY1112082T1
CY1112082T1 CY20111101150T CY111101150T CY1112082T1 CY 1112082 T1 CY1112082 T1 CY 1112082T1 CY 20111101150 T CY20111101150 T CY 20111101150T CY 111101150 T CY111101150 T CY 111101150T CY 1112082 T1 CY1112082 T1 CY 1112082T1
Authority
CY
Cyprus
Prior art keywords
liquid pharmaceutical
composition
fsh
pharmaceutical form
stimulating hormone
Prior art date
Application number
CY20111101150T
Other languages
English (en)
Inventor
Sascha Stolzenberger
Erich Kohler
Original Assignee
Biogenerix Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biogenerix Ag filed Critical Biogenerix Ag
Publication of CY1112082T1 publication Critical patent/CY1112082T1/el

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A61K47/186—Quaternary ammonium compounds, e.g. benzalkonium chloride or cetrimide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/24—Follicle-stimulating hormone [FSH]; Chorionic gonadotropins, e.g. HCG; Luteinising hormone [LH]; Thyroid-stimulating hormone [TSH]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/20—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing sulfur, e.g. dimethyl sulfoxide [DMSO], docusate, sodium lauryl sulfate or aminosulfonic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/06—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Endocrinology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Reproductive Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Dermatology (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Inorganic Chemistry (AREA)
  • Gynecology & Obstetrics (AREA)
  • Diabetes (AREA)
  • Pregnancy & Childbirth (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

Η παρούσα εφεύρεση αφορά υγρή φαρμακευτική σύνθεση περιλαμβάνουσα πεπτίδιο ορμόνης διέγερσης ωοθυλακίου και χλωριούχο βενζαλκόνιο και βενζυλική αλκοόλη ως συντηρητικά. Η σύνθεση περαιτέρω περιλαμβάνει προαιρετικώς ένα ή περισσότερα άλλα φαρμακευτικώς αποδεκτά έκδοχα. Σε μια πραγματοποίηση η σύνθεση περιέχει μεθειονίνη ως αντιοξειδωτικό. Η σύνθεση δείχνει καλή σταθερότητα αποθήκευσης και είναι ειδικά χρήσιμη για την προφύλαξη και θεραπεία διαταραχών και ιατρικών ενδείξεων όπου παρασκευάσματα ορμόνης διέγερσης ωοθυλακίου θεωρούνται ως χρήσιμες θεραπείες.
CY20111101150T 2008-02-08 2011-11-24 Υγρη φαρμακοτεχνικη μορφη fsh CY1112082T1 (el)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP08151231 2008-02-08
EP09708298A EP2249869B1 (en) 2008-02-08 2009-02-09 Liquid formulation of fsh

Publications (1)

Publication Number Publication Date
CY1112082T1 true CY1112082T1 (el) 2015-11-04

Family

ID=40568186

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20111101150T CY1112082T1 (el) 2008-02-08 2011-11-24 Υγρη φαρμακοτεχνικη μορφη fsh

Country Status (27)

Country Link
US (4) US20110054410A1 (el)
EP (2) EP2412385A1 (el)
JP (1) JP5620824B2 (el)
KR (2) KR101573773B1 (el)
CN (3) CN104688679A (el)
AT (1) ATE523209T1 (el)
AU (1) AU2009211331B2 (el)
BR (1) BRPI0908887B8 (el)
CA (2) CA2713386C (el)
CY (1) CY1112082T1 (el)
DE (1) DE202009009905U1 (el)
DK (1) DK2249869T3 (el)
EA (1) EA019530B1 (el)
ES (1) ES2372470T3 (el)
HK (1) HK1149494A1 (el)
HR (1) HRP20110801T1 (el)
IL (1) IL206759A (el)
ME (1) ME01337B (el)
MX (1) MX2010008802A (el)
NZ (1) NZ586588A (el)
PL (1) PL2249869T3 (el)
PT (1) PT2249869E (el)
RS (1) RS52106B (el)
SI (1) SI2249869T1 (el)
UA (1) UA99337C2 (el)
WO (1) WO2009098318A1 (el)
ZA (1) ZA201004457B (el)

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EP3228320B1 (de) 2008-10-17 2019-12-18 Sanofi-Aventis Deutschland GmbH Kombination von einem insulin und einem glp-1-agonisten
AR080669A1 (es) 2009-11-13 2012-05-02 Sanofi Aventis Deutschland Composicion farmaceutica que comprende un agonista de glp-1, una insulina y metionina
UY33025A (es) * 2009-11-13 2011-06-30 Sanofi Aventis Deustschland Gmbh Composicion farmaceutica que comprende un agonista de glp-1 metionina
JP5800527B2 (ja) * 2010-03-30 2015-10-28 日東電工株式会社 安定化医薬組成物、安定化医薬組成物溶液製剤、フィルム状製剤及びフィルム状製剤の製造方法
AR081755A1 (es) * 2010-04-02 2012-10-17 Hanmi Holdings Co Ltd Formulacion de accion prolongada de la hormona estimuladora de los foliculos donde se usa un fragmento de inmunoglobulina, metodo de preparacion y metodo para tratar a un sujeto que sufre un trastorno reproductivo
MX339614B (es) 2010-08-30 2016-06-02 Sanofi - Aventis Deutschland GmbH Uso de ave0010 para la fabricacion de un medicamento para el tratamiento de la diabetes mellitus tipo 2.
US9821032B2 (en) 2011-05-13 2017-11-21 Sanofi-Aventis Deutschland Gmbh Pharmaceutical combination for improving glycemic control as add-on therapy to basal insulin
RU2650616C2 (ru) 2011-08-29 2018-04-16 Санофи-Авентис Дойчланд Гмбх Фармацевтическая комбинация для применения при гликемическом контроле у пациентов с сахарным диабетом 2 типа
TWI559929B (en) 2011-09-01 2016-12-01 Sanofi Aventis Deutschland Pharmaceutical composition for use in the treatment of a neurodegenerative disease
BR112014008872A2 (pt) * 2011-11-09 2017-04-18 Adisseo France Sas dieta antes do abate que inclui metionina e seu uso em métodos para melhorar a maciez de carne
US20160024181A1 (en) 2013-03-13 2016-01-28 Moderna Therapeutics, Inc. Long-lived polynucleotide molecules
CN107206058A (zh) 2014-12-12 2017-09-26 赛诺菲-安万特德国有限公司 甘精胰岛素/利西拉来固定比率配制剂
TWI748945B (zh) 2015-03-13 2021-12-11 德商賽諾菲阿凡提斯德意志有限公司 第２型糖尿病病患治療
TW201705975A (zh) 2015-03-18 2017-02-16 賽諾菲阿凡提斯德意志有限公司 第２型糖尿病病患之治療
CN105727260A (zh) * 2016-02-03 2016-07-06 华侨大学 一种卵泡刺激素的长效制剂
GB201603280D0 (en) 2016-02-24 2016-04-13 Ferring Bv Stable liquid gonadotropin formulation
CN105726468A (zh) * 2016-02-28 2016-07-06 中国农业科学院特产研究所 梅花鹿用超数排卵聚乙烯吡咯烷酮fsh复合缓释注射剂
US10085971B2 (en) 2016-08-22 2018-10-02 Navinta Iii Inc Pharmaceutical solution of asenapine for sublingual or buccal use
CN108728465A (zh) * 2017-04-14 2018-11-02 深圳新诺微环生物科技有限公司 一种表达靶细胞-效应细胞桥接器的微环dna载体及其制备方法和应用
US20230364172A1 (en) * 2022-05-14 2023-11-16 Syncotrance, LLC Modulation of solubility, palatability, absorption, and bioavailability of mitragyna speciosa-derived compounds for oral and buccal delivery

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Also Published As

Publication number Publication date
HK1149494A1 (en) 2011-10-07
US20160303202A1 (en) 2016-10-20
PL2249869T3 (pl) 2012-02-29
DK2249869T3 (da) 2011-12-12
PT2249869E (pt) 2011-12-16
EA019530B1 (ru) 2014-04-30
AU2009211331A1 (en) 2009-08-13
EP2249869A1 (en) 2010-11-17
CN101970010A (zh) 2011-02-09
US20160303238A1 (en) 2016-10-20
RS52106B (en) 2012-08-31
ZA201004457B (en) 2011-05-25
ME01337B (me) 2013-12-20
JP2011514317A (ja) 2011-05-06
EP2412385A1 (en) 2012-02-01
HRP20110801T1 (hr) 2011-12-31
BRPI0908887B1 (pt) 2021-01-19
KR101662631B1 (ko) 2016-10-05
US20160303201A1 (en) 2016-10-20
NZ586588A (en) 2012-10-26
BRPI0908887B8 (pt) 2021-05-25
BRPI0908887A2 (pt) 2015-09-15
AU2009211331B2 (en) 2014-07-03
IL206759A (en) 2015-02-26
SI2249869T1 (sl) 2012-01-31
KR20150138428A (ko) 2015-12-09
US20110054410A1 (en) 2011-03-03
KR101573773B1 (ko) 2015-12-02
EP2249869B1 (en) 2011-09-07
IL206759A0 (en) 2010-12-30
CN110433136A (zh) 2019-11-12
CA2713386A1 (en) 2009-08-13
CA2926500A1 (en) 2009-08-13
WO2009098318A1 (en) 2009-08-13
ES2372470T3 (es) 2012-01-20
DE202009009905U1 (de) 2009-10-29
MX2010008802A (es) 2011-03-29
ATE523209T1 (de) 2011-09-15
KR20100123697A (ko) 2010-11-24
CA2713386C (en) 2016-04-19
EA201070940A1 (ru) 2010-12-30
JP5620824B2 (ja) 2014-11-05
CN104688679A (zh) 2015-06-10
UA99337C2 (ru) 2012-08-10

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